MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University

Page created by Joshua Hudson
 
CONTINUE READING
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
WINTER 2018                  MAGAZINE                      VO L . 9 3 N O. 3

                                  MINDS
                                 AT WORK
                             Special Research Issue

   G A I N I NG ON C A NC E R H A LT I NG H A BI TAT DE ST RUCT ION T R AV E L I NG
I N T I M E E XT E N DI NG BRA I N H E A LT H SUSTA I N I NG GR E AT SCHOLA R SH I P
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
Put the Law to Work
         for Your Career
                 Legal Training for Non-Lawyers
New Online Juris Master degree in Health Law and Business Law

                            “As an Emory alumna and
                             a JM student, the Emory
                             experience affords me the
                             opportunity to shape my legal
                             education in my own vision.       Gain the legal knowledge
                             By concentrating on issues        and skills to navigate complex
                             such as international human       regulatory environments,
                             rights, I am gaining invaluable
                                                               make informed decisions,
                             legal knowledge, resources,
                             and connections needed to         assess risk, and advance your
                             continue my work in aiding        career.
 displaced individuals through the nonprofit sector.”
                                                               Now Online: Complete the
 Fowzio Jama, 17C
 JM Candidate                                                  online program in 18 months
                                                               with three short residencies
                                                               in one of two concentrations:
“For a technology leader,                                      Health Care Law, Policy, and
 particularly in the financial
 services industry, balancing
                                                               Regulation or Business Law
 business risks associated with                                and Regulation
 the fast pace of innovation and
 ever-increasing regulatory and                                On Campus: Complete the
 data privacy concerns requires                                on-campus program with a
 a higher level of thinking. As a                              wide range of concentrations
 practical matter, I can already
                                                               full time in 9 months or part-
 look back at a specific work
 experience knowing that my                                    time in up to 4 years
 contracts class helped surface questions I would not have
 asked before, saving our company more than the cost of        Scholarship: 15%
 the JM.”                                                      scholarship available for
 Eric Martin
                                                               Emory alumni
 Managing Director, Deutsche Bank                                                               PHOTOGRAPHY ML AB, WINSHIP: STEPHEN NOWL AND;

 2016 JM Graduate                                                                               PA P E R S : K AY H I N TO N ; G I L L E S P I E : K AY H I N TO N

              Learn more at law.emory.edu/jm | Email us at JMadmission@emory.edu
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
C O N T E N TS

                                                                                                                                                  Emory Magazine
                                                                                                                                                  Vol. 93 No. 3

                                                                                                                                                     RESEARCH
                                                                                                                                                     ISSUE

                                                                                                                                                     22

                                                                                                                                                  All In the Mind
                                                                                                                                                  An unexpected discovery leads
                                                                                                                                                  Emory scientists to new understanding
                                                                                                                                                  of the pathology behind Alzheimer’s
                                                                                                                                                  and Parkinson’s diseases.

                                                                                                                                          22      By Gary Goettling

                                                                                                    44
                                                                                                                                                28
                                                                                  Fabulous Five                             44
                                                                      Meet a few of the Emory faculty
                                                                         members who just can’t stop
                                                                     asking questions—and won’t stop
                                                                          until they find the answers.

                                                                                                     38     38
                                                                                                           Hanging by a Thread
                                                                                                           As the world’s primate populations
                                                                                                           dwindle, so do the chances for a
                                                                                                           healthy planet where humans
                                                                                                           can thrive.
                                                                                                           By Tony Rehagen

                                                                                                    32     32                                    28
                                                                            Outpacing Cancer                                                    Our Own Indiana Jones
PHOTOGRAPHY ML AB, WINSHIP: STEPHEN NOWL AND;
PA P E R S : K AY H I N TO N ; G I L L E S P I E : K AY H I N TO N

                                                                               Winship Cancer Institute                                         How an undergraduate student
                                                                           scientists and physicians are                                        turned a seminar class into a
                                                                        in a tight race with the second-                                        research project that traces the
                                                                     highest cause of death in the US—                                          post-WWI path of an Emory
                                                                                  and they mean to win.                                         professor-turned-adventurer.
                                                                                        By Sylvia Wrobel                                        By Scott Henry
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
C O N T E N TS

                                                      10

                                                                                                   49
          POINTS OF INTEREST                                       11                               Editor                             Director
                                                                                                    Paige P. Parvin 96G                of Creative Services
    6     TWENTIETH                                                                                                                    Alex Bundrick
          RHODES SCHOLAR                                                                            Associate Editor
                                                                                                    Maria M. Lameiras                  Design
                                                                                                                                       Gordon Boice
    8     SHORT LIST                                                                                Executive Director                 Stanis Kodman
                                                                                                    of Communication
                                                                                                    Susan Carini 04G                   Photography
    9     BOARD OF TRUSTEES
                                                                                                                                       Ann Borden
          LEADERSHIP                                                                                Contributors                       Kay Hinton
                                                                                                    Carol Clark                        Stephen Nowland
                                                                                                    Elizabeth Cobb Durel
    10    SHAPE-SHIFTING
                                                                                                    Quinn Eastman                      Production Manager
          PARTICLES                                                       EMORY EVERYWHERE          Gary Goettling                     Stuart Turner
                                                                                                    Scott Henry
                                                                                                    April Hunt                         Interim Senior
    12    TWITTER, MEET BIG DATA                                49        ALUMNI HONORED
                                                                                                    Tony Rehagen                       Vice President,
                                                                          EMORY MEDALISTS 2018      Kimber Williams                    Communications
    14    AN ETHNOBOTANIST                                                                          Sylvia Wrobel                      and Public Affairs
                                                                                                                                       Vincent Dollard
          PLUMBS PLANT POWER                                    52        CLASS NOTES
                                                                                                    Copy Editor
                                                                                                    Jane Howell                        University President
    16    GUIDING GLOBAL                                        56        ALUMNI IN RESEARCH                                           Claire E. Sterk
          HEALTH ETHICS
                                                                59        CODA
    18    NEW PROJECT TO STUDY                                            EPIDEMIC DILEMMA

                                                                                                                                                                      P H O T O G R A P H Y B U R TO N : E M O R Y P H OTO/ V I D E O ; S T U D E N T: K AY H I N TO N : N U R S E S : J A C K K E A R S E
          VEHICLE SAFETY                                                                            EMORY MAGAZINE (ISSN 00136727) is published quarterly by
                                                                                                    Emory’s Division of Communications and Public Affairs. Non-
                                                                                                    profit postage paid at 3900 Crown Rd. SE, Atlanta, Georgia,
    20    HELPING ADDICTS                                                                           30304; and additional mailing offices. POSTMASTER: Send
                                                                                                    address changes to OFFICE OF ALUMNI AND DEVELOPMENT
          KICK THE HABIT                                                                            RECORDS, 1762 Clifton Road, Suite 1400, Atlanta, Georgia 30322.

                                                                                                    Emory Magazine is distributed free to alumni and friends of
                                                                                                    the university. Address changes may be emailed to eurec@
                                                                                                    emory.edu or sent to the Office of Alumni and Development
                                                                                                    Records, 1762 Clifton Road, Suite 1400, Atlanta, Georgia
                MORE ONLINE AT EMORY.EDU/MAGAZINE                                                   30322. If you are an individual with a disability and wish to
                                                                                                    acquire this publication in an alternative format, please
                                                                                                    contact Paige Parvin (address above) or call 404.727.7873.
                V I D EO : L I F E L E SS PA RT I C L E S B EC O M E “L I F E- L I K E”             No. 18-EU-EMAG-0040 ©2018, a publication of the Division
                Watch how particles collectively switch back and forth between                      of Communications and Public Affairs.

                states—even when the environment remains stable.                                    The comments and opinions expressed in this magazine do
                                                                                                    not necessarily represent those of Emory University or the
                V I D EO : W H AT N C I C O M P R E H E N S I V E D E S I G N AT I O N M E A N S
                                                                                                                                                                                                                                                                                                             PHOTOGRAPHY STEPHEN NOWL AND

                                                                                                    staff of Emory Magazine.
                Winship is changing the way cancer is treated.

