Rheumatology - Author: Jack March - Rheumatology.Physio - Clinical Scenarios For MSK Therapists

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Rheumatology - Author: Jack March - Rheumatology.Physio - Clinical Scenarios For MSK Therapists
Rheumatology
               Clinical Scenarios
              For MSK Therapists

                           Including:
                           Spondyloarthritis
                           Rheumatoid Arthritis
                           Osteoporosis
                           Systemic Lupus Erythematosus
                           And MORE…

Author: Jack March – Rheumatology.Physio
                                                          1
Rheumatology - Author: Jack March - Rheumatology.Physio - Clinical Scenarios For MSK Therapists
Rheumatology - Author: Jack March - Rheumatology.Physio - Clinical Scenarios For MSK Therapists
Throughout       my
                         Preface
                         career as    a        These case studies are based on real
Physiotherapist I have seen a lot of           patients that I have adapted to fit the
patients. A significant number of these        style of the book and to make useful
have been either in a Rheumatology             learning tools.
department or as what we would now call
a First Contact Practitioner.                  You will likely notice that there are a lot
                                               of grey areas. You may even suspect other
I have always been one to write case           diagnoses to be a likely cause of the
studies and as a result I have a large         symptoms presenting, and this good.
number stored. I wrote up cases that I         Embrace those thought patterns. I am
found interesting, unusual or sometimes        most certainly not always right.
even “typical” in varying degrees of detail.
                                               I hope you find this book useful in
In recent years I have been fortunate          practice, and makes you think about
enough to have gained a little reputation      certain patients who at first glance might
as someone to ask regarding topics and         not be obvious to you.
cases in Rheumatology, and I see various
themes repeat themselves.                      Enjoy! Jack.

As a result, I decided to adapt some of my
case studies into this book. I hope that it
helps to add some context to the
information I write in my blogs and teach
on my courses.
Rheumatology - Author: Jack March - Rheumatology.Physio - Clinical Scenarios For MSK Therapists
About the
Author

Jack March
Rheumatology.Physio

Jack is a Physiotherapist, qualified in 2008 from
Plymouth University and after rotational posts settled
into Rheumatology which I have made my specialty
since 2011. I have given seminars, lectures at
conferences and full day courses on Rheumatology
subjects mostly covering the topics of Recognition,
Investigation and Management. These have been
aimed at Allied Health Professionals (Physios, OTs,
Nurses…) but have also been attended by Medical
Colleagues from GP practices who have also provided
positive feedback.

My current roles alongside the provision of CPD
include:

Rheumatology Clinical Lead for Chews Health.

Operations Director of The Physio Matters Podcast and
Chews Media.

      @Physiojack                 @rheumatology.physio

                                                         2
Contents
     Introduction                    Page 6

01   Spondyloarthritis               Page 8

02   Rheumatoid Arthritis            Page 17

03   Osteoporosis                    Page 24

04   Gout                            Page 29

05   Systemic Lupus                  Page 34
     Erythematosus

06   Sjogren’s                       Page 38
     Syndrome

07   Polymyalgia Rheumatica          Page 41

08   Reactive Arthritis              Page 44

09   Self Assessment                 Page 51

10   Referral Letters                Page 54
Introduction
Hello! Thank You for deciding to spend        This also applies to Therapists who are
some time with this book. It is designed to   seeing patients following Medical
help you think about the complexity and       screening. Don’t assume it has been
clinical reasoning process surrounding        thorough. Do your own comprehensive
Rheumatological conditions.                   assessments and make your own clinical
                                              judgments. The aim of this book is to help
This book is aimed at clinicians who are      you with just that.
seeing patients prior to any medical
screening e.g. First Contact Practitioners    For many reasons, one being brevity, I
(FCPs) or those in Private Practice. We       have “stayed in my lane” with this book.
must make sure we are detailed in our         As you work through the case studies you
assessments, consider all possible causes     will notice the absence of red flag
for the attending person’s symptoms, and      screening, neurological symptoms and
make sure that we know what to do with        other areas of questioning. This keeps the
that information.                             length of     the cases palatable, and
                                              stopped the book from taking me years to
This book hopes to fill a gap in the          write.
reasoning process for clinicians -
Rheumatology, a complex, difficult and        I am trusting you to know other screening
sometimes intimidating set of conditions.     requirements of back pain, multiple joint
Unfortunately, delay to diagnosis in this     pain and systemically unwell people. I
cohort can have dire consequences, and        hope you will repay me with some leeway
as such we cannot afford to be                when it comes to omitting information
complacent.                                   about radicular pain, bladder and bowel
                                              function and so forth.
Poor outcomes across the board occur in
Rheumatology when diagnoses are missed        The assessment sections of this book
and patients have to wait to see a            really are what you make them. You could
specialist.                                   jump ahead to learn what I think the
                                              answer is, but I personally think that you
As Therapists we can no longer hide           will be missing a trick. I truly believe
behind prior medical screening or claims      immersing yourself in these simulated
of ignorance as we move closer and closer     scenarios will help you in the real world.
to the start of patient’s journeys. We must
take responsibility and ensure that we are
the best clinicians we can be for the
patients attending our clinics.
                                                                                           4
Introduction
Before there is the chance for me to make      I will stop now and let you get on to the
this introduction longer than the book         reason you started looking at this book.
itself, I have one final thought.
                                               I hope I will get to meet you some time
You will see that I have hinted at what we     via social media or at an in-person event
should do in certain scenarios. As we are      of some kind.
suspecting “medical” issues in these
patients we are inevitably referring them      Now pop your thinking hat on and away
out of Therapy. Consider what other value      you go!
you can add during their appointment.

Let’s not rest on our smugness of
successfully identifying a relatively rare
condition and bounce them straight on to
the appropriate location. Let’s instead
think, “how can I improve their
outcome?”. Really simple interventions
and advice can make a big difference. I
know time and resources are limited, but
spending just a little of it on reassurance,
education and guidance could make the
world of difference in the long term.

This book does not have all the answers. I
make some assumptive leaps of prior
knowledge. Feel free to use a search
engine or get in contact with me for
clarification. Use my other CPD materials
(most of which are free because I am
terrible at business) to help you along the
way as well.

To help me, please do get in touch with
feedback and if you think it’s great, tell
your colleagues about it!

                                                                                           5
1

Spondyloarthritis
Spondyloarthritis (SpA) is an umbrella term covering auto-
immune conditions affecting the Axial skeleton (the spine and
sacroiliac joints) and/or the peripheral entheses (achilles,
plantar fascia, lateral epicondyle insertions). Conditions falling
under this umbrella include Axial Spondyloarthritis and
Psoriatic Arthritis. There are familial connections with the
conditions and there is a strong association with 85-95% HLA-
B27 positivity.

