HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY

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HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
HYWEL DDA HEALTH BOARD
 DIABETES CARE PATHWAY
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
Contributors

Dr Jonathan Williams       GP Church Surgery, Aberystwyth
Dr Christine Kotonya       Consultant Physician & Diabetologist, Bronglais Hospital
Dr Nia Llewelyn             GP Llyn Y Fran, Llandysul
Carol Evans                Senior Diabetes Specialist Nurse, Bronglais Hospital
Dr Gethin Roberts          Consultant Biochemist, Bronglais Hospital
Jenny Pugh-Jones           Pharmacist Hywel Dda Health Board
Dr Karen Poyser             Principal Biochemist, Bronglais Hospital
Glenys Jones               Diabetes Specialist Dietician, Bronglais Hospital
Rhiannon Roberts            Podiatrist, Bronglais Hospital
Liz Newbury-Davies           Senior Health Promotion Specialist, Public Health Wales

This document has been approved by the following Hywel Dda wide bodies:
    Hywel Dda DPDG
    Hywel Dda Diabetes Clinical Network
    Hywel Dda Community and Chronic Conditions Management Board

                       Special acknowledgement to NHS Enfield NSF Diabetes Team for permitting us to adapt their diabetes treatment
                                                                care pathway which is based on
                       NICE CG66 Type 2 diabetes guidelines for Diabetes 2008 and NICE CG 87 Type 2 diabetes: partial update 2009
The Preventing Type 2 Diabetes section of the care pathway is based on NICE (2011) Preventing type 2 diabetes: population and community level interventions
                                      in high risk groups and the general population. NICE public health guidance 35.

                        This document has been revised and modified in September 2012. Review date will be September 2013
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
PREVENTING TYPE 2 DIABETES

For most people, type 2 diabetes can be prevented or delayed by maintaining a healthy weight, improving dietary intake, being physically active, not smoking and drinking alcohol within the
recommended units. Lifestyle interventions for example aimed at changing an individual’s diet and increasing physical activity levels can halve the number of people with impaired glucose
tolerance who develop type 2 diabetes (Gillies et al., 2007). The greatest impact on the prevalence of type 2 diabetes and associated costs is however likely to be achieved by addressing these
behavioural risk factors in whole communities and populations (NICE, 2011). Type 2 diabetes shares these common risk factors with other non-communicable diseases including cardiovascular
disease and some cancers. In addition to these individual risk factors, people from certain communities and population groups are particularly at risk, including people of South Asian, African-
Caribbean, black African and Chinese descent and those from lower socioeconomic groups. Action to address the wider determinants of health, health inequalities and inequities however
fundamentally underpins improving the health of our population.

Prevention of type 2 diabetes and non-communicable diseases and early intervention should therefore be considered as part of an integrated package of local measures aimed at empowering
individuals and communities and to promote and improve the health of the population.

Needs assessment and planning to prevent type 2 diabetes

    •    identify local communities at high risk of developing type 2 diabetes, assess their knowledge, awareness, attitudes and beliefs about the risk factors and assess their specific cultural,
         language and literacy needs.

         Through development of Hywel Dda Obesity Pathway

             •    Identify successful local interventions and gaps in service provision

             •    Identify local resources and existing community groups that could help promote healthy eating, physical activity and weight management, particularly within local
                  communities at high risk of developing type 2 diabetes.

Developing local strategies and action plans

Through development of the Obesity Pathway consider actions at level 1 and 2 to address increasing people’s physical activity levels and improve people's diet and weight management in order
to contribute to preventing type 2 diabetes and related non-communicable diseases (including cardiovascular disease).

Ensure that actions to address increasing people’s physical activity levels and improve people's diet and weight management, creating supportive environments and the wider determinants of
health and health inequalities are addressed in local areas Health, Social Care and Wellbeing Strategies/Integrated Strategy; Children and Young People’s Plans; Local physical activity action
plans

Implement the Hywel Dda Self Care Strategy which aims to support individuals
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
Training to promote a healthy lifestyle

Developing the public health and health promoting competences and skills of the NHS workforce is a priority action identified through the Public Health Strategic Framework. More
fundamental is the support and management needed for the change in the basic culture of health services and to ensure that promoting health is part of everyone’s role

Conveying healthy lifestyle messages to the local population – in particular, to groups at risk of type 2 diabetes
Ensure key public health messages are current, evidence based, consistent, clear and culturally appropriate.

Work with local practitioners, role models and peers and through mechanisms such as Siarad Iechyd/Talking Health and 10 pledges to tailor national messages for the local community about preventing type 2
diabetes and other non-communicable diseases (such as cardiovascular disease and some cancers).

Ensure messages and information are disseminated locally to groups at higher risk of type 2 diabetes than the general population, including black and minority ethnic and lower socioeconomic groups.

.
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
DIABETES CARE PATHWAY TYPE 2 DIABETES

       MILESTONE 1                        MILESTONE 2                          MILESTONE 3                       MILESTONE 4                      MILESTONE 5

     Diagnostic phase                                                     Treatment management                 Complication / risk              Maintenance phase
                                         Educative phase
                                                                                 phase                           management

a. Lifestyle changes*             a. Check and recheck               a.     - Offer dietary advice        a. Hypertension                  a. Regular review if unstable
                                  understanding                             - Trial of lifestyle                                              2 – 3 monthly
                                                                           interventions including
                                  b. Lifestyle issues*
                                                                           increased activity
b. Patients given                 Inc Smoking and physical
information booklet s             activity                                                                b. Lipid Management              b. 6 monthly review once
                                  c. Medication                      b.   Treat all co – existent                                          stabilized
c. Patient given hand held                                                pathology e.g. BP, lipids
record                                                                                                    c. Anti-platelet therapy
                                  d. Complications                        Arrange screening for                                            c. Annual review
                                                                          complications                                                      (see Appendix 2)
d.Referral to Dietitian (see
appendix for referral criteria)   e. Importance of regular                See Milestone 4                 d. Microalbuminuria
                                  review
e.Referral to group education                                                                                                              d. Ongoing review of
                                  f. Driving                         c. See medication algorithm
sessions via Diabetes Referral                                                                                                             educational needs
                                                                                                          e. Management of CKD
& Triage
                                  g. Importance of good BP
f.Regular review                  control                            d. Continued education & support                                      e. Review of dietary needs
                                                                                                          f. Management of painful
 see maintenance phase            h. Importance of good                                                      neuropathy                    f. People with existing diabetes
                                  glycaemic control HbA1c
                                  (mmol/mol )                        e. 3 – 4 monthly HbA1c                                                should have mental and
g. Assessment of emotional
                                                                     mmol / mol                                                            emotional health monitored and
wellbeing                         i. Eye examinations with dilated                                        g. Retinopathy /
                                                                                                                                           be monitored for depression
                                  pupils & retinal camera                                                    Foot care
h. People with severe
                                  j. Foot health                     f. Continue to follow medication
mental health diagnosis                                                                                                                    g. Information about monitoring
                                                                     algorithm
should be checked                                                                                         h. Erectile Dysfunction          and glucose meters where
annually for diabetes             k. Sexual health
                                                                                                                                           appropriate
                                                                     g. Once stabilised, regular review
                                  l. Travel                             See Maintenance phase
                                                                                                          i. Obesity
                                  m. Diabetes UK / support
                                  groups
                                                                                                          j. Peripheral arterial disease
                                  n. Offer structured education
                                  programme
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
MILESTONE 1: DIAGNOSIS OF DIABETES MELLITUS

                                                        PRESENTING SYMPTOMS

1. Patient presents with signs and symptoms suggestive of Type 2 diabetes
           Excessive thirst
           Polyuria especially at night
           Lethargy
           Weight loss
           Blurred vision
           Infections e.g. pruritis, balanitis
           None of the above
2. At routine /ad hoc health review patient has glycosuria
3. Increased suspicion due to risk factors
           Ethnicity
           Family history
           ≥ 40 years of age
           Previous gestational diabetes
           Polycystic ovarian syndrome
           Existing severe mental illness such as schizophrenia

