SEPIFITTM Protect Complete muscle protection for performance and recovery - From athletes to lifestyle users, SEPIFITTM Protect is a unique ...
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
SEPIFITTM Protect
Complete muscle protection for performance
and recovery
From athletes to lifestyle users, SEPIFITTM Protect
is a unique synergistic formulation that offers full
muscle protection which helps improve performance
and optimize recovery.
1 SEPIFITTM Protect Seppic
2021
SPORTS NUTRITION:
A rising and diversifying market
From bodybuilding to active lifestyle
Over the past few years, Sports Nutrition and mentally sharp, this new category
“
has evolved as a market to respond to considers exercise as a mood and energy
Staying
social changes and emerging consumer management strategy. They look for
segments. Originally, Sports Nutrition convenient, science-backed and clean
products were dedicated to athletes, but label products. Healthy agers are also a
nowadays, new consumer groups such
as active lifestyle users and healthy agers
rising consumer group of Sports Nutrition
products. They want to live longer and healthy
”
are showing a growing interest for these healthier. Sports Nutrition participates
products. The core users, embodied in maintaining their daily activities
by athletes and bodybuilders highly by protecting joints and muscles from
is the number one reason
involved in daily exercise and intense injuries1-5.
why millennials
training, seek these products for better Overall, consumer habits have been
exercise1
performance and improved aesthetic dramatically changed by social media
appearance. They are used to buying and global digitalization. Various
pre- and post- workout supplements as applications to manage and compare
well as hydration and recovery products. performance are now available,
In addition to that, a new category of encouraging active consumers to
active lifestyle users was born in the combine the use of an app with their
past few years. Mainly represented by daily workout routines to be shared
millennials, for whom working out is part amongst users of online communities.
of a healthy lifestyle to stay physically
ATHLETES AND BODYBUILDERS
Practice almost everyday
Looking for performance
and aesthetic appearance
Pre- and post-workout supplements,
hydration and recovery products
ACTIVE LIFESTYLE USERS
OR FIT CONSUMERS
Practice 3 to 5 times a week
(1.5h to 4.5h per week)
HEALTHY AGERS Looking for physical and mental
Practice 1 to 3 times per week wellbeing as part of a global healthy
lifestyle
Looking to stay active
and prevent joint and muscle Convenient, science-backed
injuries and clean label products
Easy to take products
2 SEPIFITTM Protect Seppic
2021
A dynamic market on the rise…
With $17B in 2019 expected to reach of the different offers is on the rise, and
$21B in 2023 at a CAGR of 7.9%, the steadily progresses with popular activities
global Sports Nutrition market is still like football, running or cricket standing
growing. Widely led by the US market, alongside new activities such as pilates,
representing around 60% ($10.1B) of the kinball or CrossFit. At the same time,
global market share and the European nutrition habits are moving too: the
market accounting for 18% ($3.1B), growing interest in flexitarian and vegan UNITED STATES
Sports Nutrition benefits from several key diets shows that people are changing $10.1B
drivers explaining its interesting growth6,7. what they eat8. People are also changing
The diversification of this market may how they eat, preferring nomadic and
come from an increased urbanization ready-to-use foods and beverages to
and the development of gym and health traditional lunches2,3. EUROPE
fitness centers, both modifying the Inevitably, to answer these new trends, the
way people exercise and the different Sports Nutrition market is expanding and
types of physical activities that are undergoing a movement of restructuring9.
made available. Indeed, the diversity
$17B
Sports Nutrition GLOBAL $3.1B
… And a need for innovation
Originally designed to improve diversity of ingredients composing
performance, support muscle growth or Sports Nutrition formulations is rather
aid recovery, the Sports Nutrition market weak and does not offer the innovative
In 2020,
39%
is now evolving to meet new consumers solutions that consumers expect5,9.
needs. The market actually took up quite In addition, Sports Nutrition users are
fast the need for the expected «galenic» increasingly requiring evidence-based
evolutions by proposing products formulations with fewer ingredients to
of consumers said they
were using more Sports
under new formats for a nomadic better understand the composition. The
Nutrition products
and convenient use (quick meal market is therefore beginning to offer
than the previous
replacements, healthy snacks or refreshing more clean products and, most of all, to
year10
beverages). Nevertheless, the majority of deliver more science than marketing as
these products remains protein-centric people want to trust products efficacy2,10.
formulations. Suitable for serious The expansion of Sports Nutrition as
athletes, they are no longer appropriate a market will inevitably go through
to the new segments of consumers who a phase where new science-based
look for other benefits than building ingredients will be developed, creating
muscle mass. Unlike products forms, the new opportunities to innovate.