                                                                     6
Spondyloarthritis
                                         Scenario 1
Referral                                           Aggravating/Easing
John is a 25 year old male complaining of          Sitting for extended periods at his desk,
thoracic back pain lasting for 3 months.           driving or watching TV aggravates his back
No previous past medical history or                pain. Nothing aggravates the buttock
attendance to MSK Therapists. No                   pains which are present when he wakes in
regularly prescribed medications.                  the morning and resolve over the period
                                                   of an hour. Ibuprofen eases his symptoms
Further Subjective Information
                                                   and he takes this regularly through the
Insidious onset thoracic back pain 3               day. Going to the gym does not aggravate
months ago with bilateral buttock pain             symptoms and he is possibly worse on
most days. No previous back pain, no               days he doesn’t go.
previous injuries or musculoskeletal
                                                   Past Medical History
complaints. No change in habits,
occupation or circumstances prior to               He has no known health issues. He has
onset. Has not been unwell or required             not attended his GP in the last 5 years. He
antibiotics.                                       does not take any prescribed medications.
                                                   He denies any sexually transmitted
24 hour pattern
                                                   infections and use of steroids. He feels
Feels extremely stiff when he wakes in             well in himself but slightly fatigued due to
the morning with significant back pain.            interrupted sleep. He denies feeling
This lasts for approximately 1 hour. The           anxious or depressed.
pain and stiffness will return after sitting
                                                   He has no personal or family history of
at his work desk for longer than 1 hour
                                                   psoriasis, iritis/uveitis, crohns/colitis or
and requires walking around to resolve.
                                                   inflammatory arthropathies
He has no issues during the day if he is
not at work because he can keep moving.            Social Factors
He is able to fall asleep but wakes around         He works at a desk writing software. He
2am every morning with pain and                    enjoys going to the gym and has a well
stiffness. After getting out of bed and            rounded program. He doesn’t smoke,
doing some stretches he is able to go back         drinks occasional alcohol and has a BMI of
to sleep.                                          24. He believes his pain is likely down to
                                                   his posture at work.

                                  Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                                   John could have AxSpA                                          7
Spondyloarthritis
                                          Scenario 1
John is presenting as a classical new                Reassure John that the prognosis for
onset Axial Spondyloarthritis                        these conditions is good when diagnosed
                                                     and managed early. He already lives a
-      Insidious onset back pain and buttock
                                                     healthy lifestyle and he should continue
       pain for 3 months
                                                     this as much as possible to improve his
-      Pain and stiffness in the morning for
                                                     chances of a good outcome. Consider
       >60 mins
                                                     specific therapy management if there are
-      Worse with rest, better with activity
                                                     reported functional deficits.
-      Waking in the second half of the
       night, getting out of bed to ease             Investigations
       symptoms
                                                     If appropriate and available refer for:
-      Eased by NSAIDs
                                                     -    Spondyloarthritis protocol MRI of
Next Steps
                                                          whole spine and Sacroiliac Joints
Explain to John that the clinical picture is         -    Blood tests: HLA-B27, ESR, CRP
one suspicious of an inflammatory cause
                                                     Onwards Referral
of his symptoms, which needs referring to
a      Rheumatologist      for       further         Refer to Rheumatology via the
investigations.   The    aim      of     this        appropriate local pathway for further
appointment is to confirm or rule out a              investigation of symptoms suspicious of
specific diagnosis and start appropriate             Axial Spondyloarthritis.
treatment if necessary.

                                          Learning Points.

    Symptom pattern alongside aggravating            Reassurance and general health advice at
    and easing factors are key to recognition             this early stage are important
                 in John’s case                       accompaniments to the prompt referral

                                 AxSpA should be considered in the
                             differential diagnosis for younger persons
                              (3 months

                                                                                                8
Spondyloarthritis
                                        Scenario 2

Referral                                        24 hour pattern
Jane is a 35 year old female complaining        Severe pain in the mornings when she
of insidious onset bilateral heel pain for      gets out of bed which takes 2 hours to
the last 6 weeks. She takes no regular          improve. This will return to a lesser
medication. She has a past medical              degree during the day after sitting or after
history of Psoriasis which is managed by        walking for longer periods. Her sleep is
moisturisers.      She     attended      a      unaffected.
Physiotherapist last year for repetitive
                                                Aggravating/Easing
strain in her hand.
                                                Her heel pain is worse after sitting /
Further Subjective Information
                                                driving for any period of time. This will
Insidious onset bilateral heel pain 6 weeks     resolve over a period of time relative to
ago. She awoke one morning and was              how long she was sat, from a few minutes
unable to weight bear through her heels.        to a few hours.
This improved after a few minutes and
                                                Past Medical History
she ignored it. This has gradually
worsened over the last 6 weeks and now          She has no known health issues other
she struggles to walk for the first 2 hours     than the Psoriasis. She attended her GP
in the morning. No change in habits,            for the hand symptoms last year and prior
occupation or circumstances prior to            to this the tennis elbow. She does not
onset. Has not been unwell or required          take any prescribed medications. She
antibiotics.                                    denies any sexually transmitted infections
                                                and use of steroids. She feels well in
She has had psoriasis for 10 years and
                                                herself and denies feeling anxious or
manages this with moisturiser. Last year
                                                depressed but feels fatigued constantly.
she developed pain and swelling in the
IPJs of her index and middle finger in the      She has no personal or family history of
right hand, this was diagnosed as a             iritis/uveitis or crohns/colitis. Her father
repetitive strain issue. Improved with          has Psoriatic Arthritis. She has no nail bed
physiotherapy and ergonomics over a few         changes.
months and then resolved after 6 months.
She had Lateral Epicondylopathy 5 years
ago which lasted 2 years and was quite
debilitating.

                                                                                               9
Spondyloarthritis
                                          Scenario 2
Social Factors
                                                 She has been concerned about Psoriatic
She works at a desk as an estate agent           Arthritis since she developed the hand
and often drives to view houses. She             symptoms but was reassured as they
enjoys walking her dog 3-4 miles a day,          went away.
this is not normally an issue. She smokes
10/day and has a BMI of 32.

                                  Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                                    Jane could have SpA

Jane is presenting with a possible               Discuss with Jane her general health as
Peripheral     Spondyloarthritis; likely         her high BMI and smoking status will
Psoriatic Arthritis.                             contribute to a raised level of systemic
                                                 inflammation. This may increase the
-    Insidious onset bilateral tendinopathy
                                                 likelihood of developing Psoriatic Arthritis
     (plantarfasciitis)
                                                 or the separate clinical conditions. If
-    Symptoms in the morning for >60
                                                 diagnosed with Psoriatic Arthritis, these
     mins
                                                 factors will also make a poorer outcome
-    Previous Lateral Epicondylopathy and
                                                 more likely. Consider starting specific
     previous IPJ swelling and pain
                                                 therapy management for the bilateral
-    Diagnosed Psoriasis
                                                 heel pain to plan for the possibility
-    Father has Psoriatic Arthritis
                                                 Psoriatic Arthritis is ruled out.
-    High BMI and Smoker
                                                 A trial of anti-inflammatories may be
Next Steps
                                                 worthwhile to assess impact on
Explain to Jane that the clinical picture is     symptoms.
one suspicious of an inflammatory cause
                                                 Investigations
of her symptoms which needs referring to
a      Rheumatologist       for      further     If appropriate and available refer for:
investigations.   The    aim      of     this
                                                 -    Ultrasound imaging to look for
appointment is to confirm or rule out a
                                                      Insertional Enthesitis
specific diagnosis and start appropriate
                                                 -    Blood tests: HLA-B27, ESR, CRP,
treatment if necessary.
                                                      Rheumatoid Factor

                                                                                                10
Spondyloarthritis
                                       Scenario 2
Onwards Referral
Refer to Rheumatology via the
appropriate local pathway for further
investigation of symptoms suspicious of
Peripheral Spondyloarthritis (pSpA).