                                   WHO DIAGNOSTIC CRITERIA FOR DIABETES MELLITUS

NB: In the absence of osmotic symptoms 2 consecutive venous samples are required to diagnose Diabetes Mellitus
  PLASMA                 DIABETES CONFIRMED               IMPAIRED GLUCOSE                    IMPAIRED FASTING GLYCAEMIA
                                                               TOLERANCE
     FBG                       ≥ 7.0 mmol/L                    < 7.0 mmol/L                                ≥ 6.1 mmol/L
                                                                                                           < 7.0 mmol/L
    OGTT                      ≥ 11.1 mmol/L                     ≥ 7.8 mmol/L                       Do OGTT to exclude diabetes
 2 hour value
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
Early Detection of Type 2 Diabetes and Management of Pre- Diabetes

Presentation with symptoms and raised                       Identification of more than 1 risk factor
plasma glucose≥11.1mmol/L                                       • IGT/IFG
                                                                • Age >45yrs (≥35 yrs in high risk ethnic groups) with BMI
                                                                     >30 and hypertension
                                                                • Cardiovascular disease
                                                                • Polycystic ovarian syndrome
                                                                • Previous gestational diabetes
                                                                • Family history with BMI >30
                                                                • Metabolic syndrome
                                                                •

                                                                                                               No
                          Symptoms                             Risk assessment questionnaire                               Annual risk questionnaire
                                                               above threshold?

                                                                                Yes

                                                        Check fasting plasma glucose or
                                                        Oral glucose tolerance test if previous IGT/IFG high risk

                       FBG ≥7mmol/L                                      FBG 6.0-6.9 mmol/L
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
MILESTONE 2: EDUCATION IN TYPE 2 DIABETES

    STEP 1           STEP 2                    STEP 3           STEP 4           STEP 5               STEP 6                 STEP 7
    Assess           Review                    Discuss          Discuss          Facilitate         Understanding            Review
learning needs    understanding            Lifestyle issues   Complications   Dietetic referral      the annual           understanding
                                                                                                       review

Determine first   What is diabetes?                               Eyes        Give “stop gap”     Height, weight,         Importance of
language                                          Diet                        dietary advice      BMI, waist              regular diabetes
                                                                                                  circumference           checks

                                                                  CVD
                                               Physical
Is the patient    Importance of                                               Has patient been              BP            Review
                                               activity
literate in                                                                   referred to                                 concordance with
Welsh/English?    regular diabetes                               Kidney       dietitian?                                  medication
                  checks                                                                              Routine blood
                                               Smoking
                                                                                                    tests / urine tests
                                                                                                                          Review
                                                                                    YES           •     HbA1c
                                                                                                                          concordance with
Is the patient    What to expect at                             Erectile                                mmol/mol
                                                Alcohol                          Recheck                                  healthy eating
literate in own   an Annual Review                             Dysfunction                        • U&E
                                                                                 understanding    • TFT                   regimen
language?
                                                                                                  • LFT
                                             Importance of                                        • Lipid profile
                                              medication        Neuropathy             NO         • eGFR                  Assess gaps in
                  Diabetes UK /                                                                                           knowledge and
                  Cymru e.g.                                                     Refer to         • ACR
                                                                                 dietitian                                provide
                  www.diabetes.org.uk/cy
Arrange           mru                                                                                                     education as
                                                 Social
appointments as                                                   PVD                               Foot assessment       appropriate
                                              adjustments
necessary with                                                                                    • Pedal pulses
                                                                                                  •    Neuropathy
interpreter
                                           mental and                                                  status
                                                                   Foot
                                                 emotional
Offer patient
structured                                       well being
                                                                                                     Retinopathy
diabetes                                                                                                status
education                                                                                         Enrolment onto
                                                Driving
programme                                     regulations                                         DRRSW
                                                                                                  Programme
HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
MILESTONE 3: TREATMENT MANAGEMENT IN TYPE 2
                                            DIABETES (Hywel Dda Health Board Prescribing Formulary)

          = Usual approach                          = Alternative approach
                                                IN THE FIRST INSTANCE, UNLESS THERE IS A CONTRA – INDICATION AIM FOR
                                                                                HbA1c 48 mmol/mol (6.5%)
         This will need to be reviewed on an annual basis, as diabetes progresses, HbA1c treatment target for intervention can be increased to 59 mmol/mol (7.5%)
                    INITIATE HEALTHY EATING PLAN AND INCREASED ACTIVITY FOR AT LEAST 12 – 16 WEEKS UNLESS SYMPTOMATIC
                                                             AGREE LEVEL OF HbA1C (mmol/mol) FOR INTERVENTION

Consider first
                                       METFORMIN                                                                                        SULPHONYLUREAS
     METFORMIN SHOULD NOT TO BE INITIATED IF SERUM CREATININE                                                             If not overweight , or Metformin not tolerated,
     LEVEL IS > 150 µmol/L OR eGFR < 30                                                                     or a rapid therapeutic response is required because of hyperglycaemia
     Review response to medication using the step guidelines, within 28 days in the first                   Consider a rapid-acting secretagogue for people with erratic lifestyles
     instance, then 3 – 4 monthly using HbA1c mmol/mol                                                           GLICLAZIDE                                       GLIMEPIRIDE
     Commence 500mgs BD / TDS Further increase as tolerated                                                    80 mgs OD/ 40 mgs                                      1 mg OD
        1 gm BD/TDS.                                                                                                   BD
     If unable to tolerate Metformin, or compliance issues, consider reducing current dose                         80 mgs BD                                         2 mgs OD
     or change to slow release Metformin up to 2 gm OD                                                            160 mgs AM /                                       4 mgsOD
     Review Metformin dose if serum Creatinine 130 µmol/L or eGFR 45                                               80 mgs PM
                SEE CKD PATHWAY FOR LONG TERM MONITORING                                                        160 mgs BD max                                       6mgs max

                                                                                                       nd
Consider second when HbA1c         48 mmol/mol or 6.5% if sulphonylurea is not appropriate 2                line or risk of hypoglycaemia
                                     THIAZOLIDINEDIONES (TZD)                                                                                   DPP-4 INHIBITORS
     Can be added to Metformin or sulphonylurea                                                                      If significant risk of hypoglycaemia
     Licensed for monotherapy use in patients who cannot tolerate Metformin                                          If sulphonylurea or Metformin is not tolerated or contraindicated
     Can be used with a sulphonylurea if control sub-optimal and cannot tolerate Metformin Not                       Can be used combination with Metformin when Metformin plus diet and
     recommended in patients with evidence of heart failure*or a higher risk of fractures. Check LFT                 exercise, does not provide adequate glycaemic control.
     prior to starting treatment, 2 months after & annually thereafter                                               It can also be used in combination with either a sulphonylurea or a
                                                                                                                     glitazone**.
                PIOGLITAZONE                                                                                         Continue only if > 0.5% (5-6 mmol/mol) reduction in HbA1c at 6
   *Can be used with insulin                                                                                         months which is maintained
   NOT recommended in patients with
   microscopic haematuria or history of bladder                                                                               SITAGLIPTIN                           SAXAGLIPTIN
   cancer                                                                                                                   **has triple licence           Can be used as add on to insulin
                                                                                                                          Can be used as add-on to                      5 mg OD
                  15 - 30 mg OD
               Maximum 45 mgs OD                                                                                                  insulin                    If on sulphonylurea dose may
                                                                                                                                100MG OD                   need to be reduced
      CAUTION WHEN USED WITH SULPHONYLUREAS, RESPONSE MAY NOT BE
      APPARENT FOR 6 – 12 WEEKS                                                                                                                          In mod-severe renal failure a dose of
                                                                                                                         If on sulphonylurea dose may                  2.5mg OD
                                                                                                                               need to be reduced
MILESTONE 3: TREATMENT MANAGEMENT IN TYPE 2 DIABETES

