Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP

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Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY
            BREASTFEEDING IS BEST FOR BABIES

       SCIENCE INSPIRED BY NATURE

Specially Tailored support for
  a range of feeding issues
              Practical guidance
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                                                                          INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY
                                                    START HERE
                                               Is the baby full term?

                                                         YES                                                                                                 NO

                                        Is there a family history of allergy?                                                  Is the preterm baby receiving breast milk exclusively?

                    YES                                                            NO                                            YES                                                     NO
       PAGE 32

                                                         Does the baby have special nutritional needs?

                 SMA H.A.®
                                                         NO                                    YES
                 Infant Milk
                  From birth

                                                                                                                                SMA®                           SMA                     SMA                         SMA
                                                                                                                             Breast Milk                  Gold Prem® 1            Gold Prem® 2               Gold Prem® 2
                                                                                                                               Fortifier                  Low Birthweight          Post Discharge             Post Discharge
                                                                                                                              From birth                    Formula                  Formula                     Formula
                                                                                                                              In hospital                   From birth            90 ml in hospital,          For use at home
                                                                                                                                                            In hospital            200 ml for use               Prescribable
                                                                                                                                                                                      at home                    (UK only)
  SMA® ADVANCED                         SMA® PRO Range               SMA® Organic Range                                                                                             Prescribable
                                                                                               LITTLE STEPS® Range
Range First, Follow-on                  First, Follow-on &             First, Follow-on &                                                                                            (UK only)
                                                                                                First, Follow-on &
 & Growing Up Milks                    Growing Up Milks               Growing Up Milks          Growing Up Milks
  From birth, 6 months                 From birth, 6 months &         From birth, 6 months &
     & 12 months                             12 months                      12 months
                                                                                               From birth, 6 months &
                                                                                                     12 months
                                                                                                                            FOR MEDICALLY DIAGNOSED SPECIAL NUTRITIONAL NEEDS
                                                                                                                        For babies with              For babies with                For babies                  For cows’ milk
                                                                                                                         high energy                   significant                  intolerant to                  intolerant
                                       For babies with          For hungrier                                                 needs                        reflux                  lactose/sucrose                    babies
                                        mild digestive            babies
                                         discomfort

                                                                                                                                                                       PAGE 24

                                                                                                                                                                                                   PAGE 28
                                                                                                                                           PAGE 14
                             PAGE 20

                                                                                                                             SMA                        SMA®                       SMA LF®                     SMA® Wysoy®
                                                                                                                        High Energy ®                Anti-Reflux                 Lactose Free                   Soya Infant
                                           SMA  ®
                                                                SMA Extra
                                                                     ®
                                                                                                                           From birth                 From birth                   From birth                     Formula
                                          Comfort                 Hungry                                                 Prescribable                Prescribable                 Prescribable                    From birth
                                       Easy to Digest           Infant Milk                                               (UK & ROI)                  (UK only)                   (UK & ROI)                     Prescribable
                                        Infant Milk              From birth                                                                                                                                      (UK & ROI)
                                         From birth
This chart is intended for bottle-fed babies, as a guide only and is not a diagnostic tool.
2 | SMA® Specials Range                                                                                                                                                                                        SMA® Specials Range | 3
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                             INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

        The aim of this booklet is to describe                     Contents
        some of the common feeding issues                          Feeding issues and protein intake

        experienced by infants, and to help                        Understanding feeding issues..........................................................................
                                                                   Importance of partially hydrolysed protein........................................................
                                                                                                                                                                                      6
                                                                                                                                                                                      8

        you reassure parents by offering                           Role of whey dominance.................................................................................           9

        practical guidance.                                        Reflux and regurgitation
                                                                   What is reflux and regurgitation?.....................................................................           10
                                                                   Starch thickener + NICE guidelines..................................................................             12
                                                                   SMA® Anti-Reflux...........................................................................................      14
        The advice contained within this booklet                   Comparison chart..........................................................................................
                                                                   Preparation: instructions and comparison..........................................................
                                                                                                                                                                                    15
                                                                                                                                                                                    16
        is based upon the latest guidance from                     Mild digestive discomfort
        NICE and the Department of Health,                         Signs and symptoms.......................................................................................
                                                                   Diagnosis criteria...........................................................................................
                                                                                                                                                                                    18
                                                                                                                                                                                    19
        where appropriate.                                         SMA® Comfort Easy to Digest Infant Milk..........................................................
                                                                   Comparison chart..........................................................................................
                                                                                                                                                                                    20
                                                                                                                                                                                    21

                                                                   Lactose intolerance
                                                                   What is lactose intolerance?...........................................................................          22
                                                                   Types of lactose intolerance............................................................................         23
                                                                   SMA LF ® Lactose Free Infant Milk.....................................................................           24
                                                                   Comparison chart..........................................................................................       25

                                                                   Cows’ milk allergy or intolerance
                                                                   Allergy vs intolerance?...................................................................................       26
                                                                   Soya as a protein alternative...........................................................................         27
                                                                   SMA® Wysoy® Soya Infant Formula..................................................................                28

                                                                   Allergy in infants
                                                                   Family history................................................................................................   30
                                                                   Supporting infants at risk of allergy..................................................................          31
                                                                   SMA H.A.® Infant Milk....................................................................................        32
        NICE: National Institute for Health and Care Excellence.   What do the guidelines say?...........................................................................           33

4 | SMA® Specials Range                                                                                                                                               SMA® Specials Range | 5
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
Feeding Issues
BREASTFEEDING IS BEST FOR BABIES                                                     INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