                                       Learning Points.

   pSpA should be considered in the              Family History of inflammatory conditions
presence of Psoriasis and Tendinopathy              adds a strong clinical suspicion and
   even if one or both are historical                  reduces threshold for referral

General health advice at this early stage        In this scenario it is possible that Jane has
 is important accompaniments to the               multiple distinct clinical conditions, it is
prompt referral for short and long term          not possible to rule out pSpA and as such
    outcomes regardless of the final                    warrants referral for specialist
               diagnosis                                        investigation

                                                                                                 11
Spondyloarthritis
                                        Scenario 3
Referral                                        He has never had any radicular pain or
Adam is a 45 year old male complaining of       neurological-sounding symptoms.
low back pain lasting for 3 years. He has       His back pain is activity dependent - the
Ulcerative Colitis and takes Azathioprine       busier he is at work the worse it gets. If he
to manage this.                                 is resting or on holiday it is much better.
Further Subjective Information                  He started parkrun to improve his fitness
                                                last year. His back will ache during and
3 years ago Adam was lifting crates at          after but no worse than any other day.
work. The next day he had a stiff back
which worsened over a few days and              He sometimes struggles to get to sleep at
became quite painful. He was off work for       night because he feels his back is
a month at the time. It improved enough         uncomfortable. He doesn’t wake during
that he was able to return. He has had          the night. He thinks his back is stiff for a
varying degrees of low back pain since          few minutes in the morning but certainly
and seen a physiotherapist, an osteopath        not for a protracted period of time.
and a chiropractor which have settled the       Aggravating/Easing
symptoms in the short term. Although
annoying, his back pain doesn’t bother          Lifting at work aggravates his back pain. If
him on a day to day basis.                      he has a large number of heavy things to
                                                lift his back pain will deteriorate during
Recently however he has had a flare up of       the day. He takes occasional paracetamol
symptoms, and has been off work again           to help. Usually if he aggravates his back
for the last 2 weeks. He is unsure if there     at work, he is ok the next day to work
is a trigger for these flare ups.               again. The only change to this is a flare up
He recalls a number of previous aches and       of more severe pain which happens like
pains including achilles tendinopathy 2         clockwork every 6 months.
years ago, bilateral epicondylopathy last
year, and some lateral hip pain 5 years
ago which lasted a year before settling
with a steroid injection.
Alongside various Xrays of his pelvis and
lumbar spine he had an MRI of his lumbar
spine 6 months ago which showed a small
left sided disc bulge and a report of a
degenerative disc.
                                                                                                12
Spondyloarthritis
                                          Scenario 3
Past Medical History                              Social Factors
He has Ulcerative Colitis and has been            He works as a delivery driver and this can
under the Gastroenterology team for 20            vary in intensity, less intense days are
years. This is stable and managed well            better. He does parkrun once a week. He
with Azothiaprine. He feels well in himself       eats a healthy diet, does not smoke and
except frustrated with his back. He denies        has a BMI of 26.
feeling anxious or depressed.
He has no personal or family history of
psoriasis, iritis/uveitis or inflammatory
arthropathies

                                   Clinical Reasoning Activity
                   From the case presentation note down the indicators that
                                   Adam could have AxSpA:

Adam is presenting as a possible Axial            He has had previous therapeutic input
Spondyloarthritis (likely Enteropathic)           which, while potentially settling the acute
                                                  flare ups, has never managed the
-    Chronic back pain with insidious
                                                  persistent back pain. Although he has had
     acute flare-ups
                                                  previous imaging of his back, he has not
-    Ulcerative Colitis under
                                                  had correct sequencing to determine if
     Gastroenterology
                                                  radiological signs are present.
-    4 previous tendon complaints
                                                  A referral to Rheumatology for specialist
Next Steps
                                                  investigations to rule out Axial
Explain to Adam that his symptoms may             Spondyloarthritis as the cause of his back
be explained and linked by an                     pain and previous tendon issues is
inflammatory pathology. Although none             appropriate. Beginning some therapeutic
of his symptoms are truly inflammatory in         management alongside the referral to
nature (i.e. his back pain is not a classical     Rheumatology to settle the flare up is also
picture), the linking condition is the            reasonable as this has been effective for
Ulcerative Colitis. A high proportion of          him           in         the          past.
people with this condition go on to
develop an associated inflammatory
arthropathy.
                                                                                                13
Spondyloarthritis
                                          Scenario 3
Investigations                                    Onwards Referral
If appropriate and available refer for:           Refer to Rheumatology via the
                                                  appropriate local pathway for further
-    Spondyloarthritis protocol MRI of
                                                  investigation of symptoms suspicious of
     whole spine and Sacroiliac Joints
                                                  Axial Spondyloarthritis.
-    Blood tests: HLA-B27, ESR, CRP

                                          Learning Points.

Rheumatology referral is appropriate in              Threshold
                                                    Family  Historyfor of
                                                                       referral in these types
                                                                          inflammatory           of
                                                                                          conditions
  this case despite the back pain not                cases
                                                        addsis alow.  Thisclinical
                                                                  strong   is appropriate,
                                                                                   suspicionasand
                                                                                                the
  being inflammatory in nature. It is                 incidence
                                                           reduces  of threshold
                                                                       SpA in Ulcerative   Colitis
                                                                                   for referral
 chronic and the associated Ulcerative               patients is significant, as is the current
Colitis is sufficient to meet a threshold           delay to specialist referral and diagnosis.
                for referral.

                                Offering therapy management for
                                    functional deficits and pain
                             management is also appropriate during
                             this flare up to get Adam back to work.
                              If he was outside of a flare up then I
                             would offer him the choice to undertake
                                 another episode of therapy if he
                                    thought it would be helpful.

                                                                                                       14
2

        Rheumatoid
         Arthritis
Rheumatoid Arthritis is an inflammatory polyarthropathy
characterised by acute synovitis, most commonly in the MCPJs
and MTPJs, although any synovial joint can be affected. The
persistent synovitis leads to an excess of inflammatory
infiltrate in the joint which left untreated causes irreversible
erosions. In the long term other body systems can become
affected and there is an increased risk of clinically important
conditions such as Cardiovascular Disease and Osteoporosis.

