Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA

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Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
Antimicrobial resistance (AMR)
   The role of the Swedish Board of Agriculture
     - prevention coordination prudent use

                                 Lena Hellqvist Björnerot
                                 Deputy CVO

2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
Outline

      • Background, the importance of AMR, global views
      • OIE - and EU coordinaton

      • The Swedish model and strategy
            historically
            prevention & healthy animals
            reduce the need & prudent use
            cooperation
            legislation, control
            monitoring

      • One Health, Intersectoral Coordination Function

      • Summary
2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
Swedish Board of Agriculture (SBA)
                   SBA is the Government's expert authority in the
                   agro-food sector - responsible for all matters related
                   to agriculture & horticulture

                   Task - to fulfil the overall objectives of the political
                   sectors of agriculture, food & fisheries

Aim - Sustainable agriculture, good livestock husbandry
& a varied agricultural landscape

Being prepared for crisis

   2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
SBA´s mission
              Ensure good animal health among kept animals

              Prevent spread, and control, of infections
               among kept animals

              Ensure a good animal welfare

              Work for food security and consumer trust for
               our part of the food chain

              Sustainable food production

              Profitability in farming
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Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
Antimicrobial resistance
                     (AMR)

2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
A big threat to humanity...
             WHO: Antibiotic resistance, along with the climate
             issue, is one of the biggest threats to global health,
             food security and development today!

             Global action plan to tackle antimicrobial resistance –
             2015, in Tripartite collaboration with The Food and
             Agriculture Organisation (FAO) and The World
             Organisation for animal health (OIE).

                             http://www.who.int/antimicrobial-resistance/global-
                             action-plan/en/

2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
A big threat to humanity...
             United Nations General Assembly in New York September 2016:

             A political declaration endorsed by Heads of State signaled the
             world’s commitment to taking a broad, coordinated approach
             to address the root causes of antimicrobial resistance across
             multiple sectors, especially human health, animal health and
             agriculture.

             Namely all UN countries support the Global Action Plan
             against Antibiotics Resistance, produced by the WHO in
             cooperation with FAO and OIE

             https://www.un.org/pga/71/wp-content/uploads/sites/40/2016/09/DGACM_GAEAD_ESCAB-AMR-
             Draft-Political-Declaration-1616108E.pdf

2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
A big threat to the economy...
             The World Bank estimates that antimicrobial resistance
             (AMR) has the potential to lead to economic
             consequences in the dignity of the financial crisis 2011
             by the year 2050.

             The World Bank's report also shows that low and middle
             income countries are often the hardest hit.

                               http://documents.worldbank.org/curated/en/32331149
                               3396993758/pdf/114679-REVISED-v2-Drug-
                               Resistant-Infections-Final-Report.pdf

2019-05-14
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
‘Review on Antimicrobial Resistance. Antimicrobial Resistance:
    Tackling a Crisis for the Health and Wealth of Nations. 2014.’

    If increase and spread of AMR continues in the same way & rate
    in 2050…

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                  https://amr-review.org/home.html
Antimicrobial resistance (AMR) - The role of the Swedish Board of Agriculture - prevention coordination prudent use - SVA
Use of antimicrobials in livestocks
             Increased demand for animal protein and shift to large-
             scale farms – use may increase with 67% by 2030

2019-05-14
             Comment – urging for a sustainable production
One health approach is necessary

             All sectors must work together at all levels….

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FAO

http://www.fao.org/search/en/?cx=018170620143701104933%3Aqq82jsfba7w&q=antimicrobial+resist
ance&cof=FORID%3A9&siteurl=www.fao.org%2Fabout%2Fen%2F&ref=www.fao.org%2Fhome%2Fen%2
F&ss=7432j3340152j24
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OIE - World organisation for Animal Health

 OIE Activities
 against AMR

      http://www.oie.int/fileadmin/Home/eng/Media_Center/docs/pdf/PortailAMR/EN_OIE-
      AMRstrategy.pdf

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OIE 4 main objectives
                 against AMR