Consider third when HbA1c             59 mmol/mol (or > 7.5% ) or higher than individually agreed target
         TZD                   DPP-4                                       GLP-1                                 NPH INSULIN                  OTHER INSULIN                      ALPHA
                             INHIBITOR                  If BMI ≥ 35 kg/m2 and other                                                         Ensure training course in         GLUCOSIDASE
                                                        psychological/medical problem associated with                 Ensure                insulin initiation done            INHIBITOR
     See overleaf        See above and                  raised BMI                                                    training course
          and                 If insulin is not         If BMI ≥ 35kg/ m2 for whom insulin is                         in insulin                                                 ACARBOSE
     If insulin is           acceptable or              unacceptable because of occupational implications             initiation                                                  50 mg OD
     not                     inappropriate              or where weight loss would benefit other co-                                        Can be considered if            Increase to 50 mg TDS
     acceptable or            Only Sitagliptin          morbidities.                                                                        patient requires assistance           after 6 weeks 100mg
     inappropriate           can be used in             Continue GLP-1 only if beneficial response seen               At bedtime or                                               TDS
                             combination                and maintained (>1.0% reduction in HbA1C at 6                 twice daily                                                200 mg TDS
                             with Metformin             months and weight loss of at least                            according to
                             and a                      3% at 6 months)                                               need.                 from a carer/HCP to
                             Sulphonylurea              Check SPC for contraindications                                                     administer
                                                                                                                                            If lifestyle is restricted by
                                                         EXENATIDE                  LIRAGLUTIDE
                                                                                                                                            recurrent hypoglycaemia
                                                     Prolonged Release Once      Once daily dose 1.2mg                                      If would otherwise need
                                                           WEEKLY                         max                                               BD insulin and oral OHAs
                                                               or                  Not meal related                                         If cannot manage injection
                                                                                   1.8mg dose is not                                        device for NPH
                                                          Twice daily           recommended by NICE
                                                          Meal related

 The initiation of insulin or GLP-1 to people with diabetes should only be carried out by:
     Practices that have attended an appropriate training course on insulin initiation and management and regularly maintain education update and
    use GLP-1 in accordance with NICE guidelines or discussed with secondary care

Consider fourth if HbA1c remains              59 mmol/mol or 7.5%

 NPH INSULIN                                    OTHER INSULIN                                      Consider Pioglitazone or
                               Ensure training course in insulin                                   Sitagliptin with insulin if:
     •    Ensure               initiation
          training             1. Long acting insulin analogue                                     Pioglitazone or Sitagliptin has
          course in                 See above and switch if:                                       previously had a marked
          insulin                   Target HbA1c not reached due to significant                    glucose lowering effect or
          initiation                hypoglycaemia
                                                                                                   Blood glucose is inadequate
          has been                  Cannot manage device for insulin
          done                                                                                     without high dose insulin
                                    Requires assistance from carer/ HCP to
                                    administer
                               2. Premix insulin
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT

1. Aim for Blood Pressure                                      HYPERTENSION
   measurement of:                    Step 1
      If NO microvascular             Offer ACE inhibitor
      complications are               Ramipril caps 2.5 – 10mg OD or Lisinopril 2.5-80mg OD.
      present                         (Offer contraception advice to women of childbearing age)
      ≤ 140 / 80 mmHg                 For people of African – Caribbean descent, offer ACE inhibitor plus Diuretic
      If eye or renal complications   Bendroflumethiazide no more than 2.5mg OD as maximum dosage (check U&Es prior commencing and monitor
      are present aim for
REFER TO
SPECIALIST SERVICE
IN CASES OF
UNRESOLVED
HYPERTENSION
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D…
                                                                                 LIPIDS

RAISED LIPID PROFILE:
1. Statin should be offered to all those aged 40 or above with either Type 1 or Type 2 diabetes (If  6.0 mmol /L
    •   Features of metabolic syndrome
    •   Family history of premature cardiovascular disease in a first degree relative

Step 1. Simvastatin 40mg nocte (if patient on Warfarin or is intolerant of Simvastatin, try Pravastatin up to 40mg nocte) Patients on amlodopine or diltiazem should not
          exceed 20mg dose of simvastatin.
          NB Intolerance is typically muscle or liver related: myalgia and/or rhabdomyolysis, CK > 10x or LFTs (AST/ALT) >3x normal
          Increase to 80mg simvastatin (unless poor response and/or side-effects to 40mg dose)
Step 2. Atorvastatin 40mg once daily (may wish to consider initiating 20mg due to individual patient response)
Step 3. Atorvastatin 80 mg once daily
Step 4. Consider Ezetimibe 10mg as monotherapy if statin contraindicated or not tolerated
Step 5. In patients who have not reached target, cannot tolerate statins, or who have high CV risk and TG = 2.3 – 4.5 mmol/L despite statin, consider addition of a
          fibrate (e.g.Fenofibrate) on case by case basis and consider referral to specialist services.
                       Omega-3 is not recommended for the routine treatment of raised TGs in diabetic patients.
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D…

                                                            ANTI PLATELET THERAPY:

 Primary prevention: Anti platelet therapy should only be prescribed following an assessment of patient’s individual CV              risk and a
                      review of the risks: benefits for that patient.

Secondary Prevention: Anti platelet therapy should be prescribed

 st
1 line:

Soluble aspirin 75 mg daily. This is to be given unless there is an absolute contraindication

 nd
2     line:

For patients who cannot tolerate soluble aspirin, or have a history of ulceration, add in either Lansoprazole Capsules 15mg OD or
Omeprazole Capsules 20mg OD and continue with soluble aspirin

 rd
3 line: If aspirin is still poorly tolerated, contra-indicated, has had a previous cardiovascular event, or compliance issues favour monotherapy
Clopidogrel 75mg daily
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT
                                                    OBESITY

                                                                        ASSESSMENT

   All patients with diabetes should have their BMI recorded annually
   Classification of BMI*:

 CLASSIFICATION                                   BMI                RISK OF CO-MORBIDITIES
 Underweight                                      30.0             Increased
 Class i                                          30.0 – 34.9        Moderate
 Class ii                                         35.0 – 39.9        High
 Class iii                                        >40                V High
*DoH

   Waist circumference:
   SEX                                              METRIC                                               IMPERIAL
   Male                                             >102 cm                                              ≥ 40 inches
   Asian male                                       ≥ 90cm                                               ≥ 35
   Female                                           ≥88 cm                                               ≥ 35
   Asian female                                     ≥80 cm                                               ≥ 31

   Medical history e.g. Current glycaemic control, hypothyroidism, hypertension, hyperlipidaemia, CHD, PCOS, sleep apnoea, osteoarthritis, learning disabilities,
   mental health issues
   Family history
   Social history e.g. Alcohol, smoking status
   Drug history e.g. sulphonylureas, anti-psychotics, steroids
   Dietary history
   Physical activity status
   Readiness to change: Explore how person feels. Inform about solutions. Provide insight into risks

   Active treatment of the obese person with diabetes should commence when BMI is greater than 28
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT
                                                   OBESITY CONT’D
TREATMENT OF OBESITY
Aim of treatment is to:
            Reduce calorie intake –  59 mmol/mol or 7.5% and BMI >35
    Or Refer to secondary care

