Faculty Research Interests 2020-2021 - Cardiovascular Division Washington University School of Medicine
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Cardiovascular Division
Washington University
School of Medicine
Faculty Research Interests
2020-2021
Introduction
The Cardiovascular Division and related disciplines at the
Washington University School of Medicine have a distinguished
track record of research productivity in both the clinical and basic
sciences. The objectives of this document are twofold:
1.) To provide an overview of current research activities of
individual investigators within the Cardiovascular Division,
as well as investigators in related fields of research; and
2.) To assist residents, fellows, graduate students, MSTPs and
junior faculty members in identifying potential mentors
with specific research interests.
The document is updated at least annually to reflect
evolving research interests. Questions regarding ongoing or
proposed research projects should be directed to individual
investigators. Questions about the Mentorship Program should be addressed to members of the
Research Mentorship Committee, comprising Drs. D. Brown, Davila, de las Fuentes, Gleva, Gorcsan,
Joynt Maddox, Kates, Mann, and Rich, or to Dr. Barger, Associate Program Director for Mentorship.
Comments or suggestions about the utility of this document and how it could be improved
should be addressed to Michael W Rich, MD, Professor of Medicine, at mrich@wustl.edu.
How to Use This Document
Residents, fellows, and others who wish to identify
potential mentor(s) are encouraged to browse through the
Index, which lists investigators according to their areas of
interest. Names in the Table of Contents and in the Index are
hyperlinked to the Investigator’s page within the document.
Names on each Investigator’s page are hyperlinked to the
Cardiology website (or Washington University faculty website
for investigators outside the Cardiovascular Division). The
website provides additional details about each investigator’s training, publications, and clinical
activities. Key words at the bottom of each investigator’s page indicate terms listed in the Index.
2
Table of Contents
Introduction and How to Use This Document 2
Index 6
Jose A. Alvarez-Cardona, MD 14
Amit Amin, MD 15
Richard G. Bach, MD 16
Philip M. Barger, MD, MSc 17
Anita Bhandiwad, MD 18
Alan C. Braverman, MD 19
Angela L. Brown, MD 20
David L. Brown, MD 21
Robert M. Carney, PhD 22
Murali M. Chakinala, MD 23
Sharon Cresci, MD 24
Phillip S. Cuculich, MD 25
Victor G. Davila-Roman, MD 26
Lisa de las Fuentes, MD, MS 27
Abhinav Diwan, MD 28
Gerald W. Dorn, II, MD 29
Gregory A. Ewald, MD 30
Mitchell N. Faddis, MD, PhD 31
Kenneth E. Freedland, PhD, FAHA 32
Brian F. Gage, MD 33
Edward M. Geltman, MD 34
Marye J. Gleva, MD 35
John Gorcsan III 36
Jeffrey I. Gordon, MD 37
Robert J. Gropler, MD 38
Richard W. Gross, MD, PhD 39
Justin Hartupee, MD, PhD 40
Mustafa Husaini, MD 41
Sudhir Jain MD, FACC, MBA 42
3Ali Javaheri, MD, PhD 43
Karen Joynt Maddox, MD 44
Attila Kovacs, MD 45
Sándor J. Kovács, PhD, MD, h.c. 46
Ronald J. Krone, MD 47
Gregory M. Lanza, MD, PhD 48
John M. Lasala, MD, PhD 49
Kory Lavine, MD, PhD 50
Steven J. Lavine, MD 51
Daniel J. Lenihan, MD 52
Kathryn Lindley, MD 53
Thomas Maddox, MD 54
Majesh Makan, MD 55
Douglas L. Mann, MD 56
Joshua Mitchell, MD 57
Jonathan D. Moreno, MD, PhD 58
Jeanne M. Nerbonne, PhD 59
Colin G. Nichols, PhD 60
Julio E. Perez, MD 61
Linda R. Peterson, MD 62
Nishath Quader, MD 63
Babak Razani, MD, PhD 64
Stacey L. Rentschler, MD, PhD 65
Michael W. Rich, MD 66
Yoram Rudy, PhD 67
Rajan Sah, MD, PhD 68
Robert V. Same, MD 69
Joel D. Schilling, MD, PhD 70
Clay F. Semenkovich, MD 71
Jonathan Silva, PhD 72
Jasvindar Singh, MD 73
Timothy W. Smith, MD, DPhil 74
4Sandeep Sodhi, MD 75
Phyllis K. Stein, PhD 76
Nathan Stitziel, MD, PhD 77
Amanda Verma, MD 78
Carla J. Weinheimer, MS 79
Pamela K. Woodard, MD 80
Alan Zajarias, MD 81
Kathleen W. Zhang, MD 82
5Index
Aging
Gage, Rich, Stein
Amyloid
Alvarez-Cardona, Diwan, Lenihan, Mitchell, Zhang
Aortic Dissection
Braverman
Aortic regurgitation
S. Lavine
Aortic stenosis
Lasala, Zajarias
Apolipoprotein M
Javaheri
Arrhythmias
Faddis, Moreno, Nerbonne, Nichols, Rentschler, Silva, Smith
Atherosclerosis
Razani, Semenkovich, Stitziel, Woodard
Athletes
Husaini
Atrial fibrillation
Cuculich, Faddis, Gage, Gleva, Rentschler, Rich, Sodhi
Autonomic function assessment
Stein
Autophagy
Diwan, Javaheri, Razani
Behavioral medicine
Carney, Freedland
Basic science
Gross, A. Kovacs, Lanza, Mann, Moreno, Nichols, Razani, Rentschler, Rudy, Schilling,
Semenkovich, Silva, Stitziel, Weinheimer
Bicuspid Aortic Valve
Braverman
6Biomarkers
Lenihan, Mitchell, Zhang
Cardiac CT
Woodard
Cardiac development
Nichols, Rentschler
Cardiac metabolism
Davila-Roman, Gropler, Gross, Peterson, Razani
Cardiac MRI
Bhandiwad, Woodard
Cardiac physiology
S. Kovács
Cardiac recovery
Husaini, K. Lavine
Cardiomyopathy
Krone, Lindley, Weinheimer
Cardio-oncology
Alvarez Cardona, Krone, Lenihan, Mitchell, Stein, Zhang
Cardiovascular phenotyping
Weinheimer
Cell death
Diwan
Childhood undernutrition
Gordon
Cholesterol
Javaheri
Circadian rhythms
Stein
Collateral circulation
K. Lavine
Comparative effectiveness research
D. Brown
Complex catheter ablation
Sodhi
7Complexity theory
S. Kovács
Conduction system
Rentschler
Congenital heart disease
Barger, Rentschler
Coronary artery disease
Bach, D. Brown, Carney, Freedland, Krone, Lasala, Singh
Coronary development
K. Lavine
Cost-effectiveness analysis
Amin
Depression
Carney, Freedland, Stein
Diabetes
Bach, Gross, Peterson, Sah, Schilling, Semenkovich, Stein
Diastolic function
Davila-Roman, de las Fuentes, Geltman, S. Kovács, S. Lavine
Disparities
Joynt-Maddox
Echocardiography
Bhandiwad, Davila-Roman, de las Fuentes, Gorcsan, Makan, Perez, Quader, Zhang
Electrocardiography
Rudy, Sah, Smith
Electrophysiology
Faddis, Gleva, Moreno, Nerbonne, Nichols, Rentschler, Rudy, Silva, Smith
Epidemiology
de las Fuentes, Gage, Rich, Stein
Epigenetics
Rentschler
Genetic epidemiology
Davila-Roman, de las Fuentes
8Genetics
Cresci, Stitziel
Global health
A. Brown, Davila-Roman, de las Fuentes, Gordon
Health care innovation
Maddox
Health policy
Joynt-Maddox
Health services research
D. Brown, Joynt-Maddox, Maddox
Heart failure
Alvarez-Cardona, Chakinala, Davila, Diwan, Dorn, Ewald, Faddis, Freedland, Geltman,
Gorcsan, Gross, Hartupee, K. Lavine S. Lavine, Lenihan, Mann, Moreno, Peterson,