        Feeding issues are a common                                         Infant feeding issues are very common
        part of life for young infants1                                     This is due to a baby’s digestive system still being immature
                                                                            when born.
        Research shows that Functional gastrointestinal disorders (FGIDs)
        occur in up to 55% of all infants in the first 6 months of life.1   • FGIDs include a number of symptoms that affect the
                                                                              gastrointestinal tract in otherwise healthy infants3
                            INFANTS WHO HAVE FEEDING ISSUES                 • These symptoms are often frequent, age dependent,
                                                                              and related to the ongoing physiological development
                                                                              of the gut that occurs naturally after birth
                                                                            • Although they usually resolve as the infant matures,
                                                                              they can cause considerable distress and anxiety
                                                                              for the parents as well as the infant
                                                                            • As well as FGIDs, feeding issues also encompass lactose
                                  OVER HALF                                   intolerance and cows’ milk protein allergy (CMPA),
                                                                              both of which have a defined organic cause
                             THE MOST COMMON FGIDs ARE:2
                                                                            • The prevalence of lactose intolerance varies according to
                            30%       REFLUX & REGURGITATION
                                                                              cause and ethnicity.4 CMPA affects between 1.8%-7.5% of
                            20%       COLIC                                   infants in the first year of life.5

                            15%       CONSTIPATION

6 | SMA® Specials Range                                                                                                         SMA® Specials Range | 7
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                                                               INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

      What is partially hydrolysed protein                                                        Partially hydrolysed, 100% whey
      and why is it important?                                                                    protein encourages easy digestion
      Infants who have a FGID may benefit from partially hydrolysed protein in a formula.         Breast milk contains partially hydrolysed proteins for easier digestion and
                                                                                                  absorption.7 Partially hydrolysed formulas have been shown to accelerate
      Partially hydrolysed means the protein is broken up into smaller pieces that are            gastric emptying, making the formula easy for infants to digest.8
      easier for the infant to digest.

                                                                                                                           40
                                                                                                                                                      39%*

                                                                                                  % remaining in stomach
                                               Plasmin                                                                     35

                                                                                                                           30
                  Big protein molecule        Hydrolysis   Small, more easily digested peptides

                                                                                                                           25                  26%
      • Breast milk contains enzymes that hydrolyse proteins6

      • Gastrointestinal symptoms such as constipation, fussiness, colic or spitting                                       20
                                                                                                                                                                     Breast Milk
                                                                                                                                 18%
        up are very common at an early age1
                                                                                                                                        16%                          100% whey, partially hydrolysed formula
                                                                                                                           15
      • Some trials have demonstrated the efficacy of partially hydrolysed formula                                                                                   Intact whey-predominant formula
        in the community when CMPA was not considered to be the cause                                                                                                Intact casein-predominant formula
                                                                                                                           0
        of the infant’s colic symptom2
                                                                                                                                       Type of milk
      Partially hydrolysed formula may offer some advantage over                                  After 120 minutes only 16% of 100% whey, partially hydrolysed formula
      intact protein in the dietary management of common functional                               remains in the stomach compared with 26% of intact whey-predominant formula
      gastrointestinal symptoms.2                                                                 and 39% of intact casein-predominant formula.8

                                                                                                  Both the UK and Ireland Department of Health recognise
                                                                                                  that whey protein is easier to digest.9,10

FGID: Functional gastrointestinal disorder.                                                       * p
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                                              INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

      What is infant reflux and regurgitation?                                           The importance of whey protein
      Gastro-oesophageal reflux (GOR) is an involuntary passage of gastric contents
      from the stomach into the oesophagus. Reflux is a normal physiological process
                                                                                         for infants with feeding issues
      in otherwise healthy infants and is a common FGID in an infant’s first year.11     Breast milk is whey-dominant during the first 6 months of life.7

                                                                                                                                                                                                        regurgitation
                                                                                                                                                                                                         Reflux and
      • When reflux is high enough to be seen, it is known
        as regurgitation2,3
                                                                                            WHEY-BASED INFANT FORMULAS:
      • Regurgitation or reflux occur daily in about 50%
        of infants under 3 months of age2                                                   • Are more easily digested than those which are
                                                                                              casein-based7
      • This is primarily due to the functional immaturity
                                                                                            • Contain an adequate supply of essential amino acids
        of the stomach inlet11
                                                                                              and higher protein quality, closer to that of breast milk12
      In some cases, reflux may lead to complications and/or troublesome symptoms,
      which require further medical investigation and treatment – this is when gastro-
      oesophageal reflux disease (GORD) occurs.2,11                                      Rate of gastric emptying after 120 minutes, according to the
                                                                                         type of milk8
                                                                                                                              40
                                                                                                                                           39%*
                                       Lower                Oesophagus

                                                                                                     % remaining in stomach
                                                                                                                              35
                                       oesophageal
                                       spincter (valve)
                                                                                                                              30

         Duodenum                                                                                                             25
                                                                   Stomach
                                                                                                                              20

                  Pyloric                                                                                                           16%
                                                                                                                              15
                  spincter (valve)                                                                                                                  100% whey, partially hydrolysed formula

                                                                                                                              0                     Intact casein-predominant formula

                                                                                                                                   Type of milk
FGID: Functional gastrointestinal disorder.                                              * p
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                            INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     The effect of a starch thickener                                        What the NICE guidelines say
     on symptoms of reflux                                                   In 2015, NICE recommended the following measures for managing formula-fed
                                                                             infants with frequent regurgitation associated with marked distress:11
     Starch thickener reduces the frequency of regurgitation in infants.13
                                                                             • Offer parental reassurance
     • Starch is an appropriate thickener for infants with reflux and
       regurgitation, as it is digestible by the infant                      • Review feeding history, suggest smaller, more frequent feeds
                                                                               (while maintaining appropriate daily milk volume intakes)
     • Starch-thickened formulas have shown efficacy in reducing
       the number of daily regurgitation episodes13                          • Trial of a thickened formula

                                                                             If a thickened formula does not work, stop the thickened formula and offer
                                                                             alginate therapy for a trial period of 1–2 weeks.