    IF BMI IS > 40, CONSIDER BARIATRIC SURGERY and refer to secondary care
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D MANAGEMENT OF PERIPHERAL ARTERIAL DISEASE
Patient presents with
- Intermittent Claudication (IC): A cramp like pain in the legs when walking or exercising (can be found in calf or thigh muscles and buttocks)
- Known Arterial Disease (Coronary, Carotid or renal artery disease)
- Absent or diminished Dorsalis Pedis or Posterior Tibial pulses
- Rest pain or gangrene of leg / foot
- Poorly healing / non healing wounds on leg or foot
- People who have increased risk of arterial disease e.g smokers, dyslipidaemia, hypertension,
Ankle:Brachial Pressure Index to be calculated.If this facility is not available “in –house” please refer to Community diabetes/ District nurses for neurovascular assessment using Podiatry
referral form and stating level of urgency

                                      A:BPI < 0.9 **Actively                                                                                      A:BPI > 0.9
                           treat risk factors**
BP Aim to be < 130/ 80                                                                                           The A:BPI may be falsely elevated due to medial artery calcification. This will
Aim for good glycaemic control (see Milestone 3:Treatment management )                                           elevate the A:BPI to above 1.3
Commence antiplatelet therapy                                                                                    If IC symptoms present, patient will need to be referred for an exercise Doppler
If Cholesterol > 4 mmol/L commence statin (See Milestone 4: Complications /                                      examination at via referral and triage form
Risk management)                                                                                                 If drop in A:BPI post exercise occurs, PAD is diagnosed and patient to be treated
Smoking cessation                                                                                                as if A:BPI is < 0.9 See text box opposite
Weight loss                                                                                                      If A:BPI shows no reduction other causes for painful symptoms may to be
Exercise therapy “ Keep walking”                                                                                 investigate
                             If lifestyle impairment
           SEVERE                                                 MILD
         IMPAIRMENT                                            IMPAIRMENT
 Refer to Vascular Team                         Exercise therapy
 Glangwili hospital                             Review 3/12
                                                Consider naftidrofuryl oxalate 100mg 1-2 tds if no
                                               improvement on exercise therapy alone (stop
                                               if ineffective after 3/12) (NICE TA 223)

        Referral criteria to Specialist services
        (6Ps) Rapid onset of symptoms: Pain, pulselessness, pallor, paraesthesia, paralysis, perishingly cold = Emergency referral
        Deterioration in chronic symptoms: Ischaemic rest pain, gangrene, non healing wound or ulceration, infection = Urgent referral
                              References: SIGN, TASC II, CFH guideline for management of PAD Diabetic foot protocol
MILESTONE 4 COMPLICATIONS/RISK MANAGEMENT: ALL WALES DIABETIC FOOT CARE PATHWAY
                                 All people with diabetes should be offered routine annual foot assessment

                                                                       ANNUAL REVIEW – CALL AND RECALL
                            To be undertaken by a person appropriately trained (National Minimum Skills Framework):
                     Primary care team, GP Practice Nurse District Nurse DSN, Link Nurse Health Care Worker, Podiatrist
          RISK FACTORS – Glycaemic control, Hyperlipidaemia, hypertension, weight management, Retinopathy, Nephropathy, Smoking
                                                             Assessment of social & educational needs
FOOT ASSESSMENT - callus / corns, deformities, muscle strength, amputations, ulceration, scarring, condition of nails, footwear
VASCULAR ASSESMENT - pedal pulses / Doppler (8 MHz), signs/ symptoms
NEUROLOGICAL ASSESSMENT - 10 g monofilament and 128 Hz tuning fork (Rydel Seiffer tuning fork)

                          LOW RISK                                           INCREASED RISK                                          HIGH RISK                                   VERY HIGH RISK
            Normal sensation, palpable pulses, no foot          Neuropathy or absent pulses or foot pathology or     Neuropathy or absent pulses AND deformity         Ulcerated foot, acute cellulitis, sepsis –
                           pathology                                           other risk factor                             or skin changes or previous              Urgent referral to MDT/Podiatry Tissue
                       Annual Review                                        Community Podiatry                                  ulceration/amputation                   Viability wound management team
             Management by the primary care team                              Review 3-6months                            Specialist Podiatry Management                          Revascularisation
             Basic Foot care Education/ Structured                      Proactive foot care education                            Review 0-3 months                                Infection control
                           education                                Contact numbers for foot emergencies                Proactive specific foot care education        Glycaemic Control/ medical management
                  Empowerment for self care                                                                           Assess footwear and insoles requirements               Radiological investigations
                                                                                                                      Contact numbers for foot emergencies                  Offloading/pressure relief

                                                                       Community Podiatry
                                                                          Routine Care                                  Intermediate/ Specialist                            ULCER CLINIC
                                                                            Treatment Plan                             High Risk Podiatry Clinics                           Wound Healing / Management
                                                                          including education                        Advanced neurological and vascular                     Tissue Viability
                                                                    Orthotics /Appropriate Footwear                             assessment
                                                                                                                         Specialist treatment plan

                                                                                 MULTIDISCIPLINARY DIABETIC FOOT CLINIC (where available)
                                                      Acute foot problems, cellulitus, new or chronic ulceration, trauma, acute onset of pain (charcot foot, infection. painful neuropathy
                                             Diabetologist & Diabetic Hospital Team                                           Orthotist Specialist Footwear / Insoles
                                             Podiatrist                                                                       Diabetes Specialist Nurse Review HBA1c & Control
                                             Vascular Consultant & Vascular Team- (Dedicated pathway)               Dietician (Dedicated Pathway)
                                             Orthopaedic Referral (Dedicated Pathway)                                         Pain Team (Dedicated Pathway)
                                             Plaster Technician (Dedicated Pathway)                                           Tissue Viability Specialist
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D…

                                                                    TREATMENT OF ERECTILE DYSFUNCTION (ED)
Identify and treat curable causes of ED where possible:

    Endocrine cause: Poor control of DM, Hypogonadism, Hyperprolactinaemia, Hypo / Hyperthyroidism, Cushing’s syndrome (will need Endocrine referral)
    Vascular cause: PVD, CKD
    Urological: Previous injury, Pelvic / Prostatic surgery or radiation therapy (may need urology referral)
    Neurological cause: MS, Alzheimers, Parkinson’s, spinal cord injury (may need neurology referral)
    Medications: Beta-blockers, Alpha Adrenergic Antagonists, Diuretics, Sedatives, tranquilizers, anxiolytics, antidepressants, antipsychotics, Corticosteroids, digoxin,
    NSAIDs, H2 Antagonists etc
    Lifestyle / habit / addiction: Substance abuse, smoking, alcoholism, anabolic steroids, Heroin, Marijuana
    Psychological

    Lifestyle changes and risk factor                     Education for patients and partners                                       Counselling for patients and partners
    modification                                          Describe treatments available                                             Refer for psychosexual therapy
    Send blood for hormone levels                         Assess current CV risk & medication history (e.g.nitrates)

PRESCRIBE PDE5 INHIBITORS TRIAL:                                                                       ALTERNATIVE THERAPIES:
The prescribing physician should be aware of mode of action, cautions, contra-                         NB: PATIENT NEEDS TO BE REFERRED TO UROLOGIST / ED
indications, side effects as per BNF                                                                   CLINIC TO BE TRAINED IN USE OF THESE PRODUCTS
   Frequency of treatment needs to be considered on a case by case basis. One treatment
                     per week is usually appropriate (DoH)                                                 Intracavernosal injections:Caverject, Viridal Duo
DRUG                        DOSE                          MINIMUM INFORMATION FOR                          Intraurethral alprostadil: Muse
                                                          PATIENTS                                         Vacuum devices
                            50 – 100 mg
                            Start at 50 mg and titrate      Effective 30-60 mins in                        Penile implants
SILDENAFIL                                                   presence of sexual stimulation

