Repar-Group LLC, Moscow, Russia - MEDICA
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Repar-Group LLC, Moscow, Russia
Company Repar-Group ltd. was founded in Moscow in 2002
year. In the same year, the development of technology for
producing collagen from bovine dermis was completed, In 2017, Repar-Group LLC has carried out to market the first
which is processed by a special, patented technology to product in line of the brand REPARCOL — healing 7%
remove all impurities and non-collagen proteins without collagen gel for topical use REPARCOL®GEL, tube 5 ml. In
destroying the structure of the collagen matrix, creating an 2018, withdrawn 7% collagen gel for external use
immunogenic, inert and resistant material. REPARCOL®GEL, tube 10 ml and 5% collagen gel-spray
REPARCOL®GEL-SPRAY , 20 ml. In 2019 was launched
For the development of this technology Repar-Group ltd. REPARCOL®GEL-FOAM 5% in aerosol can.
received two diplomas "for the uniqueness of the product"
at the exhibitions COSMETIC EXPO in Russia in 2008 and In the composition of these products, a second important
2011. component is propylene glycol, which has an antiseptic
effect and retains moisture in the hearth of the recovery. In
This technology made it possible to start further 2021-2022 planned an expansion of medical indications and
development and production of a line of healing agents registration of REPARCOL product line as a medical device,
based on native collagen type I, unreconstructed, with as well as the market launch of another 2-3 products
preserved fibrillar structure. Thus, in 2012, registered a new (Collagene membrane, vaginal suppositories, rectal
brand of cosmetic collagen remedy, gel and gel-spray suppositories, eye drops).
REPARCOL.
NOW PRODUCING PRODUCTS:
Brand REPARCOL®
COSMETOLOGY
• Collagen gel, 7%, tube 5 ml.
• Collagen gel, 7%, tube 10 ml.
• Collagen gel-spray, 5%, bottle, 20 ml.
• Collagen gel-spray, 5%, bottle, 30 ml.
• Collagen gel-foam, 5% aerosol can, 40 ml.
PROSPECTIVE PRODUCTS:
Brand REPARCOL® Brand GIACOL® • Collagen + low-molecular hyaluronic acid,
regenerating cream for intimate zone skin care,
MEDICAL DEVICES COSMETOLOGY 30 g.
• Collagen + low-molecular hyaluronic acid,
regenerating gel for lips, 10 g.
• Collagen vaginal suppositories, • Collagen + low-molecular hyaluronic acid, • Collagen + low-molecular hyaluronic acid,
10%, 5 pieces. regenerating day cream-facial care, 30 g. regenerating gel for eyelashes, 10 g.
• Collagen rectal suppositories, • Collagen + low-molecular hyaluronic acid, • Collagen + low-molecular hyaluronic acid,
10%, 5 pieces. regenerating night cream-facial care, 30 g. regenerating after epilation/depilation gel, 100 g.
• Collagen postoperative • Collagen + low-molecular hyaluronic acid, • Collagen + low-molecular hyaluronic acid,
regenerating eye drops, 10 g. regenerating day cream-facial care for men, 30 g. regenerating after shave gel, 50 g.
• Collagen + low-molecular hyaluronic acid, • Collagen + low-molecular hyaluronic acid,
regenerating day care cream eye contour, 10 g. regenerating hair shampoo, 200 g.
• Collagen + low-molecular hyaluronic acid, • Collagen + low-molecular hyaluronic acid,
regenerating cream for body skin care, 100 g. regenerating hair mask, 100 g.
• Collagen + low-molecular hyaluronic acid, • Collagen + low-molecular hyaluronic acid,
regenerating cream for feet skin care, 30 g. regenerating gel-spray after sun skin care, 50 g.