                V I D EO : A L Z H E I M E R’S STO RY
                A unique program reaches at-risk populations.
                                                                                                    ON THE COVER Illustration by
                                                                                                    Carlos Coelho at Infomen.

2        EMORY MAGAZINE                  WINTER 2018
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
a
                                                                                                                                                                                                                                      P R E LU D E

                                                                                                                                                                      As I drive onto the Emory campus each              The faculty and students featured in       breaking work in Madagascar has built
                                                                                                                                                                      morning, I can’t help but marvel a little.      this magazine are here because they are       new awareness around the urgent need
                                                                                                                                                                         This is an impressive place. Its build-      relentlessly curious, instinctive think-      for conservation, since it seems humans
                                                                                                                                                                      ings are beautiful, its resources plen-         ers, compelled to question and driven         and animals swap germs a lot more easily
                                                                                                                                                                      tiful, its setting lovely and well kept, its    to pursue answers. And they don’t hesitate    and often than we previously thought.
                                                                                                                                                                      facilities state of the art. And it’s forever   to cross the lines of academic disci-            There’s David Katz, a cell biologist
                                                                                                                                                                      busy; its streets and sidewalks are literally   plines to put their heads together with       who accidentally discovered a gene func-
                                                                                                                                                                      never still, and at night, its windows are      fellow scholars.                              tion that could help ward off diseases
                                                                                                                                                                      a constantly changing constellation of             There’s Andrew Hoover 20C, an              like Alzheimer’s before they start.
                                                                                                                                                                      lights. Within a thousand walls, it buzzes      undergraduate premed major who was               There’s Joseph Crespino, a history
                                                                                                                                                                      and clicks, whirs and sputters and hums,        so intrigued by the 1920s-era diaries of      professor who mined thousands of pages
                                                                                                                                                                      a million circuits aglow with signals.          Emory professor and traveler William          of newspapers and letters in his deep re-
                                                                                                                                                                         Of course, somebody has to keep all          Shelton that he took a detour from his        search for a fictional biography of Atticus
                                                                                                                                                                      those lights on, and Emory is fortunate         neuroscience and behavioral biology           Finch; and Erin Tarver, an assistant pro-
                                                                                                                                                                      to attract its share of funding—including       classes to explore, creating an interactive   fessor at Oxford who brings the weight
                                                                                                                                                                      many generous gifts and grants that sup-        website that traces Shelton’s steps.          of classical philosophy to her analysis of
                                                                                                                                                                      port both the university’s infrastructure          There’s Rafi Ahmed, a renowned im-         professional sports.
                                                                                                                                                                      and the work being done within it.              munologist who was parsing out how               As far as I know, there is no formula
                                                                                                                                                                      This issue of Emory Magazine is filled          T cells respond to chronic infection          for calculating the worth of individual,
                                                                                                                                                                      with examples.                                  when it became clear that his research        original thought. But the mysterious pro-
                                                                                                                                                                         Every element of this framework is           had major implications for cancer             cesses and connections that spark and
                                                                                                                                                                      valuable and important to the univer-           treatments, too. He’s now collaborating       catch fire every day, quietly and invisibly,
                                                                                                                                                                      sity’s mission. But in this special issue       with Winship researchers and making           inside the heads of Emory’s faculty and
                                                                                                                                                                      devoted to research, the spotlight shines       progress toward a clinical trial.             students are the truest natural resource
                                                                                                                                                                      brightest on another, less tangible, more          There’s Thomas Gillespie, an environ-      that universities have. That’s what really
                                                                                                                                                                      vital resource: minds at work.                  mental scientist whose gritty, ground-        keeps the lights on.—Paige Parvin 96G
P H O T O G R A P H Y B U R TO N : E M O R Y P H OTO/ V I D E O ; S T U D E N T: K AY H I N TO N : N U R S E S : J A C K K E A R S E

                                                                                                                                                                                                1

                                                                                                                                                                                     RO O M TO T H I N K

                                                                                                                                                                               The Stuart A. Rose Manuscript,
                                                                                                                                                                              Archives, and Rare Book Library
                                                                                                                                                                           In this special research issue, we visit a
                                                                                                                                                                         series of spaces where learning, discovery,
                                                                                                                                                                            and inspiration take place every day.
                                                                                                                                       PHOTOGRAPHY STEPHEN NOWL AND

                                                                                                                                                                         The Rose Library’s wide-ranging collections
                                                                                                                                                                            are open to anyone pursing scholarly
                                                                                                                                                                                     or personal research.

                                                                                                                                                                                                                                                               WINTER 2018         EMORY MAGAZINE             3
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
L E T T E RS

             AU T U M N 2 0 17               MAGAZINE            VO L . 9 3 N O. 2

                                                         Written
e?
                                                         In Bone
                                                        An Emory anthropologist made
                                                        history when she unearthed the
                                                         oldest-known DNA from Africa

         NOW WE’RE COOKING

         Atlanta Chef
         Linton Hopkins 92C
         ...makes his own butter

         INNOVATIONS IN UNDERGRADUATE EDUCATION

     THE ARTICLE “THIS ACTION IS
     Inevitable” (summer 2017) about women at
     Emory reminded me of the story of Marjorie
     Gates, my mother. She had completed two
     years at Agnes Scott and applied to transfer
     to Emory in 1939. When she was interviewed
     by the university president, he asked her
     if she wanted to come to Emory to get her
     “MRS” degree (that is, find a husband). She
     said Emory had a better chemistry depart-
     ment than Agnes Scott, it had a payment
     plan, and she could ride to school with her
     brother, an Emory student. From Emory,
     she received a bachelor’s degree in 1940,
     a master’s degree in 1943, and (finally) an
     “MRS” in 1943, by marrying Dr. R. A. Day Jr.,
     an Emory professor. Together, they raised
     four children, all of whom received degrees
     from Emory. Footnote: She did her graduate
     research under the direction of Dr. Evange-
     line Papageorge, mentioned in the article.

                                                           Michael A. Day 69C
                                                                                         Pine Lake

     What do you think? The editors of Emory
     Magazine welcome letters from our readers.
     Write to us at paige.parvin@emory.edu, or
     1762 Clifton Rd., Suite 1000, Atlanta, Georgia,
     30322. We reserve the right to edit letters for
     length and to correct style as needed. The
     views expressed by the writers do not nec-
     essarily reflect the views of the editors or the
                                                                                                     PHOTOGRAPHY STEPHEN NOWL AND

     administration of Emory University.

     4    EMORY MAGAZINE                                                             WINTER 2018
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
2

                                        RO O M TO T H I N K

                                  Parsons Conservation Laboratory
                                    Located in the basement of the
                                Michael C. Carlos Museum, this is where
                                conservators examine, document, and
                                  repair objects such as this Egyptian
                               funerary mask and Hittite house model in
                                   preparation for exhibition or loan.
PHOTOGRAPHY STEPHEN NOWL AND

                               WINTER 2018       EMORY MAGAZINE           5  
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
P O I N TS O F I N T E R E ST

Turning Ideas to Ideals
    EMORY’S TWENTIETH RHODES SCHOLAR
    INTENDS TO IMPROVE THE CRIMINAL
    JUSTICE SYSTEM

Chelsea Jackson 18C is one of
thirty-two American college
students selected as a 2018
Rhodes Scholar.
    Jackson, a political
science and African Ameri-
can studies double major in
Emory College of Arts and
Sciences, is the universi-
ty’s twentieth student to be
selected for the prestigious
scholarship, which supports
two to three years of study
at the University of Oxford
in England. She also is the
fourth woman and the first
African American student
from Emory to receive the
scholarship.
    “I am immediately
blessed to be selected,”
says Jackson, who is from
Lithonia, Georgia. “Just the
resources available and the
opportunity to live outside
                                      ACTIVIST HEART Rhodes Scholar Chelsea Jackson will study criminology at Oxford University, which has a research
the US and interact and           center focused on the sociology of criminal justice. She wants to examine ways to reform the criminal justice system by,
learn from scholars through-      for instance, reducing the use of solitary confinement and expanding maternal rights for incarcerated women.
out the world is immense.”
    Jackson has focused her
undergraduate research and her community leadership                               Jackson has been heavily involved with the Emory chapter
on efforts to create a more equitable campus and Atlanta                      of the NAACP and cofounded the Atlanta Black Students Unit-
community.                                                                    ed (ATLBSU), a group with black student representatives from
    “Chelsea is a passionate and committed student who uses                   every school in metro Atlanta. The ATLBSU serves as a vital
her intellectual talents and commitment to social justice to                  support system for students and a resource for allies.
                                                                                                                                                                                                     PHOTOGRAPHY ANN BORDEN
                                                                                                                                                             P H O T O G R A P H Y K AY H I N TO N

better our world,” says President Claire E. Sterk. “She will be a                 Last year, she shifted from working as the group’s media
wonderful ambassador for the United States and Emory as she representative to putting additional energy into her academic
continues her work at Oxford University.”                                     commitments.