3 SEPIFITTM Protect Seppic
2021
RECOVERY IS KEY…
…to improving
performance,
and wellbeing.
Physical activity is composed of two big lifestyle people, who want to reach a
phases: the exercise phase and the certain level of global wellbeing, the
recovery phase, which is the resting recovery phase remains a key factor
period between two training sessions. in order for everybody to reach their goals.
The recovery phase helps the body Indeed, by restoring muscle capacities
restore its performance capabilities and decreasing the feelings of
to normal status by replenishing energy soreness and fatigue, optimized
and repairing muscular tissues injured recovery will improve performance and
during exercise11. good sensations during future exercise.
This virtuous circle positively impacts
Even if the goals are different between pleasure, motivation and ability to get
athletes, who want to perform, and active back to training12.
RECOVERY INFLUENCERS
Limiting muscle damage ADEQUATE
RECOVERY
Adequate nutrition
and supplementation EXERCISE PERFORMANCE
PLEASURE
Personal behaviors
SELF-ESTEEM
Restoring energy
MOTIVATION TO GET
Regenerating lean muscle BACK TO TRAINING
Limiting joint and bone damage
Limiting muscle damage is one of supplementation is major on this
the most effective ways to enhance recovery cycle, and it may positively
recovery. Personal behaviors like impact user experience. Restoring energy,
warm-ups before training, hydration regenerating lean muscle or limiting
during exercise or stretching after may joint and bone damage are other ways of
reduce muscle damage and soreness. enhancing recovery13.
The role of adequate nutrition and
4 SEPIFITTM Protect Seppic
2021
HOW EXERCISE CAN CAUSE
muscle damage and fatigue?
Intense or prolonged physical exercise can lead to a decline in Muscle Soreness). Muscle soreness refers to the immediate
performance and difficulties in getting muscle cells to contract. soreness perceived by the athlete while or right after exercise,
When the phenomenon is reversible in minutes or hours, it is in combination with muscle stiffness, aching pain or muscular
known as muscle fatigue and described as the result of the inability tenderness. These symptoms are experienced only for hours and
of muscles to meet the increased energy demand. are relatively transient. The symptoms associated with DOMS are
If muscle recovery fails to take effect quickly to reverse muscle the same as for immediate soreness but their onset occurs
fatigue, especially during a strenuous exercise, it is named later, continues for 48-72 hours and slowly resolves. DOMS is
Exercise-Induced Muscle Damage (EIMD) and it is associated with perhaps one of the most common and recurrent forms of sport
structural damage within the muscle. These muscle damages injury. All these muscle phenomena generally contribute to a
cause immediate muscle soreness or even DOMS (Delayed-Onset decreased performance, poor recovery and declining motivation.
EXERCISE Biomarkers of muscle fatigue & damage
Phosphorylation by Creatine Kinase (CK)
MUSCLE CONTRACTION
BY ATP SYNTHESIS
Anaerobic pathway Aerobic pathway
MUSCLE FATIGUE INTENSE OR PROLONGED lactate
Reversible in minutes or hours
strength, endurance, pain, soreness
PHYSICAL EXERCISE IL-6
MUSCLE DAMAGE (EIMD = EXERCISE-INDUCED MUSCLE DAMAGE) STRENUOUS PHYSICAL
Slowly or poorly reversible and characterized by structural abnormalities extracellular CK
EXERCISE
stiffness, aching pain, tenderness
MUSCLE SORENESS DOMS (DELAYED-ONSET MUSCLE SORENESS)
During or immediately after exercising One or two days after exercising
Lactate, Interleukin-6 and Creatine fatigue, and from the other side induces the release of lactate. The
ATP deficiency occuring during exercise also leads to an increasing
Kinase as markers of muscle fatigue consumption of glycogen, which can in turn induce the production
and damage of interleukin-6 (IL-6). Both release of lactate and IL-6 are then
considered as energy sensors and markers of muscle fatigue.