Rich, Sah, Schilling, Stein, Verma
Heart rate variability
Stein
Heart transplantation
Alvarez-Cardona, Ewald, Moreno
Hospital readmissions
Joynt-Maddox
Human gut microbiome
Gordon
Hypertension
A. Brown, Davila-Roman, de las Fuentes, Nichols, Sah, Stein
Hypertrophic cardiomyopathy
Bach, Cresci, Husaini, Moreno
Imaging
Bach, Bhandiwad, Davila-Roman, Gorcsan, A. Kovacs, S. Kovács, Lanza, Makan,
Mitchell, Perez, Weinheimer, Woodard
Implantable devices
Faddis, Geltman, Gleva
Insulin resistance
Razani
Interventional cardiology
Amin, Lasala, Singh, Zajarias
9Ion channels
Nerbonne, Nichols, Rentschler, Moreno, Silva,
Ischemia-reperfusion
Diwan, Weinheimer
Kupffer Cells
Schilling
Left ventricular assist devices
Alvarez Cardona, Hartupee, Moreno
Lipid metabolism
Gross, Razani, Semenkovich
Lipidomics
Peterson
Lysosomes
Diwan, Javaheri, Razani
Macrophage
K. Lavine, Razani, Schilling
Marfan Syndrome
Braverman
Mathematical modeling
S. Kovács, Moreno, Silva
Metabolic Regulation
Gordon
Meta-analysis
D. Brown
Mitophagy
Dorn
Molecular cardiology
Dorn, Gross, A. Kovacs, Lanza, Rentschler, Silva, Weinheimer
Molecular genetics
Nerbonne
Noninvasive cardiac ablation
Cuculich
10Nanomedicine
Lanza
Novel murine surgical models
Weinheimer
Nutrition
Peterson
Obesity
Gordon, Peterson, Razani, Sah
Outcomes research
Amin, D. Brown, Joynt-Maddox, Maddox
Patient-centered Care
D. Brown
Peripartum cardiomyopathy
Lindley, Verma
Pharmacogenomics
Gage
Practice improvement
Lenihan
Prebiotics/probiotics/synbiotics
Gordon
Precision Medicine
Cresci, Gordon, Moreno
Pregnancy
Lindley, Verma
Premature ventricular contractions
Sodhi
Prevention
A. Brown, Rich, Same
Proteomics
Nerbonne
Pulmonary arterio-venous malformations
Chakinala
Pulmonary hypertension
Chakinala
11Quality of care
Joynt-Maddox, Maddox
Remodeling
Nerbonne
Reprogramming
Rentschler
Reverse remodeling
Barger
Right heart failure
Chakinala, Gorcsan
Risk factors
de las Fuentes, Same, Stein
Robotic navigation
Sodhi
Skeletal and cardiac muscle performance
Peterson
Sleep disorders
Carney, Freedland, Stein
Sports Cardiology
Husaini
Systems biology
Gordon
Thoracic Aortic Aneurysm
Braverman
Translational research
Cresci, Cuculich, Davila-Roman, Mann, Moreno, Razani, Rentschler, Silva, Stitziel
Transdisciplinary research
Cuculich, Rentschler,
Transplant vasculopathy
K. Lavine
Valvular heart disease
Lasala, Makan, Quader, Zajarias
Vascular biology
A. Kovacs, Nichols, Razani
12Ventricular tachycardia
Cuculich, Rentschler, Sodhi
Women and minorities
A. Brown, Joynt-Maddox, Lindley, Stein, Verma
Zebrafish
Nichols
13Jose A. Alvarez-Cardona, MD
Assistant Professor of Medicine
Current Research Interests
Advanced heart failure and transplant cardiology
Mechanical circulatory support
Cardio-oncology
Cardiac amyloidosis
Representative Publications
1. Alvarez-Cardona J, Mitchell J, Lenihan D. Vascular Toxicity in Patients with Cancer: Is There a
Recipe to Clarify Treatment? CME. Methodist Debakey Cardiovasc J. 2019 Oct-Dec;15(4):289-99.
doi: 10.14797/mdcj-15-4-289. PMID: 31988690; PMCID: PMC6977563.
2. Alvarez-Cardona J, Lenihan DJ. Anthracycline Cardiotoxicity: It Is Possible to Teach an Old Dog
Some New Tricks. Cardiol Clin. 2019 Nov;37(4):355-63. doi: 10.1016/j.ccl.2019.08.001. PMID:
31587778.
3. Zhang KW, Miao J, Mitchell JD, Alvarez-Cardona J, Tomasek K, Su YR, Gordon M, Cornell RF,
Lenihan DJ. Plasma hepatocyte growth factor for diagnosis and prognosis in light chain and
transthyretin cardiac amyloidosis. J Am Coll Cardiol CardioOnc. 2020 Mar; 2:56–66. doi:
10.1016/j.jaccao.2020.01.006.
4. Adusumalli S, Alvarez-Cardona J, Khatana SM, Mitchell JD, Blaes AH, Casselli SJ, O'Quinn R,
Lenihan DJ. Clinical Practice and Research in Cardio-Oncology: Finding the "Rosetta Stone" for
Establishing Program Excellence in Cardio-oncology. J Cardiovasc Transl Res. 2020 May 22. doi:
10.1007/s12265-020-10010-x. Epub ahead of print. PMID: 32444945.
5. Lenihan D, Carver J, Porter C, Liu JE, Dent S, Thavendiranathan P, Mitchell J, Nohria A, Fradley
M, Pusic I, Stockerl-Goldstein K, Blaes A, Lyon A, Ganatra S, Lopez-Fernandez T, O’Quinn R,
Minotti G, Szmit S, Cardinale D, Alvarez-Cardona J, Curigliano G, Neilan T, Herrmann J. Cardio-
Oncology Care in the Era of the Coronavirus (COVID-19) Pandemic: An International Cardio-
Oncology Society (ICOS) Statement. CA A Cancer J Clin. In press
Key Words: cardio-oncology, amyloidosis, advanced heart failure, heart transplant, mechanical
circulatory support, left ventricular assist devices
14Amit Amin, MD
Associate Professor of Medicine
Current Research Interests
Improving outcomes of percutaneous coronary intervention (PCI)
• Reducing PCI complications, including bleeding and acute kidney injury
• Reducing costs of PCI and acute coronary syndromes
• Cost-effectiveness of adjunctive therapies in interventional cardiology
• Optimizing care pathways of PCI
• Transradial PCI
Representative Publications
1. Amin AP, Spertus JA, Kulkarni H, McNeely C, Rao SV, Pinto D, House JA, Messenger JC, Bach RG,
Goyal A, Shroff A, Pancholy S, Bradley SM, Gluckman TJ, Maddox TM, Wasfy JH, Masoudi FA.
Improving care pathways for acute coronary syndrome: patients undergoing percutaneous coronary
intervention. Am J Cardiol. 2019 Oct 26. Pii:S0002-9149(19)31166-X. doi:
10.1016/j.amjcard.2019.10.019. PMID: 31812224
2. Amin AP, Spertus JA, Curtis JP, Desai N, Masoudi FA, Bach RG, McNeely C, Al-Badarin F, House JA,
Kulkarni H, Rao SV. The evolving landscape of Impella® use in the United States among patients
undergoing percutaneous coronary intervention with mechanical circulatory support. Circulation.
2019 Nov 17. doi:10.1161/CIRCULATIONAHA.119.044007. PMID: 31735078
3. Kwok CS, Amin AP, Shah B, Kinnaird T, Alkutshan R, Balghith M, Ratib K, Nolan J, Bagur R, Mamas
MA. Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day
unplanned readmission in the United States. Catheter Cardiovavsc Interv. 2019 Dec 26.
doi:10.1002/ccd.28660. PMID: 31876371
4. Amin AP, McNeely C, Spertus JA, Bach RG, Frogge N, Lindner S, Jain S, Bradley SM, Wasfy JH, Goyal
A, Maddox T, House JA, Kulkarni H, Masoudi FA. Incremental cost of acute kidney injury after
percuranteous coronary intervention in the United States. Am J Cardiol. 2020 Jan 1;125(1):29-33.
doi: 10.1016/j.amjcard.2019.09.042. PMID: 31711633
5. Lindner SM, McNeely CA, Amin AP. The value of transradial: impact on patient satisfaction and
health care economics. Interv Cardiol Clin. 2020 Jan;9(1):107-15. doi:10.1016/j.iccl.2019.08.004.