                                                                   15
Rheumatoid Arthritis
                                        Scenario 1
Referral                                        Aggravating/Easing
Mary is a 20 year old female complaining        Any form of activity with her hands
of bilateral hand pain and swelling over        aggravates the pain. The stiffness is worse
the Metacarpal Phalangeal Joints (MTPJs)        following any period of rest and then
for the last 2 weeks. She takes no              frees up with activity, although that is also
prescribed medications.                         painful. Activity seems to aggravate the
                                                swelling, redness and warmth of the
Further Subjective Information
                                                MTPJs.
Insidious onset bilateral hand swelling and
                                                Past Medical History
pain of the MCPJs for the last 2 weeks.
She is struggling with all functional tasks     She has no known health issues and does
as she has decreased range of motion in         not take any prescribed medications. She
both hands, the joints are very stiff to        denies any sexually transmitted infections
move and it is painful to grip anything.        and use of steroids. She feels well in
There is a constant swelling and the joints     herself but feels very fatigued which she
can also be warm and red at times. She          puts down to a lack of sleep. She feels a
has also noticed she is very tired all the      little anxious about her symptoms as they
time since the symptoms began. She is           are so restrictive. She denies feeling
having to take paracetamol and ibuprofen        depressed.
to take the edge off the pain. She has
                                                She has no personal or family history of
been off work since the onset of the
                                                psoriasis, iritis/uveitis, crohns/colitis or
symptoms.
                                                inflammatory arthropathies. She has not
24 hour pattern                                 had any previous joint or soft tissue
                                                problems or injuries. She has a positive
Her hand joints are stiff all day without
                                                MCPJ squeeze test bilaterally and a
resolution. The pain is worst in the
                                                positive MTPJ squeeze test on the right
mornings and eases very slightly around
                                                foot.
lunchtime. She struggles to get to sleep at
night because of the pain and then is           Social Factors
awoken regularly as well. Bathing her
                                                She works as a designer which requires
hands in warm water and doing some
                                                some computer work and some artwork.
gentle movements can free up her hands
                                                She has been off work for the duration of
a little in the morning.
                                                the symptoms. She normally attends the
                                                gym regularly to keep fit. She doesn’t
                                                smoke, doesn’t drink alcohol and has a
                                                BMI of 22.
                                                                                                16
Rheumatoid Arthritis
                                       Scenario 1

                                Clinical Reasoning Activity
                From the case presentation note down the indicators that
                         Mary could have Rheumatoid Arthritis:

Mary is presenting as a classical new             Investigations
onset Rheumatoid Arthritis (RA)
                                                  If appropriate and available refer for:
-   Insidious acute onset bilateral MCPJs
                                                  -    Ultrasound scanning of the MCPJs
    swelling, stiffness, redness, heat and
                                                       and MTPJs looking for synovitis
    pain
                                                  -    Blood tests: Anti-CCP, ESR, CRP,
-   Pain and joint stiffness all day
                                                       Rheumatoid Factor
-   Waking in the night with pain and
    joint stiffness                               Onwards Referral
-   Stiffness reduces with activity               Refer to Rheumatology via an Early
-   Female                                        Inflammatory Arthritis Pathway if
-   MCPJ and MTPJ squeeze tests                   available locally.
    positive
Next Steps
Explain to Mary that her symptoms are
suggestive of Rheumatoid Arthritis, which
warrants a referral to Rheumatology for
specialist investigation and instigation of
appropriate medical management.
Reassure Mary that prognosis is good for
Rheumatoid Arthritis when diagnosed and
managed early, and that as many as 50%
of people are in clinical remission at 1
year following diagnosis. Her good
general health make this a more likely
outcome. Consider specific therapy
management by a hand specialist for her
reported functional deficits.

                                                                                            17
Rheumatoid Arthritis
                                       Scenario 1

                                     Learning Points.

Insidious onset bilateral symptoms in the          In Mary’s case symptoms are clearly
    peripheral joints are suspicious of        inflammatory in nature (swelling, redness,
   inflammatory arthritis in a younger                heat, protracted joint stiffness)
                  person

Onwards referral to Rheumatology by a           Reassurance and general health advice at
 quick access pathway is the priority                this early stage are important
               action                            accompaniments to the prompt referral

                                                                                            18
Rheumatoid Arthritis
                                           Scenario 2
Referral                                           These symptoms will return if he spends a
                                                   significant period of time sitting or
Andrew is a 60 year old male complaining
                                                   driving. He manages walking without too
of right knee pain and swelling lasting 3
                                                   much trouble, except after periods of
months. He has no other medical
                                                   rest.
conditions and takes no prescribed
medications.                                       He does occasionally wake at night with
                                                   his knee aching, usually in the early hours
Further Subjective Information
                                                   of the morning. This is reduced if he takes
Andrew reports his right knee swelled up           ibuprofen before bed.
after being on holiday. He had done a lot
                                                   Aggravating/Easing
of walking and his knee had been sore
towards the end of the day. When he got            Periods of keeping the knee still aggravate
back it remained sore and swelled quite            the knee stiffness and pain when he goes
significantly. It was occasionally warm to         to move again. Stairs are difficult in the
the touch but not red. He finds it stiff at        morning, but otherwise the knee is
times but this eases with movement.                tolerable. Ibuprofen helps ease the
                                                   symptoms.
He is struggling functionally with the
stairs, especially in the morning. If he has       Past Medical History
been sat in the car for a protracted period
                                                   He is generally fit and well and does not
he finds walking difficult until the stiffness
                                                   take any prescribed medications. He
eases. Andrew thinks he has arthritis now
                                                   denies any sexually transmitted infections
because he had a number of football knee
                                                   and use of steroids. He feels well in
injuries when he was younger including a
                                                   himself, not fatigued, and denies anxiety
couple of meniscal surgeries.
                                                   or depression.
He has no other joint pains, has not been
                                                   He has no personal or family history of
unwell or required to visit his GP or MSK
                                                   psoriasis, iritis/uveitis, crohns/colitis. His
therapist over the last 5 years. He is
                                                   Grandmother and his Sister have
finding ibuprofen helpful.
                                                   Rheumatoid Arthritis.
24 hour pattern
                                                   Social Factors
His knee is stiff and painful in the
                                                   He is a retired police officer and enjoys
mornings for approximately 30 minutes.
                                                   gardening, reading and movies. He
                                                   smokes 15/day, drinks alcohol most days
                                                   and has a BMI of 32.

                                                                                                    19
Rheumatoid Arthritis
                                      Scenario 2

                                Clinical Reasoning Activity
                From the case presentation note down the indicators that
                       Andrew could have Rheumatoid Arthritis:

Andrew is presenting as a possible new           Depending on Andrew’s preference,
onset Rheumatoid Arthritis (RA)                  commencing a graded exercise program
                                                 for his knee will be beneficial regardless
-   Insidious onset (no overt injury) right
                                                 of diagnosis.
    knee pain with swelling and stiffness
-   Pain and swelling in the morning             Investigations
    lasting 30 minutes
                                                 If appropriate and available refer for:
-   Waking in the night with pain and
    joint stiffness                              -    MRI most likely to be useful in this
-   Worse with rest                                   case to assess joint and synovium
-   Improvement with NSAIDs                      -    Blood tests: Anti-CCP, ESR, CRP,
-   Strong family history                             Rheumatoid Factor

Next Steps                                       Onwards Referral

Explain to Andrew that his symptoms              Refer to Rheumatology via an Early
indicate the possibility of RA, which            Inflammatory Arthritis Pathway if
warrants a referral to Rheumatology for          available locally.
specialist investigation and instigation of
appropriate medical management.
Discuss with Andrew that his symptoms
could be due to Osteoarthritis but due to
his strong family history of RA it is
necessary to rule this out as a cause.
Regardless of the end result a reduction in
his BMI, smoking and alcohol intake will
significantly improve the likelihood of a
positive outcome for him. Consider
concurrent referrals to appropriate
services to facilitate this.

                                                                                              20
Rheumatoid Arthritis
                                         Scenario 2

                                       Learning Points.