                                                                                NICE Guideline on gastro-oesophageal reflux11
                                                                                • Regurgitation of foods is a normal and common occurrence in infants
                                                                                • Does not usually require investigation
                                                                                • Reassure and advise parents and carers
                                                                                • Look out for ‘red flags’ that may indicate a need to refer, e.g. blood in stool, fever
                                                                                • In formula-fed infants with frequent regurgitation associated with marked
                                                                                  distress, use a stepped-care approach:
                                                                                  – Review feeding history
                                                                                  –R  educe food volumes only if excessive for the infant’s weight
                                                                                  – T rial of smaller, more frequent feeds (while maintaining appropriate total
                                                                                     daily amount of milk)
                                                                                  – T rial of thickened formula
                                                                                  – If above is unsuccessful, stop the thickened formula and offer alginate
                                                                                     therapy for a trial period of 1–2 weeks

                                                                             NICE: National Institute for Health and Care Excellence.

12 | SMA® Specials Range                                                                                                                               SMA® Specials Range | 13
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                                        INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     SMA® Anti-Reflux                                                                  How does SMA® Anti-Reflux compare?

                                                                                                                SMA®           Aptamil        Cow & Gate           HiPP           Enfamil A.R.
                                                           REDUCES FREQUENCY                                 Anti-Reflux14   Anti-Reflux 15   Anti-Reflux16    Anti-Reflux 17   (‘Anti-Reflux’)18
                                                           OF REGURGITATION13
                                                           Starch-thickened formulas    Whey:casein             100:0            40:60            40:60            60:40               NS
                                                           have shown efficacy in
                                                           reducing the number                                 Partially
                                                                                        Type of protein                          Intact           Intact           Intact            Intact
                                                           of daily regurgitation                             hydrolysed
                                                           episodes13
                                                                                        Protein content
                                                                                                                 1.3              1.3              1.3              1.4               1.72
                                                                                        (g/100 ml)

                                                                                                                                                                Carob bean
                                                           THICKENED FORMULA            Type of thickener   Potato starch    Carob bean gum   Carob bean gum                       Rice starch
                                                                                                                                                                   gum
                                                           2015 NICE guidelines
                                                           recommend trial of a         Vegetarian
                                                           thickened formula in
                                                           formula-fed infants with
                                                                                        Halal
                                                           GOR11

                                                           SPECIALLY TAILORED
                                                           Unique combination of
                                                           easily digestible starch
                                                           and 100% whey, partially
                                                           hydrolysed protein, to
                                                           help manage reflux and
                                                           regurgitation13-14.

GOR: Gastro-oesophageal reflux.
NICE: National Institute for Health and Care Excellence.                               NS: Not stated.

14 | SMA® Specials Range                                                                                                                                               SMA® Specials Range | 15
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                                                              INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

      SMA® Anti-Reflux is easy to prepare                                                                      Comparison of AR formulas*
                           1 Ptheulllid.theLiftsafetythe seal
                                                                                                                                    SMA®                            Aptamil                          Cow & Gate                             HiPP
                                                               and open the lid. The scoop is provided under                     Anti-Reflux14                    Anti-Reflux15                      Anti-Reflux16                      Anti-Reflux17
                                                          tab, pull on the foil seal, carefully and safely      Step 1                         Wash hands and sterilise all utensils according to the manufacturer’s instructions.

                               remove the seal and dispose of it.                                                                        Boil 1 litre of freshly run water. Do not use artificially softened or repeatedly boiled water.
                                                                                                                           Allow to cool for no more        Leave kettle to cool for           Measure the required amount        Leave to cool for no longer
                                                                                                                Step 2     than 30 minutes.                 no longer than 45 mins.            of boiled water into a large       than 30 minutes.

                           2 Wtoashmanufacturer’s
                                                                                                                                                            Measure the required amount        sterilised bottle. Seal bottle
                                      hands well. Wash and sterilise all utensils according                                                                 of water into a sterilised         and allow to cool for
                                                                                                                                                            bottle. Be careful of scalding.    45 minutes.
                                                   instructions.
                                                                                                                           Place the sterilised teat        Using the scoop provided           Using the scoop provided,          Measure the required amount
                                                                                                                           and cap on the bottle. Cool      level off the powder with the      level the powder with the          of water into a sterilised bottle,
                                                                                                                           bottle under cold running        built in leveller. Do not press/   built-in leveller. Do not          following the feeding guide
                                                                                                                           water or in a bowl or jug of     heap the powder.                   press/heap the powder.             on the pack. Using the scoop

                           3 BMeasure
                                                                                                                           cold water until lukewarm,                                                                             provided, add the correct
                                oil 1 litre of tap water. Allow to cool for no more than 30 minutes.            Step 3
                                                                                                                           do not immerse the teat.                                                                               number of scoops of powder
                                                                                                                                                                                                                                  – one level scoop of powder
                                          the required amount of water (see feeding guide) into a                                                                                                                                 for each fluid ounce of water
                                                                                                                                                                                                                                  (approx. 30 ml). Level off
                               sterilised bottle, carefully – the water is hot. Do not use artificially                                                                                                                           the powder with the back of
                               softened or repeatedly boiled water.                                                                                                                                                               a clean dry knife, but don’t
                                                                                                                                                                                                                                  press the powder down into
                                                                                                                                                                                                                                  the scoop.