6    EMORY MAGAZINE                  WINTER 2018
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
She presented a conference paper                                                       with an abundance of brain power
                                                                 last year with her adviser, Andra                                                          and the willingness to do the work to
                                                                 Gillespie, associate professor of polit-                                                   develop her skills. Her keen intellect
                                                                 ical science and director of Emory’s                      CHELSEA’S KEEN                   and commitment to public service and
                                                                 James Weldon Johnson Institute for                         INTELLECT AND                   social justice make her the student you
                                                                 the Study of Race and Difference. The                     COMMITMENT TO                    dream of having the honor to teach.”
                                                                 project explores how different back-                   PUBLIC SERVICE AND                  œ Jackson plans to earn a master’s
                                                                 stories influence public opinion when                 SOCIAL JUSTICE MAKE                  degree in criminology at Oxford, home
                                                                 it comes to police shootings. She also                HER THE STUDENT YOU                  to a cutting-edge research center that
                                                                 was named Emory’s first Truman                        DREAM OF HAVING THE                  focuses on the sociology of criminal
                                                                 Scholar since 2011.                                      HONOR TO TEACH.                   justice. She hopes to examine how the
                                                                     “Chelsea truly embodies the ideals                                                     law can be used to reform the criminal
                                                                 of liberal arts and sciences education.                                                    justice system by—for example—re-
                                                                 Her pursuit of knowledge and inquiry                                                       ducing the use of solitary confinement
                                                                 informs her activism and her dedica-                                                       and expanding the maternal rights of
                                                                 tion to making our society a more just                                                     incarcerated women.
                                                                 one for all,” says Michael Elliott, dean                                                   œ “I want to learn how race and poli-
                                                                 of Emory College and Charles Howard                                                        tics play out in other countries’ crimi-
                                                                 Candler Professor of English. “We are extremely proud of her,     nal justice systems to see how that shapes their worldview, and
                                                                 and I am looking forward to watching her career unfold as she     to consider new ideas and ways to solve problems that I have
                                                                 leaves our campus to have an impact on the world beyond it.”      not thought of yet,” Jackson says.
                                                                     This year, Jackson is focused on her master’s thesis as           After completing her Oxford degree, she plans to return to
                                                                 Emory’s sole BA/MA candidate in political science. Her topic:     the US to attend law school to become a civil rights attorney,
                                                                 examining whether the race of the prosecutor can affect racial either with the Department of Justice or a broad-reaching
                                                                 discrepancies in the criminal justice system when looking at      nonprofit focused on social justice.
                                                                 matters of discretion, such as whether to charge the accused          “The more empirical ideas I can learn, the more I can see
                                                                 with a felony or misdemeanor.                                     how things are done elsewhere, the more I can be a better ac-
                                                                     “Chelsea is brilliant,” Gillespie says. “She came to Emory    tivist and propose better solutions,” Jackson says.—April Hunt

                                                                     City Life
                                                                                                                                   annexation, we will pursue our shared mission of serving
                                                                     Emory’s annexation into Atlanta approved                      the common good in the greater metropolitan area and
                                                                                                                                   well beyond.”
                                                                     The City of Atlanta and Emory announced in early Decem-           Emory and the City of Atlanta have built alliances over
                                                                     ber that the annexation of Emory had been approved by the     many years. In addition to Emory University Hospital Mid-
                                                                     City Council, effective January 1, 2018.                      town and Emory’s historical affiliations with Grady Hospital
                                                                        “Working together, Emory and the City of Atlanta will      and the Morehouse School of Medicine, Georgia Tech and
                                                                     continue building a stronger future for neighborhoods         Georgia State, Emory’s stewardship of and investments in
                                                                     across the metropolitan area,” says President Claire E.       key business, arts, culture, and scholarship resources drive
                                                                     Sterk. “We enter this new stage of our relationship with      economic activity to the region.
                                                                     enthusiasm and great optimism for what lies ahead.                “Emory and the city are entering an exciting new phase
                                                                        “Emory is not leaving DeKalb County,” adds Sterk.          in their shared history and development,” says Robert God-
                                                                     “We remain steadfastly committed to our colleagues and        dard, chair of the Emory Board of Trustees. “Our collabora-
                                                                     neighbors in county leadership and beyond. Alongside          tive partnership will help Emory strengthen its commitment
                                                                     the Centers for Disease Control and Prevention, Children’s    as a leading liberal arts research university to improving
                                                                     Healthcare of Atlanta, and the other entities involved in     society on a local, national, and international scale.”
                                        PHOTOGRAPHY ANN BORDEN
P H O T O G R A P H Y K AY H I N TO N
MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
SHORT LIST                                          Georgia research universites to share space
                                                                                         All eight universities in the Georgia Research Alliance (GRA) will now

                  $73.5M
                                                                                         share the use of core research facilities at each of their institutions.
                                                                                                    The aim of the partnership agreement is to create a greater
                                                                                                    availability of research support services for faculty at all
                                                                                                    Georgia research universities, minimize duplication of
                                                                                                    resources, and maximize collaborative research opportu-
                          Emory Healthcare helps the                                                nities. GRA institutions include Emory, UGA, Morehouse
                            patients who need it most                                               School of Medicine, Mercer, Georgia State, Georgia Tech,
     Emory Healthcare provided $73.5 million in charity                                             Clark Atlanta University, and Augusta University.
    care in fiscal year 2017, reaching patients with no
     health insurance, including Medicare or Medicaid,
                                                                                 Emory leaders named as influencers
    and no resources of their own. The term also includes
                                                                                 Emory President Claire E. Sterk and Emory Health-
     catastrophic care for patients who may have some
                                                                                 care chair, president, and CEO Jonathan Lewin were
     coverage but for whom health care bills are
                                                                                 among Georgia Trend magazine’s one hundred “Most
    devastating. During this same time, Emory
                                                                                 Influential Georgians,” made up of leaders “who have
     medical faculty also provided $24.6
                                                                                 exhibited the character necessary to inspire, chal-
    million in unreimbursed care at
                                                                                 lenge, lead, and influence us.” Doug Shipman 95C,
     Grady Memorial Hospital.
                                                                                 president and CEO of the Woodruff Arts Center,
                                                                                 also made the 2018 list.

                                                            Emory
                                                  Professor wins                                                     Justice at Emory Law
                                                      Japan Prize                                                      Sonia Sotomayor, associate justice of
                                       Emory Professor Max D.                                                           the US Supreme Court, visited the
                                  Cooper was named a laureate of                                                         School of Law on February 6, partic-
                             the 2018 Japan Prize for the discov-                                                         ipating in a Q&A with Professor Fred
                                ery of the dual nature of adaptive                                                        Smith Jr., who clerked for her during
                                immunity, which identified the                                                            the October 2013 term. Sotomayor
                                cellular building blocks of the                                                          advised the rapt audience to engage
                                immune system as we understand                                                          fully in civic life. “Otherwise, we will be
                                it today. The annual awards recog-                                                     nothing but bystanders,” she warned.
                                nize pioneers in medicinal science                                                   “Every one of us is here to make a contribu-
                                and resources, energy, and envi-                                                   tion, but you have to have the heart to do it.”
                                ronment and social infrastructure.
                                Cooper is one of three
                                scientists recognized this                                  Emory nursing graduates get a pass
                                year for achievements                                       Recent graduates of the Nell Hodgson Woodruff School of Nursing
            contributing to the advancement of science                                      Accelerated Bachelor of Science in Nursing (ABSN) program
            and technology and promoting peace and                                          achieved a 100 percent pass rate on the NCLEX national
            prosperity for all mankind.                                                     licensure exam, making it one of the top-performing ABSN
                                                                                            programs in the nation. The school was ranked No. 4 nationally
                                                                                            in the US News and World Report Best Graduate Schools guide
                                                                                            and No. 1 in NIH funding among nursing schools.