Any physical exercise involves muscular contractions that are Exercise-Induced Muscle Damage (EIMD) is characterized by
dependent upon energy provided by ATP hydrolysis. In the first structural abnormalities and membrane damage, resulting in an
stage, stored ATP is consumed in a few seconds, then fast production increase in muscle protein degradation and cell permeability, and
of ATP is set up thanks to the creatine kinase (CK) enzyme during also, inflammatory processes. Loss of muscular proteins into the
the following seconds. For more long lasting exercises, cellular blood may occur at several stages along the continuum of muscle
respiration and glucose, even glycogen, become the major source injury to muscle soreness. Creatine kinase is one of the proteins
of ATP. Energy and ATP can be brought via anaerobic respiration that are leaked into the circulation when muscle damage occurs.
which can lead to lactic acid production, that from one side can Moreover, as CK is almost exclusively present in muscular tissue, it
block muscle contractions through acidosis and lead to muscle is considered as a relevant marker of muscle damage and injury(14-16).
5 SEPIFITTM Protect Seppic
2021
SEPIFITTM PROTECT:
A complete action
on muscle protection
and performance
SEPIFITTM Protect is a patented The exclusive polyphenol composition
antioxidant formulation specifically from red wine contained in
designed to offer a full protection SEPIFIT TM
Protect has shown to rise nitric
against exercise-induced damages. oxide (NO) release from endothelial
Individually, each ingredient plays a role cells. NO is known to play important
in exercise performance or recovery. roles in physical activity including the
For example, zinc is a co-factor of regulation of neuromuscular activity, the
several metabolic reactions thought muscle contraction system and the
to be involved in antioxidant activity, mitochondrial respiration. Maintaining
muscle mass construction, muscle cell an appropriate level of NO during exercise,
reconstruction and regulation of lactate and particularly during intense workout,
concentration. The zinc level, and thus is essential to support activity and
the zinc activity, seems to be potentiated preserve muscular performance19,20.
in presence of vitamin E17,18.
Zinc
Exclusive
Vitamin E polyphenols
SEPIFITTM Protect from red wine
Global action
on sport
MUSCLE ANTIOXIDATIVE
PERFORMANCE PROTECTION
MUSCLE RECOVERY
PROTECTION OPTIMIZATION
Interestingly, the combination of these three ingredients shows a synergistic effect on
muscle protection against exercise-induced damage demonstrated on a proprietary in
vitro model.
6 SEPIFITTM Protect Seppic
2021
A DEMONSTRATED SYNERGISTIC ACTIVITY
on muscle fatigue and damage
Synergistic activity of SEPIFITTM Protect contraction. This in vitro test showed the fatigue and damage (lactate, IL-6 and
complex has been demonstrated in a unique formulation of SEPIFIT TM
Protect intracellular CK), while ingredients alone
proprietary model of human skeletal had a significant action on three did not show any significant effect21.
muscle cells that mimics muscle recognized biomarkers of muscle
Muscle fatigue
Effect on lactate (nmol/µg of DNA)
Untreated cells 292 Exercise effect
Stressed cells
Wine polyphenols
498
502
85%
Zinc 567
Vitamin E 547
SEPIFITTM Protect 322 Protection effect 85 % Reduction of lactate release
induced by exercise.
> Prevention of muscle acidification
Effect on IL-6 (pg/µg of DNA)
Untreated cells 4
Stressed cells
Wine polyphenols 11
12
63%
Zinc 12
Vitamin E 16
SEPIFITTM
Protect 7 PE 63% Reduction of IL-6 release induced
by exercise.