                           4 Pcoldlacerunning
                                                                                                                           Using only the scoop             Add one scoop per                  Add one scoop to every             Place the sterilised teat and
                                        the sterilised teat and cap on the bottle. Cool bottle under                       provided, add the correct        30ml (1 fl oz) of boiled and       30ml (1 fl oz) of boiled           cap on the bottle and shake
                                                                                                                           number of scoops of powder       cooled water. Add the correct      cooled water. Add the correct      well until all the powder
                                                water or in a bowl or jug of cold water until                              (see feeding guide), levelling   number of scoops to the water.     number of scoops to the water.     has dissolved (approx.
                                                                                                                           off each scoop with the back     Adding too many or too few         Adding too many or too few         15 seconds).
                                lukewarm, do not immerse the teat.                                                         of a clean, dry knife. Store     scoops can be harmful.             scoops can be harmful.
                                                                                                                           the scoop in suspension inside   Place the sterilised teat and      Replace seal on bottle and
                                                                                                                           the can and replace lid.

                           5 Uofsingpowder
                                                                                                                                                            cap on the bottle.                 roll the bottle upright between
                                                                                                                Step 4
                                        only the scoop provided, add the correct number of scoops                                                           Hold the bottle horizontally       the palms of hands – roll it
                                                                                                                                                                                               strongly for 5 seconds.
                                                                                                                                                            and shake from left to right
                                            (see feeding guide), levelling off each scoop with the                                                          for 10 seconds, then hold it       The time between adding the
                                                                                                                                                                                               scoops and rolling the bottle
                                back of a clean, dry knife. Store the scoop in suspension inside                                                            vertically and shake from top
                                                                                                                                                            to bottom for 10 seconds. The      should be as short as possible.
                                the can and replace lid.                                                                                                    time between adding the
                                                                                                                                                            scoops and shaking the bottle
                                                                                                                                                            should be as short as possible.

                           6 Sbyhakeshaking
                                        bottle well until powder has fully dissolved. Test temperature                     Shake bottle well
                                                                                                                           until powder has
                                                                                                                                                            Leave the bottle to stand for
                                                                                                                                                            5 minutes to allow it to
                                                                                                                                                                                               Shake the bottle for
                                                                                                                                                                                               20 seconds and then
                                                                                                                                                                                                                                  Cool the milk to drinking
                                                                                                                                                                                                                                  temperature (approx 37°C)
                                             a few drops on to the inside of your wrist – milk should                      fully dissolved.                 thicken. Turn the bottle           leave to stand for 7 minutes       by holding the bottle under
                                be lukewarm.                                                                               Test temperature by              upside down just before
                                                                                                                                                            feeding. Check temperature
                                                                                                                                                                                               to allow it to thicken. Turn
                                                                                                                                                                                               the bottle upside down just
                                                                                                                                                                                                                                  cold running water. ALWAYS
                                                                                                                                                                                                                                  test the temperature of
                                                                                                                           shaking a few drops
                                                                                                                Step 5     on to the inside of your         of feed. Feed immediately.         before feeding and test the        the milk before feeding by
                                                                                                                                                                                               temperature on your wrist.         dripping a bit onto the inside
      Reconstitute SMA® Anti-Reflux as per pack instructions for                                                           wrist – milk should
                                                                                                                           be lukewarm.                                                                                           of your wrist; the milk should
                                                                                                                                                                                                                                  feel warm, not hot.
      baby’s age and shake bottle.                                                                                         SMA Anti-Reflux should
                                                                                                                           usually not thicken after
                                                                                                                           it has been prepared.**
                                                                                                                *	The preparation instructions have been taken from label and website information (accessed February 2020).
      Thicker formula, may require a fast flow teat.                                                               SMA Anti-Reflux, because of use of potato starch, usually thickens when the powder is dissolved in water.
                                                                                                               ** If prepared according to preparation instructions, it should not thicken after the bottle has been prepared.
16 | SMA® Specials Range                                                                                                                                                                                                         SMA® Specials Range | 17
Specially Tailored support for a range of feeding issues - Practical guidance INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY - SMA HCP
BREASTFEEDING IS BEST FOR BABIES                                                  INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     Mild digestive disorders are common                               Rome IV diagnostic criteria3
     in an infant’s first weeks or months                              • About 20% of infants are reported by caregivers to have the
                                                                         prolonged periods of crying known as colic20
     • At this time an infant’s digestive system is still developing
                                                                       • The prevalence of constipation in the first year of life is 2.9%3
     • Mild digestive disorders can present as colic-like symptoms,
       constipation, wind or crying after a feed
                                                                                Diagnostic criteria for                      Diagnostic criteria for
     • Tummy troubles can be difficult for both infant
                                                                                    infant colic3                           functional constipation3
       and parents/caregivers

                                                                                                                                                                          Mild digestive
                                                                        For clinical purposes, must include all       Must include 1 month of at least two of

                                                                                                                                                                           discomfort
                                                                        of the following:                             the following in infants up to 4 years of age:

