FCF Fox Corporate Finance GmbH - FCF Life Science Venture Capital Monitor May 2019 05/2019

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FCF Fox Corporate Finance GmbH

FCF Life Science Venture Capital Monitor
May 2019                                                                        Antibody

Part of FCF Life Science Research Series   „Thinking Strategic Finance in Life Science”
Agenda

F C F L i f e S c i e nc e O v e r v i ew

                                            2
FCF Life Sciences

 Life Science Overview                                                                   Advisory Services                           Facts and Figures

       Focus on Biotechnology, MedTech and HealthTech                                                                                                                                          Over                 Over
                                                                                                                                         Life Science                      Life Science
                                                                                                             Management                    Team of                                           100 years            EUR 2bn
FCF advises innovative companies on arranging, structuring and placing                                                                                                      Advisory       in aggregated       Life Science
                                                                                                             Presentation                      ~10
equity and debt transactions in a holistic financing strategy approach.                                                                                                      Board          Life Science        transaction
                                                                                               Integrated                             based in Munich
Together with its FCF Life Science Advisory Board, FCF Life Science                                                                                                                          experience           volume1
                                                                                                Financial
provides valuable support on the strategic positioning of its clients                           Modeling
                                                                                                                 Post-                         Over                                                                  4
                                                                                                                                                                              Access to
       Strategic Financing Advisory                                                                           Transaction                          80                                        Leading            regularly
                                                                                                                Support                                                        > 1000
                                                                                                                                       completed Life                                       EIB advisor       published Life
                                                                                                                                                                           international
 FCF advises with its dedicated Life Science team on the following                             Investor                                    Science                                           in Europe          Science
                                                                                                                                                                             investors
 transaction types:                                                                            Screening                                transactions1                                                            reports
                                                                                                                                    1 comprising   Professionals and Advisory Board
                                                                                                              Investor / IB
    Venture                             Venture                                                                Roadshow              Life Science Research Series
    Capital                              Debt                                                     Due
                                                                                                Diligence                            FCF Life Science                                      FCF Life Science
                                                                                                Support                              Venture Capital Monitor                               Public Equity Monitor
                                                                                                             Equity & Debt                                        is     a    monthly                      is the most detailed
       Life Science Team                                                                                      Fundraising
                                                                                                                                                                  published overview                       analysis           of
                                                                                               Financing                                                          of venture capital                       European publicly
                                                                                                Strategy                                                                                                   listed   companies,
                                                                                                                                                                  transactions of Life
                                                                                                Advisory
                                                                                                                                                                  Science companies                        from     the    Life
                                                                                                               Closing                                                                                     Science sectors
                                                                                                              Assistance
   Arno Fuchs          Dr. Mathias Schott       Sebastian Sommer         Colin Saß
       CEO                   Director                 Analyst              Analyst             Term Sheet
                                                                                                                                     FCF Life Science                                      FCF Life Science
                                                                                               Negotiation                           Venture Capital Report                                IPO Report
                                                                                                                                                                  analyses the latest                      examines       recent
                                                                                                                 IPO
                                                                                                               Execution                                          Venture       Capital                    IPO trends in the
                                                                                                                Support                                           funding activities in                    Life Science sector,
                                                                                                  Life
                                                                                                Science                                                           the Life Science                         with a strong focus
Dr. Alexandra Goll        Prof. Dr.              Claus Schalper       Dr. Holger Bengs         Advisory
     Former             Horst Domdey            Co-Founder & former    Founder & CEO                                                                              sector in Europe                         on the comparison
                                                                                                 Board         (extract from
  General Partner   Co-Founder of Medigene AG    CFO Pieris Pharma    BCNP Consultants                                                                            and the US                               of European and US
   TVM Capital
                                                                                                               service portfolio)
                     board member of BioM AG
                                                                                                                                                                                                           characteristics