REPARCOL 7% COLLAGEN GEL
The principle of operation
Largely rapid healing of the skin due to the positive effect of the so-called circulation and nutrition of the affected area. Experience in the use of collagen
"wet environment." This concept stems from experiments conducted by materials in various procedures to restore the tissue has led to the
George Winter in 1962 on young piglets. He found that if the experimental development and implementation of the absorbable implant based on
wound contain wet under plastic covers, the wound epithelialized in two collagen to regenerate skin tissue. It is logical to assume that if we treat the
times faster than that under air. It is proved that in order for the wound heal wound site with a product that is related to the body tissue, must occur for
faster and without the formation of scar, it is necessary to maintain in a state successful wound healing.
of constant humidity. According to the literature, for successful wound healing
requires that cells could move freely and produce the necessary restoration Given that the active components of the Reparcol gel are collagen (the
work. The movement of the cells is favored by humid environment and the supporting matrix for the growth tissue stimulator of the immune system, cell
presence in the wound supporting matrix consisting of a special class of adhesion) and propylene glycol – a substance that helps create the moist
molecules. These molecules are called adhesive, so as to cause adhesion of wound environment, prevents tissue dehydration and cell death, it can be
the cells. The adhesive molecules are collagen, hyaluronic acid, laminin and assumed that this gel is the best remedy for healing and reparation of
fibronectin. Cells will not move if it does not receive signal from other cells. damaged or diseased tissues.
Therefore, the wound should be signal molecules such as growth factors,
cytokines, etc. The main source of such molecules are macrophages. The The effectiveness of the Reparcol gel are to the following factors. It is the
response of the organism to the exogenous collagen is the release of large ability to create a suitable substance for rapid and sustained contact with the
amount of macrophages, cytokines, growth factors, when the presence of a wound surface; the presence of the structure, allowing cellular migration,
humid environment on the wound surface promotes rapid recovery of proliferation, growth of new tissue and the formation of extracellular matrix;
damaged tissues. the absence of toxicity and antigenicity, biological integration; prevent the
rapid proliferation of flora on the wound surface; a noticeable decrease in
To cover abrasion wound a wound-healing preparation is to create optimal itching, burning, and pain caused by covering exposed nerve endings, reducing
environment for healing, providing reduction of pain, protection from the time of rehabilitation.
infection, maintaining a moist damaged area while improving blood
BIOCOMPATIBLE PRODUCT WITH FAST AND EVIDENT EFFECT
WOUND – MECHANICAL DAMAGE OF THE ORGANISM, WHICH IS ACCOMPANIED BY INFRINGEMENT OF INTEGRITY OF INTEGUMENTARY TISSUES (SKIN, MUCOUS SHELL) PAIN — depends on the location of the wound, damage to nerve structures, the nature of the traumatic agent a psychological state of the organism BLEEDING — depends on the type of vessels and nature of vascular injury, wound location, status of local and general hemodynamics, state of the blood system. DEHISCENCE — is determined by the direction of Langer's lines relative to the wounds.
ACCORDING TO THE REASON
OF THE DAMAGE
Related to surgery Accidental
CLASSIFICATION OF WOUNDS
ACCORDING TO THE NATURE
OF INJURY
• cut or incised wound — vulnus incisum
• stub or pierced wound — vulnus punctum
• sabre or slash wound — vulnus caesum
• contused wound — vulnus contusum
• crushed wound — vulnus conguassatum
• poisonous wound — vulnus venenatum
• gunshot wound — vulnus sclopetarium
• mixed wound — vulnus mixtum
• bite wound — vulnus morsum
• lacerated wound — vulnus lacerum
Classification according to the level Classification according to the
of infection: complexity:
• Aseptic, • Simplex,
• Fresh infected, • Comple
• Suppurative.
According to the character of wound According to the zone of damage:
canal:
• Anatomic area of the body
• Blind,
• Thorough damage,
• Tangential
Combinative wounds
Classification in dependence of the
relation to the cavities of the body:
• Penetrated,
• Not penetratedFACTORS AFFECTING
THE WOUND HEALING
• Age of the patient;
• The condition of nutrition and body mass;
• The presence of secondary infection of the wound;
• The immune status of the organism;
• The condition of blood circulation in zone of damage and organism
in general;
• Chronic co-morbidities (diseases of the cardiovascular and
• respiratory systems, diabetes mellitus, malignant tumors, etc.);
• Some kind of therapy (using of anti-inflammatory drugs,
• radiation therapy, etc.)