                                                                        • An infant who is
BREASTFEEDING IS BEST FOR BABIES                                                        INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     SMA® Comfort Easy to Digest                                           How does SMA® Comfort compare?
     Infant Milk
                                                                                                 SMA® Comfort        Aptamil     Cow & Gate              HiPP
                                                                                                 Easy to Digest22   Comfort 23    Comfort 24           Comfort 25

                                    EASY TO DIGEST                         Whey:casein               100:0            100:0         100:0                100:0
                                    Contains partially hydrolysed,
                                    100% whey protein which is                                      Partially        Partially     Partially            Partially
                                                                           Type of protein
                                    easier to digest than intact protein                           hydrolysed       hydrolysed    hydrolysed           hydrolysed
                                    molecules8.
                                                                           Protein content
                                                                                                       1.6             1.5           1.5                  1.25
                                                                           (g/100 ml)

                                    NUTRITIONALLY COMPLETE
                                    Contains all essential nutrients to    No added thickener
                                    support babies’ nutritional needs.

                                                                           Lactose (g/100 ml)          3.9             2.7           2.7                  2.7

                                    SPECIALLY TAILORED
                                    Contains an SN-2-enriched fat          Contains SN-2
                                    blend20 and reduced lactose
                                    to help manage mild digestive
                                    discomfort21.                          Vegetarian

                                                                           Halal

20 | SMA® Specials Range                                                                                                                       SMA® Specials Range | 21
BREASTFEEDING IS BEST FOR BABIES                                                                            INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     What is lactose intolerance?                                                               Types of lactose intolerance
     In infants who are unable to metabolise lactose, undigested lactose stays in the           Primary lactose intolerance is the most common cause of lactose intolerance
     intestine, where it can cause diarrhoea, abdominal distension, nausea, bloating            worldwide with prevalence related to ethnicity.4
     and wind:4,26
                                                                                                Secondary lactose intolerance is common but a temporary cause of diarrhoea.4
     • These symptoms can be distressing for both infant and
                                                                                                • Secondary lactose intolerance often occurs because
       parents/caregivers
                                                                                                  of damage to the intestinal brush border – the site of
     • Infants fed lactose-free formulas have shown comparable                                    lactase production
       growth and key nutrient absorption to those fed formula
                                                                                                • Secondary lactose intolerance may also develop in
       containing lactose27,28
                                                                                                  some children with gut-related symptoms associated
     • Studies have also shown that infants with diarrhoea fed                                    with non-IgE-mediated CMPA, which resolves following
       a lactose-free formula recovered in significantly less time                                exclusion of cows’ milk protein
       than those fed a formula containing lactose29-31
                                                                                                • Temporary lactose intolerance is due to immaturity of the
                       Normal Lactose Digestion               Lactose intolerant                  small intestine
                                                                                                • Usually improves as affected babies get older and their gut

                                                                                                                                                                                                    intolerance
                                                                                                  fully develops

                                                                                                                                                                                                      Lactose
                                     Lactose        Small         Lactose
                                                  intestine
                                                                                                Congenital lactose intolerance is a rare condition where newborn babies produce
                                                                                                very little or no lactase as a result of an inherited genetic fault that runs in families.
                                                               No/Insufficient      Water
                                                                  Lactase
                                                                                                Developmental lactose intolerance can be a problem with preterm babies born
                                     Lactase
                                                                                                before the 34th week.4
                                                              Bacteria ferment
                           Glucose
                                                    Large
                       Galactose                  intestine

                                                                                   Irritation
                                                                                     caused
                                                               Acids and gases

22 | SMA® Specials Range                                                                                                                                                 SMA® Specials Range | 23
BREASTFEEDING IS BEST FOR BABIES                                                       INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     SMA LF® Lactose Free Infant milk                                     How does SMA LF® Lactose Free Infant
                                                                          milk compare?

                                                                                                   SMA LF®            Aptamil               Enfamil
                                    MANAGES SYMPTOMS OF                                          Lactose Free 33   Lactose Free 34          O-Lac 35
                                    LACTOSE INTOLERANCE
                                    For use in conditions
                                    where dietary lactose is               Whey:casein               60:40             0:100                 20:80
                                    contraindicated32

                                                                           Lactose content
                                                                           (g/100 ml)
BREASTFEEDING IS BEST FOR BABIES                                                                            INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     What’s the difference between cows’                                                     Protein is vital for infants’ growth
     milk allergy and lactose intolerance?                                                   When infants are intolerant to cows’ milk protein,
     In some infants, cows’ milk can cause the following problems (both of which have
                                                                                             an alternative must be found.
     a defined organic cause but are otherwise unrelated):                                   Under 6 months
                                                                                             To ensure infants receive adequate protein, it is acknowledged that there is
     • Cows’ milk protein allergy (CMPA)                                                     a clinical need for soya formulas for infants under 6 months in the following:36,37

     • Lactose intolerance                                                                   • Infants with CMPA or intolerance who refuse extensively
     There is often confusion between an allergy and an intolerance, both of which             hydrolysed or elemental formulas
     can affect breast- and formula-fed infants.
                                                                                             • Infants whose parents want to offer a vegan diet.
     A food allergy occurs when the immune system reacts to a usually harmless food            Vegan parents/caregivers who are unable to breastfeed
     protein. This immune response leads to the release of substances, such as histamine,
     resulting in allergic symptoms, such as gut, skin and respiratory symptoms:               or choose not to do so

     • A common food allergy is CMPA which affects approximately                             • Infants with galactosaemia, galactokinase deficiency
       1.8%-7.5% of infants in the first year of life                                          and lactose or sucrose intolerance

     Contrastingly, a food intolerance does not involve the immune system, and may be        From 6 months
     enzymatic or pharmacological:                                                           • The BDA and FSAI state that soya infant milk may be used
                                                                                               for babies from 6 months with CMPA and/or lactose
     • Lactose intolerance is one example of an enzymatic food
                                                                                               intolerance when soya is being used/considered
       intolerance that occurs in infants causing gastrointestinal
                                                                                               for the weaning diet36-37
       symptoms such as diarrhoea and bloating

                                                                                                                                                                                             intolerance
                                                                                                                                                                                              Cows’ milk
                                                                                            * Child has been shown to have no soya allergy.
                                                                                              BDA: British Dietetic Association.
                                                                                              FSAI: Food Safety Authority of Ireland.