PMID: 31733737
6. Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz A, Masoudi FA,
Messenger JC, Parzynski CS, Ngufor C, Girotra S, Amin AP, Shah ND, Desai NR. Association of use of
intravascular microaxial left ventricular assist device vs intra-aortic balloon pump with in-hospital
mortality and major bleeding among patients with acute myocardial infarction complicated by
cardiogenic shock. JAMA. 2020 Feb 10.doi: 10.1001/jama.2020.0254. PMID: 32040163.
Key words: cost-effectiveness analysis, interventional cardiology, outcomes research
15Richard G. Bach, MD
Professor of Medicine
Current Research Interests
Hypertrophic cardiomyopathy: physiology, treatment, and genetics
Acute coronary syndromes
Diabetes and coronary artery disease
Coronary physiology and imaging
Representative Publications
1. Subherwal S, Bach RG, Chen AY, Gage BF, Rao SV, Newby LK, Wang TY, Gibler WB, Ohman EM, Roe MT,
Pollack CV Jr, Peterson ED, Alexander KP. Baseline Risk of Major Bleeding in Non-ST-Segment Elevation
Myocardial Infarction: The CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress
Adverse outcomes with Early implementation of the ACC/AHA guidelines) Bleeding Score. Circulation
2009;119:1873-82.
2. Cresci S, Wu J, Province MA., Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL,
Bach RG. PPAR-Pathway Gene Polymorphisms Associated with Extent of Coronary Artery Disease in
Patients with Type 2 Diabetes in the BARI 2D Trial. Circulation 2011;124:1426-34.
3. Bach RG, Brooks MM, Lombardero M, Genuth S, Donner TW, Garber A, Kennedy L, Monrad ES, Pop-
Busui R, Kelsey SF, Frye RL; BARI 2D Investigators. Rosiglitazone and outcomes for patients with diabetes
mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2
Diabetes (BARI 2D) trial. Circulation. 2013;128(8):785-94.
4. Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA, Bach RG. Cytochrome p450
gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.
Circ Cardiovasc Genet. 2014;7(3):277-86.
5. Depta JP, Lenzini PA, Lanfear DE, Wang TY, Spertus JA, Bach RG, Cresci S. Clinical outcomes associated
with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups
following acute myocardial infarction. Pharmacogenomics J. 2015;15:20–5.
6. Depta JP, Patel JS, Novak E, Gage BF, Masrani S, Raymer D, Facey G, Patel Y, Zajarias A, Lasala J, Amin AP,
Kurz HI, Singh J, Bach RG. Risk model for estimating the one-year risk of deferred lesion intervention
following deferred revascularization after fractional flow reserve assessment. Eur Heart J,
2015;36(8):509-15.
7. Bach RG, Cannon CP, Giugliano RP, White JA, Lokhnygina Y, Bohula EA, Califf RM, Braunwald E, Blazing
MA. Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary
Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial. JAMA
Cardiol. 2019;4(9):846–54.
8. 8. Ho CY, Mealiffe ME, Bach RG, Bhattacharya M, Choudhury L, Edelberg JM, Hegde SM, Jacoby D,
Laksawala NK, Lester SJ, Ma Y, Marian AJ, Nagueh SF, Owens A, Rader F, Saberi S, Sehnert AJ, Sherrid
MV, Solomon SD, Wang A, Wever-Pinzon O, Wong TC, Heitner SB. Safety and Efficacy of Mavacamten in
Patients with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy: The MAVERICK-HCM Study.
J Am Coll Cardiol. 2020;75(21):2649-60.
Key words: coronary artery disease, diabetes, hypertrophic cardiomyopathy, imaging
16Philip M. Barger, MD, MSc
Associate Professor of Medicine
Current research interests
Adult congenital heart disease
Mechanisms of cardiac reverse remodeling and recovery
Representative Publications
1. Mann DL, Barger PM, Burkhoff D. Myocardial recovery and the failing heart: myth,
magic, or molecular target? J Am Coll Cardiol. 2012 Dec 18;60(24):2465-72.
2. Tzeng HP, Evans S, Gao F, Chambers K, Topkara VK, Sivasubramanian N, Barger PM,
Mann DL. Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial
ischemia reperfusion injury. J Am Heart Assoc. 2014 Feb 26;3(1):e000662.
3. Zhang W, Lavine KJ, Epelman S, Evans SA, Weinheimer CJ, Barger PM, Mann DL. Necrotic
myocardial cells release damage-associated molecular patterns that provoke fibroblast
activation in vitro and trigger myocardial inflammation and fibrosis in vivo. J. Am. Heart
Assoc.2015: 4:e001993.
4. Topkara VK, Chambers KT, Yang KC, Tzeng HP, Evans S, Weinheimer C, Kovacs A,
Robbins J, Barger P, Mann DL. Functional significance of the discordance between
transcriptional profile and left ventricular structure/function during reverse remodeling.
JCI Insight. 2016: 1(4):e86038.
5. Carvajal HG, Lindley KJ, Shah T, Brar AK, Barger PM, Billadello JJ, Eghtesady P. Impact of
pregnancy on autograft dilatation and aortic valve function following the Ross
procedure. Congenit Heart Dis. 2018 Mar;13(2):217-21. doi: 10.1111/chd.12554.
6. Evans S, Tzeng HP, Veis DJ, Matkovich S, Weinheimer C, Kovacs A, Barger PM, Mann DL.
TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB
signaling. JCI Insight. 2018 Feb 8;3(3). pii: 98278. doi: 10.1172/jci.insight.98278.
7. Sodhi SS, Zhang TJ, McDonald R, Al Rashida V, Kondapalli N, Barger P, Ludbrook P, Cedars
AM. Effects of eplerenone on markers of myocardial fibrosis, 6-minute walk distance, and
quality of life in adults with tetralogy of Fallot and complete transposition of the great
arteries. Proc (Bayl Univ Med Cent). 2018 Jan 3;31(1):12-9. doi: 10.1080/08998280.2017.
1396176. eCollection 2018 Jan.
8. Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ,
Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL. Modulation of subsets of
cardiac B lymphocytes improves cardiac function after acute injury. JCI Insight. 2018 Jun
7;3(11). pii: 120137. doi: 10.1172/jci.insight.120137.
9. Rocha-Resende C, Weinheimer C, Bajpai G, Adamo L, Matkovich SJ, Schilling J, Barger PM, Lavine KJ,
Mann DL. Immunomodulatory role of non-neuronal cholinergic signaling in myocardial injury. JCI
Insight. 2019 Jun 4;5(14):e128961. doi: 10.1172/jci.insight.128961.
Key words: congenital heart disease, reverse remodeling
17Anita Bhandiwad, MD
Associate Professor of Medicine
Current Research Interests
Cardiac magnetic resonance imaging
Echocardiography
Nuclear cardiology
Representative Publications
1. Danias PG, Bhandiwad AR: Cardiac Magnetic Resonance Imaging. In Heller, GV and Hendel, RC
(Eds): Nuclear Cardiology: Practical Applications. McGraw-Hill, p. 227-42, 2004.
2. Fuisz AR, Pohost GM, Bhandiwad AR. Clinical utility of cardiovascular magnetic resonance
imaging. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2005, 2006, 2007.
3. Bhandiwad AR, Cummings WK, Crowley M, Woodard PK. Cardiovascular magnetic resonance
with an MR compatible pacemaker. Journal of Cardiovascular Magnetic Resonance. 2013;15:18.
4. Thangam M, Bhandiwad AR. Cardiac Computed Tomography and Magnetic Resonance Imaging.
Washington Manual Cardiology Subspecialty Consult 4th Edition (in press).