> Prevention of muscle stress
Effect on intracellular CK activity (U/mg of DNA)
77%
Untreated cells 38
Stressed cells 17
Wine polyphenols 13
Zinc 11
Vitamin E 27
Prevention from the decrease
SEPIFITTM Protect 33 of CK induced by exercise.
PE 77% > Prevention of muscular structural
damage
7 SEPIFITTM Protect Seppic
2021
AN ORIGINAL CLINICAL DESIGN
to assess the effects
of SEPIFITTM Protect on muscle
fatigue and performance
A clinical study was conducted to evaluate the effect of 12 days
of supplementation with SEPIFITTM Protect on muscular
recovery management. Thirty healthy men aged 18 to 38 years
old and practicing a regular physical activity (from 1.5 to 4.5
30 men 12 days 135 mg/day hours) were randomly assigned to SEPIFITTM Protect group (135
aged 18 - 38 of supplementation mg per day) or placebo group22.
A global approach to assess the clinical efficacy
FUNCTIONAL TEST BIOLOGICAL TEST PERCEIVED EFFICACY
Muscular Power Capacity
(MPC)
Jump power The MPC score, measured
(W/kg) by vertical elasticity (jump height,
in cm) and jump power (with
an accelerometer, in W/kg)
during a functional test
consisting of jump squats.
The MPC score decreases Creatine Kinase (CK) test Questionnaire
as the muscle fatigue rises. The measurement of the Self-assessment questionnaire
capillary blood Creatine on participants’ perception
Jump height
Kinase level assesses of product efficacy on muscle
(cm)
the muscular damage. soreness, performance and
physical shape.
The protocol consisted of inducing muscle fatigue and pain, were measured before and after muscle fatigue induction, after 12
by performing series of little hurdles’ jump and drop jump, in days of supplementation at 135 mg per day of SEPIFITTM Protect
order to observe the effects of SEPIFIT TM
Protect on or placebo. At the end of the study, participants were asked to fill
instant muscle recovery and performance. The Muscular in a self-assessment questionnaire on their perception of product
Power Capacity (MPC) score and the capillary blood CK levels efficacy on muscle soreness, performance and physical shape.
D0 D1 D12
SEPIFITTM Protect or placebo
1 caps/day
Inclusion Initiation Pre induction Muscle fatigue Post induction
of product induction
treatment CK test Auto-assessment
Regular physical MPC (jump squat) CK test
activity MPC (jump squat)
Series of little hurdles’ jump
and drop jump
8 SEPIFITTM Protect Seppic
2021
A CLINICALLY PROVEN EFFICACY
on performance and recovery
Parameter Assessed effect
Muscle instant performance
MPC score
Muscle fatigue
CK level
Questionnaire
Muscle damage
Perceived efficacy on muscle soreness
50%
1 SEPIFITTM Protect
helps maintain the performance
Improvement of MPC
score variation versus
placebo
MPC score
The MPC naturally decreases when
Vertical elasticity (in cm) Accelerometer (in W/kg) exercising due to the induced muscle
Difference before and after muscle
0.00
0.00
fatigue and damage, and the difficulty for
-0.50 the muscle cells to contract.
-52% -50%
fatigue induction
-2.00
-1.00
-1.50 -4.00 SEPIFITTM Protect helps reduce the loss
of muscular power capacity and maintain
-2.00 -6.00
performance during an intense or
-2.50 p=0.092
-8.00 prolonged exercise.
p=0.086
PLACEBO
SEPIFITTM Protect
70%
2
SEPIFITTM Protect helps prevent Improvement of CK level
muscle damage and optimize recovery variation versus placebo
The Creatine Kinase is an indicator of
Capillary blood CK level (IU/L) muscle damage as it is one of the proteins
40 p=0.017 which leaks into blood circulation when
Difference before and after muscle
muscle damage occurs.
30
fatigue induction
After 12 days of supplementation,
20
SEPIFITTM Protect significantly reduced
10 -70% PLACEBO the release of CK in capillary blood by
SEPIFITTM
Protect 70% versus placebo, demonstrating its
0
effect on muscle protection and its role in
optimizing recovery.