                                                                                                                                                                                                                               3
Executive Summary

The FCF Life Science
Venture Capital                    FCF Life Science Venture Capital Monitor                                                Recipients
Monitor is a monthly     is a monthly published overview of biotechnology, pharmaceutical,      The FCF Life Science Venture Capital Monitor targets the following
published overview       medical technology and healthcare technology companies,                recipients:
focusing on the          displaying venture capital financing trends in the European life             ▪ Corporates / Executives  ▪ Venture capital investors
venture capital          science industry                                                             ▪ Institutional investors  ▪ Family Offices / High-
financing environment                                                                                 ▪ Private equity investors     net-worth individuals
in the biotechnology,                                                                                                            ▪ Advisors
                                                        Scope
pharmaceutical,
medical technology       The selection of companies is based on the following criteria:                                    Availability
and healthcare
technology segments,     ▪ Sole focus on transactions with obtainable deal volume and           The FCF Life Science Venture Capital Monitor is available on FCF’s
and can be used as a        involving European headquartered life science companies             website at “https://www.fcf.de/de/research/life-science-research“
quick reference for      ▪ Companies operating in the biotechnology, pharmaceutical,
investors, corporates       medical technology, healthcare technology, services or other life                                  Data
and professionals           science related sectors
                                                                                                All input data is provided by Pitchbook or GlobalData and is not
                         ▪ The therapeutics sector is further divided into the following        independently verified by FCF. Ratio and multiple calculations are
                            indications: Oncology, Cardiovascular, Central Nervous System,
More advanced,                                                                                  driven based on the input data available. For additional information
                            Gastrointestinal,     Hematological,    Infectious   Diseases,      and disclaimer, please refer to the last page
detailed and / or           Immunology, Metabolic, Ophthalmology, Rare Diseases,
customized reports          Respiratory, Diversified and Others.
are available upon
request
                           To recommend colleagues or fellow investors to be added to the       If you have questions, comments or ideas, please do not hesitate
                             mailing list, kindly send an email with the respective contact                               to contact us
                                                       information

                                                                                                                                                                       4
Agenda

V e n t ur e C a p i t a l T r a n s a c t i ons
May 2019

                                                   5
European Venture Capital Transactions in Life Sciences
                                                                May 2019

                                                                                                                                                                     Vertical -                                                    Deal  Total
                                                                                                                                                                     Indication /                                                Volume Raised
Overview (YTD)                                                                                                       # Date         Company        HQ   Subsector    Stage          Company Description                   Series (EURm) (EURm) Investors                      Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                   Central        Developer of medical therapeutics
                                                                                                                                                                                                                                                                              The company raised $3.9 million of venture funding from Seventure
  5,000                                                                                                                                                              Nervous        intended for the treatment of
                                                                                                      4,156          1 28/05/2019                       Biotech                                                             -      3      35   Seventure Partners             Partners on May 28, 2019. The funds will be used to accelerate the
                                                                                                                                                                     System /       Central Nervous System (CNS)
  4,000                                                                                                                                                                                                                                                                       company's next growth phase.
                                                                                                                                                                     Phase II       diseases and cancer.
  3,000
                                                 1,737
  2,000
                                                                                                                                                                                                                                                                       The company raised GBP 500,000 of venture funding in a deal led by
  1,000                                                                                                                                                                             Manufacturer of medical devices                                                    Maven Capital Partners on May 28, 2019. GMC Fund and Chinese
                                                                                                    2019                                                             Back Care /                                                               GMC Fund, Maven Capital
                                                                                                    2018             2 28/05/2019                       MedTech                     designed to offer back care             -
European Venture Capital Transactions in Life Sciences
                                                                May 2019