Key words: imaging, cardiac MRI, echocardiography
18Alan C. Braverman, MD
Alumni Endowed Professor in Cardiovascular Diseases, Department of
Medicine
Current Research Interests
Genetically triggered aneurysm syndromes (Marfan, Loeys-Dietz, Vascular Ehlers-Danlos,
Heritable Thoracic Aortic Diseases)
Aortic dissection
Bicuspid aortic valve and aortopathy
Aortic disease in pregnancy
Exercise and aortic disease
Representative Publications
1. Braverman AC, Harris KM, Kovacs RJ, Baron BJ. Eligibility and Disqualification Recommendations for
Competitive Athletes With Cardiovascular Abnormalities: Task Force 7: Aortic Diseases, Including Marfan
Syndrome: A Scientific Statement From the American Heart Association and American College of
Cardiology. J Am Coll Cardiol.2015 Dec 1;66(21):2398-405.
2. Braverman AC, Schermerhorn. Diseases of the Aorta. In, Zipes DP, Libby P, Bonow RO, Mann DL,
Tomaselli GF. Braunwald’s Heart Disease, 11th Edition, Elsevier, Philadelphia, 2018, pp 1295-327.
3. Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Di Eusanio M, Sechtem U, Ehrlich MP,
Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O’Gara P, Suzuki T, Nienaber CA, Eagle
on behalf of the IRAD Investigators. Insights From the International Registry of Acute Aortic Dissection: A
20-Year Experience of Collaborative Clinical Research. Circulation; 2018;137:1846-60.
4. Silberbach M, Roos-Hesselink JW, Andersen NH, Braverman AC, Brown N, Collins RT, De Backer J, Eagle
KA, Hiratzka LF, Johnson WH Jr, Kadian-Dodov D, Lopez L, Mortensen KH, Prakash SK, Ratchford EV, Saidi
A, van Hagen I, Young LT; American Heart Association Council on Cardiovascular Disease in the Young;
Council on Genomic and Precision Medicine; and Council on Peripheral Vascular Disease. Cardiovascular
Health in Turner Syndrome: A Scientific Statement From the American Heart Association. Circ Genom
Precis Med. 2018 Oct;11(10):e000048.
5. Braverman AC. Aortic replacement for bicuspid aortic valve aortopathy: When and why? J Thorac
Cardiovasc Surg. 2019 Feb;157(2):520-5.
6. Braverman AC, Roman MJ. Bicuspid Aortic Valve in Marfan Syndrome. Circ Cardiovasc Imaging. 2019
Mar;12(3):e008860. doi: 10.1161/CIRCIMAGING.119.008860.
7. Braverman AC, Cheng A. The Bicuspid Aortic Valve and Associated Aortic Disease. In, Valvular Heart
Disease, 5th Edition. Otto CM, Bono RO, eds. A companion to Braunwald’s Heart Disease.
Saunders/Elsevier, Philadelphia, 2020.
8. Milewicz DM, Braverman AC, De Backer J, Morris S, Boileau C, Jondeau G, Evangelista A, Pyeritz R.
Marfan Syndrome. Nature Reviews Disease Primers 2020 (in press)
9. Braverman AC, Mittauer E, Harris K, Evangelista A, Pyeritz RE, Brinster D, Conklin L, Suzuki T, Fanola C,
Ouzounian M, Chen C, Myrmel M, Bekeredjian R, Hutchison S, Coselli J, Gilon D, O’Gara P, Davis M,
Isselbacher E, Eagle K. Aortic Dissection Related to Pregnancy: Results from the International Registry of
Acute Aortic Dissection (IRAD) 2020, JAMA Cardiology (in press).
Key Words: Marfan syndrome, bicuspid aortic valve, aortic dissection, thoracic aortic aneurysm
19Angela L. Brown, MD
Associate Professor of Medicine
Current Research Interests
Hypertensive Heart Disease
Resistant hypertension
Tools/strategies for implementing community education on cardiovascular disease
prevention
Representative Publications
1. de las Fuentes L, Brown AL, Waggoner AD, Davila-Roman VG. Plasma Triglyceride Level is an
Independent Predictor of Altered Left Ventricular Relaxation. J Am Soc Echocardiogr 2005 Dec;
18(12):1285-91.
2. de las Fuentes L, Brown AL, Reagan JL, Towler DA, Waggoner AD, Dávila-Román VG. Increased
Carotid Intima-Media Thickness in Metabolic Syndrome. Circulation 2005:122: II-384.
3. Dong SJ, de las Fuentes L, Brown AL, Waggoner AD, Ewald GA, Dávila-Román VG. NT-proBNP
Levels: Correlation with Echocardiographically-determined Left Ventricular Filling Pressures in
An Ambulatory Cohort. J Am Soc Echocardiog 2006;19:1017-25.
4. de las Fuentes L, Brown AL, Mathews SJ, Waggoner AD, Soto P, Gropler RJ, Dávila-Román VG.
Metabolic Syndrome is Associated with Abnormal Left Ventricular Diastolic Function
Independent of LV Mass. Eur Heart J. 2007 Mar;28(5):553-9.
5. Brown AL. Obesity and Metabolic Syndrome in African American Women. J Cardiometab Syndr.
2008 Spring;3(2):126-8.
6. Flack JM, Sica DA, Bakris G, Brown AL, Ferdinand KC, Grimm RH, Hall WD, Jones WE, Kountz DS,
Lea JP, Nasser S, Nesbitt SD, Saunders E, Scisney-Matlock M, Jamerson KA. Management of high
blood pressure in Blacks: an update of the International Society on Hypertension in Blacks
consensus statement. Hypertension 2010 Nov;56(5):780-800.
7. Brown A, Captain B. 50 years of thiazides: should thiazide diuretics be considered third-line
hypertension treatment? Am J Ther 2011 Nov;18(6):e244-e254,
doi:10.1097/MJT.0b013e3181e90863
8. Brown AL, Lau JMC. Cardiovascular Disease in Special Populations. In: Cuculich PS, Kates AM.
The Washington Manual of Cardiology Subspecialty Consult. 3rd ed. Philadelphia: Wolters
Kluwer, 2014:467-85.
9. Egan BM, Bland VJ, Brown AL, Ferdinand KC, Hernandez GT, Jamerson KA, Johnson WR, Kountz
DS, Li J, Osei K, Reed JW, Saunders E. Hypertension in African Americans aged 60 to 79 years:
statement from the International Society of Hypertension in Blacks. J Clin Hypertens
(Greenwich). 2015 Apr;17(4):252-259. doi: 10.1111/jch.12511.
Key words: global health, hypertension, prevention, women and minorities
20David L. Brown, MD
Professor of Medicine
Current Research Interests
Use of Existing Public and Proprietary Databases to Answer Clinical Questions in Cardiovascular
Disease
Comparative effectiveness research of treatments for cardiovascular disease
Meta-analysis
Ischemic Heart Disease including microvascular dysfunction and coronary spasm
Representative Publications
1. Dunn T, Saeed MJ, Shpigel A, Novak E, Alhamad T, Stwalley D, Rich MW, Brown DL. The
Association of Preoperative Cardiac Stress Testing with 30-day Death and Myocardial Infarction
Among Patients Undergoing Kidney Transplantation. PLoS ONE 2019;14(2): e0211161.
https://doi.org/10.1371/journal.pone.0211161
2. Shpigel AA, Saeed MJ, Novak E, Alhamad T, Rich MW, Brown DL. Center-Related Variation in
Cardiac Stress Testing in the 18 months Prior to Renal Transplantation. JAMA Intern Med.
Published online May 13, 2019. doi:10.1001/jamainternmed.2019.0423
3. Rashid A, Agarwala A, Novak E, Brown DL. The Association of High Birth Weight with Incident
Heart Failure in the Atherosclerosis Risk in Communities Study. J Am Heart Assoc.
2019;8:e011524. doi: 10.1161/JAHA.118.011524.