9 SEPIFITTM Protect Seppic
2021
3 SEPIFITTM Protect’s
efficacy validated by consumers
The self-assessment questionnaire filled 60% of subjects supplemented with
by the participants at the end of the study SEPIFITTM Protect felt that they were in
revealed they were generally satisfied better physical shape.
with SEPIFITTM Protect’s efficacy on muscle
soreness, performance and physical 87% of subjects supplemented with
shape, with an important difference SEPIFITTM Protect assessed good product
versus placebo. efficacy on performance.
67% of subjects supplemented with
SEPIFITTM Protect felt less muscle soreness
after exercising.
Better physical 29 %
shape
60 %
64 %
Good efficacy
on performance 87 %
43 %
Less muscle
soreness
67 %
PLACEBO
SEPIFITTM Protect
Consumers
benefits:
Improves physical wellbeing
Increases performance
Decreases soreness
10 SEPIFITTM Protect Seppic
2021A READY TO USE INGREDIENTS FOR
performance and recovery
supplements
Various galenic forms are possible with SEPIFITTM Protect*
Only Easy
135 mg/day to
12 days formulate
Capsules Tablets Shots Softgel Bars Drinks
With authorized health claims
Approved for use in food supplements in the EU and the US
Authorized health claims
Specific claims based Safety Manufactured
& quality
on clinical results in France
«Vitamin E and Zinc contribute
to the protection of (muscle) cells «Helps protect muscle cells»
from oxidative stress» • Vegan
+ other claims on zinc • No WADA substances
and possibility of genral «Optimizes recovery» • GMO free
health claims • Produced according
to HACCP guidelines
«Improves performance during
exercise»
When to use
Who can use SEPIFIT TM
Protect? SEPIFITTM protect?
Athletes & bodybuilders Active lifestyle users Healthy agers For specific purposes
Before a particular event like a sports competition
Before a focused or unacostumed exercise
Before a more intense training period
For continuous use
To maintain a daily regular activity
To preserve muscle integrity and help maintaining
a daily activity
*Local regulations must be checked before using SEFIFITTM Protect in a food or food supplement formulation.
11 SEPIFITTM Protect Seppic
2021References
1. Nutraceuticals World. Getting Ahead of the Curve: The Fit Consumer. 11. Kellmann M, Bertollo M, Bosquet L, et al. Recovery and Performance
Published 2019. Accessed January, 2021. https://www.nutraceuticalsworld. in Sport: Consensus Statement. Int J Sports Physiol Perform.
com/issues/2019-03/view_trendsense/getting-ahead-of-the-curve-the-fit- 2018;13(2):240-245. doi:10.1123/ijspp.2017-0759
consumer/v
12. Institut National du Sport, de l’Expertise et de la Performance (INSEP).
2. Natural Products Insider. Sports nutrition: Four mainstream consumer Recovery for Performance in Sport.; 2013.
segments driving category growth. Published 2015. Accessed January,
13.
Järvinen TAH, Järvinen TLN, Kääriäinen M, et al. Muscle injuries:
2021. https://www.naturalproductsinsider.com/sports-nutrition/sports-
optimising recovery. Best Pract Res Clin Rheumatol. 2007;21(2):317-331.
nutrition-four-mainstream-consumer-segments-driving-category-growth
doi:10.1016/j.berh.2006.12.004
3.
Watson Inc. Sports Nutrition Trends 2019: What Consumers Want.
14. Fatouros I, Jamurtas A. Insights into the molecular etiology of exercise-
Published 2019. Accessed January, 2021. https://blog.watson-inc.com/
induced inflammation: opportunities for optimizing performance. J
marketing/sports-nutrition-trends-2019-what-consumers-want
Inflamm Res. 2016;Volume 9:175-186. doi:10.2147/JIR.S114635
4. Watson Inc. Which Factors Are Driving Consumer Purchases in Sports
15. Hotfiel T, Mayer I, Huettel M, et al. Accelerating Recovery from Exercise-
Nutrition Products? Published 2019. Accessed January, 2021. https://
Induced Muscle Injuries in Triathletes: Considerations for Olympic
blog.watson-inc.com/marketing/which-factors-are-driving-consumer-
Distance Races. Sports Basel Switz. 2019;7(6). doi:10.3390/sports7060143
purchases-in-sports-nutrition-products
16. Spriet L. Anaerobic metabolism during exercise. Exerc Metab. Published
5. Nutrition Insight. Sports boosters: Wide-ranging consumer bases and
online January 1, 2006:7-27.