26 | SMA® Specials Range                                                                                                                                          SMA® Specials Range | 27
BREASTFEEDING IS BEST FOR BABIES                                            INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     SMA® Wysoy® Soya Infant Formula                                  SMA® Wysoy® Suitability

                                    The only soya-based infant
                                    formula in the UK and Ireland.*
                                                                                                Suitable for:
                                                                                   SMA® Wysoy® Soya Infant Formula
                                                                             is a nutritionally complete, soya protein-based
                                    A nutritionally
                                                                           infant formula that is suitable from birth onwards.
                                    complete formula.38                 It can be used as the sole source of nutrition for infants
                                                                           up to 6 months of age and used as the milk part of
                                                                          a mixed weaning diet. SMA® Wysoy® is lactose free,
                                                                              cows’ milk free and is suitable for vegetarians.
                                    Suitable for vegetarians.
                                                                              It is prescribable for milk protein intolerance,
                                                                            lactose and sucrose intolerance, galactosaemia
                                                                                       and galactokinase deficiency.

                                                                                           Not suitable for:
                                                                                  1. Soya protein intolerance/allergy.
                                                                         2. The inborn error of metabolism; phenylketonuria.

                                                                                     For suitability in vegan diets,
                                                                                   please contact our SMA Careline.

*As of July 2015.

28 | SMA® Specials Range                                                                                                 SMA® Specials Range | 29
BREASTFEEDING IS BEST FOR BABIES                                                       INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     Supporting infants at risk of allergy                                  Supporting infants at risk of allergy
                                                                            • SMA H.A.® Infant Milk uses a unique two step process to reduce
                                                                              the level of allergenicity in the protein: a heat treatment and a two
                                                                              stage enzymatic hydrolysis (a process which imitates natural digestion)

                                        One in three babies has
                                       a family history of allergy39

                                                                                                                                2. Specific
                                                                                             1. Heat
                                                                                                                                enzymatic
                                                                                             treatment
     • Allergies are increasing – with a three-fold increase                                                                    hydrolysis

       in the prevalence of atopic eczema over 15 years40
                                                                             Whole protein                Unfolds the protein                   Cuts the protein
     • 60–80% of babies with two parents with allergy will
       develop allergies41
     • Supporting infants at risk of allergy – if exclusive breastfeeding
       is not possible, formulas that have been clinically proven to        • This unique process cuts the proteins in exactly the right place to reduce
                                                                              allergenicity while retaining some larger protein strands to help train
       reduce the risk of allergy are recommended41
                                                                              the immune system42

                                                                                                                                                                         Family history
                                                                                                                                                                           of allergy
30 | SMA® Specials Range                                                                                                                      SMA® Specials Range | 31
BREASTFEEDING IS BEST FOR BABIES                                                                              INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

     SMA H.A.® Infant Milk                                                                  Supporting infants at risk of allergy
     SMA H.A.® is an infant milk clinically proven to reduce the risk of developing         What do the guidelines say?
     eczema in infants with a family history of allergy.43

                                                                                             EAACI Food Allergy and Anaphylaxis Guidelines (2014)41
                                                          In SMA H.A.®, cows’ milk           “If breastfeeding is insufficient or not possible for the first 4 months, infants at high
                                                          proteins have been broken          risk can be recommended a hypoallergenic formula with documented preventive
                                                          up into smaller pieces,            effect for the first 4 months of life”
                                                          which reduces the risk
                                                          of infants developing
                                                          an allergic response.
                                                                                             ESPGHAN (2014)44
                                                                                             “In high-risk infants, when breast-feeding is not possible, hydrolysates of documented
                                                          Partially hydrolysed whey
                                                                                             safety and efficacy have an indication in infant feeding up to the age 4 to 6 months.”
                                                          protein formula containing
                                                          1.3 g protein per 100 ml.

                                                          SMA H.A.® Infant Milk reduces
                                                          the risk of developing eczema
                                                          by over 50% in the first year
                                                          of life;43 it is easy to digest
                                                          and available on the Healthy
                                                          Start scheme (UK only).