      Give stroke patients
      more time
      Although current guidelines
      suggest clot removal only
      within six hours of stroke onset,

                                                                                                                                                                      PHOTOGR APHY ELLMAN N: STEPH EN NOWL AN D; GOD DARD: AN N BORD EN
      a study published in the New England
      Journal of Medicine shows that clot
      removal up to twenty-four hours after
      a stroke led to significantly reduced
      disability for some patients. Of 206                                                                                                               Emory
      stroke patients who randomly received                                                                                              experiment to board
      either endovascular clot removal therapy                                                                                  International Space Station
      or standard therapy of clot-busting                                                                                 Researchers at Emory School of
      medication, almost half of those who                                                                            Medicine and Children’s Healthcare of
      had clot removal showed a considerable                                          Atlanta have been awarded a two-year grant from the Center for the
      decrease in disability, compared to                                       Advancement of Science in Space supporting their work enhancing the abil-
      13 percent of the medication group.                                 ity of pluripotent stem cells to turn into cardiac muscle cells. Now the cells they’ve
                                                                     carefully cultured will be tested on the International Space Station. Stem cell–derived
                                                                     cardiac muscle cells have been used to treat heart failure in animal models and to study
                                                                     inherited cardiac diseases separately from the heart of the source patient.

8     EMORY MAGAZINE                 WINTER 2018
P O I N TS O F I N T E R E ST

                                                                      ‘Twisted                                                                    New Board
                                                                      Roots and                                                                   of Trustees
                                                                      Branches’                                                                   Chair
                                                                      ELLMANN LECTURES
                                                                      TRACE FAMILY TIES

                                                                                                                                                  Robert Goddard

                                                                    T
                                                                                                                                                  Emory’s Board of Trustees has elected busi-
                                                                           he 2017 Ellmann Lectures, given by acclaimed Irish author Colm         ness executive Robert Goddard III to serve
                                                                           Tóibín in November, turned on the subject of familial inher-           as its new chair. The resolution passed at the
                                                                           itance—or what Geraldine Higgins, codirector of the lecture            full board’s annual meeting in November.
                                                                    series, calls “all the twisted roots and branches of the family tree.”             Goddard, who has served as a trustee
                                                                        Tóibín’s subject was also personal, for he lost his own father when       since 2008 and as vice chair of the board
                                                                    he was twelve and told a Guardian reporter in 2014, “Every writer has         since 2016, succeeds John Morgan 67OX
                                                                    something in their childhood that nurtures them while seeming to be           69B, who is retiring as chair after serving in
                                                                    very damaging at the time.”                                                   the role since 2013 and as an Emory trustee
                                                                        During the course of three lectures, Tóibín examined the lives and        since 1996. Morgan will remain active as an
                                                                    relationships of Oscar Wilde, James Joyce, and W. B. Yeats with their         emeritus trustee.
                                                                    fathers. He began with the scandalous libel suit Oscar Wilde brought               “Bob Goddard is a dynamic, thoughtful,
                                                                    against John Douglas, the Ninth Marquess of Queensberry, after the            and creative leader who understands the
                                                                    latter—enraged over the affair between Wilde and his son, Lord Alfred         breadth and depth of Emory’s strengths and
                                                                    “Boisie” Douglas—left an accusing card in plain view at Wilde’s club.         responsibilities as a leading research univer-
                                                                        After a libel suit against his mother when Wilde was a child, the         sity,” says Emory President Claire E. Sterk.
                                                                    family maintained its social status. Based on this experience, Tóibín         “His collaborative approach and his commit-
                                                                    observed, Wilde “seriously misjudged how the judge, jury, and public          ment to our faculty, students, patients, and
                                                                    would view him.” Despite being the toast of London in 1895, when The          alumni make him a compelling leader of, and
                                                                    Importance of Being Earnest was entertaining audiences, Wilde would           advocate for, Emory University.”
                                                                    lose his trial, be sentenced to two years of hard labor, and fall out of           Goddard is chairman and CEO of God-
                                                                    favor with the public.                                                        dard Investment Group, a privately held firm
                                                                        Tóibín took on the father of poet W. B. Yeats, John Butler Yeats, who     investing in commercial real estate, primarily
                                                                    abandoned his family to pursue life as a painter, only to have his success    in Atlanta, Dallas, Denver, Houston, Miami,
                                                                    eclipsed by his sons, W. B. as a poet and Jack as a painter. Says Tóibín,     and Washington, D.C.
                                                                    “the father’s exile was enabling and inspiring for the son’s work.”                “One of the qualities that sets Emory
                                                                        In the final lecture, Tóibín characterized James Joyce’s father           apart is our commitment to working togeth-
PHOTOGR APHY ELLMAN N: STEPH EN NOWL AN D; GOD DARD: AN N BORD EN

                                                                    as incapable of managing the family finances and was, according to            er to transform society on a local, national,
                                                                    James’s brother Stanislaus, “a man of absolutely unreliable temper.”          and international scale,” says Goddard. “I see
                                                                    Despite this, the elder Joyce would inspire his son’s work. “Hun-             that commitment across the university, from
                                                                    dreds of pages, and scores of characters in my books, came from him.          our colleges and graduate and professional
                                                                    I got from him his portraits, a waistcoat, a good tenor voice, and an         schools, to our research and health care en-
                                                                    extravagant, licentious disposition, out of which, however, the great-        terprises, each of which draws people from
                                                                    er part of any talent I may have springs,” Joyce wrote to his mentor,         all over the world.”
                                                                    T. S. Eliot.                                                                       Goddard, who holds a bachelor’s degree
                                                                        Tóibín concluded, “instead of openly killing his father, James Joyce      in economics from Mercer University, grad-
                                                                    sought not only to memorialize him but . . . use what he needed from          uated from Harvard University’s Owners and
                                                                    his father’s life to nourish his own art.”—Susan Carini 04G                   Presidents Management program.

                                                                                                                                                 WINTER 2018       EMORY MAGAZINE             9
P O I N TS O F I N T E R E ST

                                                  Many living systems—from fireflies to      over time if I set the parameters of the
                                              neurons—switch behaviors collectively,         chamber at a low gas pressure, enabling
                                              firing on and then shutting off. But the       them to move freely,” Gogia says. “After
                                              current paper involved a nonliving sys-        a few minutes I could see with my naked
                                              tem: Plastic particles, tiny as dust specks,   eye that they were acting strangely.”
                                              that have no “on” or “off” switches.                From anywhere between tens of
                                                  “The individual particles cannot           seconds to minutes, the particles would
                                              change between crystalline and fluid           switch from moving in lockstep, or a

Particles                                     states,” Burton says. “The switching
                                              emerges when there are collections of
                                                                                             rigid structure, to being in a melted
                                                                                             gas-like state. It was surprising because