                                                                                                                                                                 Vertical -                                                   Deal  Total
                                                                                                                                                                 Indication /                                               Volume Raised
Overview (YTD)                                                                                                       # Date          Company   HQ   Subsector    Stage          Company Description                  Series (EURm) (EURm) Investors                      Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                              Developer a fish-skin
                                                                                                                                                                 Wound                                                                                                   The company raised $1.61 million of venture funding from undisclosed
  5,000                                                                                                                                                                         transplantation technology
                                                                                                      4,156          9 17/05/2019                   MedTech      Treatment /                                           -      1       4    na                            investors on May 23, 2018. The amount was originally raised in the form
                                                                                                                                                                                designed to facilitate healing
  4,000                                                                                                                                                          On market                                                                                               of convertible debt and subsequently converted to equity.
                                                                                                                                                                                through tissue regeneration.
  3,000
                                                 1,737                                                                                                                                                                                     Bpifrance, Idinvest           The company raised $38.5 million of Series B venture funding in a deal
  2,000
                                                                                                                                                                                                                                           Partners, Illumina            led by Life Sciences Partners on May 16, 2019. Merck Ventures,
  1,000                                                                                                                                                                       Developer of enzymatic DNA                                   Ventures, Kurma Partners,     Idinvest Partners, Sofinnova Partners, Kurma Partners, Illumina
                                                                                                    2019                                                         Immunology /
                                                                                                    2018             10 16/05/2019                  Biotech                   synthesis platform intended to           B      33     47    Life Sciences Partners,       Ventures, M Ventures and Bpifrance also participated in the round. The
                                                                                                                                                                 On market
       0                                                                                                                                                                      facilitate genome scale synthesis.                           Merck Ventures,               funds will be used to accelerate the development of the company's first
                    Jan Feb Mar             Apr May Jun         Jul     Aug Sep Oct Nov Dec                                                                                                                                                MVentures, Sofinnova          products based on its industry-leading enzymatic technology for de novo
                                    Financing Volume (May 2019): EUR 357m                                                                                                                                                                  Partners                      synthesis of nucleic acids.

Subsectors                                                 Indications1                                                                                                                                                                                                  The company raised $4.5 million of Series B venture funding from
                                                                                                                                                                                                                                                                         Innovation Fund, SambrInvest and Jean-Pierre Delwart on May 16,
                  Healthcare                                                                                                                                     Patient        Developer of patient                                       Innovation Fund, Jean
                                                                                                                                                                                                                                                                         2019. Jean Stephenne also participated in the round. The company
                   Services                                                                        Central Nervous   11 16/05/2019                  HealthTech   Analysis /     characterization tools intended to     B      4       4    Stephenne, Jean-Pierre
       Pharmaceuticals                                                                             Systems                                                                                                                                                               intends to use the funds to advance commercialization of Placebell©™,
                                                                                                                                                                 Developing     improve patients condition.                                Delwart, SambrInvest
                                                                                                                                                                                                                                                                         its product that limits the effect of the placebo response on clinical trials,
                              3%
                                           Biotechnology   Others                                                                                                                                                                                                        and to expand its product portfolio.
                        12%                                                              20%

                              EUR     42%                               40%      EUR
               17%
                         1,737m                                               1,067m         16%         Oncology
                                                                                                                                                                                Developer of coupling fluid
                                                                                                                                                                                                                                           Cofounders Capital, Sarsia
                                                                                                                                                                                                                                                                      The company raised NOK 10 million of venture funding from Sintef
MedTech                                                                                                                                                          Diagnostic /                                                              Seed, Sintef
                                                                                                                     12 16/05/2019                  MedTech                     technology designed to identify        -      1       2                               Energiforskning, Cofounders Capital and Sarsia Seed on May 16, 2019.
                                                                              4% 7%    13%                                                                       Developing                                                                Energiforskning,
                         26%                                                                                                                                                    tumor remnants.                                                                       Sparebank 1 Smn Invest also participated in the round.
                                                                                                                                                                                                                                           Sparebank 1 Smn Invest