4. Soares A, Brown DL. The fallacies of fractional flow reserve. Int J Cardiol 2019; Online before
print. DOI: https://doi.org/10.1016/j.ijcard.2019.12.040
5. Ge A, Brown DL. Assessment of cardiovascular diagnostic tests and procedures offered in
executive screening programs at top-ranked cardiology hospitals. JAMA Intern Med. Published
online January 13, 2020. doi:10.1001/jamainternmed.2019.6607
6. Sechtem U, Brown DL, Good S, Lanza GA, Shimokawa H, Sidik N, Coronary microvascular
dysfunction in stable ischaemic heart disease (NOCAD and OCAD), Cardiovascular Research
2020; https://doi.org/10.1093/cvr/cvaa005
7. Camici PG, Bairey Merz N, Beltrame J, Brown DL, Crea F, Kaski JC, Maas A, Ong P, Pepine C,
Rimoldi O, Sechtem U, Shimokawa H, Elias-Smale S, Berry C. Commentary - The ISCHEMIA trial.
Int J Cardiol 2020; Online ahead of print.
8. Gdowski M, Murthy VL, Doering M, Monroy-Gonzalez AG, Slart R, Brown DL. Association of
isolated coronary microvascular dysfunction with mortality and major adverse cardiac events: a
systematic review and meta-analysis of aggregate data. Originally published 29 Apr 2020.
Journal of the American Heart Association. https://doi.org/10.1161/JAHA.119.014954
9. Wolfe NK, Mitchell JD, Brown DL. The independent reduction in mortality associated with
guideline-directed medical therapy in patients with coronary artery disease and heart failure
with reduced ejection fraction, European Heart Journal - Quality of Care and Clinical Outcomes
2020; https://doi.org/10.1093/ehjqcco/qcaa032
Key Words: outcomes research, comparative effectiveness research, meta-analysis, coronary
artery disease, health services research, patient-centered care, ischemic heart disease,
microvascular dysfunction, coronary spasm
21Robert M. Carney, PhD
Professor of Psychiatry
Current Research Interests
The effects of psychiatric depression on the course and outcome of coronary heart
Disease
Potential mechanisms underlying the risk of depression on cardiac related morbidity and
Mortality
The effects of treating depression on course and outcome of coronary heart disease
Representative Publications
1. Whooley MA, deJonge P, Vittinghoff E, Otte C, Moos R, Carney RM, Ali S, Dowray S, Na B,
Feldman MD, Schiller NB, Browner WS. Depressive symptoms, health behaviors, and risk of
cardiovascular events in patients with coronary heart disease. JAMA. 2008; 300:2379-88.
2. Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS. Omega-3
augmentation of sertraline in the treatment of depression in patients with coronary heart
disease: a randomized controlled trial. JAMA, 2009; 302(15):1651-7.
3. Freedland KE, Skala JA, Carney RM et al. Treatment of depression after coronary artery
bypass surgery: a randomized controlled trial. Arch Gen Psychiatry 2009 April; 66(4):387-
96.
4. Carney RM, Freedland KE. Treatment-resistant depression and mortality after acute
coronary syndrome. Am J Psychiatry 2009 April; 166(4):410-7.
5. Carney RM, Freedland KE. Depression and coronary heart disease. Nature Reviews Cardiology,
2017; 14(3):145-55. PM: 27853162.
6. Carney RM. Additional approaches to treatment of depression. JAMA, 2019; 32(16): 1634-6.
7. Carney RM. The course of emotional distress and late mortality following acute myocardial
infarction: Implications for screening and treatment: Editorial. European Journal of Preventive
Cardiology 2019; (online: https://doi.org/10.1177/2047487319845122).
Key words: behavioral medicine, coronary artery disease, depression, sleep disorders
22Murali M. Chakinala, MD
Professor of Medicine
Current Research Interests
Therapeutics in pulmonary arterial hypertension
Non-invasive evaluation in pulmonary hypertension
Representative Publications
1. Taichman DB, McGoon M, Harhay MO, Archer-Chicko C, Sager JS, Murugappan M, Chakinala MM,
Palevsky HI, and Gallop R. Wide Variation in Clinicians’ Assessment of New York Heart Association /
World Health Organization Functional Class in Patients with Pulmonary Arterial Hypertension. Mayo
Clinic Proceedings. 2009; 84(7): 586-92.
2. Bradley EA, Chakinala MM, and Billadello JJ. Delayed atrial septal defect closure in the presence of
pulmonary arterial hypertension: Medical therapy may improve closure candidacy. Am J Cardiol. 2013;
112(9): 1471-6.
3. Lahm T and Chakinala MM. World Health Organization Group 5 Pulmonary Hypertension. Clin Chest
Med. 2013; 34 (4): 753-78.
4. Chakinala MM and Barst RJ. From short-term outcomes to long-term benefits: the evolution of clinical
trials in pulmonary arterial hypertension. Pulmonary Circulation. 2013; 3(3): 507-22. PMID: 24618537.
5. Frantz RP, Schilz RJ, Chakinala MM, Badesch DB, Frost AE, McLaughlin VV, et al. Hospitalization and
Survival in Patients Utilizing Epoprostenol for Injection in the PROSPECT Observational Study. Chest.
2015; 147(2): 484-94.
6. Bourge RC, Waxman AB, Gomberg-Maitland M, Shapiro S, Tarver JH, Zwicke DL, Feldman JP, Chakinala
MM, Frantz RP, Torres F, Cerkvenik J, Morris M, Thalin M, Peterson L, and Rubin LJ. Implantable
Intravascular Delivery System for Treprostinil Therapy of PAH. Chest 2016: 150(1): 27-
34. PMID: 27396777.
7. Chakinala MM, Feldman J, Rischard F, Mathier M, Howell M, Leedom N, Laliberte K, and White
RJ. Transition from Parenteral to Oral Treprostinil in Pulmonary Arterial Hypertension. J Heart Lung
Transplant 2017: 36(2): 193-201. PMID: 27469018.
8. Rahaghi FF, Feldman JP, Allen RP, Tapson V, Safdar Z, Balasubramanian VP, Shapiro S, Mathier MA,
Elwing JA, Chakinala MM, White RJ. Recommendations for the use of oral treprostinil in clinical practice:
a Delphi consensus project pulmonary circulation. Pulm Circ 2017: 7(1): 167-74.
9. Chakinala MM, Coyne DW, Benza RL, Frost AE, McGoon MD, Hartline BK, Frantz RP, Selej M, Zhao C,
Mink DR, Farber HW. Impact of declining renal function on outcomes in pulmonary arterial
hypertension: A REVEAL Registry analysis. J Heart Lung Transplant. 2018: 37(6):696-705. PMID:
29174533.
10. Bradley EA, Ammash N, Martinez SC, Chin K, Hebson C, Singh HS, Aboulhosn J, Grewal J, Billadello J,
Chakinala MM, Daniels CJ, Zaidi AN. “Treat-to-Close”: Unrepaired ASD-PAH in the Adult. Intl J
Cardiol. 2019: 291:127-33.
Key words: pulmonary hypertension, pulmonary arterio-venous malformations, right heart failure
23Sharon Cresci, MD
Associate Professor of Medicine and Genetics
Current Research Interests
• Genetic variation and clinical outcomes in individuals with cardiovascular disease
• Precision medicine
• Hypertrophic cardiomyopathy
Representative Publications
1. Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye
RL, Bach RG. Peroxisome proliferator-activated receptor pathway gene polymorphism associated with
extent of coronary artery disease in patients with type 2 diabetes in the Bypass Angioplasty
Revascularization Investigation 2 Diabetes Trial. Circulation 2011; 124(13):1426- 34. PMID:21911782.
2. Cresci S, Dorn GW, Jones PG, Beitelshees AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE.
Adrenergic-pathway gene variants influence β-blocker-related outcomes after acute coronary syndrome
in a race-specific manner. J Am Coll Cardiol 2012; 60:898-907. PMCID: PMC3678950.
3. Cresci S, Depta J, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA, Bach RG. Cytochrome P450
gene variants, race, and mortality among clopidogrel treated patients following acute myocardial
infarction. Circ Cardiovasc Genet 2014; 7:277-86. PMCID: PMC4104276.
4. Depta J, Lenzini PA, Lanfear DE, Wang TY, Spertus JA, Bach RG, Cresci S. Clinical outcomes associated
with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups
following acute myocardial infarction. Pharmacogenomics J 2015; 15:20-5. PMCID: PMC4287459.