4 COMPONENTS OF WOUND HEALING:
• Formation of new blood vessels (angiogenesis)
• Migration and proliferation of fibroblasts
• Production of extracellular matrix
• Maturation and organization of connective tissueTYPES OF REPARATION OF WOUNDS Reparation by primary tension (sanatio per primam intentionem) Is the most profitable heal of the wound. In such case thin and strong stitch is created in short time. Primary tension heals aseptic operating wounds and without suturing — superficial wounds of small size with insignificant divergence of edges. is No wound cavity exists between the wound edges and walls in case of such kind of healing. Adjacent to each other wound edges are glued together by fibrin, resulting from the exudate, effused in the narrow gap between them. At the same time the epithelium is grown from the wound edges – forming the barrier for germ penetration. Healing by primary tension does not cause complications and functional changes are minor Reparation by secondary tension(sanatio per secundam intentionem) It occurs during the large gaping of the wound, suppuration and formation of excessive granulation tissue. Inflammation phase is expressed, and on the 2-3 days of the second period of inflammation areas of granulation appear on necrotic areas. Reparation under the crust This reparation takes place during the insignificant superficial damages (abrasions, scratches, wear, etc). On the surface of the wound blood, lymph, interstitial fluid clotting occurs. That result in a formation of the dense crust (eschar), which plays the role of protective bandage. The epidermis quickly regenerates under this crust and the scab is torn away
THE CLASSICAL EXAMPLE OF WOUND HEALING IS THE HEALING OF PURE, NOT INFECTED
SURGICAL WOUNDS CONNECTED BY SURGICAL STICHES. THE INCISION CAUSES DEATH OF SOME
QUANTITY OF EPITHELIAL AND CONNECTIVE CELLS AND DAMAGE OF AN INTEGRITY OF
EPITHELIAL BASAL MEMBRANES.
After 24 hours
neutrophils appear on the edges of incision that move to the incision. Epidermis reaches normal thickness, and superficial
fibrin clot. The epidermis at the edges of incision thickens as cell differentiation approaches the level of architecture of
a result of mitotic activity of the basal layer of keratinocytes mature epidermis with superficial keratinization.
and fibroblasts, and after 24-48 hours chain of epithelial cells
both migrating and growing along the edges of the incision Within 2-nd week
create components of basal membranes. They merge in the
of continuing accumulation of collagen and fibroblast
middle of the top of the crust forming a continuous, but the
proliferation. Leukocyte infiltration and swelling usually
thin epithelium layer.
disappear. At this time, the process of continuous blanching
of scar tissue begins, that is caused by accumulation of
After 3 days collagen in the scar and decreased vascularization.
neutrophils are usually replaced by macrophages. Granulate
tissue gradually fills the incision space. Collagen fibers exist At the end of the 1st month
on the edges of incision but in the beginning they are
the scar tissue contains cellular connective tissue, free of
oriented vertically and do not form bridges through the
inflammatory infiltrate and covered by intact epidermis. Skin
incision. Proliferation of epithelial cells is continuing and
appendices, destroyed along the incision, are completely
covering layer of epidermis is thickening.
lost. The strength of the wound tension (contraction)
increases, but still may take several months to complete
After 5 days healing
the space of incision is filled by granulate tissue. Vascular
neoplasia reaches the highest intensity. Collagen fibrils
become more numerous, begin to form bridges through theSCARS AND THEIR COMPLICATIONS
• Normotrophic
• Atrophic
• Hypertrophic
• Keloid
COMPLICATION OF SCARS:
• Scar contracture
• Scar ulceration
• Scar papillomatosis
• Malignant transformation of scar tissue
(malignancy)COLLAGEN THE MOST COMMON PROTEIN IN THE WORLD, FORMING AN ANCHOR OF EXTRA-CELLULAR NETWORK FOR ALL MULTICELLULAR ORGANISMS. Currently, 19 different types of collagen are found. Interstitial fibrous collagens of I and III types provide the tension of healing wounds Collagen – is the main structural protein of the extracellular matrix. It consists of 25 to 33% of the total protein in the body, i.e. 6% of body weight. The name 'collagen' unites the family of fibrous proteins, which are the main protein compound of the skin, bones, tendons, cartilage, blood vessels, teeth.
COLLAGEN
Synthesis and maturation of the collagen — a complex multi-step process that begins in the
cell, and ends in the intercellular matrix. Collagen synthesis of maturation includes a variety
of posttranslational modifications
• Hydroxylation of proline and lysine
residues to form hydroxyproline (Hyp)
and hydroxylysine (Hyl);
• Glycosylation of hydroxylysine
• Partial proteolysis — cleavage of
'signal' peptide and the N- and C-
terminal propeptides -O;
• The formation of the triple helix.COLLAGEN
Proline hydroxylation is necessary for the
stabilization of collagen triple helix. The OH
groups of hydroxyproline (Hyp) are involved in
the formation of hydrogen bonds.