          HealthTech                                              Metabolic                      Immunology
                                                                  Disorders Infectious
                                                                            Diseases
                                                                                                                                                                                                                                                                         The company raised EUR 80 million of Series E venture funding in a
                                                                                                                                                                                Developer of an medical
                                                                                                                                                                                                                                           Enern, Goldman Sachs          deal led by One Peak Partners and Goldman Sachs Private Capital
                                                                                                                                                                                appointment scheduling platform
Top Company Origins                                        Top Investor Origins                                      13 14/05/2019                  HealthTech
                                                                                                                                                                 Platform /
                                                                                                                                                                                designed to improve patient flow       E      80     128
                                                                                                                                                                                                                                           Private Capital Investing     Investing Group on May 14, 2019. Piton Capital, Enern and other
                                                                                                                                                                 On market                                                                 Group, One Peak Partners,     undisclosed investors also participated in the round. The funds will be
                                                                                                                                                                                and help digitise healthcare
                                                                                                                                                                                                                                           Piton Capital                 used continue the company's push in core European and Latin
          Others                                                                                                                                                                practices.
                                                               Others                                                                                                                                                                                                    American markets, purse R&D activities and expand their team.
                    24%             23%                                                    22%
                                                                         27%
                              EUR                                                EUR
                                                                                                                                                                                                                                                                       The company raised $18 million of Series B venture funding in a deal
                   5%    1,737m                                         6%
                                                                              1,737m                                                                             Imaging /
                                                                                                                                                                                Provider of imaging software                               Capricorn Venture
                                                                                                                                                                                                                                                                       led by Forestay Capital on May 14, 2019. Optum Ventures and
                   7%                                                                        21%                     14 14/05/2019                  HealthTech                  platform intended to be used for       B      15     18    Partners, Forestay Capital,
                                    23%                                  6%                                                                                      On market                                                                                             Capricorn Venture Partners also participated in the round. The funds will
                                                                                                                                                                                multiple sclerosis (MS).                                   Optum Ventures
                         18%                                                    18%                                                                                                                                                                                    be used by the company to continue to develop its technology.

                                                                                                                                                                                                                                                                         The company raised EUR 7.1 million of Series A venture funding on
Top 5 Deals                                                Top 5 Investors                                                                                                      Developer of stem cells intended                           Aquitaine Science
                                                                                                                                                                 Central                                                                                                 May 13, 2019. The funds will be used by the company to proceeds its
                                                                                                                                                                                to secure cell production and                              Transfert, AQUITI Gestion,
                                     Deal                                                     Deal          # of                                                 Nervous                                                                                                 transition for their technology to cGMP standards by 2021 and to
 # Company                    HQ    Volume     Series      # Investor                 HQ     Volume2       Deals     15 13/05/2019                  Biotech                     quality, fasten clinical               A      7       8    Galia Gestion, Irdi Soridec
                                                                                                                                                                 System /                                                                                                develop proprietary and collaborative cell therapy research programs in
     Arvelle                                                                                                                                                                    development and facilitate market                          Gestion, XAnge Private
 1                                   155          A        1 Bpifrance                           63         9                                                    Pre-clinic                                                                                              a wide array of indications with the objective of a first-in-man clinical trial
     Therapeutics                                                                                                                                                               access.                                                    Equity
                                                                                                                                                                                                                                                                         in 2024.
                                                             Life Sciences
 2 Doctolib                          150          -        2                                     50         4
                                                             Partners
                                                                                                                                                                                                                                                                         The company raised GBP 2.4 million of Series A venture funding from
                                                             Andera
 3 Ynsect                            110         C         3                                     48         4                                                    Care           Developer of an integrated                                 Cambridge Angels, IQ          IQ Capital Partners, Longwall Ventures and Cambridge Angels on May
                                                             Partners
                                                                                                                                                                 Tracking       healthcare technology intended to                          Capital Partners, Longwall    9, 2019, putting the pre-money valuation at GBP 2.8 million. Martlet,
                                                             Idinvest                                                16 09/05/2019                  HealthTech                                                         A      3       4
 4 ZnanyLekarz                        80          E        4                                     39         4                                                    platform /     improve patient outcomes and                               Ventures, Martlet, Peter      Sherry Coutu and Peter Cowley also participated in the round. The
                                                             Partners                                                                                            Developing     health system performance.                                 Cowley, Sherry Coutu          funds will be used by the company to support the development of a drug
   Sophia                                                    BRV Capital                                                                                                                                                                                                 + digital approach and to treat and manage major health conditions.
 5                                    66          E        5                                     31         1
   Genetics                                                  Management