Gone Wild
                                              these particles—in fact, as few as forty.      the particles were not just melting and
                                              Our findings suggest that the ability for a    recrystallizing but going back and forth
                                              system to switch behaviors over any time       between the two states.
                                              scale is more universal than previously             “Imagine if you left a tray of ice out
     WATCHING HOW PARTICLES                   thought.”                                      on your counter at room temperature,”
     SWITCH STATES COULD REALLY                   Burton’s lab studies the tiny, plastic     Gogia says. “You wouldn’t be surprised
     SHAKE PHYSICS UP                         particles as a model for more complex          if it melted. But if you kept the ice on the
                                              systems. They can mimic the properties         counter, you would be shocked if it kept
A system of lifeless particles can become     of real phenomena, such as the melt-           turning back to ice and melting again.”
“lifelike” by collectively switching back     ing of a solid, and reveal how a system             Gogia conducted experiments to con-
and forth between crystalline and fluid       changes when it is driven by forces.           firm and quantify the phenomenon. The
states—even when the environment                  The particles are suspended in a vacu-     findings could serve as a simple model
remains stable.                               um chamber filled with a plasma-ionized        for the study of emerging properties in
    Particles may be small, but in the        argon gas. By altering the gas pressure        nonequilibrium systems.
field of physics, this is huge.               inside the chamber, the lab members can             “Switching is a ubiquitous part of our
    Physical Review Letters recently pub-     study how the particles behave as they         physical world,” Burton says. “Nothing
lished the findings by Emory physicists,      move between an excited, free-flowing          stays in a steady state for long—from
the first experimental realization of such    state into a jammed, stable position.          the earth’s climate to the neurons in a
dynamics. “We’ve discovered perhaps               The current discovery occurred after       human brain. Understanding how sys-
the simplest physical system that can         Emory graduate student Guram “Guga”            tems switch is a fundamental question
consistently keep changing behavior           Gogia 22PhD tapped a shaker and slowly         in physics. Our model strips away the
over time in a fixed environment,” says       “salted” the particles into the vacuum         complexity of this behavior, providing
Justin Burton, assistant professor of         chamber filled with the plasma, creat-         the minimum ingredients necessary.
physics. “In fact, the system is so simple    ing a single layer of particles levitating     That provides a base, a starting point, to
we never expected to see such a complex       above a charged electrode. “I was just         help understand more complex systems.”
property emerge from it.”                     curious how the particles would behave         —Carol Clark

                                                                                             Nothing stays in a steady
                                                                                             state for long—from the
                                                                                             earth’s climate to the
                                                                                             neurons in a human brain.
                                                                                                                                            P H O T O G R A P H Y E M O R Y P H OTO/ V I D E O

                                                                                                                                                                                                 P H O T O G R A P H Y K AY H I N TO N

 Justin Burton

10    EMORY MAGAZINE                 WINTER 2018
A MAT TER OF DEGREE
                                                                                             The Mellon Mays Undergraduate Fellowship program puts doctorates within reach for minority students

                                                                                             A
                                                                                                      n Emory program that expands opportunities for under-        pipeline has a profound impact on knowledge production, the
                                                                                                      represented minorities to earn doctorates and faculty        retention of a diverse student body, and the intellectual strength
                                                                                                      positions has received renewed funding from the Andrew       that diversity brings to academic communities, Anderson says.
                                                                                             W. Mellon Foundation.                                                     “This is why we do this work. Because of the initial leadership of
                                                                                                  Emory’s Mellon Mays Undergraduate Fellowship (MMUF) pro-         the late professor Rudolph Byrd and then professor Dianne Stewart,
                                                                                             gram will receive $131,000 for the current year. Emory selects its    the MMUF program at Emory is, without question, first rate,” Ander-
                                                                                             own fellows, rising juniors in Emory College with demonstrated        son says. “Our fellows are completing their doctorates at Harvard,
                                                                                             academic excellence and serious intent to pursue a doctoral           Northwestern, Michigan, Brown, Rutgers, and more. They are the
                                                                                             degree in selected humanities and social sciences.                    recipients of major fellowships, including the Fulbright.”
                                                                                                  “As we prepare our diverse student body to contribute as
                                                                                             scholars and thought leaders in the academy and beyond, we
                                                                                             are committed to sustaining an environment at Emory that
                                                                                             promotes full participation and inclusivity. The MMUF program
                                                                                             provides an ideal platform to advance this objective and to
                                                                                             support our students as they pursue their education and devel-
                                                                                             opment as thought leaders with diverse intellectual interests and
                                                                                             perspectives,” says Dwight McBride, provost and executive vice
                                                                                             president for academic affairs.
                                                                                                  The latest grant will pay stipends and research support to ten
                                                                                             junior and senior fellows during the academic year. The Mellon
                                                                                             Foundation
                                                                                             also provides
                                                                                             funding to culti-
                                                                                             vate the kind of
                                                                                             social capital—
                                                                                                                                                                                           SERIOUS STUFF The Mellon Mays program pre-
                                                                                             mentoring,                                                                                pares the next generation of college professors, helped
                                                                                             grant writing,                                                                            by leaders like Cynthia Neal Spence (left), UNCF/Mellon
                                                                                                                                                                                       programs director at Spelman College.
                                                                                             conference
                                                                                             presentations,
                                                                                             how-to-publish
                                                                                             workshops—                                                                                  Since the 1990s, Emory also has served as
                                                                                             that often makes                                                                        the formal launching point annually for 106
                                                                                             the critical differ-                                                                    fellows by hosting the UNCF/Mellon Summer
                                                                                             ence in gradu-                                                                          Institute, which introduces the newly selected
                                                                                             ate school and                                                                          students to life as an academic. In addition to
                                                                                             faculty success.                                                                        Emory, they come from colleges across the
                                                                                                  “MMUF is essential,” says Carol Anderson, Charles Howard         country as well as two universities in South Africa.
                                                                                             Candler Professor and chair of the Department of African Amer-            Fellows in the four-week immersion institute attend lectures
                                                                                             ican Studies, who leads the Emory program. “The glaring lack of       on topics such as research, work-life balance, and the art and
                                                                                             diversity in the professoriate is evident across the United States,   philosophy of teaching, as well as engage in weekly writing
                                                                                             where, for example, Hispanic males comprise only 2 percent of         exercises to hone their critical thinking and analysis abilities.
                                                                                             all tenure-track faculty. The numbers are nearly as low or lower      They also create a prospectus that forms the foundation for a
                                                                                             for African American and Native American men and women, as            two-year research project with faculty mentors.
                                                                                             well as Hispanic women.”                                                  The summer program prepares fellows for the MMUF, which,
                                                                                                  Since it was established in 1988, MMUF has supported 762         in addition to stipends, provides each cohort with ongoing
P H O T O G R A P H Y E M O R Y P H OTO/ V I D E O

                                                                                             PhD graduates. Emory, which joined the program in 2000, has           mentoring, research support, and professional guidance from
                                                                                             launched seven so far, many of whom are now in tenure-track           faculty, coordinators, and graduate students.
                                                     P H O T O G R A P H Y K AY H I N TO N

                                                                                             positions, along with several former students currently in gradu-         Fellows enrolled in PhD programs up to thirty-nine months
                                                                                             ate programs pursuing doctorates.                                     after earning a bachelor’s degree are also eligible for up to
                                                                                                  Bringing more underrepresented students into the doctoral        $10,000 in loan forgiveness.—April Hunt

                                                                                                                                                                                      WINTER 2018            EMORY MAGAZINE                  11
P O I N TS O F I N T E R E ST

# I See the
Future
     Using Twitter and big data tools
     to read minds—many, many minds

People who think farther into the future are more
likely to invest money and to avoid risks, accord-
ing to new findings by Emory psychologists.
    While that conclusion may not seem reve-
latory, previous findings on the subject have
been inconsistent—possibly due to factors such as observer         son is that prior studies explicitly asked individuals how far
bias in a lab setting and small sample sizes. What’s notable       they thought into the future, while the PNAS paper used the
about this research, published by the Proceedings of the           implicit measure of previous tweets.
National Academy of Sciences (PNAS), is that it tapped big             The researchers used a suite of methods to automatical-
data tools to conduct text analyses of nearly forty thousand       ly analyze Twitter text trails previously left by individual
Twitter users and to run online experiments of behavior of         subjects. Experimental data was gathered using the Ama-
people who provided their Twitter handles.                         zon crowdsourcing tool Mechanical Turk, a website where
    “Twitter is like a microscope for psychologists,” says         individuals can complete psychology experiments and other
coauthor Phillip Wolff, associate professor of psychology.         internet-based tasks.
“Naturalistic data mined from tweets ap-                                              œ In one experiment, Mechanical Turk par-
pears to give insights not just into tweet-                                           ticipants answered a classic delay discount-
ers’ thoughts at a particular time, but into                                          ing question, such as: Would you prefer $60
a relatively stable cognitive process. Using                                          today or $100 in six months?
social media and big-data analytical tools         Twitter is like a                  œ The participants’ tweets were also
opens up a new paradigm in the way we
study human behavior.”
                                                   microscope for                     analyzed. Future orientation was measured
                                                                                      by the tendency of participants to tweet
    Coauthor Robert Thorstad 16G 22PhD,            psychologists.”                    about the future compared to the past.
a grad student in the Wolff lab, came up                                              Future-sightedness was measured based on
with the idea for the research, worked on                                             how often tweets referred to the future, and
the design and analyses, and conducted the                                            how far into the future.
experiments.                                                           The results showed that future orientation was not asso-
    “I’m fascinated by how peoples’ everyday behavior can          ciated with investment behavior, but that individuals with
give away a lot of information about their psychology,”            far-future-sightedness were more likely to choose to wait
Thorstad says. “Much of our work was automated, so we              for future rewards than those with near-future-sightedness.
were able to analyze millions of tweets from thousands of          That indicates that investment behavior depends on how far
individuals’ day-to-day lives.”                                    individuals think into the future, rather than their tendency
    The future-sightedness found in individuals’ tweets was        to think about the future in general.
                                                                                                                                     PHOTOGRAPHY STEPHEN NOWL AND