    Andrew’s symptoms are arguably                His lifestyle factors may have a significant
  consistent with Osteoarthritis but the            impact on his systemic inflammation,
 strong family history in the presence of         contributing to the inflammatory picture
     even mild inflammation justifies                        that he presents with.
          Rheumatology referral

Interventions instigated at this stage e.g.
 weight loss, smoking cessation, graded               Peak onset for RA is 40-60 so he is
exercise program, have a good chance of                       within this range
being effective regardless of the outcome

                                                                                                 21
3

       Osteoporosis
Osteoporosis is a combination of reduced bone mass and
reduced bone quality which understandably results in an
increase in the fragility of the bone structure. These changes
lead to the bone being at a higher susceptibility to fracture,
classically presenting as low trauma (areas such as the wrist or
neck of femur), or pathological and sometimes asymptomatic
in the spine.

                                                                   22
Osteoporosis
                                        Scenario 1
Referral                                          She does not have any absorption issues,
                                                  problems with her gut or bowel and
June is an 85 year old female who
                                                  reports eating a varied diet.
fractured her wrist after a fall. She is
otherwise fit and well.                           She has no family history of Osteoporosis
                                                  and does not think either of her parents
Further Subjective Information
                                                  sustained any fractures.
6 weeks ago, June slipped in her kitchen
                                                  Social Factors
landing on her outstretched right arm.
She fractured her wrist and was casted.           June is a retired teacher. She enjoys
She did not require a Open Reduction and          socialising with friends and doesn’t
Internal Fixation. Since coming out of the        formally exercise. She doesn’t smoke or
cast her wrist is stiff and lacks strength.       drink alcohol and has a BMI of 19.
She is relatively pain free.
She reports her balance as reasonable,
and although is a little concerned she may
fall again has been going out, doing her
shopping and socialising
Past Medical History
June is fit and well other than her recent
fracture. She does not take any prescribed
medications and has never required
steroids. She is a little concerned about
her balance following her fall but denies
true anxiety or depression. She sustained
a tibia and fibula fracture 2 years ago
after falling down some steps. She reports
she recovered well from this.

                                 Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                               June could have Osteoporosis:

                                                                                              23
Osteoporosis
                                          Scenario 1
June   warrants         investigation     for       Investigations
Osteoporosis.
                                                    Complete a bone density risk assessment
-      2 fractures in the last 2 years              (a FRAX score is well validated)
-      BMI on the low end of normal range
                                                    If appropriate and available refer for:
-      Female aged 85
                                                    -      DEXA scanning
Next Steps
                                                    Onwards Referral
Explain to June that because of her recent
fractures,it would be prudent to                    Refer to GP if DEXA scan shows
investigate her bone density further,               Osteoporosis or Osteopenia OR if the
Osteoporosis is extremely common in                 FRAX score is high enough to warrant
older people and can be well managed                commencing bone protection.
with a combination of bone protection
and load based exercise.
Provide June with a graded exercise
program that includes load bearing and
balance components. Manage her
functional   deficits  in  the    wrist
appropriately.

                                          Learning Points.

    Osteoporosis is likely underdiagnosed in               Increasing age and being female
               the population                                  significantly increase risk

                                                        Exercise can improve bone density and
    Assessment of fracture risk is simple and
                                                          reduce falls risk and should be very
                     quick
                                                                  strongly encouraged

                                                                                                 24
Osteoporosis
                                        Scenario 2
Referral                                          He has no family history of Osteoporosis,
                                                  He does not think either of his parents
Mark is a 50 year old male with long
                                                  sustained any fractures.
standing Rheumatoid Arthritis (RA). He
takes biologic medications and has a              Social Factors
limited walking distance.
                                                  Mark has not worked since he was
Further Subjective Information                    diagnosed with RA. He doesn’t go out
                                                  much and has quite a low activity level.
Mark has relatively poor function, his
                                                  He smokes 15/day, drinks 2 glasses of
walking distance is limited and he fatigues
                                                  wine/day and has a BMI of 26.
easily. He was diagnosed with RA aged 20
and has taken a great many medications
over this time frame including multiple
courses of high dose steroids to manage
his arthritis symptoms.
He has multiple joint pains and joint
deformities.
Past Medical History
Mark fatigues easily, takes ramipril for
high blood pressure, biologics and
Methotrexate for his RA and codeine for
pain. He has had multiple courses of high
dose steroids, the most recent of which
was last year where he had 40mg for 4
weeks and then the dose was titrated.
He does not have any absorption issues,
problems with his gut or bowel and
reports eating a varied diet.

                                 Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                              Mark could have Osteoporosis:

                                                                                              25
Osteoporosis
                                            Scenario 2
Mark    warrants         investigation      for        Discuss his general health behaviours.
Osteoporosis.                                          Smoking and alcohol are detrimental to
                                                       bone density but also to outcomes in RA.
-      Long        term        inflammatory
                                                       Consider onward referrals to assist with
       arthropathies increase the risk of
                                                       this.
       Osteoporosis
-      High dose steroids are a strong risk            Try to determine the circumstances that
       factor for Osteoporosis                         are leading to such low activity levels.
-      He has a low activity level and poor            Anxiety, depression and/or loneliness may
       general health including smoking and            be factors keeping Mark from increasing
       alcohol                                         his activity. Social prescribing may be of
                                                       benefit in his case.
Next Steps
                                                       Investigations
Explain to Mark that he has a number of
risk factors for low bone density and it               Complete a bone density risk assessment
would be prudent to investigate this                   (a FRAX score is well validated)
further. Osteoporosis can be well
                                                       If appropriate and available refer for:
managed with a combination of bone
protection and load based exercise and is              -      DEXA scanning
easier to maintain bone density if                     Onwards Referral
assessed earlier.
                                                       Refer to GP if DEXA scan shows
Discuss with Mark a graded exercise                    Osteoporosis or Osteopenia OR if the
program that includes load bearing and                 FRAX score is high enough to warrant
balance components tailored to his                     commencing bone protection.
individual circumstances.

                                         Learning Points.

    Inflammatory Arthropathies increase the                 General health, including mental health
     risk of low bone density via a number of               can increase risk and also contribute to
                  different routes                                     low activity levels

    A FRAX should be carried out yearly in all             Recognising people at risk of low bone
    patients with inflammatory arthropathy                 density before they sustain a fracture is
                                                                   of very high importance
                                                                                                       26
4

                      Gout
Gout is a type of inflammatory arthritis. It is characterised by
acute attacks of pain, redness, swelling and heat of the joint.
Onset of symptoms is usually during the night and will peak
after 12-24 hours. The pain is severe and many attend A+E
with the symptoms. Gout has overtaken Rheumatoid Arthritis
as the Rheumatological condition with the most hospital
admissions per year.
Aspiration of the joint often reveals urate crystals which are
what set off the synovitis. The formation of these crystals can
be either due to an excess of Urea in the body (90%), or a
reduced ability to produce Urate (which metabolises Urea).