A hydroxylation of lysine is very important for
the subsequent formation of covalent bonds
between the collagen molecules in the
assembly of collagen fibrils
Collagen synthesis is stimulated by growth factors and Cytokines, which secreted by
leucocytes and fibroblasts in healing wound. The formation of the collagen network,
however, depends not only on the synthesis, but also from the destruction of collagen
and other extracellular matrix componentsTHERE ARE STRICT REQUIREMENTS FOR
THE MODERN PRODUCTS FOR “WOUND”
HEALING
An assessment of their quality is done by
the following criteria:
• Removal of excess exudate;
• Provision of gas exchange (air exchange);
• Isolation of a wound from an environment;
• Mechanical and microbiological defense
of the wound;
• Not traumatic painless replacement
of a bandage.GEL FOR EXTERNAL
APPLICATION 7%
PROPYLENE GLYCOL
WATER
Collagen, purified neutral, not reconstructed with the conserved
biological properties of fibrillary structure. Excipients: propylene
glycol, purified waterINDICATION FOR USAGE
MEDICINE COSMETOLOGY
• Wounds (fresh wounds, wounds with wet • Mesotherapy
exudate – postoperative, traumatic – • Dermabrasion
accidental)
• Peeling
• Burns
• Hair Removal (different types)
• Decubitus • Wrinkle correction
• Ulcers
• Tattoo
• Damages of a vaginal mucous membrane;
• Anal fissures
• Damage to mucous membranes of the
nose and oropharynx
• Seborrhea
• Is applied to damaged areas (fresh wounds,
• Acne
wounds with a wet discharge, on wet ulcers),
• Stomatitis
• Gingivitis on the clean wound with thick layer
• Periodontitis 2–3 times/ day.
• Applications of the gel should be continued
until the complete epithelialization and / or
formation of elastic scar tissue.EFFECT
• Collagen not reconstructed with • A Activation of synthesis and
preserved biological properties of fibroid degradation of collagen;
structures.
• Activation of the synthesis of the
• Ensuring the moisture-holding properties extracellular matrix - providing rapid
with features of wet compress epithelialization;
• Formation of air-penetrable
biocompatible protection of wounds
• Biological and mechanical protection of
damaged and new cells and tissues.
• Prevention of formation of hyper
granulation, hypertrophic scars and
keloidsREPARCOL™ GEL-SPRAY
The complex treatment of wounds with bioactive wound dressings Reparcol™ gel-spray
For hundreds of years to cover wounds used gauze and cotton, since by associated with the hydration of the stratum corneum of the skin due to the
nature it is soft, sustainable and absorbent material. Gauze bandage serves as formation in the affected area humid environment and prevent evaporation
a barrier damaged tissue with the external environment. However, gauze that leads to the restoration of the water balance in the epidermis. It provides
bandage leads to drying of the wound and adhesion to the damaged surface, optimal conditions for oxygen permeability and prevents possible tissue
which slows down wound healing. In addition, when you remove the gauze hypoxia. These changes normalize the functional activity of fibroblasts and
bandages can be injured of the surface of the newly formed layer of skin. In prevent further uncontrolled growth of connective tissue, which can lead to
recent years, created a number of active drugs for the local treatment of the formation of rough scars.
wounds of various origins, nature and localization.