short—usually just a few days—which differs from prior re-             “Twitter can provide a much broader participant pool
search suggesting future-sightedness may stretch years.            than many psychology experiments that primarily use under-
    “One possible interpretation is that the difference is due     graduates as subjects,” Thorstad says. “Big data methods may
to a feature of social media,” Wolff says. Another possible rea-   ultimately improve generalizability for psychology results.”

12    EMORY MAGAZINE                 WINTER 2018
CHEMISTS UNITE
                               EMORY’S CCHF CONNECTS UNIVERSITIES AND INDUSTRIES TO ADVANCE INNOVATION IN ORGANIC CHEMISTRY

                               T
                                          he National Science Foundation                                                      making it faster and more efficient.
                                          has awarded another $20 million                                                         The CCHF is not only transforming
                                          to Emory’s Center for Selective       WE’VE GOT THIS INCREDIBLE                     organic synthesis—it’s also creating new
                               C-H Functionalization (CCHF) to fund the                                                       models for the way organic chemistry is
                                                                                COLLABORATIVE ENVIRON-
                               next phase of a global effort to revolution-                                                   taught and how labs conduct research.
                               ize the field of organic synthesis.              MENT WHERE ORGANIC                            Where previously individual labs tended
                                   “Our center is at the forefront of a ma-     CHEMISTS AREN’T                               to work in isolation to tackle problems,
                               jor shift in the way that we do chemistry,”      JUST SHARING RESULTS,                         the CCHF has broken down walls across
                               says Huw Davies, professor of chemistry                                                        specialties, institutions, and even countries
                                                                                THEY’RE SHARING IDEAS.
                               and the director of the CCHF. “This shift                                                      to collectively take on the remaining chal-
                               holds great promise for creating new             THAT’S RARE.                                  lenges of selective C-H functionalization.
                               pathways for drug discovery and the                                                                “We’ve got this incredible collaborative
                               production of new materials to benefit ev-      tionalization flips this model on its head.    environment where organic chemists aren’t
                               erything from agriculture to electronics.”          “We’ve devised ways to make C-H            just sharing results—they’re sharing ideas,”
                                   The CCHF began in 2009 as an NSF            bonds react so that they become func-          Davies says. “That’s rare. And we’ve expand-
                               Center for Chemical Innovation, with a          tional,” Davies says. “And we’ve reached       ed beyond our network of universities to
                               seed grant of $1.5 million and four col-        the stage where it is no longer the molecule   also engage the pharmaceutical industry.”
                               laborating universities. In 2012, the NSF
                               awarded the CCHF its first $20 million,          Huw Davies
                               enabling it to grow to encompass sixteen
                               US institutions and seven industrial affili-
                               ates, including six major pharmaceutical
                               companies and one of the largest US
                               chemical suppliers. The center also built
                               global connections with major players
                               in C-H functionalization in Japan, South
                               Korea, and the UK.
                                   The CCHF has led the way for explosive
                               growth in the field of C-H functionalization,
                               publishing more than two hundred papers
                               on the topic through its collaborators. It
                               has developed dozens of new catalysts for
                               C-H functionalization, including four major
                               classes from the Huw Davies group.
                                   “During the past five years, we’ve
                               developed the fundamentals for C-H
                               functionalization and documented that
                               the concept is viable,” Davies says. “Now       itself that determines the process of the          In 2015, the CCHF launched online sym-
                               we’re ideally positioned to maximize the        reaction—we’ve developed advanced              posia on recent advances in C-H function-
                               further development of this chemistry and       catalysts that allow us to control which       alization. Graduate students and chemistry
                               move forward to apply it.”                      carbon-hydrogen bond within a molecule         faculty from up to forty-five countries join
                                   Traditionally, organic chemistry has        will react and when.”                          the symposia, held about four times a year.
                               focused on the division between reactive,            C-H functionalization opens unex-             “We have leading voices in the field
                               or functional, molecular bonds and the          plored chemical space by taking petro-         give these free talks that are easy to join
                               inert, or nonfunctional bonds carbon-car-       leum byproducts, which have a lot of           live and participate in,” Davies says. “The
PHOTOGRAPHY STEPHEN NOWL AND

                               bon (C-C) and carbon-hydrogen (C-H).            carbon-hydrogen bonds, and transform-          aim is to further expand the field of C-H
                               The inert bonds provide a strong, stable        ing them from waste into useful materials.     functionalization by introducing it to grad-
                               scaffold for performing chemical synthe-        It also strips out steps from the linear       uate students and other chemists around
                               sis with the reactive groups. C-H func-         process of traditional organic synthesis,      the world.”—Carol Clark

                                                                                                                        WINTER 2018          EMORY MAGAZINE             13
P O I N TS O F I N T E R E ST

                                                                                                            IF YOU LOOK AT
                                                                                                            THE SCIENCE,
                                                                                                            YOU CAN SEE
                                                                                                            THERE IS A LOT
                                                                                                            OF POTENTIAL
                                                                                                            IN PLANTS.

     The Power
     of Plants                                                                                    GROWING NEW CURES Cassandra Quave
                                                                                               leads antibiotic drug discovery research focused
                                                                                               on identification and analysis of botanical remedies
                                                                                               used in the traditional treatment of infectious
                                                                                               disease.

C
          assandra Quave, an ethnobotanist          With a patent on a compound she            pH of the vinegar can balance the alkaline
          with Emory College’s Center for the   teased from the roots of an elmleaf black-     pH that comes from such infections, effec-
          Study of Human Health, elicits a      berry that helps battle antibiotic-resistant   tively slowing the growth of the fungus.
handful of nods when she asks whether her       staph, Quave is a sought-after instructor.         “Homeopathy has given botanicals a
students have seen or grabbed a bottle of       She starts with the ancient history and        bad rap, I think. But if you look at the sci-
aloe juice at a high-end grocery checkout.      cultural interactions of botanical medicine    ence, you can see there is a lot of potential
     So-called green juices are restorative,    before zipping through the plants that         in plants. It’s good science,” says Pintas,
according to ads propped up by the bottles.     form the basis of drugs for everything         who is further exploring her research in
Good for the skin, one student murmurs.         from infectious diseases to cancer and         Quave’s lab as part of her honor’s thesis.
     But today Quave is talking to her med-     the safety and ethical issues in ongoing           Such knowledge is important not just
ical botany class about plants used for         research.                                      for would-be physicians but also for any-
gastrointestinal needs. She explains that           “Once they understand the Latin            one who wants to think more deeply about
an Egyptian medical papyrus of herbal           names of the plants and see how related        their own health care.
knowledge, dating to 1550 BC, first iden-       species share chemistry, they can con-             First-year student Kat Bagger 21C de-
tified aloe vera as a treatment that still      nect the dots to see how it all works,”        veloped an understanding of the fine line
works today: the stimulant from the family      Quave says. “That’s when it is really great,   between toxicity and treatment that comes
of flowering plants solves constipation by      because so many of them say they think         with plant-based medicines.
quickly speeding up the colon muscles.          about the world and their health in a              Digitalis, for instance, comes from the
     “It always makes me laugh, because         whole new way.”                                poisonous foxglove plant, but controlled
it’s basically a jug of laxative that people        A course that details the plant com-       use of the plant’s
shouldn’t be chugging, but will, right as       pounds and the underlying mechanisms           cardiac glyco-
they stand in line,” Quave says of the neon     of action of botanical drugs is also a prime   sides helps with
green aloe juices. “It makes me wonder if       example of the human health program, a         congestive heart
they make it home without stopping.”            pioneering effort that highlights Emo-         failure.
     From aspirin to the chemotherapy drug      ry’s diverse efforts in health education,          “I was one of
Taxol, some of the world’s most common          research, and the liberal arts.                those people who
and important medicines come from plants.           Stephanie Pintas 18C, a human health       thought natu-
                                                                                                                                                                                              P H O T O G R A P H Y C O U R T E S Y O F M I R KO PA I A R D I N I