holistic health impact industry. Published 2020. Accessed January, 2021.
https://www.nutritioninsight.com/news/sports-boosters-wide-ranging- 17. Khaled S, Brun JF, Bardet L, et al. Importance physiologique du zinc
consumer-bases-and-holistic-health-impact-industry.html dans l’activité physique. Sci Sports. 1997;12(3):179-191. doi:10.1016/
S0765-1597(97)84576-5
6.
Grand View Research. Sports Nutrition Market Size, Share & Trends
Analysis Report By Product (Drinks, Supplements, Foods), By Distribution 18. Patlar S, Boyali E, Baltaci AK, et al. Elements in Sera of Elite Taekwondo
Channel (Ecommerce, Bricks & Mortar), By Region, And Segment Athletes: Effects of Vitamin E Supplementation. Biol Trace Elem Res.
Forecasts, 2020 - 2027. Published 2019. Accessed January, 2021. https:// 2011;139(2):119-125. doi:10.1007/s12011-010-8648-7
www.grandviewresearch.com/industry-analysis/sports-nutrition-market
19.
Baskurt OK, Ulker P, Meiselman HJ. Nitric oxide, erythrocytes and
7.
Research Drive. Impact analysis of Covid-19 on Sports Nutrition and exercise. Clin Hemorheol Microcirc. 2011;49(1-4):175-181. doi:10.3233/
supplements market. Published 2020. Accessed January, 2021. https:// CH-2011-1467
www.researchdive.com/covid-19-insights/198/sports-nutrition-and-
20. Jones AM, Thompson C, Wylie LJ, et al. Dietary Nitrate and Physical
supplements-market
Performance. Annu Rev Nutr. 2018;38(1):303-328. doi:10.1146/annurev-
8. Tate&Lyle. A look inside the sports nutrition market – what are the latest nutr-082117-051622
consumer trends? Published 2020. Accessed January, 2021. https://www.
21. De Pooter A, Catuzzato L, Kern C, et al. In vitro protective effect of the
tateandlyle.com/news/look-inside-sports-nutrition-market-what-are-
association of wine polyphenols, vitamin E and zinc on muscle fatigue
latest-consumer-trends
and damages induced by physical exercise. J Int Soc Antioxid Nutr
9. Food Processing. What’s Fueling the Sports Nutrition Market? Published Health. 2016;Vol 3:No 4 (2016). doi:10.18143/JISANH_V3I4_1375
2020. Accessed January, 2021. https://www.foodprocessing.com/
22. Kern C, Garcia C. Supplementation with SEPIFITTM Protect, a complex
articles/2020/sports-nutrition/
of a natural red wine extract, vitamin E and zinc, improves exercise
10.
Innova Market Insights. New Trends in Powder Sports Nutrition recovery in healthy men. Nutrafoods. 2020;1(1):149-158. doi:10.17470/
Products.; 2020. NF-020-0021
SEPPIC SA | NUTRITION.SEPPIC@AIRLIQUIDE.COM
The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product.
9968/GB/March 2021
Except as set forth above, SEPPIC* makes no warranties, whether express, implied of statutory, as to the product which is the subject of this document
Without limiting the generality, of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any
particular purpose. Buyer assumes all risk and liability resulting from the use or sale of the product, whether singly or in combination with other goods.
The information set forth herein is furnished free of charge and is based on technical data that SEPPIC* believes to be reliable. It is intended for use by
persons having technical skill and their own discretion and risk. Since conditions of use are outside SEPPIC*’s control, SEPPIC* makes no warranties,
express or implied, and assumes no liability in connection with any use of this information. Nothing herein is to be taken as a license to operate under
or a recommendation to infringe any patents.
A company of
seppic.comYou can also read