Bioactive wound dressings Reparcol ™gel-spray is a native absorbable,
The development of biological and synthetic coatings began with the unreconstructed collagen derived from the dermis of cattle by special
recognition of the fact that wounds need protective barrier that would technology and is designed to cover:
prevent infection and dehydration would contribute to the filling of the
dermis cellular elements for improving healing. The goal of wound dressings is • postoperative surgical wounds at the end of surgical intervention;
to create an optimal environment for healing by reducing pain, protection
from infection, saving the damaged area wet, while improving its blood supply • shallow chronic wounds in the treatment of bedsores, diabetic and venous
and nutrition. ulcers, as well as hard-to-heal chronic wounds;
Currently increasingly used interactive dressings. These are headbands that • burns 1-St and 2-nd degree;
are able to not only create, but also to provide an optimum wound healing
environment by controlling its moisture content, gas composition and pH, as • radiation dermatitis;
well as to be atraumatic, due to its physical-chemical properties. Such
dressings with good reason can be attributed to collagen/sea buckthorn • fresh, shallow wounds, irritate and abrasions of the skin;
propylene glycol bio- active wound bandage Reparcol . Experience in the use
of collagen materia ls in various procedures to restore the fabric has led to the • irritation of the skin after mechanical, chemical or laser dermabrasion;
development and implementation of absorbable of the implant based on
collagen to regenerate skin tissue. It is logical to assume that the treatment of • donor skin;
the wound site with a product that is related to the body tissue, must occur
for successful wound healing. The beneficial effects of propylene glycol • cover the wounds with the purpose of absorption of wound exudate.The mechanism of action
Collagen is the main protein involved in wound healing, creates the Methods of rejuvenation, such as chemical skinpeels, mechanical
physiological conditions for wound healing, provides damaged on the key dermabrasion or laser treatment can significantly improve the look wrinkled
biological resources that are required for healing damaged tissue. Producing skin. The essence of these interventions is to create a controlled loss of
new collagen to fill a wound in the area of damage with the growth of new several outer damaged layers of cells. Thus exposing new, fresh layer of skin
healthy skin. Under the influence of Reparcol ™gel-spray in the woun- with a healthier color and a more smooth structure. A brief flash of intense
dactivated proliferation of all cellular elements of the tissue and occurs its fast light energy of laser evaporated the surface layer of skin. After the
regeneration. In addition to stimulating and hemostatic effects, Reparcol- intervention, the treated areas are initially red, then turn pink within a few
P™spray, being biocompatible, absorbable tissue matrix contributes to the months. The skin looks like after a severe sunburn or a burn. During the
directed tissue regeneration. Fibroblasts, blood and lymph vessels, nerve healing process may experience pain, an intense burning sensation. Coating
fibers, from the surrounding healthy tissue, penetrating into collagen matrix, abrasion wounds bio-active wound bandage Reparcol ™spray for several days
spread strictly through the matrix. Not happening the disorderly growth of after cosmetic dermabrasion is the optimal solution to the damaged skin
granulation tissue as a response of the organism to rapid closure of the because covering exposed nerve endings, pain is reduced, the coating
exposed tissue, thus eliminating the formation of rough scars. accelerates healing, reduces the risk of infection and complications, and
reduces the possibility of scarring and functional impairment. To protect fresh,
Reparcol-™gel-spray cosmetically improves the appearance of the new skin shows the use of a collagen coating Reparcol- P™spray immediately
postoperative scar, as filling the damaged tissue between the joints, promotes after the intervention.
the primary tension, "calm" of the body from the rapid closure of the wound,
avoiding the formation of hypertrophic scars. Strengthens joints and The purpose of using Reparcol ™gel-spray to cover burns 1st and 2nd degree,
maintains the wound after suture removal. Reduces the need for local fresh, not deep wounds to the skin, radiation dermatitis, irritate and abrasions
application of anesthetics and anxiety of patients, associated with injections skin is the creation of an optimal environment for healing. Creating an
of anesthetics. environment under cover, Reparcol ™gel-spray activates the process of wound
healing, helps stop bleeding and reduce pain, keeps the wound moist while
Bioactive wound dressings Reparcol ™spray is a new kind of wound dressing improving blood circulation and nutrition of the affected area. Directly
for the treatment of bedsores, diabetic and venous ulcers and difficult-to-heal contacting with the wound surface, Reparcol ™gel-sprayaccelerates the
wounds. Allows you to create the physiological conditions for wound healing natural ability of wound healing by supplying the body with collagen to form
by creating the optimal conditions for activation, migration and division of new tissue. When using Reparcol ™gel-spray el imitates the need to use
cells involved in tissue regeneration. As a result of increased phagocytic bandages on the wound, thereby eliminating the possibility of removing the
capacity of granulocytes and macrophages, proliferation of fibroblasts and newly formed epithelial layer when removing dressings. Reparcol ™gel-spray
stimulation of angiogenesis makes possible the formation of new tissue, also serves as the affected area, most wounds heal quickly and without side
accelerating wound healing. Reparcol ™spray fills the empty space reaches the effects. a physical barrier against infection of the affected area. Creating such
bed of the wound and activates the proliferation of all cellular elements of conditions in the affected area most wounds heal quickly and without side
granulation tissue, promoting faster healing of chronic wounds due to the effects.
