TUD Bachelor 2019 Possibilities at IMC / IPF - Dr. Franziska Lissel Institute for Macromolecular Chemistry (IMC) Leibniz Institute for Polymer ...
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
TUD Bachelor 2019 Possibilities at IMC / IPF Dr. Franziska Lissel Institute for Macromolecular Chemistry (IMC) Leibniz Institute for Polymer Research (IPF)
Institut Makromolekulare Chemie (IMC) Hohe Straße 6 - D-01069 Dresden www.ipfdd.de/index.php?id=683&type=0&L=1
Institute of Macromolecular Chemistry Tailoring of polymers for specific applications • Control of architecture, functionality and nano-structure • Full understanding of the correlations between chemical structure / architecture and material properties Expertise • Defined polymer architectures and complex, multifunctional polymers • Bio-hybrid structures and bioactive polymer systems • (Poly)reactions in melt, during processing and in nanocomposite formation • Analytical investigation of multifunctional polymer architectures and resp. method development Applications • Organic electronics, microsystems technology, functional layers • Drug delivery systems, therapeutics and synthetic biology • Materials for energy storage and production 3
Department Polymer Structures
AB-type
t
10 ppm of Pd(P Bu3)
Br ZnCl
23°C, 1 h n
R R TON = 100 000 R R
TOF up to 280s-1
AA/BB-type
Br Br
t
R R 1000 ppm of Pd(P Bu3)
+ 23°C, 32 h n
TON = 2 600 R R
ClZn ZnCl
TOF < 1.6 s-1
R R
Controlled Synthesis High Mobility Polymers
Single-Molecule Electronics Conductivity Doping
4
Dr. Kiriy, Department „Polymer Structures“ Contact: kiriy@ipfdd.de
Controlled Polymerizations
AB-type
t
10 ppm of Pd(P Bu3)
Br ZnCl
23°C, 1 h n
R R TON = 100 000 R R
TOF up to 280s-1
AA/BB-type
Br Br
t
R R 1000 ppm of Pd(P Bu3)
+ 23°C, 32 h n
TON = 2 600 R R
ClZn ZnCl -1
TOF < 1.6 s
R R
Angew. Chem. Int. Ed. 2014, 53, 2402
5
Dr. Kiriy, Department „Polymer Structures“ Contact: kiriy@ipfdd.de
Conductivity dopants
• Efficient doping
Karpov, Kiriy, Al-Hussein, Hambsch, Beryozkina, Bakulev, Mannsfeld, Voit, Kiriy. Chem. Comm. 2018, 54, 307
6
Dr. Kiriy, Department „Polymer Structures“ Contact: kiriy@ipfdd.de
Functional Electronic Materials
Stretchable & Melt-Processable Semiconductors Organometallic Electronics
Nanocars and Molecular Rotors Polymer Matrices for MALDI MS and MSI
“Team GAZE”
7
Dr. Lissel, Group „Functional Electronic Materials“, Department „Polymer Structures“ Contact: lissel@ipfdd.de
MALDI goes 2D/3D – MALDI MS Imaging
High concentration Low concentration
Tumor
of A of B
position Tumor markers Tumor metabolism
Chaurand et al, Anal. Chem. 2013
8
Dr. Lissel, Group „Functional Electronic Materials“, Department „Polymer Structures“ Contact: lissel@ipfdd.de
Polymers as Dual-Mode Matrices for MALDI MS and
Imaging
Conjugated Polymers Positive and Negative Mode MALDI
0 100 200 300 400 500 600 700 800 900 1000 0 100 200 300 400 500 600 700 800 900 1000
Matrix: (-) ; Analyte: (-) Matrix: (-) ; Analyte: (-)
6x103
1x104
392 5x103 3x103
697
PNDI(T2)
39
0 0
Matrix: (-) ; Analyte: Reserpine (1 mg/ml) Matrix: (-) ; Analyte: Citric acid (1 mg/ml)
6x103
523 549 1x104
P3DDT 601
Absolute Intensity
Absolute Intensity
5x103 3x103
Relative Absorption
363 622 0 0
Matrix: PNDI(T2) (0.1 mg/ml) ; Analyte: (-) Matrix: PNDI(T2) (0.1 mg/ml) ; Analyte: (-)
6x103
1x104
PTQ1
3
5x103 3x10
626
42
686
413 0 0
PII(T2) Matrix: PNDI(T2) (0.1 mg/ml) ; Analyte: Reserpine (1 mg/ml) Matrix: PNDI(T2) (0.1 mg/ml) ; Analyte: Citric acid (1 mg/ml)
6x103
607
1x104
191
386
5x10 3 3x103