Source: PitchBook as of 04.06.2019; FCF Equity Research; GlobalData                                                                                                                                                                                                                                                                                   7
Note: All volumes in EURm; financing rounds without deal values are excluded
1Only includes biotechnology and pharmaceutical deals; 2 Proportional attribution of deal values to investors participating in a transaction (transaction volume / # investors by financing round)
European Venture Capital Transactions in Life Sciences
                                                                May 2019

                                                                                                                                                                 Vertical -                                                 Deal  Total
                                                                                                                                                                 Indication /                                             Volume Raised
Overview (YTD)                                                                                                       # Date          Company   HQ   Subsector    Stage          Company Description                Series (EURm) (EURm) Investors                             Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                           Provider of e-medicine platform                                                                  The company raised EUR 2 million of venture funding in a deal led by
                                                                                                                                                                 Communicati
  5,000                                                                                                                                                                      intended to serve medico-social                                                                  Crédit Mutuel Arkéa on May 9, 2019. Other undisclosed investors also
                                                                                                      4,156          17 09/05/2019                  HealthTech   on /                                                -      2       2    Crédit Mutuel Arkéa
                                                                                                                                                                             establishments and home care                                                                     participated in this round. The funds will be used by the company to
  4,000                                                                                                                                                          On market
                                                                                                                                                                             services.                                                                                        expand its business.
  3,000
                                                 1,737
  2,000                                                                                                                                                                                                                                                                       The company raised $12 million of Series A venture funding in a deal
                                                                                                                                                                                Provider of a medical health
                                                                                                                                                                                                                                                                              led by Optum Ventures and Qiming Venture Partners on March 28,
  1,000                                                                                                                                                                         testing platform designed to
                                                                                                    2019                                                         Diagnostic /                                                            Optum Ventures, Qiming               2018. Other undisclosed investors also participated in the round. The
                                                                                                    2018             18 08/05/2019                  HealthTech                  connect customers and global         A      10     11
                                                                                                                                                                 On market                                                               Venture Partners                     funds will be used to continue expanding to the U.S., grow the full
       0                                                                                                                                                                        laboratories for personal health
                                                                                                                                                                                                                                                                              clinical support team and further invest in the company's technology
                    Jan Feb Mar             Apr May Jun         Jul     Aug Sep Oct Nov Dec                                                                                     testing.
                                                                                                                                                                                                                                                                              platform that links customers to laboratories.
                                    Financing Volume (May 2019): EUR 357m
                                                                                                                                                                                                                                         Beyond Next Ventures, CI:Z
Subsectors                                                 Indications1                                                                                                                                                                  Holdings, CMBCC Co-High Medical
                                                                                                                                                                                                                                         Investment Fund, Cyril Janssen,      The company raised EUR 39.7 million of Series D venture funding on
                  Healthcare                                                                                                                                     Genetic        Developer of stem cell therapy                           Itochu, Korea Investment Partners,
                                                                                                                                                                                                                                                                              May 7, 2019. The funds will be used by the company for its
                   Services                                                                        Central Nervous   19 07/05/2019                  Biotech      Disorders /    intended to treat liver diseases     D      40     104   Marc Speeckaert, Medipal Holdings,
       Pharmaceuticals                                                                             Systems                                                                                                                               Mirae Asset Capital, Mitsui Global   manufacturing scale-up, preclinical programs and overall operations of
                                                                                                                                                                 Phase II       easily.
                                                                                                                                                                                                                                         Investment, Olivier van der Rest,    the company and the group.
                              3%                                                                                                                                                                                                         Shibuya, Shinsei Capital Partners,
                        12%                Biotechnology   Others                        20%                                                                                                                                             Six Snow, Sosei