strengthening of collagenogenesis.The purpose and properties of bioactive wound dressings Reparcol ™gel-spray
Bioactive wound dressings Reparcol ™gel-spray was designed to activate the Reparcol™ gel-s pray also forms abarrier, which protects the wound from
body's own natural healing process. The collagen material interacts with the bacterial invasion, maintaining a moist wound surface. This barrier maintains
wound at every stage of the reparative process, to reduce pain and activate optimum temperature and humidity, prevents infection of the wound from
healing. When a skin injury you should first focus on stopping the bleeding the external environment. With the elimination of infection and protection of
from the wound. By direct contact Reparcol ™gel-spray bleeding there is a the wound, the injured area begins to recover. Bioactive wound dressings
rapid aggregation of platelets on the collagen and release coagulation factors Reparcol ™gel-spray is not only a matrix for the growth of new cells and
that lead to the formation of fibrin and, ultimately, the formation of a blood protein that feeds directly to the wound area. Bioactive wound dressings
clot. Inflammation is the second stage of the healing process. Wound Reparcol™gel-spray actively affects the final phase of wound healing is
treatment at this stage requires control over the drainage of fluids and maturation. Due to the gradual conversion of collagen, increases the strength
improve blood supply to damaged area. Reparcol ™gel-spray removes of the scar because there is a maturation and consolidation of newly formed
inflammatory fluid and provides the proper environment to begin the healing tissue. Saturation of the wound cells gradually decreases, as a result, the
process. During this stage, it is important to eliminate factors that may wound covered by newly formed tissue in place has resolved the collagen
impede the healing process, the type of infection. Reparcol ™gel-spray material.
removes bacteria and decay products, as it absorbs wound fluid.
The potential efficacy of bioactive wound dressings Reparcol™ gel-spray boils down
to the following factors:
• the ability to create a suitable substance for rapid and sustained contact • biological integration;
with the wound surface;
• transparency, allowing to judge about the healing process without
• internal surface structure that allows cell migration, proliferation, growth removal of the coating;
of new tissue and the formation of extracellular matrix; the absence of
toxicity and antigenicity; • no need to use bytovyh dressings.Clinical benefits of bioactive wound dressings Reparcol™ gel-spray : • visual control of wound healing; • prevent drying of the wound surface; • biological activation of the healing process; • prevent the formation of scars; • noticeable reduction of pain caused by covering exposed nerve endings; • promotion of epithelialization; • reduce moisture loss; • stimulation autocatalytical cleansing wounds; • reduce wound inflammation; • the lack of effect of tightening of the skin; • prevent surface infections; • reduction of terms of treatment. BIOACTIVE WOUND DRESSINGS REPARCOL ™GEL-SPRAY A SIGNIFICANT AND NECESSARY PART OF ANY KIT OF THE AMBULANCE.