    Important:
    • SMA H.A.® Infant Milk should NOT be used if a baby
      has already been diagnosed with allergy to cows’ milk
      protein or is suspected of already having an allergy to
      cows’ milk protein

    • Use from first formula feed

32 | SMA® Specials Range                                                                                                                                                  SMA® Specials Range | 33
BREASTFEEDING IS BEST FOR BABIES                                                                                                                                                                        INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY

References: 1. Iacono G et al. Dig Liv Dis 2005; 37(6): 432–438. 2. Vandenplas Y et al. JPGN 2015 (61); 5: 531–537. 3. Benninga M et al. Gastroenterology 2016;         IMPORTANT NOTICE: The World Health Organisation (WHO) has recommended that pregnant women and new mothers be informed on the benefits
150: 1443–1455. 4. Heyman MB. Pediatrics 2006; 118(3): 1279–1286. 5. NICE (2019). Clinical Knowledge Summaries: Cows’ milk protein allergy in children. Available       and superiority of breastfeeding – in particular the fact that it provides the best nutrition and protection from illness for babies. Mothers should be given
at https://cks.nice.org.uk/cows-milk-protein-allergy-in-children#!topicsummary (accessed February 2020). 6. Armaforte E et al. International Dairy Journal 2010;        guidance on the preparation for, and maintenance of, lactation, with special emphasis on the importance of a well-balanced diet both during pregnancy
20: 715–723. 7. Martin CR et al. Nutrients 2016; 8(5): 279. 8. Billeaud C et al. Eur J Clin Nutr 1990; 44: 577–583. 9. NHS (2019). Types of formula milk. Available     and after delivery. Unnecessary introduction of partial bottle-feeding or other foods and drinks should be discouraged since it will have a negative effect
at https://www.nhs.uk/conditions/pregnancy-and-baby/types-of-infant-formula/ (accessed February 2020). 10. DoH (2006) https://www.hse.ie/eng/services/                  on breastfeeding. Similarly, mothers should be warned of the difficulty of reversing a decision not to breast-feed. Before advising a mother to use an
publications/children/unit-7-food-and-nutrition.pdf (accessed February 2020). 11. NICE (2015). Gastro-oesophageal reflux disease in children and young people.          infant formula, she should be advised of the social and financial implications of her decision: for example, if a baby is exclusively bottle-fed, more than
Available at https://www.nice.org.uk/guidance/ng1 (accessed February 2020). 12. Sidnell A et al. British Nutrition Foundation Nutrition Bulletin 2009; 34: 395–400.     one can (400 g) per week will be needed, so the family circumstances and costs should be kept in mind. Mothers should be reminded that breast milk
13. Indrio F, et al. Effect of a Partially Hydrolysed Whey Infant Formula Supplemented with Starch and Lactobacillus reuteri DSM 17938 on Regurgitation and Gastric     is not only the best, but also the most economical food for babies. If a decision to use an infant formula is taken, it is important to give instructions on
Motility. Nutrients 2017, 9, 1181. 14. SMA® Anti-Reflux data card. Available at https://www.smahcp.co.uk/formula-milk/anti-reflux-formula (accessed February            correct preparation methods, emphasising that unboiled water, unsterilised bottles or incorrect dilution can all lead to illness. SMA® Wysoy® milk-free
2020). 15. Aptamil Anti-Reflux datacard (June 2018). Available at https://eln.nutricia.co.uk/range/specialist-milks/ (accessed February 2020). 16. Cow & Gate           formula is intended to meet the nutritional needs of babies and children who are intolerant to cows’ milk protein, lactose or sucrose. Soya infant formulae
Anti-reflux datacard. Available at https://eln.nutricia.co.uk/range/specialist-milks/ (accessed February 2020). 17. Hipp Organic anti-reflux datacard. Available at     are not recommended for preterm babies or those with kidney problems, where medical guidance should always be sought. SMA® PRO Follow-on
https://www.hipp4hcps.co.uk/resources/helpsheets/data-sheets/ (accessed February 2020). 18. Enfamil AR datacard. Available at https://hcp.nutramigen.co.uk/             Milk and SMA® Organic Follow-on Milk are only suitable for babies over 6 months as part of a mixed diet. They should not be used as a substitute
files/6614/6304/6719/Filofax_Insert_UK_June_2015_8.pdf (accessed February 2020). 19. St James-Roberts I et al. Early Dev Parent 1995; 4: 177–189. 20. Yao               for breast milk during the first 6 months of life. The decision to start weaning or to use a follow-on milk before 6 months, should be made only on the
M et al. J Pediatr Gastroentrol Nutr 2010; 50(Suppl 2): PO-N-444. 21. Infante D et al. World J Gastroenterol 2011; 17: 2104–2108. 22. SMA® Comfort Easy to Digest       advice of a doctor, midwife, health visitor, public health nurse, dietitian or pharmacist, based on baby’s individual needs. SMA® PRO Growing up
Infant Milk datacard. Available at https://www.smahcp.co.uk/formula-milk/comfort-infant-milk (accessed February 2020). 23. Aptamil Comfort datacard. Available at       Milk is suitable for young children from 1-3 years, as part of a healthy balanced diet and it is not a breast milk substitute. SMA® Organic Growing
https://eln.nutricia.co.uk/product-info/aptamil-comfort-from-birth-2/ (accessed February 2020). 24. Cow & Gate Comfort datacard. Available at https://eln.nutricia.     up Milk is suitable for young children from the 12th month, as part of a healthy balanced diet and it is not a breast milk substitute. The following
co.uk/product-info/cow-gate-comfort-from-birth-2/ (accessed February 2020). 25. Hipp Organic Comfort Milk datacard. Available at https://www.hipp4hcps.co.uk/           products must be used under medical supervision. SMA® Anti-Reflux is a special formula intended for the dietary management of bottle-fed
resources/helpsheets/data-sheets/ (accessed February 2020). 26. Thomas B, Bishop J (eds.) Manual of Dietetic Practice. Fourth Edition. Oxford: Blackwell Publishing     babies when significant reflux (regurgitation) is a problem. It is suitable as the sole source of nutrition up to 6 months of age, and in conjunction with
2007: 458–459. 27. Moya M et al. Acta Paediatr 1999; 88: 1211–1215. 28. Heubi J et al. J Am Diet Assoc 2000; 100: 212–217. 29. Saneian H et al. Iran J Pediatr          solid food up to 12 months of age. If the baby’s reflux does not improve within 2 weeks of starting SMA® Anti-Reflux, or if the baby fails to thrive,
2012; 22: 82–86. 30. Xu JH et al. Contemp Pediatr 2009; 11: 532–536. 31. Vandenplas Y et al. Nutrition 2013; 29: 184–194. 32. NHS (2019). Lactose Intolerance.          the family doctor should be consulted. SMA LF® is a lactose-free milk based formula for babies and young children who are intolerant to lactose or
Available at https://www.nhs.uk/conditions/lactose-intolerance/ (accessed: January 2020). 33. SMA® LF ® Lactose Free Infant Milk datacard. Available at https://        sucrose, or who are experiencing symptoms such as diarrhoea, tummy ache or wind caused by temporary lactose intolerance. It is suitable as the sole
www.smahcp.co.uk/formula-milk/lactose-free-formula (accessed February 2020). 34. Aptamil Lactose Free datacard. Available at: https://www.eln.nutricia.co.uk/           source of nutrition up to 6 months of age, and in conjunction with solid food up to 18 months of age. SMA High Energy® is a milk based formula for
media/4354/datacard_aptamil_ lactose_free.pdf (accessed December 2018). 35. Mead Johnson, Enfamil 0-Lac, information from Mead Johnson customer careline,               the dietary management of babies and young children with medically determined high energy requirements as identified by a healthcare professional.
2016. 36. British Dietetic Association. Paediatric Group Position Statement Use of Infant Formulas based on Soy Protein for Infants. BDA, April 2019. 37. Food Safety   It is suitable as the sole source of nutrition up to 6 months of age, and in conjunction with solid food up to 18 months of age. SMA High Energy® is not
Authority of Ireland, Best Practice for Infant Feeding in Ireland (2012). Available at https://www.lenus.ie/handle/10147/252765 (accessed February 2020). 38. SMA®      intended for use with preterm babies, for whom fortified breast milk or a low birthweight formula such as SMA Gold Prem® 1 is more appropriate.
Wysoy® Soya Infant Formula datacard. Available at https://www.smahcp.co.uk/formula-milk/soya-infant-formula (accessed February 2020). 39. Bergmann RL et al.            SMA® Breast Milk Fortifier is a nutritional supplement designed to be added to expressed breast milk for the dietary management of feeding preterm
Clin Exp Allergy 1997; 27: 725–760. 40. Eichenfield LF et al. Pediatrics 2003; 111: 608–616. 41. Muraro A et al. EAACI Food Allergy and Anaphylaxis Guidelines.         low birthweight babies. SMA Gold Prem® 1 is a special formula intended for the dietary management of preterm low birthweight babies who are not
Primary prevention of food allergy. Allergy 2014; 69(5): 590–601. 42. Jost R et al. Bibl Nutr Dieta 1991; 48: 127–137. 43. von Berg A et al. J Allergy Clin Immunol     solely fed breast milk. It is suitable for use as the sole source of nutrition for preterm babies from birth. SMA Gold Prem® 1 is not intended for use with
2008; 121: 1442–1447.                                                                                                                                                   older preterm babies, for whom a special catch-up formula such as SMA Gold Prem® 2 is more appropriate. SMA Gold Prem® 2 is a special catch-up
                                                                                                                                                                        formula intended for the dietary management of preterm low birthweight babies who are not solely fed breast milk. It is a nutritionally complete formula
                                                                                                                                                                        for use on discharge from hospital or when a low birthweight formula is no longer appropriate. It is suitable for use as the sole source of nutrition up to
                                                                                                                                                                        6 months corrected age. SMA Gold Prem® 2 is not intended for use with newborn preterm babies, for whom fortified breast milk or a low birthweight
                                                                                                                                                                        formula such as SMA Gold Prem® 1 is more appropriate.