                              EUR     42%                               40%      EUR                                                                                                                                                     BioGeneration Ventures,
               17%                                                                                                                                                                                                                       Capricorn Venture Partners, The company raised EUR 30 million of Series A venture funding on May
                         1,737m                                               1,067m         16%         Oncology
                                                                                                                                                                 Musculoskele Developer of a drug discovery                              Fund+, Perceptive Advisors, 7, 2019. The funds will be used by the company to accelerate its
MedTech
                                                                                                                     20 07/05/2019                  Biotech      tal Disorders / technology designed to address      A      30     37    PMV, Qbic Fund, University ConfoBodyTM-enabled drug discovery activities and to develop its
                         26%                                                  4% 7%    13%                                                                       Discovery       unmet medical needs.                                    of Michigan Endowment, V- pipeline of GPCR modulating compounds to produce drug candidates
                                                                                                                                                                                                                                         Bio Ventures, VIB,          for clinical trials.
          HealthTech                                              Metabolic                      Immunology                                                                                                                              Wellington Partners
                                                                  Disorders Infectious
                                                                            Diseases                                                                                                                                                                                          The company raised EUR 8 million of venture funding in a deal led by
                                                                                                                                                                                                                                         Banco de Sabadell, Caixa             Caixa Capital Risc and Sabadell Asabys Health Innovation Investments
                                                                                                                                                                                Developer of a virtual reality                           Capital Risc, Carlos                 on May 7, 2019. Banco de Sabadell and Carlos Gallardo also
Top Company Origins                                        Top Investor Origins                                      21 07/05/2019                  HealthTech
                                                                                                                                                                 VR /
                                                                                                                                                                                platform designed to bring value     -      8       9    Gallardo, Sabadell Asabys            participated in the round. The funds will be used to complete the VR
                                                                                                                                                                 On market
                                                                                                                                                                                to mental health treatment.                              Health Innovation                    platform that can be used to treat anxiety disorders, stress management,
          Others                                                                                                                                                                                                                         Investments                          depression, attention problems such as ADHD, autistic spectrum and
                                                               Others
                                                                                                                                                                                                                                                                              psychotic disorders.
                    24%             23%                                                    22%
                                                                         27%                                                                                                                                                                                                  The company raised CHF 9.5 million of Series A venture funding in a
                              EUR                                                EUR                                                                                                                                                                                          deal led by Panakes Partners on May 6, 2019. btov Partners, Brabantse
                                                                                                                                                                                                                                         Brabantse Ontwikkelings
                   5%    1,737m                                         6%
                                                                              1,737m                                                                             Imaging /
                                                                                                                                                                                Developer of medical imaging
                                                                                                                                                                                                                                         Maatschappij, btov
                                                                                                                                                                                                                                                                              Ontwikkelings Maatschappij, Sioux Group and other undisclosed
                   7%                                                                        21%                     22 06/05/2019                  MedTech                     devices intended to improve          A      8      13                                         existing investors also participated in the round. The funds will be used
                                    23%                                  6%                                                                                      On market                                                               Partners, Panakes
                                                                                                                                                                                cancer treatment care.                                                                        to commercialize the patented Histolog system, notably the recently CE
                         18%                                                    18%                                                                                                                                                      Partners, Sioux Group
                                                                                                                                                                                                                                                                              mark Histolog Scanner v2, for enabling precise tumor removal at first
                                                                                                                                                                                                                                                                              surgery.

Top 5 Deals                                                Top 5 Investors                                                                                                    Manufacturer of high quality
                                                                                                                                                                              growth factors designed to use in                                                               The company graduated from Babraham Bioscience Technologies on
                                     Deal                                                     Deal          # of                                                 Immunology /                                                            Babraham Bioscience
 # Company                    HQ    Volume     Series      # Investor                 HQ     Volume2       Deals     23 01/05/2019                  Biotech                   stem cell science and                  -
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