Viagra                      according to response and         Effect reduced by fatty meal
                            side effects                      Half life 4 hours
                                                                                                                         ASSESS THERAPEUTIC OUTCOMES
                            5 – 20 mg
                            Start at 10mg and titrate         Effective after 25 – 60 mins in              IT IS ESSENTIAL IN DIABETES TO ADVISE PATIENTS TO TAKE ORAL
                                                             presence of sexual stimulation
VARDENAFIL                  according to response and                                                      MEDICATION APPROXIMATELY 4 HOURS PRIOR TO SEXUAL
                                                              (can be as early as 10 mins)
Levitra                     side effects                                                                   ACTIVITY AS IT HAS BEEN OBSERVED THAT ONSET OF ACTION MAY
                                                              Effect reduced by fatty meal
                                                              Half life 4.5 hours
                                                                                                           BE DELAYED IN MEN WITH DIABETES.
                            5 – 20mg                                                                       IF SILDENAFIL IS INEFFECTIVE CHANGE TO ANOTHER PDE5
                            Start at 10mg and titrate         Effective after 30 mins in                   INHIBITOR VARDENAFIL CURRENTLY IS THE MOST COST
TADALAFIL                                                    presence of sexual stimulation                EFFECTIVE ALTERNATIVE
                            according to response and        Effect not reduced by food
Cialis
                            side effects                     and alcohol
                                                             Half life 17.5 hours
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONTD…

                                              RENAL COMPLICATIONS / MICROALBUMINURIA SCREENING

                                                           ** PLEASE NOTE THAT THESE TESTS
                                                             ARE IN ADDITION TO THE eGFR **

                                             DIPSTICK URINE FOR PROTEIN USING MULTISTIX / ALBUSTIX

                                 IF NEGATIVE                                                                IF POSITIVE
                                                                                    st
 Refer to local laboratory guidelines for EMU collection protocol                If 1    specimen is abnormal exclude UTI (collect MSU)
                                                                                    nd
Collect EMU for Albumin / Creatinine ratio                                       If 2 specimen is abnormal quantify proteinuria by albumin /
                                                                                 creatinine ratio (ACR).
Normal A : C Ratio Males    < 2.5 mg / mmol
                   Females < 3.5 mg / mmol                                       Treat to target
                                                                                     1. BP (Aim < 130 / 80)
If specimen is within normal range retest annually                                   2. Glycaemic control HbA1c ≤ 48 mmol/mol (7.5%)
                                                                                     3. Commence ACE inhibitor or ARB if intolerant to ACEI
                                                                                        (Irbesartan has licence in microalbuminuria)

                                                                                 Repeat ACR after 6 months

                                                                                 If specimen is abnormal, refer to specialist care according to
                                                                                 local CKD guidelines

                                                                                                     SEE eGFR GUIDELINES
   NICE Clinical Guideline 66 Management of Type 2 diabetes mellitus, May 2008
MILESTONE 4: RENAL COMPLICATIONS- Annual albumin screening

                                                     Annual urine microalbumin
                                                     screening
         Raised Values                                                                            Normal Values
         ≥ 2.5 mg/mmol, males                                                                  < 2.5 mg/mmol, males
         ≥ 3.5 mg/mmol, females                                                                < 3.5 mg/mmol, females

                                                                   NO
                 First high reading                                                          Established microalbuminuria or proteinuria

                   YES

                    Ensure urine sample obtained
                    under appropriate conditions
                    (exclude UTI)

                                                                                               Titrate to highest recommended dose of ACE-I/ A2RB to
Repeat early morning urine on 2 separate mornings to confirm                                   target BP < 130/80
level of microalbuminuria*                                                                     Optimise HbA1c to 48-59 mmol/mol (6.5-7.5%)
 (Positive test - if 2 out of 3 samples elevated. Repeat samples         positive
                                                                                               Commence statin and aspirin.
tested one week apart.                                                                          Urge smoking cessation
In the event of negative tests – return to annual screening
                                                                                              If proteinuria persistent over 6-12 months
                                                                                              arrange USS kidneys and refer to secondary care
                                                                                              services

       If proteinuria confirmed (alb/creat ≥ 30mg/mmol) in the absence of significant retinopathy investigate for non-diabetic causes

      N.B. Refer to nephrologists if eGFR < 30 ml/minute/1.73m2 or if non diabetic aetiology suspected e.g. short duration of diabetes, the presence of the nephritic
      syndrome, collagen vascular disease, haematuria with a structurally normal urinary tract, or rapid worsening of GFR or proteinuria.
MILESTONE 4: RENAL COMPLICATIONS - Microalbuminuria

Lifestyle measures

    •    Brief intervention on smoking, signposting to cessation support service Stop Smoking Wales
    •    Restrict dietary salt. (Unrestricted salt intake can virtually eliminate the antiproteinuric effect of an ACE inhibitor.)
    •    All patients with chronic renal disease (stage 3: National Kidney Foundation) should undergo nutritional screening. Individuals identified as
         having an inadequate dietary intake should have identifiable causes corrected, in addition to receiving appropriate advice from a registered
         dietitian.
    •    Advice on weight reduction if obese (and has not received this as a part of diabetes care to date)
Pharmacotherapy

    •    Begin or titrate ACE or if intolerant A2RB to maximum tolerated dose irrespective of initial blood pressure. Check serum creatinine and
         potassium 2 weeks after initial dose and after subsequent increases in dose. A stable rise in creatinine of up to 20% or a 15% fall in eGFR does
         not require dose adjustment. If serum creatinine continues to rise then ACE/A2RB should be stopped and the possibility of renal artery stenosis
         considered.
    •    Treat with Statin and attend to glycaemic control
    •    Aspirin 75 mg od (given due to increased cardiovascular risk)

Treatment Targets:

Blood pressure control
Target blood pressure to: ≤ 140/80 in all diabetic patients
                          ≤ 130/80 in microalbuminuria/proteinuria
Glycaemic control:      HbA1c 48-59 mmol/mol (6.5 - 7.5 %)
The risk of hypoglycaemia increases as renal disease progresses. This needs to be balanced against the benefit of tight control

Lipids
Commence lipid-lowering therapy unless contra-indicated in all patients with microalbuminuria or proteinuria.
Lipid Targets
Total cholesterol < 4 mmol/L
OR
LDL cholesterol < 2 mmol/L
HDL cholesterol ≥ 1.0 mmol/L

These guidelines are based on: CG73 NICE Guideline: Early Identification and management of Chronic Kidney Disease in adults in primary
and secondary care, September 2008
Chronic Kidney Disease (CKD) and the estimated Glomerular Filtration Rate (eGFR)

•    Chronic Kidney Disease (CKD) is common. It affects approx 10% of the population and is often asymptomatic until renal function is
     severely reduced.
•    Serum creatinine has traditionally been the mainstay for the initial identification of renal disease. Serum creatinine on its own does not
     detect minor degrees of kidney impairment and is not directly related to the GFR.
•    eGFR forms the basis for the classification and management of CKD.
•    CKD is an important risk factor for cardiovascular problems. eGFR makes it easier to tell who should be offered treatment.
•    DoH has recommended a formula-based eGFR calculation which is used for the identification and initial staging and monitoring of
     CKD patients being ml/ minute / 1.73 m2.
•    eGFR is not applicable in people < 18 years, acute renal failure, pregnancy, amputees, extremes of body weight, 1 kidney.

                   eGFR result            Severity of CKD                 Frequency of
                                                                            testing
    1/2             60 - > 90                Normal/Mild                    Annually

                                                                  6 months (12 months if
                                                                            stable)
                                                                Refer to secondary care if not
    3                30-59            Moderate renal impairment    stable or rapid decline

                                                                       3 months if stable
                                                                    Refer to nephrology if not
    4                15-29              Severe kidney disease        stable or rapid decline
MILESTONE 4: Management of Chronic Kidney Disease (CKD)

                              Annual estimated eGFR)
                               (MDRD*); serum creatinine
                               Dipstick urine for blood and protein (as
                              above)