5. Buchanan DM, Arnold S, Li Y, Jones PG, Longmore LS, Spertus JA, Cresci S. The association of smoking
status with angina and health-related quality of life after acute myocardial infarction. Circ Cardiovasc
Qual Outcomes 2015; 8:493-500.
6. Coverstone ED, Bach RG, Chen LS, Bierut LJ, Li AY, Lenzini PA, O’Neill HC, Spertus JA, Sucharov CC, Stitzel
JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after
acute myocardial infarction. Basic Res Cardiol. 2018;113:38. PMCID: PMC6292447.
7. Tang Y, Lenzini PA, Busui RP, Perkins BA, Callaghan B, Wagner MJ, Motsinger-Reif, AA, Buse JB,
Mychaleckyj JC, Cresci S, Shah H, Doria A. A genetic locus on chromosome 2q24 predicting peripheral
neuropathy risk in type 2 diabetes: results from the ACCORD and BARI 2D studies. Diabetes. 2019; PMID:
31127053.
8. Cresci S (Chair), Pereira N (Vice-Chair) Ahmad F, Byku M, de las Fuentes L, Lanfear DL, Owens A, Reilly C,
Wolf M. AHA Scientific Statement: Heart failure in the era of precision medicine. Circ Genom Precis Med.
2019.
Key words: genetics, precision medicine, hypertrophic cardiomyopathy, translational research
24Phillip S. Cuculich, MD
Associate Professor of Medicine
Clinical Cardiac Electrophysiology
Current Research Interests
Development of an entirely noninvasive cardiac ablation platform combining cardiac imaging,
cardiac mapping and focused radiation
Noninvasive electrical mapping of uterine contractions to guide therapeutic interventions to
prevent preterm birth
Representative Publications
1. Cuculich PS, Wang Y, Lindsay BD, Faddis MN, Schuessler RB, Damiano RJ Jr, Li L, Rudy Y. Noninvasive
characterization of epicardial activation in humans with diverse atrial fibrillation patterns. Circulation.
2010 Oct 5;122(14):1364-72. PMID: 20855661
2. Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, Faddis MN, Lindsay BD, Smith TW,
Rudy Y. Noninvasive electroanatomic mapping of human ventricular arrhythmias with
electrocardiographic imaging. Sci Transl Med. 2011 Aug 31;3(98):98ra84. PMID: 21885406
3. Cuculich PS, Zhang J, Wang Y, Desouza KA, Vijayakumar R, Woodard PK, Rudy Y. The electrophysiological
cardiac ventricular substrate in patients after myocardial infarction: noninvasive characterization with
electrocardiographic imaging. J Am Coll Cardiol. 2011 Oct 25; 58(18):1893-902. PubMed PMID:
22018301; PubMed Central PMCID: PMC3365586.
4. Zhang J, Sacher F, Hoffmayer K, O’Hara ZT, Strom M, Cuculich P, Silva J, Cooper D, Faddis M, Hocini, M,
Haissaguerre M, Scheinman M, Rudy Y. The Cardiac Electrophysiologic Substrate Underlying the ECG
Phenotype and Electrogram Abnormalities in Brugada Syndrome Patients. Circulation 2015; 131: 1950-9.
5. Zhang J, Cooper DH, Desouza KA, Cuculich PS, Woodard PK, Smith TW, Rudy Y. Electrophysiologic Scar
Substrate in Relation to VT: Noninvasive High-Resolution Mapping and Risk Assessment with ECGI.
Pacing Clin Electrophysiol. 2016 Aug; 39(8):781-91. PMC: 27197804
6. Vijayakumar R, Vasireddi SK, Cuculich PS, Faddis MN, Rudy Y. Methodology Considerations in Phase
Mapping of Human Cardiac Arrhythmias. Circ Arrhythm Electrophysiol. 2016 Nov; 9(11). pii: e004409.
PMID: 27906655.
7. Junjie Zhang, Mélèze Hocini, Maria Strom, Phillip S. Cuculich, Daniel H. Cooper, Frédéric Sacher, Michel
Haïssaguerre, Yoram Rudy. The Electrophysiological Substrate of Early Repolarization Syndrome. JACC:
Clinical Electrophysiology Mar 2017 Aug; 3(8):894-904. doi: 10.1016/j.jacep.2016.12.017.
8. Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, Faddis M, Gleva M, Noheria A, Smith TW,
Hallahan D, Rudy Y, Robinson CG. Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia.
N Engl J Med. 2017 Dec 14; 377(24): 2325-36. PMID: 29236642; PMCID: PMC5764179
Key words: Translational research, transdisciplinary research, noninvasive cardiac ablation, noninvasive
mapping, ventricular tachycardia, atrial fibrillation, uterine mapping
25Victor G. Davila‐Roman, MD
Professor of Medicine, Anesthesiology, and Radiology
Current Research Interests
Cardiovascular imaging: echocardiography, vascular ultrasound, nuclear cardiology, cardiac
CT
Cardiac metabolism, Hypertensive heart disease, Diastolic function
Cardiovascular genetic epidemiology
Representative Publications
1. Gu CC, Flores HR, de las Fuentes L, Davila-Roman VG. Enhanced detection of genetic association
of hypertensive heart disease by analysis of latent phenotypes. Genetic Epidemiol 2008;
32(6):528-38.
2. de las Fuentes L, Waggoner AD, Mohammed BS, Stein RI, Miller BV 3rd, Foster GD, Wyatt HR,
Klein S, Davila-Roman VG. Effect of moderate diet-induced weight loss and weight regain on
cardiovascular structure and function. J Am Coll Cardiol 2009; 54(25):2376-81.
3. Mathews SJ, de las Fuentes L, Podaralla P, Cabellon A, Bierhals A, Spence K, Slatopolsky E,
Davila-Roman VG, Delmez JA. Effects of Sodium Thiosulfate on Vascular Calcification in ESRD: A
Pilot Study of Feasibility, Safety, and Efficacy. Am J Nephrol 2011; 33:131-8.
4. Lin CH, Kurup S, Herrero P, Schechtman KB, Eagon JC, Klein S, Dávila-Román VG, Stein RI, Dorn
GW, Gropler RJ, Peterson LR. Myocardial Oxygen Consumption Change Predicts Ventricular
Relaxation Improvement in Obese Humans after Weight Loss. Obesity 2011; 19:1804-12.
5. de las Fuentes L, Yang W, Dávila-Román VG, Gu CC. Pathway-based genome-wide association
analysis of coronary heart disease identifies biologically important gene sets. Eur J Hum Genet.
2012 Nov; 20(11):1168-73. doi:10.1038/ejhg.2012.66.
6. Barve RA, Gu CC, Yang W, Chu J, Davila-Roman VG, de Las FL. Genetic association of left
ventricular mass assessed by M-mode and two-dimensional echocardiography. J Hypertens
2016 January; 34(1):88-96. doi:10.1097/hjh.
7. Vader JM, LaRue SJ, Stevens SR, Mentz RJ, DeVore AD, Lala A, Groarke JD, AbouEzzeddine OF,
Dunlay SM, Grodin JL, Davila-Roman VG, de Las FL. Timing and Causes of Readmission After
Acute Heart Failure Hospitalization-Insights From the Heart Failure Network Trials. J Card Fail
2016 Nov; 22(11):875-83. doi:10.1016/j.
8. Kadkhodayan A, Lin CH, Coggan AR, Kisrieva-Ware Z, Schechtman KB, Novak E, Joseph SM,
Davila-Roman VG, Gropler RJ, Dence C, Peterson LR. Sex affects myocardial blood flow and fatty
acid substrate metabolism in humans with nonischemic heart failure. J Nucl Cardiol 2017
Aug;24(4):1226-35.
Key words: cardiac imaging, cardiac metabolism, hypertension, genetic epidemiology, translational
research, diastolic function, echocardiography, global health
26Lisa de las Fuentes, MD, MS
Associate Professor of Medicine and Biostatistics
Current Research Interests
Genetic epidemiology of cardiovascular disease and drug response
Hypertensive heart disease
Metabolic and inflammatory cardiovascular risk factors
Representative Publications
1. de las Fuentes L, Herrero P, Peterson LR, Kelly DP, Gropler RJ, Dávila-Román VG. Myocardial fatty acid
metabolism: Independent predictor of left ventricular mass in hypertensive heart disease.