     Quave’s Botanical Medicine and Health      major, says the course has reinforced her      ral meant safe,
course combines botany, chemistry,              plans to focus on integrative medicine—        but it’s so much
anthropology, and pharmacology to give          with its approach to preventive, holistic      more complex
students the practical ability to suss out      care—after medical school.                     than that,” says
                                                                                                                                                      P H O T O G R A P H Y K AY H I N TO N

what is marketing and what is science               Pintas had her own success in              Bagger. “It’s so
when it comes to plant-based “cures”            researching apple cider vinegar as a treat-    eye-opening.”—
such as the aloe juice.                         ment for skin fungal infections. The acidic    April Hunt

14   EMORY MAGAZINE                  WINTER 2018
SEEKING THE CELLS WHERE HIV HIDES
                                                                                                              Yerkes experts have identified new targets in HIV-infected patients already on antiviral treaments

                                                                                                              Scientists at Yerkes National Primate          and bone marrow, and contain replica-          HIV-positive individuals who had been
                                                                                                              Research Center have identified an addi-       tion-competent and infectious virus.”          on antiviral drugs for an average of three
                                                                                                              tional part of the HIV reservoir, immune            Guido Silvestri, division chief of        years.
                                                                                                              cells that survive and harbor the virus de-    microbiology and immunology at Yerkes              Based on the team’s findings, Paiar-
                                                                                                              spite long-term treatment with antiviral       and a Georgia Research Eminent Schol-          dini says, CTLA4 should be considered
                                                                                                              drugs. The findings are published online       ar, is a coauthor of the study. The Yerkes     as an additional target when designing
                                                                                                              in the journal Immunity.                       team worked with researchers at NCI/           immunotherapies aimed at purging the
                                                                                                                  The cells display a molecule called        Leidos Frederick, led by Jacob Estes,          viral reservoir.
                                                                                                              CTLA4, the target of an FDA-approved           using a technique called “DNAscope,” to
                                                                                                              cancer immunotherapy drug, ipilimum-           visualize latently infected cells in lymph
                                                                                                              ab. This information should help those         nodes. Previous research had shown
                                                                                                              trying to eradicate HIV from the body.         HIV-infected cells persist in regions of
                                                                                                                  Researchers led by Mirko Paiardini,        the lymph nodes called B cell follicles.
                                                                                                              associate professor of pathology and           The newly identified group of infected
                                                                                                              laboratory medicine at the School of           cells is found outside the B cell follicles.
                                                                                                              Medicine and Yerkes and part of the Em-             Working in collaboration with Rafick
                                                                                                              ory Vaccine Center, infected macaques          Sekaly at Case Western Reserve Univer-
                                                                                                              with HIV’s relative SIV and treated            sity, the research team also showed the
                                                                                                              them with standard antiviral drugs sim-        CTLA4-positive PD1-negative cells have
                                                                                                              ilar to what humans receive for HIV. At        the characteristics of regulatory T cells,
                                                                                                              the time of analysis, eight out of nine of     whose job is to put a brake on the im-
                                                                                                              the animals showed undetectable SIV in         mune system and prevent it from getting
                                                                                                              their blood. The team probed for CD4+          too excited.
                                                                                                              memory T cells, which are known to                  “It provides a strong rationale for
                                                                                                              shelter persistent virus.                      targeting these cells,” Paiardini says. “De-
                                                                                                                  “We found that a certain group             pleting latently infected T-regs can not
                                                                                                              of memory CD4+ T cells displaying              only reduce the reservoir, but also induce
                                                                                                              CTLA4, but not another co-inhibitor            a stronger antiviral immune response.”
                                                                                                              receptor called PD1, harbor viral DNA               The researchers also worked with
                                                                                                              at higher frequencies than other groups        Vincent Marconi, a physician treating
                                                                                                              of memory CD4+ T cells,” Paiardini says.       HIV in Atlanta, to confirm similar cells
                                                                                                                                                                                                               LET’S BE SPECIFIC Mirko Paiardini has
                                                                                                              “These cells can be found in multiple          were present in human lymph nodes.             identified particular cells that harbor latent HIV.
                                                                                                              tissues, such as lymph node, spleen, gut,           The human samples came from six

                                                                                                              The Biggest Gift Yet                                                       For decades, the Woodruff Foundation has served as the
                                                                                                                                                                                     university’s advocate and partner, supporting education and mak-
                                                                                                              The Robert W. Woodruff Foundation has pledged $400 million to          ing greater quality of life possible for Emory’s patients. In 1979,
                                                                                                              find new cures for disease, develop innovative patient care models,    Robert W. Woodruff, the late leader of The Coca-Cola Company,
                                                                                                              and improve lives while enhancing the health of individuals in need.   and his brother, George Woodruff, gave Emory the then-record
                                        P H O T O G R A P H Y C O U R T E S Y O F M I R KO PA I A R D I N I

                                                                                                                  The transformational gift, the largest ever received by Emory      sum of $105 million, the first nine-figure gift to an institution of
                                                                                                              University, will change the lives of patients and their families.      higher education.
                                                                                                              Through a new Winship Cancer Institute Tower in Midtown and                The recent gift “will allow us to accelerate the scientific dis-
                                                                                                              a new Health Sciences Research Building on Emory’s Druid Hills         coveries needed for breakthroughs in patient care and to extend
P H O T O G R A P H Y K AY H I N TO N

                                                                                                              campus, the gift will help advance new solutions for some of           our reach in reducing the burden of disease for patients and their
                                                                                                              medicine’s most challenging diagnoses and improve the out-             families,” says Jonathan Lewin, Emory executive vice president for
                                                                                                              comes for future generations.                                          health affairs.

                                                                                                                                                                                                       WINTER 2018             EMORY MAGAZINE                     15
P O I N TS O F I N T E R E ST

                                                     In Global Health,
                                                     Context Is Critical
                                                     JAMES LAVERY IS THE FIRST CONRAD N. HILTON
                                                     PROFESSOR IN GLOBAL HEALTH ETHICS

                                                    G
                                                              lobal biomedical and public health research—whether
                                                              introducing genetically modified mosquitoes to fight
                                                              dengue fever or testing new medicines to prevent HIV
                                                            transmission from mother to child—is aimed at finding
                                                              and implementing solutions to some of the world’s most
                                                               pressing health problems. That’s obviously a fundamen-
                                                                tally ethical pursuit. Isn’t it?
                                                                 š Yes, says James Lavery, recently named the first
                                                                 Conrad N. Hilton Professor in Global Health Ethics. But
                                                                  failure to understand the social and political context in
                                                                  which the work is being done, or to know and address
                                                                   how stakeholders perceive a project’s implications, has
                                                                   the potential to sink even the most well-intentioned,
                                                                   well-funded, otherwise well-designed research study.
                                                                    š Lavery, who also is a faculty member in the
                                                                    Emory Center for Ethics, likens what he does to be-
                                                                    ing an architect. He works with people who may be
                                                                     designing lovely and functional structures to make
                                                                     sure they don’t build upon unstable foundations or
                                                                     in unsuitable locations.
                                                                                       š Consider the mosquito net
                                                                                       program that died because the white
                                                                                       color of the net represented death
                                                                                       in the country where it was being
                                                                                       tested. Or the HIV pre-exposure
                                                                                       study that was abruptly shut down
                                                                                      after the sex workers involved in the
                                                                                    study, who felt their concerns had not
                                                                                  been taken seriously, staged a protest at an
                                                                                international AIDS meeting. Both projects
                                                                       likely looked great on the blueprint but fell apart in
                                                                 the construction phase.
                                                                                                                                 I L L U S T R AT I O N S T E P H E N N O W L A N D

                                                                  š Global research is especially tricky, says Lavery,
                                                                   since the majority of programs are conducted in
                                                                    low- and middle-income countries by research-
                                                James Lavery         ers and funding from high-income countries.