                                                                   27
Gout
                                         Scenario 1
Referral                                           It is not better or worse at night, in the
                                                   morning or during the day.
Arnold is a 65 year old male complaining
of episodic right big toe pain and swelling.       Aggravating/Easing
He takes ramipril for high blood pressure.
                                                   He doesn’t think anything causes          an
Further Subjective Information                     episode to occur. When he has            the
                                                   symptoms, weightbearing, having          the
Arnold reports having approximately 5
                                                   sheets touching his toe and moving       the
episodes of severe right big toe pain over
                                                   joint will aggravate his pain.
the last year. Once it was so severe he
thought he had suffered a fracture so              Past Medical History
attended A+E. They performed an Xray
                                                   He has high blood pressure and takes
and there was no fracture.
                                                   ramipril. He does not take any other
He does not currently report any pain as           prescribed medications. He denies any
the most recent episode settled while he           sexually transmitted infections and use of
was waiting for this appointment. He               steroids. He feels well in himself and
describes the episodes as being of                 denies feeling anxious or depressed.
insidious onset, with pain, redness,
                                                   He has no personal or family history of
swelling and heat at the 1st Metatarsal
                                                   psoriasis, iritis/uveitis, crohns/colitis, or
Phalangeal Joint (MTPJ). He can struggle
                                                   inflammatory arthritis.
to walk and the pain will throb and keep
him awake at night. The episodes of pain           Social Factors
last for approximately 4-6 days and then           He works at a supermarket on checkout
start to improve.                                  and walks a mile to and from work. He
Arnold is concerned due to the number of           smokes 20/day and has done for 40 years.
episodes of pain he has had, and that they         He drinks 2-4 bottles of wine a night at
keep occurring even though he doesn’t              the weekend and has a BMI of 36.
think he is triggering them in any way.
24 hour pattern
During an episode of pain, the big toe is
constantly painful until it resolves.

                                  Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                                                                                                   28
                                  Arnold could have Gout:
Gout
                                           Scenario 1
Arnold is presenting with symptoms                   Discuss general health improvement
typical of gout.                                     strategies with Arnold. Reducing BMI,
                                                     alcohol intake and smoking, and
-      Most commonly affected joint is the
                                                     increasing his exercise levels are
       1st MTPJ
                                                     important for both his high blood
-      Severe, episodic pain with swelling,
                                                     pressure and gout. Cardiovascular disease
       redness and heat.
                                                     risk assessment would also be
-      Gout is more likely in men and the
                                                     appropriate.
       risk is increased with vascular issues,
       smoking, alcohol intake and high BMI          Initial management of the gout should be
-      Characterised by severe pain, people          under the GP.
       with gout often describe it as the
                                                     Investigations
       worst pain they have experienced.
                                                     If appropriate and available refer for:
Next Steps                                           -      Blood tests: Uric Acid, ESR, CRP
Explain to Arnold that his symptoms are              Onwards Referral
typical of episodic gout flare ups. His
general health and alcohol intake will               Refer to GP for management
make him much more susceptible to
suffering further flare ups.

                                         Learning Points.

     Poor general health and Male sex are                   The 1st MTPJ is the most common
     strong risk factors for developing gout                   location for gout symptoms

    Alcohol intake and smoking increase the
                                                            Episodic flare ups are common
             risk of developing gout

                                Severe pain and inflammation are
                                    characteristic symptoms

                                                                                                 29
Gout
                                       Scenario 2
Referral                                       The stiffness will reoccur if he rests. He
                                               struggles to sleep at night as the ankle
Chris is a 40 year old male complaining of
                                               aches.
ankle pain and swelling for 4 days
following a particularly intense crossfit      Aggravating/Easing
session. He is insulin dependent due to
                                               Rest will aggravate the symptoms when
Type 1 Diabetes.
                                               he then starts to walk and the ankle can
Further subjective information                 feel very stiff. Activity does not aggravate
                                               the symptoms other than for 30 minutes
5 days ago Chris took part in a very
                                               after rest.
difficult crossfit session which involved
many more box jumps than he is used to.        Past Medical History
He attends crossfit 5 times per week and
                                               He has Type 1 Diabetes and takes insulin.
has not had any previous issues with this.
                                               He reports that the diabetes is well
He does not recall a specific injury and
                                               controlled and he has regular reviews. He
managed the workout well. The pain
                                               does not take any other prescribed
started in the middle of the night. He
                                               medications. He denies any sexually
awoke with ankle pain around 3am and
                                               transmitted infections and use of steroids.
the pain deteriorated from there. He
                                               He feels well in himself but slightly
considered attending A+E in the morning
                                               fatigued due to interrupted sleep. He
due to the pain. It had become swollen,
                                               denies feeling anxious or depressed.
hot and red and he was struggling to
weightbear. He thought he might have a         He has no personal or family history of
fracture. The pain started to improve a        psoriasis, iritis/uveitis, crohns/colitis. His
little so he decided to wait it out.           father and uncle had gout.

The ankle remains diffusely swollen,           Social Factors
warm and painful. He has stiffness most        He works at a desk as a mechanical
of the time in the ankle. The pain remains     engineer. He attends crossfit regularly and
relatively constant irrelevant of the          describes himself as very fit. He doesn’t
amount of activity he does. There is some      smoke or drink alcohol and has a BMI of
relief with ibuprofen.                         24. He remains concerned about a stress
24 hour pattern                                fracture.
The pain and stiffness is worst in the
morning     and       improves    after
approximately 1 hour.
                                                                                                30
Gout
                                           Scenario 2

                                    Clinical Reasoning Activity
                    From the case presentation note down the indicators that
                                     Chris could have Gout:

Chris is presenting       with    symptoms           His symptoms are not consistent with a
suspicious of gout.                                  stress fracture and he did not sustain a
                                                     clear injury during the session. Reassure
-    Pain onset during the night,
                                                     Chris he already lives a healthy lifestyle
     escalating and peaking after a few
                                                     and he should continue this as much as
     hours
                                                     possible to improve his chances of a good
-    Pain and stiffness in the morning for
                                                     outcome. Initial management of gout
     1 hour
                                                     should be under the GP.
-    Worse with rest
-    Strong Family history of gout and               Investigations
     Type 1 Diabetes
                                                     If appropriate and available refer for:
-    Eased by NSAIDs
                                                     -     Blood tests: Uric Acid, ESR, CRP
Next Steps
                                                     Onwards Referral
Explain to Chris that his symptoms are
consistent with an onset of gout. His                Refer to GP for initial management of
diabetes and family history make him                 Gout flare
more susceptible to gout.

                                           Learning Points.

    Symptom onset in this case is important              Gout is the most prevalent inflammatory
     as the timing and initial escalation give            arthritis and men are more susceptible
             the clue to the diagnosis

                                 Chronic conditions such as diabetes
                                 increase the risk of developing gout

                                                                                                   31
5

   Systemic Lupus
   Erythematosus
Systemic Lupus Erythematosus is a highly variable, multi-
systemic, auto-immune condition. It can affect a variety of
organs with different severity and timelines. It is most
common in Women and has an increased prevalence in Afro-
Caribbeans. Musculoskeletal symptoms are vague and diffuse
and significant fatigue often accompanies these muscle and
joint aches. Characteristic rashes are important clinical
entities. SLE is often mistaken for other conditions such as
Fibromyalgia.