Hypertension 2003;41:83-7.
2. de las Fuentes L, Brown AL, Mathews SJ, Waggoner AD, Soto PF, Gropler RJ, Dávila-Román VG.
Metabolic Syndrome is Associated with Abnormal Left Ventricular Diastolic Function Independent of
LV Mass. European Heart J 2007;28:553-9.
3. de las Fuentes L, Waggoner AD, Mohammed BS, Stein RI, Miller BV, Foster GD, Wyatt H, Klein S,
Dávila-Román VG. Effect of moderate diet-induced weight loss and weight regain on cardiovascular
structure and function. J Am Coll Cardiol 2009;54:2376–81. PMCID: PMC2818984.
4. de las Fuentes L, Spence KE, Dávila-Román VG, Waggoner AD. Are Normative Values for LV Geometry
and Mass Based on Fundamental Imaging Valid With Use of Harmonic Imaging? J Am Soc Echocardiog
2010;23:1317-22. PMCID: PMC2993783.
5. Vader JM, LaRue SJ, Stevens SR, Mentz RJ, DeVore AD, Lala A, Groarke JD, AbouEzzeddine OF, Dunlay
SM, Grodin JL, Dávila-Román VG, de las Fuentes L. Timing and Causes of Readmission after Acute
Heart Failure Hospitalization – Insights from the Heart Failure Network Trials. J Cardiac Fail
2016;22:875-83. PMCID: PMC5085925.
6. Levine GN, O'Gara PT, Beckman JA, Al-Khatib SM, Birtcher KK, Cigarroa JE, de las Fuentes L, et al.
Recent Innovations, Modifications, and Evolution of ACC/AHA Clinical Practice Guidelines: An Update
for Our Constituencies: A Report of the American College of Cardiology/American Heart Association
Task Force on Clinical Practice Guidelines. Circulation. 2019;139:e879-3886. PMID: 30892927.
7. Boutjdir M, Aromolaran AS, de las Fuentes L, et al. Research Education and Mentoring Program in
Cardiovascular Diseases for Under-Represented Junior Faculty From NHLBI SIPID/PRIDE. J Am Coll
Cardiol 2019;14:1861-1865. DOI: 10.1016/j.jacc.2019.01.042. PMCID: PMC6464379.
8. Sung YJ, de las Fuentes L, Winkler TW, et al. A multi-ancestry genome-wide study incorporating gene-
smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum
Mol Genet. 2019 Apr 10. pii: ddz070. doi: 10.1093/hmg/ddz070. PMID: 31127295.
9. de las Fuentes L, Sung YJ, Sitlani CM, et al. Genome-wide meta-analysis of variant-by-diuretic
interactions as modulators of lipid traits in persons of European and African ancestry.
Pharmacogenomics J. 2019 Dec 6. doi: 10.1038/s41397-019-0132-y. PMCID: PMC7260079.
10. de las Fuentes L, Sung YJ, Noordam R, et al. Gene-educational attainment interactions in a multi-
ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry 2020
May 5. doi: 10.1038/s41380-020-0719-3. PMID: 32372009. PMCID: Pending.
Key words: hypertension, risk factors, genetic epidemiology, global health, diastolic function,
echocardiography
27Abhinav Diwan, MD, FACC , FAHA
Professor of Medicine, Cell Biology and Physiology, Obstetrics and Gynecology
Current Research Interests
Regulation of lysosome function in cardiac myocytes and macrophages in heart failure
Maternal dietary exposures as a determinant of offspring cardiovascular risk.
Regulation of lysosomal machinery in Alzheimer’s disease and amyloid heart disease
Role of lysosomal pathways in beta cell regeneration in pancreatic islets
Representative publications
1. Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, Diwan A. Impaired autophagosome
clearance contributes to cardiomyocyte death in ischemia-reperfusion Injury. Circulation.
2012 Jun 26;125(25):3170-81.
2. Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A*, Lee
JM* (*contributed equally, co-corresponding authors). Astrocytic lysosome biogenesis facilitates Aβ
clearance and attenuates amyloid plaque pathogenesis. The Journal of Neuroscience. 2014 Jul
16;34(29):9607-20. PMCID:PMC4099542
3. Yang KC, Ma X, Liu H, Kovacs A, Barger PM, Mann DL, Diwan A. TNF-receptor associated factor-2
mediates mitochondrial autophagy. Circulation Heart Failure. 2015 Jan;8(1):175-87.
4. Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P, Diwan A. Repetitive
stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to
ischemia-reperfusion injury. Autophagy. 2015 Sep 2;11(9):1537-60.
5. Liu H, * Javaheri A,* Godar RJ, Murphy JT, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C,
McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A. (*contributed equally) Intermittent fasting
preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy.
2017;13(11):1952-68.
6. Ma, X*; Mani, M*; Kovacs, A; Liu, H; Murphy, JT; Foroughi L; French, B; Benjamin, IJ; Hill, JA; Javaheri, A;
Diwan A. (*contributed equally). TFEB rescues advanced mutant αB-crystallin-induced cardiomyopathy
by normalizing desmin localization. J Am Heart Assoc. 2019 Feb 19;8(4):e010866.
7. Ferey J, Boudoures A, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch B, Thompson M,
Diwan A*, and Moley K* (*contributed equally). A maternal high-fat, high-sucrose diet induces
transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial
inheritance. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1202-H1210.
8. Murphy, JT*; Liu, H*; Ma, X; Shaver, S; Oh, C; Boyko, A; Mazer, T; Ang, S; Khopkar, R; Javaheri, A; Kumar,
S; Jiang X; Ory, D; Mani, K; Matkovich, SJ; Kornfeld K *; Diwan A *. (*contributed equally.) Simple
nutrients activate a HLH-30-independent pathway for coupling lysosomal nutrient sensing to TOR
activation. PLoS Biol. 2019 May 14;17(5):e3000245.
9. Javaheri, A; Bajpai, G; Picataggi, A; Mani, S; Foroughi, L; Evie, H; Kovacs, A; Weinheimer, C; Hyrc, K;
Xiao, Q; Ballabio, A; Lee, JM; Matkovich, SJ; Razani, B; Schilling, JD; Lavine, K; Diwan A. Transcription
factor EB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction
independently of ATG5-mediated Autophagy. JCI Insight, 2019 Nov 1;4(21):e127312.
Key words: autophagy, lysosome, amyloid, ischemia-reperfusion, heart failure, cell death
28Gerald W. Dorn, II, MD
Philip and Sima K. Needleman Professor of Medicine
Current Research Interests
Biology of mitochondria in the heart; metabolic remodeling
Molecular and biochemical signaling for cardiac hypertrophy and heart failure
Genetic diseases affecting mitochondrial dynamism and mitophagy
Representative Publications
1. Chen Y and Dorn GW II. PINK1-phosphorylated Mitofusin 2 is a Parkin receptor for culling
damaged mitochondria. Science 2013; 340:471-75.
2. Kasahara A, Cipolat S, Chen Y, Dorn GW II*, Scorrano L* (* co-contributing authors).
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin/notch signaling.
Science 2013; 342:734-37.
3. Matkovich SJ, Hu Y, Dorn GW II, Regulation of cardiac microRNAs by cardiac microRNAs. Circ
Res 2013; 113:62-71.
4. Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II. Mitochondrial contagion induced by Parkin
deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res 2014;
114:257-65.
5. Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn GW II. Super-suppression of
mitochondrial ROS signaling impairs compensatory autophagy in primary mitophagic
cardiomyopathy. Circ Res 2014; 115:348-53.
6. Matkovich SJ, Edwards JR, Grossenheider TC, de Guzman Strong C, Dorn GW II. Epigenetic
coordination of embryonic heart transcription by dynamically regulated lncRNAs. Proc Natl
Acad Sci USA 2014; 111:12264-9.
7. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW II. Mitochondrial fission and fusion factors
reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell
Metab 2015; 21:273-285.
8. Picard M, McManus M, Csordas G, Varnai P. Dorn GW II, Williams D, Hajnoczky G, Wallace DC.
Trans-mitochondrial coordination of cristae at regulated membrane junctions. Nat Commun
2015; 6:6259.