16   EMORY MAGAZINE               WINTER 2018
5
                                                                                                                                      NURSING
                                                                                                                                      SCHOOL
                                                                                 I’M NOT TRYING                                       IN TOP FIVE
                                                                                 TO INTRODUCE
                                                                                   ADDITIONAL
                                                                                                                                      FOR NIH
                                                                                 OBSTACLES FOR
                                                                                   SCIENTISTS.
                                                                                                                                      FUNDING
                                                                                                                                      The Nell Hodgson Woodruff School of
                                                                                                                                      Nursing is again among the top five nursing
                                                                                                                                      schools in the US for funding from the Na-
                                                                                                                                      tional Institutes of Health (NIH).
                                                                                                                                          In 2017, the school received $7.8 million
                                                                                                                                      in NIH funding as part of a total portfolio
                                                                                                                                      of $14.9 million. This includes twenty NIH
                                                     Researchers face different cultures, different languages, an imbalance           research awards, among which six were
                                                     of power and knowledge, and, sometimes, lingering distrust and fear              training and/or career development awards.
                                                     of exploitation.                                                                     The School of Nursing’s leading research
                                                         Lavery works to ensure that the core commitments and ethical inten-          is reflected in several current projects. This
                                                     tions of global health research are translated into action and preserved         trend marks a notable uptick in NIH funding
                                                     through relationships with stakeholders, beginning with the scientists           in less than a decade; the school was No. 38
                                                     and people who fund them, and extending throughout the communities               in funding in 2009.
                                                     touched by studies.
                                                         He’s most interested in what he calls the human infrastructure of

                                                                                                                                                                    3
                                                     global health ethics, and community engagement is how this infrastruc-
                                                     ture comes about—how researchers identify and manage non-obvious
                                                     stakeholder interests, demonstrate respect and trustworthiness, and
                                                     build legitimacy by creating opportunities for dialogue and deliberation.
                                                         “I’m not trying to introduce additional obstacles for scientists,”
                                                     says Lavery. Instead, he consults with them—and the people who fund              THREE
                                                     them—to help plan, design, manage, and evaluate strategies for engaging
                                                     with stakeholders in order to make their research more successful and
                                                                                                                                      IN GOOD
                                                     ethically robust.
                                                         Creating a community engagement strategy is like imagining and
                                                                                                                                      COMPANY
                                                     creating a building, Lavery says. He sits with the scientists, discussing
                                                     their vision, what they hope their “building” will accomplish and for            Three Emory professors are among only
                                                     whom. Who are the stakeholders? What are constraints of space, budget,           seventeen researchers around the country
                                                     regulations? Will it fit? Be appropriate? Accepted?                              to receive Distinguished Investigator grants
                                                         “Our work has been to figure out analogous elements, such as terms           from the Brain and Behavior Research
                                                     of research partnerships, ethical commitments, and guiding principles—           Foundation. The $100,000, one-year grant
                                                     methods for integrating community engagement activities with program             is the foundation’s largest award, designed
                                                     management,” Lavery says. “We then help researchers and funders                  to support innovative projects that seek
                                                     integrate these elements to develop blueprints and project management            new potential targets for understanding
                                                     strategies.”                                                                     and treating a wide range of mental health
                                                         Based on years of investigating such “buildings,” including many that        disorders. No other university had more than
                                                     never got off the ground, Lavery and his team are constructing a “Learn-         two researchers earn the award.
                                                     ing Platform” to facilitate the process for funders and researchers. Each            Emory College psychology professor Pa-
I L L U S T R AT I O N S T E P H E N N O W L A N D

                                                     new building, or project, is completely different and customized.                tricia Brennan, and J. Douglas Bremner and
                                                         James Curran, dean of the Rollins School of Public Health, believes          Andrew H. Miller, both physicians and pro-
                                                     Lavery will “provide leadership in public health ethics across the university    fessors in the School of Medicine, received
                                                     and serve as a resource to Emory’s global ethics partners.”—Sylvia Wrobel        the 2017 awards, announced in December.

                                                                                                                                     WINTER 2018       EMORY MAGAZINE             17
P O I N TS O F I N T E R E ST

SALVAGING                                          “Data from CIREN centers help drive
                                               rulemaking to make vehicles safer for pas-
                                                                                                 CIREN centers are awarded funding
                                                                                             for research for either a medical center

WRECK AGE                                      sengers,” says Jonathan Rupp, associate
                                               professor of emergency medicine and
                                                                                             arm or an engineering center arm. The
                                                                                             Emory/Grady collaboration is one of two

W
                                               principal investigator of the newly formed    programs in the country that have been
           ith more than three hundred         CIREN center at Emory and Grady. “CIREN       awarded both a medical center and an
           thousand motor vehicle deaths       relies on high-volume trauma centers like     engineering center designation.
           in the US each year, and more       Grady’s Marcus Trauma Center to conduct           “This is an incredible honor that re-
than one thousand in Georgia alone, most       research on injuries following car crashes.   flects the national prominence of Grady’s
of us either have been directly affected by    This CIREN award would not have been          Marcus Trauma Center and the expertise
a car accident or worry that we will be.                                                     of the engineering and medical teams
    A new research project could steer                                                       brought together for this project,” says
those statistics in a better direction.                                                      David Wright, professor of emergency
Emory’s Injury Prevention Research Cen-                                                      medicine at Emory and coprincipal inves-
ter, along with Grady Memorial Hospital        Data from CIREN                               tigator of the CIREN award. “Collaborators
and collaborators at the University of                                                       will spend the next five years collecting
Michigan, have been awarded almost $4          centers help drive                            and analyzing data to better understand
million for a five-year project to study
motor vehicle crashes in the metro-
                                               rulemaking to make                            the mechanisms of injuries from modern
                                                                                             automobiles.”
Atlanta area that result in injuries treated   vehicles safer for                                Researchers expect to investigate six-
at Grady. The project is funded by the                                                       ty to sixty-five metro-Atlanta automobile
National Highway Traffic Safety Admin-         passengers.                                   crashes per year that result in injury. At
istration (NHTSA) and will create a Crash                                                    the completion of the study, the investiga-
Injury Research and Engineering Network                                                      tors hope to have data on more than three
(CIREN) center for research.                                                                 hundred patients injured in crashes.
    With a goal to improve vehicle safety                                                        “Motor vehicle accidents are the No. 1
and support injury prevention, CIREN           possible without the strong, collaborative    trauma we see at Grady, resulting in thou-
centers collect data on the performance        relationship between Emory and Grady.”        sands of crash victims each year,” says
of vehicles in crashes and the resulting           Participants will be enrolled in the      Peter Rhee, chief of acute care surgery at
injuries. CIREN is one of the NHTSA’s          study when brought by ambulance or            Grady Health System. “We are excited to
major data collection systems for motor        helicopter to Grady, Georgia’s busiest        continue contributing to the work in the
vehicle crashes. Following an extensive        Level 1 trauma center, following a crash.     new CIREN center, in hopes of better un-
quality-control process, CIREN case data       The Emory/Grady center is one of seven        derstanding how to continually improve
are then made available to the public.         designated CIREN centers in the US.           the safety of our drivers and passengers.”

                                                                                                                                           P H O T O G R A P H Y B R A I N I L L U S T R AT I O N : B O N A K I M

18   EMORY MAGAZINE                  WINTER 2018
You can also read