• Improve awareness & understanding
• Strengthen knowledge through
  surveillance & research
• Support good governance &
  capacity building
• Encourage implementation of
  international standards
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AMR in OIE TERRESTRIAL & AQUATIC CODES
                Chapter 6.7.               Chapter 6.1.
                Introduction to the        Introduction to the
                recommendations for        recommendations for
                controlling antimicrobial controlling antimicrobial
                resistance                 resistance
                Chapter 6.8.
                                           Chapter 6.2.
                Harmonisation of
                                           Principles for responsible
                national antimicrobial
                                           and prudent use of
                resistance surveillance
                                           antimicrobial agents in
                and monitoring
                programmes
                                           aquatic animals              MANUAL OF
                Chapter 6.9.               Chapter 6.3.
                Monitoring of the          Monitoring of the
                                                                        DIAGNOSTIC TESTS
                quantities and usage       quantities and usage
                patterns of antimicrobials patterns of antimicrobial
                                                                        AND VACCINES FOR
                agents used in food        agents used in aquatic       TERRESTRIAL
                producing animals          animals
                                           Chapter 6.4.                 ANIMALS
                Chapter 6.10.              Development and
                Responsible and prudent harmonisation of national
                                                                        Chapter 2.1.2
                use of antimicrobial       antimicrobial resistance     Laboratory
                agents in veterinary       surveillance and
                medicine                   monitoring programmes        methodologies for
                                           for aquatic animals
                                           Chapter 6.5.                 bacterial
                Chapter 6.11.
                Risk analysis for
                                           Risk analysis for
                                           antimicrobial resistance
                                                                        antimicrobial
                antimicrobial resistance
                arising from the use of
                                           arising from the use of
                                           antimicrobial agents in
                                                                        susceptibility testing
                antimicrobials in animals
                                           aquatic animals

http://www.oie.int/en/standard-setting/terrestrial-code/access-online/
http://www.oie.int/index.php?id=171&L=0&htmfile=titre_1.6.htm
http://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.01.01_ANTIMICROBIAL.pdf
   2019-05-14
OIE activities against AMR continued

 List of antimicrobial agents of
 veterinary importance,
 in parallel with the existing
 WHO list for human medicine

  Global database on
  antimicrobial agents
  intended for use in animals

                     Network

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EU legislates & EU coordinates its positions
related to OIE & other international organisations

EU cooperates on OIE issues with other
regions, such as Africa                     2019-05-14
EU – AMR Strategy key objectives
                                     2. Boosting research,
 1. Making the                       development and innovation
 EU a best practice region

3. Shaping the global agenda

                                                        2019-05-14
https://ec.europa.eu/health/amr/action_eu_en
The Swedish animal health situation,
  Swedish model & AMR strategy

2019-05-14
Sweden has a unique high
               animal health status
•   Geographically favourable situation & climate
•   No recent wars
•   Financial resources
•   Not so dense animal population
•   Strict legislation
•   Long tradition cooperation government &
    stakeholders - “prevention is better than cure”
•   Low volume & strict control for safe trade/imports
    of live animals – but promoting trade of products
•   Animal Welfare                              Etc…
History of animal health activities

             • Tuberculosis and Brucellosis eradication schemes in 1940-60

             • Organizations for insemination and bovine fertility started
               preventive fertility and disease control ~ 1940

             • Dairy industry started preventive udder health scheme in ~1950

             • Salmonella Control programme started after an outbreak 1953

             • Voluntary eradication of EBL (free 2007) & BVD (free 2013)
               started in the 1990-ties

             • Eradication program for IBR, paratuberculosis,
               Aujeszky's Disease & PRRS
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               Now free for most of these and several other diseases!
A composite strategy
     against AMR is needed

 Remove unnecessary use
       growth promoters, routine prophylaxis
 Reduce need
       keep animals healthy
       prevention and infection control
 Avoid spread
       biosecurity, infection control, food hygiene...
 Optimize use when needed
       correct diagnosis, selection and dose
 Monitoring of resistance and use

LONG-TERM WORK. AWARENESS &
COOPERATION AT ALL LEVELS!
Our tools
     • Legislation

     • Financial resources –
       to fight epizootic diseases & support programmes
       and projects run by farmers organisations to
       promote animal health

     • Incentives & understanding of
       risks and benefits

     • Cooperation
2019-05-14
Remove unnecessary use
 Antibiotics as growth promoters prohibited in SE 1986
  Corresponding prohibition in EU 2006
  - important to reduce and end the use globally!

 Avoid routine prophylaxis - only use after veterinary
  prescription, clinical examination and diagnosis, sampling
  and sensitivity analysis!
  - problem solving at the root!