9. Song M, Matkovich SJ, Zhang Y, Hammer DJ, and Dorn GW II. Combined cardiomyocyte PKC
and PKC gene deletion uncovers their central role in restraining developmental and reactive
heart growth. Sci Signal, 2015; 8(373):ra39.
10. Song M, Guong G, Burelle Y, Gustafsson AB, Kitsis RN, Matkovich SJ, and Dorn GW II.
Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse
hearts. Circ Res 2015;117:246-351.
Key words: mitophagy, heart failure, molecular cardiology
29Gregory A. Ewald, MD
Professor of Medicine
Current Research Interests
Mechanical circulatory support in advanced heart failure
Medical therapy in patients with heart failure
Device therapy in patient with heart failure
Remote monitoring in management of heart failure
Cardiac transplantation/donor evaluation and management
Depression in heart failure
Representative Publications
1. Park SJ, Milano CA, Tatooles AJ, Rogers JG, Adamson RM, Steadley E, Ewald GA, Sundareswaran KS,
Farrar DJ, Slaughter MS. Outcomes in advanced heart failure patients with left ventricular assist devices
for destination therapy. Circ Heart Fail 2012; 5:241-8.
2. Lavine KJ, Sintek M, Novak E, Ewald G, Geltman E, Joseph S, Pfeifer J, Mann DL. Coronary collaterals
predict improved survival and allograft function in patients with coronary allograft vasculopathy. Circ
Heart Fail 2013; 6:773-84.
3. Starling RC, Moazami N, Silvestry SC, Ewald G, Rogers JG, Milano CA, Rame JE, Acker MA, Blackstone EH,
Ehrlinger J, Thuita L, Mountis MM, Soltesz EG, Lytle BW, Smedira NG. Unexpected abrupt increase in left
ventricular assist device thrombosis. N Engl J Med 2014 Jan 2; 370(1):33-40.
4. Topkara VK, O’Neill JK, Carlisle A, Novak E, Silvestry SC, Ewald GA. Heartware and Heartmate II left
ventricular assist devices as bridge to transplantation: a comparative analysis. Ann Thorac Surg 2014
Feb; 97(2):506-12.
5. Fang JC, Ewald GA, Allen LA, Butler J, Westlake Canary CA, Colvin-Adams M, Dickinson MG, Levy P,
Stough WG, Sweitzer NK, Teerlink JR, Whellan DJ, Albert NM, Krishnamani R, Rich MW, Walsh MN,
Bonnell MR, Carson PE, Chan MC, Dries DL, Hernandez AF, Hershberger RE, Katz SD, Moore S, Rodgers
JE, Rogers JG, Vest AR, Givertz MM; Heart Failure Society of America Guidelines Committee. Advanced
(stage D) heart failure: a statement from the Heart Failure Society of America Guidelines Committee. J
Card Fail. 2015 Jun; 21(6):519-34.
6. Adamo L, Nassif M, Tibrewala A, Novak E, Vader J, Silvestry S, Itoh A, Ewald GA, Mann DL, LaRue SJ. The
Heartmate risk score predicts morbidity and mortality in unselected left ventricular assist device
recipients and risk stratifies INTERMACS Class 1 patients. JACC Heart Fail 2015; 3:283-90.
7. McNamara DM, Elkayam U, Alharethi R, Damp J, Hsich E, Ewald G, Modi K, Alexis JD, Ramani GV,
Semigran MJ, Haythe J, Markham DW, Marek J, Gorcsan J, Wu W-C, Lin Y, Halder I, Pisarcik J, Cooper LT,
Fett JD, for the IPAC Investigators. Clinical outcomes for peripartum cardiomyopathy in North America:
Results of the Investigations of Pregnancy Associated Cardiomyopathy (IPAC) study. JACC 2015; 66:905-
14.
8. Nassif ME, LaRue SJ, Raymer DS, Novak E, Vader JM, Ewald GA, Gage BF. Relationship Between
Anticoagulation Intensity and Thrombotic or Bleeding Outcomes Among Outpatients With Continuous-
Flow Left Ventricular Assist Devices. Circ Heart Fail. 2016 May; 9(5). Pii: e002680.
9. Carney RM, Freedland KE, Steinmeyer BC, Rubin EH, Ewald G. Collaborative care for depression
symptoms in an outpatient cardiology setting: A randomized clinical trial. 2016 Sep 15; 219:164-71. doi:
10.1016/j.ijcard.2016.06.045.
Key words: heart failure, heart transplantation
30Mitchell N. Faddis, MD, PhD
Professor of Medicine
Current Research Interests
Catheter ablation techniques
Treatment of atrial fibrillation
Cardiac resynchronization therapy for advanced heart failure
Representative Publications
1. Marrus S, Andrews C, Cooper D, Faddis MN, Rudy Y. Repolarization changes underlying long-
term cardiac memory due to right ventricular pacing: noninvasive mapping with ECGI.
Circulation Arrhythmia Electrophysiol. 2012; 5(4):773-81.
2. Burkhard, J, Talcott M, Faddis M. Evaluation of a novel robotic system for remote control of a
fixed curve sheath in a porcine model; BAF#11. J Cardiovascular Electrophysiology. 2012;
23(6):681-2.
3. Zhang J, Sacher F, Hoffmayer K, O’Hara T, Strom M, Cuculich P, Silva J, Cooper D, Faddis M,
Hocini M, Haissaguerre M, Scheinman M, Rudy Y. Cardiac electrophysiological substrate
underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients.
2015; Circulation 131(22):1950-9.
4. Vijayakumar R, Vasireddi S, Cuculich P, Faddis M, Rudy Y. Methodology consideration in phase
mapping of human cardiac arrhythmias. Circulation: Arrhythmia and Electrophysiology. 2016;
9(11):e004409.
5. Roberts C, Wofford J, Hoy H, Faddis M. Implementation of a screening program for patients at
risk for posttraumatic stress disorder. Clinical Medicine Insights. Cardiology. 2016; 10:129-37.
6. Rao P, Faddis M. Cardiac resynchronization therapy: current indications, management, and
basic troubleshooting. Heart 2017; 103(24):2000-7.
Key words: arrhythmias, atrial fibrillation, electrophysiology, heart failure, implantable devices
31Kenneth E. Freedland, PhD, FAHA
Professor of Psychiatry
Current Research Interests
Depression, anxiety, stress, and physical inactivity in patients with coronary heart disease or
heart failure
Roles of depression and inadequate self-care in heart failure rehospitalizations
Interventions for depression and inadequate self-care in heart failure
Clinical trials in behavioral medicine and behavioral trial methodology
Representative Publications
1. Freedland KE, Carney RM, Rich MW, Steinmeyer BC, Skala JA, Dávila-Román VG. Depression
and multiple rehospitalizations in patients with heart failure. Clin Cardiol. 2016
May;39(5):257-62. doi: 10.1002/clc.22520. PMID: 26840627
2. Freedland KE, Hesseler MJ, Carney RM, Steinmeyer BC, Skala JA, Dávila-Román VG, Rich
MW. Major depression and long-term survival of patients with heart failure. Psychosom
Med. 2016 Oct;78(8):896-903. doi: 10.1097/PSY.0000000000000346. PMID: 27187847
3. Freedland KE. Purpose-guided trial design in health-related behavioral intervention
research. Health Psychol. 2020 Jun;39(6):539-48. doi: 10.1037/hea0000867. PMID:
32212768
4. Freedland KE. Pilot trials in health-related behavioral intervention research: Problems,
solutions, and recommendations. Health Psychol. 2020 Jul 2. doi:
10.1037/hea0000946. PMID: 32614197
5. Freedland KE, Steinmeyer BC, Carney RM, Skala JA, Rich MW. Antidepressant use in patients
with heart failure. Gen Hosp Psychiatry. 2020 Jul-Aug;65:1-8. doi:
10.1016/j.genhosppsych.2020.04.006. PMID: 32361659
Key words: behavioral medicine, coronary artery disease, depression, depressive disorders, heart
failure, sleep disorders, heart failure self-care
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