REPARCOL™ SUPPOSITORIES
Vaginal collagen Reparcol™ suppositories
The contemporary pharmaceutical industry produces a variety of medicines in of life. The clinical picture of urogenital disorders in menopause distinguish
the form of suppository. Suppositories, pharmaceutical form, considered to be the symptoms associated with vaginal atrophy and disorders urination
one of the most effective medicines. Their main feature is the preservation in (cystourethrogram atrophy). Unlike vasomotor symptoms, which usually
solid form at room temperature and rapid melting at body temperature. disappear with time, vaginal atrophy symptoms, usually occur in
premenopausal women and progressing in the postmenopausal period,
In gynecological practice suppositories are used in complex therapy of resulting in functional and anatomic changes. Atrophy of the mucosa of the
inflammatory and urogenital atrophic disorders of the vagina and cervix; vulva and vagina is characterized by thinning of the epithelium, reducing
prevent the development of infectious-inflammatory complications in vaginal folding, blanching, presence of petechial hemorrhages, signs of
obstetric and gynecological manipulations: before childbirth and abortion inflammation. 15% of women in premenopausal women and 40-57% of
before surgical treatment of gynecological diseases, before and after the women in postmenopause, the symptoms of vaginal atrophy, such as vaginal
installation of the IUD before and after cauterization of erosion (laser, radio dryness 27-55%, burning and itching 18%, dyspareunia 33-41%, and increased
waves, etc) the cervix prior to intrauterine research. The purpose of vaginal susceptibility to infectious diseases of small pelvis organs 6-8%, which
candles helps to eliminate a lot of symptoms. Due to the local impact they significantly impairs the health, negatively affecting General and sexual quality
eliminate the clinical manifestations of various diseases in the form of itching, of life. 41% of women aged 50-79 years there is at least one of the symptoms
discomfort, redness, bleeding and swelling. The main advantage of vaginal of vaginal atrophy. A significant decrease in the content of the main hormones
plugs is the speed of impact, due to instant absorption of the drug in the in the plasma leads naturally to a decrease in the rate of cell division. The
mucosa. The drug bypasses the digestive tract without causing harm to the result is a different degree of dystrophic processes in the urogenital tract.
liver and causing allergic reactions. Reducing the thickness of the water-lipid film, and germ layer leads to
increased evaporation of water, reducing the amount of acid
Erosion is any ulcerative lesions of the mucous membrane of the stomach, mucopolysaccharides in normal holding near a water molecule, which leads to
intestines, vagina, cervix. In gynecological practice cervical erosion starts after dehydration of the tissue. In elastic and collagen fibers occur degenerative
the transferred inflammatory processes, various hormonal disruptions. Like all changes. The vascular networks sklerosiruta partially partially expands with
epithelial tissues react to changes in the natural hormonal environment in a the release of plasma elements into the surrounding tissue, leading to edema,
similar way, but none of them can compare to the epithelium of the vaginal hypoxia, disruption of the flow of lymph.
vault and cervix at the speed and clarity of response to hormones, primarily
on the sex steroids. Thus, the urogenital tract is particularly sensitive to lower
levels of estrogen and about half of all postmenopausal women experience
symptoms related to urogenital atrophy, affecting sexual function and qualityEstrogens are the main regulators of physiological processes in the vagina.
As in the stromal cells of the vagina contains receptors to estrogens, collagen,
part of connective tissue of the vaginal walls, is an estrogen-sensitive
structure whose content decreases with the progression of estrogen
deficiency. The decrease in the content of collagen in the vaginal tissue leads Indications
to morphological changes in the tissues and a lot of negative functional and
physiological changes, such as: Vaginal collagen candle Reparcol™suppositories is
indicated in all cases when you need a quick tissue
• the smoothing of the vaginal folds; regeneration.
• vaginal dryness and lack of hydration;
• reduction in vaginal secretion;
Contraindications.
There are practically no contraindications, except for the
presence of sensitivity to collagen. As a result, may
The mechanism of action of collagen candles experience burning and itching in the injection area of the
candle. If you notice such symptoms, its use should be
Reparcol™suppositories. discontinued.
After the introduction of suppositories into the vagina, there is a thinning of
the bases of the candles with the release of the collagen matrix, which is
having pronounced adhesive properties is firmly fixed to the damaged areas
of the vagina. When the implant contacts the wound, connective tissue cells,
blood and lymph vessels, nerve fibers from the surrounding healthy tissue,
Dosing regime
penetrating into collagen lattice, are distributed strictly in it. Creates a
transition matrix that stimulates the body's immune system and activation of Vaginal collagen candle Reparcol™suppositories inserted
granulocytes, macrophages, and enhances migration of growth factors vaginally. For the treatment of diseases used 1 candle
released from the cells, enhances the migration and proliferation of epithelial 1 times a day, at bedtime, for 7-10 days. For the
cells. Responsible for the generation of new collagen fibers, filling the cavity in prevention of diseases, 1 suppository a day (after
the damaged region, and the exogenous collagen is gradually dissolving, unprotected intercourse – no later than 2 hours, or
replaced by autotint. overnight).
Vaginal collagen candle Reparcol™suppositories, modern and effective means
of treatment and prevention of various diseases of female sexual sphere, has
a strong regenerating, metabolic effect, helps to restore natural vaginal flora.You can also read