Abnormal eGFR < 60                                                         eGFR ≥ 60 ml/min/1.73m2 (
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D - PAINFUL NEUROPATHY
DIAGNOSIS
     HISTORY
      - Consider differential diagnosis (alcohol excess, B12 deficiency, malignancy)
      -   Sometimes acute, sometimes insidious onset and progressive
      -   Paraesthesia in toes, feet and shins
      -   Anaesthesia
      -   Hyperaesthesia
      Symptoms often worse at night or at rest
      PAIN
         - A wide variety of descriptions of peripheral symptoms can be present.
         - Careful patient questioning is necessary as symptoms can be confusing
         - Consider use of Pain Pictures or S-LANNS assessment questionnaire

             Symptoms may include:
             - Numbness
             - Tingling
             - Prickling
             - Pins and Needles
             - Aching
             - Dull pain
             - Burning
             - Buzzing
             - Cold
             - Sharp
             - Knife – like
             - Electric shocks

The severity of individual patient symptoms will influence which step of the care pathway is appropriate for commencement of treatment

SIGNS
        WEAKNESS
           - Distal and/or proximal
           - Loss of reflexes
        NEUROPATHIC EXAMINATION
          - 10 g Monofilament
          - Vibration perception (tuning fork 128 Hz), calibrated tuning fork, Bio / Neurothesiometer)
          - Proprioception
          - Light touch
          - Sensory loss glove and stocking distribution
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D - PAINFUL
                                       NEUROPATHY
                                                                PERIPHERAL NEUROPATHY HAS BEEN DIAGNOSED

  STEP 1
           Improve glycaemic control. Liaise with diabetes nursing team / dietician if appropriate. Aim for normoglycaemia
           Prescribe Amitriptylline 10-75mg at night or Duloxetine 60mg daily (child and adolescent under 18 years not
           recommended)
           If patient is experiencing night time cramps only, consider prescribing:
           - Quinine sulphate 200 – 300 mg nocte (Inform patient that it may take up to 1 month to see an improvement)
           - May benefit from low calorie Indian tonic water (not available on FP10)
           Reassure. (Use of pain diary may be useful)
           Review in 1 month
           If patient is reluctant to take oral medication consider Capsaicin cream 45 g, noting that initially there may be an intense burning sensation.

STEP 2
           Review symptoms, pain and glycaemic
           control If pain still present, reassure
           Check concordance with 1st line treatment and consider the alternative as
           in Step 1
           Review in 1 month

  STEP 3
           Review symptoms, pain and glycaemic control
           If pain still present / no improvement in symptoms, refer for specialist input
           Monitor therapy, and increase, up to maximum licensed dosage.
           Consider prescribing in place of previous medication:
      -         Pregabalin 150 – 600 mg in divided doses
      -         Consider addition of Tramadol 50mg – 150 mg tds

STEP 4
           Review symptoms, pain and glycaemic control
           If pain is not controlled referral to specialist pain clinic

Updated NICE Guidance May 2010
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONTINUED

                                                                    FOOT CARE:
1. Ensure that feet are assessed including foot pulses, vibration, sensation by a competent practitioner annually (See also
   Milestone 4: Peripheral Arterial Disease – [PAD])
2. Record results on diabetes template
3. Ensure that principles of good foot care are reiterated at each review
4. Refer for podiatry treatment as appropriate
5. Refer URGENTLY TO RAPID ACCESS FOOT CLINIC / DIABETES TEAM if any of the following problems occur:
      Acute foot injury (including any penetrating foot injury) Foot
      ulcer present
      Signs of infection
      Evidence of ischaemia noted
      Suspicion of Charcot’s neuropathy

                                                               RETINOPATHY:

1. Ensure that patient understands the importance of annual retinopathy screening
2. Ensure that patient is enrolled on the Diabetes Retinal Screening Service for Wales for digital photography. Please contact DRSSW
   Telephone 01443 844244
3. At annual review, check that a result is present in the patient records dated within the last 12 months
4. Results of retinal screening should be discussed with patient
MILESTONE 5: MAINTENANCE

1. Regular review if unstable 2-3 monthly BP
          Lipids
          Glycaemic control (there is no benefit to repeating HbA1c reading more frequently than 3 monthly) Diet
          Lifestyle

2. 6 monthly review
           As above

3. Annual review
          Weight / BMI
          BP
          Review of medication
          Review of diet
          Review of glycaemic control
          Review of investigations
                 - HbA1c
                 - Lipids
                 - U&E including eGFR
                 - TFT
                 - LFT if taking Glitazone or Statin
                 - Albumin / Creatinine ratio (ACR)
       Foot examination
                   - Shoes, socks, stockings MUST be removed
                   - Observation of colour, warmth, sensation, symptoms, general appearance of nails, skin, callus etc.
                   - Pedal pulses at Dorsalis Pedis and Posterior Tibial points
                   -10gm Monofilament and vibration perception on BOTH feet

       Lifestyle issues
                    - Driving
                    - Physical Activity levels
                    - Smoking
                    - Alcohol
                    - Sexual health/ contraception
                    - Mental and emotional health(Assess Stress and depression)
FOR HDHB BILINGUAL FIRST LINE ADVICE SHEET – ‘HEALTHY EATING WITH
APPENDIX 1             LIFESTYLE CHANGES                                    DIABETES’ (SEE APPENDIX 8)

                                                     HEALTHY EATING (STOP GAP INFORMATION)

                                ADVICE TO BE GIVEN                                                           EXAMPLES

Regular meals that include carbohydrates                                    High fibre low salt and low fat breakfast cereals
This will help to control blood glucose levels*                              Wholemeal / whole grain breads, including pitta, crackers,
                                                                            crispbreads
                                                                            Pasta and noodles
                                                                            Potatoes
                                                                            Rice
Foods that are high in fibre*                                               Beans
                                                                            Lentils
                                                                            Bran
                                                                            Wholemeal and wholegrain breads and cereals
                                                                            Fruit and vegetables
Cut down / Eat less saturated fat*                                          Less animal fats and fatty foods
                                                                            Choose olive oil, rapeseed oil or other vegetable oils
                                                                            Grill, steam ,bake food
                                                                            Use less butter, margarine, cheese and fatty meats
                                                                            Use low fat dairy foods like skimmed or semi skimmed milk, low fat
                                                                            yoghurt
Reducing salt*                                                              Less processed food
                                                                            Leave out salt in cooking
                                                                            Buy reduced salt versions of food
                                                                            Use herbs and spices instead of salt
Five a day*                                                                 Try to eat five portions of fruit or vegetables a day, but limit fruit
                                                                            intake to no more than 3 – 4 portions a day
                                                                            A portion is a handful of fruit or vegetables
Cut down on sugar / sugary foods*                                           This does NOT mean a sugar free diet
                                                                            Sugar can be used as an ingredient in foods in small quantities
                                                                            Use sugar free, diet or low sugar squashes and fizzy drinks
APPENDIX 1                     LIFESTYLE CHANGES CONT’D

                                                                       INCREASING PHYSICAL ACTIVITY

                               ADVICE TO BE GIVEN                                                                                   EXAMPLES

 Aim to be active daily
 ncrease physical activity levels gradually until over a week activity builds up to at least
 150 minutes (2 ½ hours) of moderate intensity activity in bouts of 10 minutes or
 more. One way to do this is 30 minutes of activity on at least 5 days of the week                Brisk Walking daily

Moderate intensity activity means activity that makes you feel warm and slightly
breathless but you should still be able to talk                                                   Increase distance and speed
                                                                                                    Once exercising regularly, try cycling, swimming etc.
                                                                                                    Housework / gardening if mobility is limited
                                                                                                     If immobile teach armchair exercises
                                                                                                    Refer to National Exercise Referral Scheme (NERS)
                                                                                                    Recommend community based physical activity opportunities e.g. walking groups,
                                                                                                    activity classes
                                                                                                    If heart problems consider referral to cardiac rehab