                                                                                                                                                                        NWP089; CHLWP022; FRJNP008;
                                                                                                                                                                        IRFI1P002; NWH200-1; IRGMAP005; FRJNP008; NLNW031; DSHL003-1; DENWHS016;
                                                                                                                                                                        DSS005-1; DEDWHL008; DSHL001-2; DSH204; DSH001; NW102; LE136; JN070; NW101; LE135 ;JN069
                                                                                                                                                                        NWHP315F; NWHP315G; NWHP315H

34 | SMA® Specials Range                                                                                                                                                                                                                                                                           SMA® Specials Range | 35
INFORMATION FOR HEALTHCARE PROFESSIONAL USE ONLY
                       BREASTFEEDING IS BEST FOR BABIES

SMA® Nutrition’s Specialist formula range:
Individually tailored to meet the challenges
of specific infant feeding issues

               The broadest, most comprehensive range
               of solutions for feeding issues

               Based on latest advances in scientific
               and clinical research

               Wide availability in retail or to be ordered
               via pharmacy

 SMA Nutrition, 1 City Place, Gatwick, RH6 0PA
 In the Republic of Ireland: SMA Nutrition, 3030 Lake Drive, Citywest Business Campus, Dublin 24, Ireland

Learn more:

               UK 0800 081 81 80
               www.smahcp.co.uk
               ROI 1800 931 832
               www.smahcp.ie

SMA® Nutrition UK and Ireland
®Reg. Trademark of Société des Produits Nestlé S.A.                                             ZTC4732/02/20
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