P9OFL
87
42
395
432 0 0
300 Laser-Wavelength 400 500 600 700 800 0 100 200 300 400 500 600 700 800 900 1000 0 100 200 300 400 500 600 700 800 900 1000
(355 nm)
Wavelength [nm] Laser Intensity: 10% m/z Mode: Reflectron positive Laser Intensity: 20% m/z Mode: Reflectron negative
Complex Sample MALDI MS Imaging
Matrix Positive Mode Peaks with I >100 Negative Mode Peaks with I >100
DHB 2980 (3.5e+03) -
9AA - 2972 (2.7e+03)
PNDI(T2) 2980 (3.3e+03) 2966 (7.6e+02)
P3DDT 2986 (2.8e+03) 2260 (3.3e+03)
K. Horatz, M. Giampà, Y. Karpov, K. Sahre, H. Bednarz, A. Kiriy, B. Voit, K. Niehaus, N. Hadjichristidis, D. L. Michels, and F. Lissel
J. Am. Chem. Soc. 2018 140, 36, 11416-11423
9
Dr. Lissel, Group „Functional Electronic Materials“, Department „Polymer Structures“ Contact: lissel@ipfdd.de
Functional principles of polymersomes, hollow capsules and
multicompartmentalized systems for mimicking cell functions
Stimuli-responsive Artifical organelles
polymersomes and with specific biological
hollow capsules functions
pH, T, pH/T, light…. e.g. lysosome
Multicompartments Interaction of
as protocells proteins/peptides
with polymersomes
e.g. combining polymersomes
with hollow capsules e.g. location
Spatiotemporal control over biological
pathways and membrane permeability
Multicompartments Orthogonal-responsive membranes Biological actions
communication between of artifial organelles
Self-regulated/adaptive system
single compartments and protocells
Final
Challenges!?
Next generation therapeutics
for substituting protein lack, capturing pathogens
and degrading undesired ECM materials
10
Dr. Appelhans, Department „Bio-active and Responsive Polymers“ Contact: applhans@ipfdd.deTopics for Bachelor Theses
New kind of block copolymers for the fabrication of steadly permeable enzymatic
nanoreactors at room temperature and 37°C (lysosome-like compartment)
Redox-active polymersome membrane for integration of enzyme to switch on/off
on demand (out-of-equilibrium materials)
Light-/proton-switchable polymersome membrane through the fabrication of
new block copolymers (out-of-equilibrium materials)
Protein integration in/on polymersome membrane for the design of artificial
organelles or drug delivery system
Publications:
Chem. Commun. 2011; Macromolecules 2011; Angew. Chem. Int. Ed. 2012; Small 2012; Chem. Eur. J. 2012; Biomacromolecules
2012; ACS Nano 2012; Soft Matter 2014; Nanoscale 2014; Small 2015; Chem. Mater. 2016; ACS Appl. Mater. & Interfaces 2016;
Polym. Chem. 2017; Adv. Sci. 2017; Angew. Chem. Int. Ed. 2017; Macromol. Rapid Commun. 2017; Macromolecules 2018; J. Am.
Chem. Soc. 2018; Adv. Sci. 2018, accepted
Homepage:
https://www.ipfdd.de/index.php?id=2436&type=0&L=1 or
https://www.ipfdd.de/en/organization/departments/institute-of-macromolecular-chemistry/bioactive-and-responsive-polymers/
11
Dr. Appelhans, Department „Bio-active and Responsive Polymers“ Contact: applhans@ipfdd.deThank you for your attention!
Homepages with Contact Information:
Institute of Macromolecular Chemistry:
https://www.ipfdd.de/en/organization/departments/institute-of-macromolecular-chemistry/
Department Bioactive and Responsive Polymers,
Dr. D. Appelhans, appelhans@ipfdd.de:
https://www.ipfdd.de/index.php?id=2436&type=0&L=1
Department Polymer Structures,
Dr. A. Kiriy, kiriy@ipfdd.de:
https://www.ipfdd.de/en/organization/departments/institute-of-macromolecular-chemistry/polymer-structures/
Group Functional Electronic Materials,
Dr. F. Lissel, lissel@ipfdd.de:
http://www.fralis.de/
12You can also read