                                                               32
Systemic Lupus Erythematosus
                                        Scenario
Referral                                      When she does wake, the aching is there
                                              to a similar level as before she fell asleep.
Mary is a 30 year old female with diffuse
aching all around her body, she doesn’t       There is no clear pattern through the day.
take any regular medications.                 The aching is better when she is
                                              distracted.
Further Subjective Information
                                              Past Medical History
Mary has had diffuse aching all around
her body for approximately 6 weeks. The       Mary does not report any other medical
intensity and location of the aching is       issues with regards to her heart, thyroid,
variable and seems related to how tired       neurological issues, asthma or diabetes.
she is. She has always been a poor sleeper    She has not been unwell over the last
but in the last 6 weeks she has had           year, denies any sexually transmitted
significantly worse fatigue. She generally    infections and has never taken steroids.
feels unwell and run down but denies any      She denies any anxiety but is feeling down
specific symptoms like nausea, dizziness      lately because of the symptoms.
or pyrexia.
                                              Mary reports she has had 3 miscarriages
She was previously fit and well. She has      over the last 7 years. She and her husband
always slept poorly but this has not          are continuing to try and have a baby. She
previously impacted on her function. Now      has also had a rash across her face at
she struggles to concentrate and feels        times over the last 6 weeks which has not
very lethargic.                               been itchy or sore. It is not visually
                                              present in clinic today.
The aching around her body does not
particularly affect her function but is       Social Factors
significant enough to affect her mood.
                                              Mary moved to the UK from Jamaica 3
She is fed up of not feeling well and not
                                              years ago with her husband. She does not
having an answer to what is happening.
                                              work, but spends her time cooking,
24 hour pattern                               cleaning and meeting with her friends.
                                              Her husband works in the banking sector
Mary is tired all the time. The general
                                              and they travel back to Jamaica
aching is more noticeable when she is not
                                              approximately every 3 months for his
distracted and this making it difficult to
                                              work or to visit family.
fall asleep at night. She has always woken
through the night and does not think this     Mary does not smoke or drink alcohol.
is worse.                                     Her BMI is 26.

                                                                                              33
Systemic Lupus Erythematosus
                                         Scenario

                                Clinical Reasoning Activity
                From the case presentation note down the indicators that
                  Mary could have Systemic Lupus Erythematosus (SLE):

Mary warrants investigation for SLE.                She already leads quite a healthy lifestyle
                                                    so encourage her to continue this as
-    Diffuse aching and fatigue
                                                    much as possible.
-    Females carry a far higher risk of
     developing SLE                                 Investigations
-    Afro-Caribbeans carry a higher risk of
                                                    Blood tests: (personally I would leave this
     developing SLE
                                                    to the Rheumatology department)
-    Multiple miscarriages may indicate
     anti-phospholipid syndrome which is            ANA
     sometimes associated with SLE                  Onwards Referral
-    Peak age of onset is in the
     reproductive years (15-44)                     Refer to Rheumatology for further
                                                    investigations and commencement of
Next Steps                                          appropriate treatment as necessary.
Explain to Mary that her symptoms
warrant further investigation under
Rheumatology for SLE. This is the best
place to determine the diagnosis and rule
out any other causes. Discuss with her
that although SLE is relatively rare, female
sex     and    Afro-Caribbean       ethnicity
significantly increase her likelihood of
developing the condition.
Discuss pacing strategies that may help
her during the day to manage her fatigue
symptoms. Encourage her to maintain her
activity levels as much as possible as this
will be beneficial in the longer term and
mitigate any loss of fitness levels.

                                                                                             34
Systemic Lupus Erythematosus
                                         Scenario

                                      Learning Points.

  SLE masquerades as any number of                Understanding multisystem effects is key
musculoskeletal condition so it is easy to        to recognition. Look for renal disorders,
 misdiagnose as fibromyalgia or other              blood disorders, rashes, serositis, and
        similar clinical entities                                  arthritis

                           Significantly more common in women
                           (approx. 10:1 ratio) and higher risk in
                             people of Afro-Caribbean descent

                A vital point is that rashes and skin conditions in text books
               are often shown on Caucasian skin. These changes in people
               who are not of Caucasian descent may look different to these
                images and are often more subtle. Be mindful of this when
                         assessing for skin changes and conditions.

                                                                                              35
6

            Sjogren’s
            Syndrome
Sjogren’s Syndrome is an inflammatory connective tissue
disorder affecting the secretory glands, such as in the mouth
and the eyes. Musculoskeletal symptoms are often vague and
diffuse with associated fatigue. Significantly more common in
women and peak onset of 50-60. Sjogren’s Syndrome can be
the primary condition or it be secondary to another clinically
important inflammatory condition such as RA or SLE

                                                                 36
Sjogren’s Syndrome
                                          Scenario

Referral                                         She remains tired when she wakes up
                                                 regardless of the number of hours she has
Anna is a 40 year old female with diffuse
                                                 slept for.
muscle aching in her legs. She doesn’t
take any prescribed medication.                  Past Medical History
Further Subjective Information                   Anna does not report any other medical
                                                 issues with regards to her heart, thyroid,
Anna has had diffuse muscle aching in her
                                                 neurological issues, asthma or diabetes.
legs for approximately 6 months. There
                                                 She has not been unwell over the last
was no triggering onset and no change in
                                                 year, denies any sexually transmitted
habits prior. More recently over the last
                                                 infections and has never taken steroids.
4-6 weeks she has felt very tired all of the
                                                 She denies any anxiety or depression.
time. She reports sleeping well but never
feels refreshed.                                 Anna reports very dry eyes. She uses false
                                                 tears regularly through the day and also
The muscle aching does not appear to be
                                                 has a very dry mouth. She denies any
related to anything she does, and remains
                                                 change in vaginal dryness. She carries a
at a similar intensity whether she is busy
                                                 bottle of water everywhere with her and
or resting. It does not impact on her
                                                 drinks from it regularly during the
function but she is feeling down about its
                                                 appointment.
relentless nature. The fatigue is more of
an issue as she finds it difficult to            Her mother has Rheumatoid Arthritis.
concentrate at work and doesn’t feel like        There is no other family history of
she wants to engage in her hobbies.              inflammatory conditions.
She has not had any previous injuries.           Social Factors
Over the last 6 months she has had very
                                                 Anna is an accountant and works at a
occasional hand and foot pains which
                                                 desk. She usually enjoys playing regular
have been a similar type of aching, but
                                                 tennis but has not being doing this
resolve after 6 hours or by the next day.
                                                 recently due to the worsening fatigue.
24 hour pattern
                                                 Anna does not smoke or drink alcohol.
She thinks the aching may be slightly            Her BMI is 24.
worse in the mornings but not
significantly. She does not struggle to
sleep and is not woken at all by the
symptoms.
                                                                                              37
Sjogren’s Syndrome
                                        Scenario

                                 Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                           Anna could have Sjogren’s Syndrome:

Anna     warrants   investigation       for        Her Mother having RA slightly increases
Sjogren’s Syndrome.                                her risk of developing an inflammatory
                                                   condition.
-     Muscle aching (myalgia) and fatigue
      with possible hand and foot joint            Discuss pacing strategies that may help
      aching (arthralgia)                          her to manage her fatigue symptoms
-     Females carry a far higher risk of           during the day. Encourage her to maintain
      developing Sjogren’s Syndrome                her activity levels as much as possible as
-     Dry eyes and dry mouth are                   this will be beneficial in the longer term
      characteristic of Sjogren’s Syndrome         and mitigate any loss of fitness levels.
-     A family history of inflammatory
                                                   Investigations
      arthropathy
-     Peak age of onset is 40-60                   If you are confident performing a
                                                   Schirmer’s test then this can provide an
Next Steps
                                                   objective measure of eye dryness in clinic.
Explain to Anna that her symptoms
                                                   Onwards Referral
warrant further specialist investigation.
The dry eyes, dry mouth, fatigue and               Refer to Rheumatology for further
aching may all be related to the one               investigations and commencement of
condition.                                         appropriate treatment as necessary.