 Legislation (SBA)

 Global standards!
Reduce need & avoid spread

Healthy animals do not need antibiotics

Infection prevention & control
”THE SWEDISH MODEL”
                     AMR is not in isolation

• Long tradition in Sweden of “prevention is better than cure”
• Close dialogue & cooperation between stakeholders &
  governmental authorities
• Knowledge & understanding of benefits!
• Stakeholder platform, yearly meetings
• Stakeholders run programs for improving animal health &
  biosecurity in general (pig-, cattle-, sheep-, fish- & poultry sector)
• Focus on ”production diseases” – free of serious diseases
• One Health
• Prudent use of antimicrobials
• Animal welfare
     2019-05-14
Infection prevention & control
                                (IPC)
            Important tool also in the veterinary medicine to

         - prevent emergence of healthcare associated infections*
         - prevent the spread of infectious agents between
           animals, farms & bet ween animals – humans
           Clean hands, working clothes, equipment…

         - Reduce the need of antimicrobials

         Mandatory for all veterinary services in                                              Photo; Bengt Ekberg, SVA
         Sweden to have IPC-plans!                                                             *e.g. MRSA
         https://distriktsveterinarerna.se/download/18.1487953d1697560ebcfc49d3/1552654159983/Hygienguiden.pdf

http://www.svf.se/sv/Forbundet/Policydokument (IPC small animal veterinary clinics/hospitals; horse practice;
handling dogs & cats with specific AMR,)

http://www.jordbruksverket.se/download/18.2ae27f0513e7888ce22800010291/1370040513684/2013-014.pdf
Optimize use when needed

 Correct diagnosis
 Correct substance, dose & time
 Guidelines & treatment
  recommendations

- considering risks for AMR when prescribing
- Mastitis policy; Guidance on medicated feed;
- Swedish Veterinary Association general policy (1998) &
  specific guidelines for use of antibiotics in: dogs & cats;
  cattle & pigs; horses; sheep & goats
- Medical Products Agency recommendations on antibiotic use
           https://saveantibiotics.se/ http://skyddaantibiotikan.se/
http://www.svf.se/sv/Forbundet/Policydokument/
https://lakemedelsverket.se/veterinara-behandlingsrekommendationer
Use & monitoring of
                         antimicrobials
             • SBA is responsible for regulating the use of VMPs,
               risk management and the overall control
                    - requirement for veterinary prescription
                    - veterinarians not allowed to sell VMP
                    - veterinary obligation to report use

             • SBA obligation to compile & report the sales of VMPs
                 - Swedish Government - yearly report on sales
                   of VMPs (including antibiotics)
                 - ESVAC – yearly report antibiotics (Europe)
                 - OIE (as of 2015)

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                  Working for harmonised EU legislation
Sweden - use of antibiotics

             Källa: Swedres-Svarm 2018

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Europe – use of antibiotics
                          Sales for food-producing species, in mg/PCU,
                          for 30 European countries, in 2016

Eighth ESVAC report

     2019-05-14

                      Sales of veterinary antimicrobial agents in 30 European countries in 2016. Eighth ESVAC report
One health approach is necessary

             All sectors must work together at all levels….

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The Swedish AMR Strategy
                          - overall framework
Overarching goal:

Preserve the possibility for effective treatment of
bacterial infections in people and animals

First joint National Action Plan in year 2000
Joint work on zoonosis since 1990ties

 https://www.government.se/contentassets/168838e186de455ca7f
 e868bee92d209/swedish-strategy-to-combat-antibiotic-
 resistance.pdfrnment.se/information-material/2016/05/swedish-
 strategy-to-combat-antibiotic-resistance/
    2019-05-14
Intersectoral Coordination Function

• 2012 – formalised AMR cooperation
• 25 governmental authorities & organisations
• National Action plan updated for 2018-2020
• Yearly forum during the European
  AMR-awareness day (November)
• Joint communication strategy updated 2019
• https://saveantibiotics.se/
  http://skyddaantibiotikan.se/
• E.g. recommendations to prevent MRSA from
  infected humans working with animals
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In summary

                       Cooperation
Prevention & control    all levels
disease management                       Animal welfare
      AH+PH

                                          Knowledge
  Prudent use of                     Understanding benefits
  antimicrobials                          Incentives
                       Financing
                       Legislation

 Long term cooperative work – understanding & motivation
 is needed to achieve a change in behaviour!
 2019-05-14
It is possible!

             Thank you for your attention

                Lena Hellqvist Björnerot
                Deputy Chief Veterinary Officer (Deputy CVO)
                Department of Animal Health and Welfare
                lena.bjornerot@jordbruksverket.se
                https://www.jordbruksverket.se

2019-05-14
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