                                                                                STOPPING SMOKING

                               ADVICE TO BE GIVEN                                                                                 WHAT TO DO

                                                                                                   Give information about Stop Smoking Wales smoking cessation support service
     Assess smoking status
                                                                                                   Refer client to Stop Smoking Wales as this offers the best chance of quitting
                                                                                                   •Give client a Stop Smoking Wales referral card and encourage them to contact the
     Brief intervention on smoking, harms of continuing, benefits of stopping                      service for an appointment
     Accessing free Stop Smoking Service can support patients to stop smoking
   NICE (2006) guidance on Brief intervention for Smoking Cessation recommends
   that
   •Everyone who smokes should be advised to quit. People who smoke should be
   asked how interested they are in quitting
   •Health professionals and those who work with clients should refer people who
   smoke to an intensive support service such as Stop Smoking Wales                            Contact Stop Smoking WalesFREEPHONE 0800 085 2219 or
                                                                                               www.stopsmokingwales.com
ALCOHOL ADVICE

                       ADVICE TO BE GIVEN                                                                        EXAMPLE

Consume alcohol in moderation and within the recommended guidelines for       1 unit of alcohol = half a pint of ordinary strength beer or lager at 3.5% abv
alcohol consumption                                                           1 standardglass (125 ml)of wine at 8% abv
                                                                              1 single standard measure (25ml) spirits at 40% abv
                                                                              (abv = alcohol by volume)

                                                                              Men should drink no more than 3 units a day/ 21 units per week
                                                                              Women should drink no more than 2 units a day / 14 units per week

                                                                              These rough alcohol units however are ineffective at calculating the actual amounts
                                                                              of alcohol consumed and can be misleading. Therefore recommended to calculate
                                                                              accurate alcohol units by the following formula:
                                                                               ABV x Amount in mls= 1000 = Unit value
                                                                              So a pint of Stella Artois would be:5.2 x 568 = 1000 = 2.9 units

                                                                              Both men and women should have at least 2 days per week where no alcohol is
                                                                              consumed and no binge drinking. (A binge is regarded as being half or more of the
                                                                              recommended allowance beign consumed in one drinking session i.e. 10.5 units for
                                                                              men and 7 units for women)

                                                                              Prism Generic Alcohol Services for Adults tel 01267 231634
                                                                             Free, open access service to people who have difficulties with their own or someone
                                                                             elses use of alcohol, for adults over 18 in Pembrokeshire, Carmarthenshire and
                                                                             Ceredigion
                                                                              Alcoholics Anonymous NationalHelpline0845769555
*Diabetes UK Patient information www.diabetes.org.uk

                                                            Mental and Emotional Health

                                ADVICE TO BE GIVEN                                                             EXAMPLES

  How to cope with a diagnosis of diabetes                                         Talking to your healthcare professional about how you feel and how you are
                                                                                   coping. Healthcare professional giving support and reassurance.

                                                                             www.diabetes.org.uk has section on coping with diabetes.

                                                                            10 positive steps – keeping active, eating well, drinking in moderation, talking about
                                                                            your feelings, keeping in touch with friends and loved ones, asking for help, taking a
                                                                            break, doing something you are good at, valuing yourself and others, caring for
                                                                            others.(Mental Health Foundation – website below)
Maintain and protect and your mental and emotional health                   www.mentalhealth.org.uk
APPENDIX 2         PATIENT EDUCATION

After diagnosis it is essential that education is given at a level appropriate to individual needs.

                                                                        EDUCATION CHECKLIST

INFORMATION TO BE GIVEN                                                                                           SIGN OFF WHEN GIVEN
Patient information booklet given (Specify)
Patient hand held record given
What is diabetes
Causes of diabetes
The Annual Review - what care to expect
HbA1c normal ranges
Lifestyle issues:
    Diet
    Physical activity
    Smoking
    Alcohol
    Mental and emotional health
Medication – relevant information about current medication
Hypoglycaemia
Hyperglycaemia
Driving What / when to report to DVLA
Sick day rules
Possible complications associated with poor control:
Retinopathy and importance of annual screening
Renal problems
Arterial problems
Neuropathy
Foot problems / foot care
Travel
Fasting / feasting
Blood glucose monitoring
Sexual Health – women (see appendix)
Sexual Health – men (Erectile Dysfunction)
Diabetes UK info
Yearly Flu immunization recommendation and review pneumococcal
status
Appendix 3: Blood glucose monitoring in Primary Care

All patients monitoring blood glucose levels should be advised to check the accuracy (Quality Assurance) of the blood glucose meter on a monthly basis. Control solutions used to
carry out this procedure are, in most cases, available free of charge from the manufacturer.
                                                                                 FREQUENCY OF TESTING
                                  Type 1 diabetes                                                                              Type 2 diabetes
                                                                                        If on diet and physical activity
    Blood glucose testing is essential for ALL people with type 1 diabetes If taking         - Patients do not need to monitor blood glucose levels on a daily basis. Ensure HbA1c is
                                                                                                 undertaken regularly.
    basal bolus regimen this could be up to 6 times a day
                                                                                        If on diet, physical activity and Metformin (+/- Glitazone)
    Frequency may be increased during intercurrent illness
                                                                                                - As above
    Ketone testing equipment should be available for times of acute illness
                                                                                        If on sulphonylurea / Insulin secretagogue
    Drivers should maintain a record (as per DVLA recommendations) and test                     -   Increased risk of hypoglycaemia. Testing may be necessary to confirm or avoid this
    prior to all journeys including those on sulphonylureas
                                                                                        Type 2 on conventional insulin therapy
    Pre Pregnancy and pregnancy - may be necessary to test up to 6 times daily
                                                                                                -   If stable, 2 – 3 times a week at different times
                                                                                                -   If unstable, once daily testing at different times of the day until stability achieved
Approximate usage                                                                               -   See Type 1 diabetes for DVLA recommendations

    Six tests per day            = 48 boxes (50 strips each) per year                   Type 2 on intensive insulin therapy
                                 = 4 boxes per month
                                                                                                -   May be necessary up to 6 times daily
    One test per day             = 8 boxes per year                                             -   See Type 1 for DVLA recommendations

                                                                                        Pre Pregnancy and pregnancy
    Three tests per week          = 4 boxes per year

(This includes extra strips for testing when ill & accidental wastage)                          -   May be necessary up to 6 times daily                                            PTO…

    An annual assessment of self-monitoring skills, quality and frequency of
  testing, the use made of results, impact on quality of life and equipment used
                                     is essential.
Appendix 3: Blood glucose monitoring in Primary Care cont’d

When considering suitability for blood glucose monitoring the following points should be considered:

   Visual acuity
   Manual dexterity
   Ability to use blood glucose meter
   Willingness of patient to perform tests

When initiating blood glucose monitoring the following process should take place:

   Offer choice from standardised range of meters ONLY according to patient needs
   Demonstrate chosen meter and finger pricking device, identifying procedure for patient to follow Give
   information on the safe disposal of sharps
   Issue blood glucose monitoring diary indicating agreed individual target range and frequency of testing (See previous page) Give
   information to patient regarding what to do with self testing results
   Ensure patient has a contact number for access to HCP advice
   Arrange to review self testing results at a suitable interval
Appendix 4: Nutrition and Dietetic Services Hywel Dda Health Board
                                                         Draft of Referral Criteria for Diabetes 2011

    Referral Criteria for Diabetes     Referral Details / Notes              Evidence Base              First Line Advise / Signposting

Newly Diagnosed Type 1               Referred to structured group   Consensus Guidelines for the     www.diabetes.org.uk is a reliable
                                     education programme (as        Management of Adults with        evidence based website for HCP and
                                     appropriate) after 1:1 with    Diabetes across Wales (2008)     all patients with Diabetes
               Urgent                Dietitian
                                                                    NICE Guidance: Type 1
                                                                    Diagnosis & Management (2010)