                                    Learning Points.

    Musculoskeletal symptoms of Sjogrens               It is key to ask about fatigue levels and
    syndrome are often vague and diffuse                             possible causes

     Ensuring in-depth questioning about
    eye, mouth and vaginal secretions are a         Sjogrens syndrome is far more common
       vital component of recognising a             in women than men (approx. 9:1 ratio)
                potential case
                                                                                                   38
7

        Polymyalgia
        Rheumatica
Polymyalgia Rheumatica is an inflammatory condition,
characterised by shoulder and/or pelvic girdle pain and
stiffness. The mainstay of treatment is pharmacological,
usually involving steroids. Onset is very unlikely prior to the
age of 50, peak onset is 65 with women being affected at 3x
more than men. There shouldn’t be any muscle weakness
at presentation and likely proximal muscle tenderness to
palpation.

                                                                  39
Polymyalgia Rheumatica
                                           Scenario
Referral                                           The pain feels quite diffuse across the
                                                   whole of the shoulders and between her
Sally is a 65 year old female with bilateral
                                                   scapulae.
shoulder pain. She doesn’t take any
prescribed medications.                            She is not woken at night with the
                                                   symptoms and feels her sleep in general is
Further Subjective Information
                                                   unaffected.
Sally has had bilateral shoulder pain for
                                                   Past Medical History
approximately 3 months. She thinks this
started after she helped her daughter              Sally does not report any other medical
move house. She denies true loss of range          issues with regards to her heart, thyroid,
of motion but both shoulders feel very             neurological issues, asthma or diabetes.
stiff when she tries to move her arms over         She has not been unwell over the last
her head or behind her back.                       year, denies any sexually transmitted
                                                   infections and has never taken steroids.
She has not previously had any
                                                   She denies any anxiety but has suffered
musculoskeletal problems. She is finding
                                                   from depression for a number of years.
the pain and stiffness limits her from her
                                                   She currently does not take any
favourite hobby gardening, and reports
                                                   medications for this but has done in the
less motivation because of the
                                                   past.
discomfort. She denies any other current
joint pains or problems.                           Sally denies any other joint pains, history
                                                   of inflammatory conditions and has no
24 hour pattern
                                                   family history of inflammatory conditions.
Sally finds the symptoms are worse first
                                                   Social Factors
thing in the morning for approximately 1
hour which really affects her dressing as          Sally is a retired vet. She gardens for a few
her shoulders are very stiff and painful.          hours every day and is finding it
They ease up to a degree after this time           frustrating that she can’t maintain this
but remain uncomfortable and stiff                 level of activity.
through the day.
                                                   Mary does not smoke or drink alcohol.
                                                   Her BMI is 30.

                                   Clinical Reasoning Activity
                   From the case presentation note down the indicators that
                       Sally could have Polymyalgia Rheumatica (PMR)
                                                                                                   40
Polymyalgia Rheumatica
                                            Scenario

Sally warrants investigation for PMR.                 A graded exercise program can be helpful
                                                      to maintain function in the shoulders and
-      Bilateral shoulder pain and stiffness
                                                      increase current function. Unfortunately
-      Symptoms worse in the mornings
                                                      it tends not to affect the pain levels or
-      Diffuse symptoms around the whole
                                                      feelings of stiffness. Discuss her general
       shoulder girdle
                                                      health as her high BMI will be
-      65 year old female with a high BMI is
                                                      contributing      to    raised    systemic
       the classic demographic for PMR
                                                      inflammation and reducing this will
       onset
                                                      improve the likelihood of a positive
-      Depression is linked to PMR in many
                                                      outcome regardless of the diagnosis.
       cases
                                                      Investigations
Next Steps
                                                      Blood tests:
Explain to Sally that her symptoms may be
related to PMR and further investigation              -      ESR (>40), CRP
is warranted to enable appropriate
                                                      Currently no valid imaging unless to rule
treatment and rule out any other cause
                                                      out other implicated conditions.
for the symptoms. Discuss that her
demographics and symptom presentation                 Onwards Referral
make it suspicious that this is the cause             Refer according to local pathways, this is
for her symptoms.                                     either to the GP or to a Rheumatology
                                                      consultant.

                                        Learning Points.

     Bilateral shoulder pain and stiffness is a        ESR of >40 is almost always present in
    key symptomatic feature of PMR (90% of            PMR and a negative result all but rules out
                      cases)                                        the condition

                                                           65 years old is the peak onset, women
       Pelvic girdle symptoms may also be
                                                          have a higher incidence (approx. 3:1) and
      implicated and in 10% of cases will be
                                                          high BMI will increase risk of developing
         the only symptom presentation
                                                                        the condition
                                                                                                      41
8

Reactive Arthritis
Reactive arthritis is a varied condition triggered by an extra-
articular infection usually of gastrointestinal (GI) or
Genitourinary (GU) origin. Reactive arthritis is often
clinically indistinguishable from other arthropathies such as
AxSpA or RA. Recognition of the triggering event is key.
Occurring in younger Caucasian people aged 20-40, men are
much more likely to have the GU origin than women. GI
origin has an equal prevalence. Symptom onset is usually
within 2-6 weeks of infection.

                                                                  42
Reactive Arthritis
                                         Scenario 1
Referral                                            He wakes in the second half of the night
                                                    with back pain and he has to get out of
Dean is a 20 year old Caucasian male with
                                                    bed and walk around to ease it enough
low back pain. He doesn’t take any
                                                    for him to lay down and go back to sleep.
prescribed medications.
                                                    Past Medical History
Further Subjective Information
                                                    Dean does not report any other medical
Dean reports 6 weeks of severe low back
                                                    issues with regards to his heart, thyroid,
pain and stiffness. He has no prior history
                                                    neurological issues, asthma or diabetes.
of back pain and can not think of a
                                                    He has not been unwell over the last year,
specific trigger to his symptoms. He has
                                                    denies any history of sexually transmitted
been off work for the whole 6 weeks since
                                                    infections and has never taken steroids.
the symptoms started.
                                                    He does not suffer from anxiety or
He denies being unwell over the last 6              depression.
months and is usually very fit and healthy.
                                                    Dean denies any other joint pains, history
He was recently (8 weeks ago) on holiday
                                                    of inflammatory conditions. His father has
in Magaluf and admits to having
                                                    Ankylosing Spondylitis.
unprotected intercourse with several
partners while he was there. He has not             Social Factors
considering getting checked for an STI.
                                                    Dean is a bricklayer. He is extremely
24 hour pattern                                     active, going to the gym most days after
                                                    work and playing rugby at the weekends.
Dean’s symptoms are severe in the
mornings. The pain is much worse with               Dean smokes very occasionally and drinks
significant stiffness for up to 4 hours. He         alcohol on holiday only. His BMI is 25.
finds he is much better during the day if
he keeps moving. If he sits to watch
television or even to eat a meal his back
stiffens up again and he has to walk
around to ease it off.

                                  Clinical Reasoning Activity
                  From the case presentation note down the indicators that
                             Dean could have Reactive Arthritis:

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