Poorly controlled Type 1 Diabetes    Referred to structured group   Consensus Guidelines for the     www.diabetes.org.uk is a reliable
                                     education programme where      Management of Adults with        evidence based website for HCP and
                                     available, otherwise please    Diabetes across Wales (2008)     all patients with Diabetes
          Routine                    complete Dietetic referral
                                     form with detail to enable     NICE Guidance:Type 1 Diagnosis
                                     effective/optimal problem      & Management (2010)
                                     solving

Carbohydrate Counting for Insulin    Structured Group Education     Consensus Guidelines for Wales   www.diabetes.org.uk is a reliable
Dose Adjusting - Education           Programme when possible.       (2008)                           evidence based website for HCP and
                                                                                                     all patients with Diabetes
                                     Refer to Dietetic service if   NICE Guidance: Type 1 (2010)
                                     programme not available / if
         Routine                     patient prefers individual     NICE Guidance: Insulin Pump
                                     consultation                   Therapy (2008)
Appendix 4: Dietetic referral criteria
Diabetes in Pregnancy/Gestational Urgent 1:1 consultation            Consensus Guidelines for Wales (2008)   www.diabetes.org.uk is a reliable evidence
        Dietetic Referral Criteria HDHB April 2011
                                     required
             Diabetes                                                                                        based website for HCP and all patients with
                                     Refer to Dietetic service &     NICE Guidance: Diabetes in Pregnancy    Diabetes
              Urgent                 contact service to enable       (March 2008)
                                     combined appointment when
                                     possible

 Type 2 Diabetes (new or poorly    First choice: XPERT structured    Consensus Guidelines for Wales (2008)   First line advice from HCP
          controlled)              group education programme for
                                   people with Type 2 diabetes.      The Diabetes National Service           The Health Board’s Dietetic Service ‘First Line
                                   XPERT referral form need to be    Framework NSF for Wales (2003)          Advice’ booklet is available for use by HCP
                                   completed & forwarded to local
            Routine                diabetes team.                    NICE Guidance: The Management of
                                   Refer for 1:1 consultation with   type 2 Diabetes (2008)
                                   Dietitian if the patient is not
                                   appropriate for group education   The Implementation of Nutritional
                                                                     Advice for People with Diabetes:
                                                                     Diabetes UK (2003)

Type 2 Diabetes progressing onto   First choice: XPERT structured    Consensus Guidelines for Wales (2008)   www.diabetes.org.uk is a reliable evidence
        insulin therapy            group education programme,                                                based website for HCP and all patients with
                                   Refer for 1:1 consultation with   NICE Guidance (2008)                    Diabetes
                                   Dietitian if the patient is not
                                   appropriate for group education   NSF (2003)
            Routine

       IGT/IFG                                                       Consensus Guidelines for Wales (2008)   First line advice from HCP

         Routine                                                     NICE Guidance:Type 2 (2008)             The Health Board’s first line weight management
                                                                                                             patient information leaflet can be used by HCP

                                                                                                             Encouraged to increase physical exercise & consider
                                                                                                             referral to Exercise for Life programme
                                                                                                             www.food.gov.uk/healthiereating/eatwellplate/
                                                                                                             Reliable information on healthy eating for HCP and
                                                                                                             patients
Appendix 4: Dietetic referral criteria

Referrals to the Dietetic Service should include the following information as a minimum:

Full Name:

D.O.B.

Address:

NHS number:

Contact details:

Reason for Referral:

Medical History (& relevant family history), including height, weight, BMI and recent biochemistry results.

Current Medication:

Other Information:
Appendix 5: Pregnancy and Diabetes/IGT

                                              Ask patient if she is planning pregnancy

    No, not planning pregnancy                                                             Yes, thinking of pregnancy

                                                    Check HbA1c if                Screen for            Review all meds                 Offer / refer to
                                                    none within last 6            complications         Commence folic acid 5mg         pre-conception
Check she is taking effective
                                                    months                        Retinal/              Advice smoking cessation        clinic
contraception
                                                                                  microalbuminuria
Advise to seek advice if she                                                      Check U/E, TFT,
wishes to be pregnant                                                             rubella

                          HbA1c >7% (53mmol/mol),             HbA1c
Appendix 6: HbA1c Conversion Chart. Older DCCT-aligned (%) and newer IFCC-standardised (mmol/mol) concentrations

 DCCT (%)      IFCC       DCCT (%)      IFCC        DCCT (%)      IFCC        DCCT (%)      IFCC       DCCT (%)      IFCC
             (mmol/mol)               (mmol/mol)                (mmol/mol)                (mmol/mol)               (mmol/mol)

    5.0          31          6.0          42          7.0§          53           8.0          64          9.0         75
    5.1          32          6.1          43           7.1          54           8.1          65          9.1         76
    5.2          33          6.2          44           7.2          55           8.2          66          9.2         77
    5.3          34          6.3          45           7.3          56           8.3          67          9.3         78
    5.4          36          6.4          46           7.4          57           8.4          68          9.4         79
    5.5          37          6.5†,‡       48           7.5†,‡       58           8.5          69          9.5         80
    5.6          38          6.6          49           7.6          60           8.6          70          9.6         81
    5.7          39          6.7          50           7.7          61           8.7          72          9.7         83
    5.8          40          6.8          51           7.8          62           8.8          73          9.8         84
    5.9          41          6.9          52           7.9          63           8.9          74          9.9         85

 DCCT (%)      IFCC       DCCT (%)      IFCC        DCCT (%)      IFCC        DCCT (%)      IFCC       DCCT (%)      IFCC
             (mmol/mol)               (mmol/mol)                (mmol/mol)                (mmol/mol)               (mmol/mol)

   10.0          86          11.0         97          12.0         108          13.0         119          14.0        130
   10.1          87          11.1         98          12.1         109          13.1         120          14.1        131
   10.2          88          11.2         99          12.2         110          13.2         121          14.2        132
   10.3          89          11.3         100         12.3         111          13.3         122          14.3        133
   10.4          90          11.4         101         12.4         112          13.4         123          14.4        134
   10.5          91          11.5         102         12.5         113          13.5         124          14.5        135
   10.6          92          11.6         103         12.6         114          13.6         125          14.6        136
   10.7          93          11.7         104         12.7         115          13.7         126          14.7        137
   10.8          95          11.8         105         12.8         116          13.8         127          14.8        138
   10.9          96          11.9         107         12.9         117          13.9         128          14.9        139
Appendix 7: Useful Telephone Contacts

Locality                     Carmarthenshire   Ceredigion                    Pembrokeshire

Diabetes Consultant          01267 227869      01970 635749                  01437 774358

Diabetes Specialist nurses   01267 227746      01970 635750                  01437 773329

Dietetics                    01267 227067      01970 635730                  01437 774356

Community nurse                                07964109694

Podiatry                     01267 227058      01970 635987 / 01239 615302

Vascular surgeon             01267 227951      01267 227951                  01437 773399

Tissue viability nurse       01267 227761      07974962716
                                                                             01437 773122

Stop Smoking Wales           0800 085 2219     0800 085 2219                 0800 085 2219

Retinal screening            01443 844244      01443 844244                  01443 844244

Ophthalmology                01267 227749
Consultant Biochemist        01267 227454      01970 635784/5836             01437 773232
Exercise referral programme   01269 590234                      01970 633610

Alcohol support service       PRISM 01267 231634
                              West Wales Substance Misuse       West Wales Substance Misuse       West Wales Substance Misuse Service
                              Service 01267 244442              Service Tel: 01970 636340         Tel: 01646 690327

Mental and Emotional health   Primary Care mental health team
support                       stress control programme 01269    Primary care mental health team
                              833368
Appendix 8
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