Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA

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Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Connecting
    Chronic Kidney
    Disease: the link with
    Diabetes

               Primary Care Education Workshop
               This module was conceived and developed by PEAK*

               Presented by:
1
                                                                  V0617
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Collaborators
       *This Education was conceived and
     developed by the ‘Primary Care Education
       Advisory Committee for KHA’ (PEAK)

      KHA’s Primary Care Education program is proudly supported by
                    unrestricted educational grants from:

2
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Learning outcomes
    At the end of this workshop participants will be able to:

        State the major risk factors for developing chronic kidney
        disease (CKD)
        Determine the stage of chronic kidney disease (CKD)
        through accurate interpretation of kidney function test
        results
        Outline the adverse outcomes of a combined diabetes and
        CKD diagnosis (Diabetic Kidney Disease, DKD)

        Explore the nurse's role in early detection, reducing the
        modifiable risk factors and management of DKD

        Develop a system to screen at risk patients that includes
        CKD testing and management

3
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
What is CKD?
     Chronic kidney disease is defined as:
          Glomerular Filtration Rate (GFR) < 60
       mL/min/1.73m2 for ≥3 months with or without
               evidence of kidney damage.
                                                    OR

     Evidence of kidney damage (with or without
           decreased GFR) for ≥3 months:
                         •    albuminuria
                         •    haematuria after exclusion of urological
                              causes
                         •    pathological abnormalities
                         •    anatomical abnormalities
4      Chronic Kidney Disease (CKD) Management in General Practice, 3rd edition. Kidney Health Australia:
                                                                                        Melbourne, 2015
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
A snapshot of kidney disease
    in Australia
                                                                     It’s harmful
                                                                     In the top 10 causes
    It’s common                                                      of death2. Kills more
    1 in 10 adults has                                               people each year
    at least one clinical                                            than breast cancer,
    sign of kidney                                                   prostate cancer and
    disease1.                                                        road deaths.

                     It’s manageable
                     If detected early and
                     treated properly the
                     decline in kidney function
                     can be significantly
                     reduced.

                                                            1 Australian Health Survey, 2013
5                                  2   Australian Bureau of Statistics, Causes of Death, 2012
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Australians living with signs
    of CKD
       > 12% of
    population with
     signs of CKD

       8-11% of
    population with
     signs of CKD

        < 7% of
    population with
     signs of CKD

    No data available

6
                        State of the Nation Report 2016, Kidney Health Australia
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
General chemistry results
                   Combine eGFR, albuminuria and
               underlying diagnosis to specify CKD stage

    GENERAL CHEMISTRY
    Sodium      144 mmol/L             (136-146)
    Pot.        4.3 mmol/L             (3.5-5.2)
    Chlor.      106 mmol/L             (98-109)
    Bicarb.     26 mmol/L              (20-32)
    Urea        6.5 mmol               (3.0-9.0)
    Creat.      55 µmol/L              (40-85)
    eGFR        84 mL/min/1.73m2
    Urate       0.35 mmol/L            (0.15-0.45)
    *Gluc       9.5 mmol/L             (Random: 30-6.9; Fasting: 3.0-5.4)
    Albumin     40 g/L                 (35-50)

7
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Staging CKD
    Combine eGFR stage, albuminuria stage and underlying diagnosis to specify
     CKD stage e.g. stage 3b CKD with microalbuminuria secondary to diabetic kidney disease

                                                   Albuminuria Stage
                                   Normal               Microalbuminuria           Macroalbuminuria
      GFR       GFR
             mL/min/1.     urine ACR mg/mmol urine ACR mg/mmol urine ACR mg/mmol
     Stage     73m2            Male: < 2.5       Male: 2.5-25       Male: > 25
                              Female: < 3.5     Female: 3.5-35     Female: > 35

       1        ≥90           Not CKD unless
                           haematuria, structural
                              or pathological
       2       60-89       abnormalities present

      3a       45-59

      3b       30-44
                                                                X
       4       15-29
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Connecting CKD and diabetes
           Every second patient*
        you see with Type 2 diabetes
              WILL have CKD
     A patient with diabetes has CKD if they
                have 1 or more:

    • Persistent microalbuminuria or proteinuria
    • An eGFR < 60mL/min/1.73m2 and/or
    • Haematuria after exclusion of urological
      causes or structural abnormalities
9
                                     *NEFRON Study 2007
Connecting Chronic Kidney - Disease: the link with Diabetes Primary Care Education Workshop - ADEA
Connecting CKD and diabetes
     • Health care burden associated with DKD and DM-
       ESKD in Australia is significant and expanding
     • Diabetes is the leading cause of incident end-stage
       kidney disease (DM-ESKD)
     • The growing prevalence of T2DM in Australia,
       indicates the prevalence of DKD will continue to grow
       substantially
      The first priority in screening for DKD should be
              the detection of microalbuminuria
     Pharmacological intervention in DKD is stabilising
        the incidence of ESKD at the population level

10
Connecting CKD and diabetes

            • Monitoring for kidney disease must
              be made a high priority for all people
              with type 2 diabetes
            • Concerted effort needs to made to
              ensure that glucose control is
              optimised, blood pressure and lipids
              targets are met
            • Opportunities for prevention across
              the entire disease continuum

     Sarah White and Steve Chadban, Kidney Research Node Royal Prince Alfred Hospital and Charles Perkins Centre, University of Sydney
11                                                                                                                                April
An eGFR less than
     60mL/min/1.73m2 indicates
     •   High risk of heart attack or stroke
     •   Decreased survival after a heart attack
     •   More common adverse drug reactions
     •   Slow wound healing
     •   Difficulty in achieving BP goals
     •   Difficult fluid control i.e. ankle swelling, fluid
         retention

12
                                                 *NEFRON Study 2007
An eGFR less than
60mL/min/1.73m2 indicates

       Less than 1 in    • Increased likelihood of
                           fractures with falls
          every 20
                         • Increased likelihood of
       patients with
                           hypoglycaemia
        diabetes and
                         • Increased likelihood of
        CKD will live      hospitalisation in next 12
      long enough to       months
      require dialysis   • Increased likelihood of
             or            heart failure
     transplantation*

13
                                         *NEFRON Study 2007
Diabetes’ affect on the body

14
Diabetes progression to dialysis
                                             In the last 10 years there has been a 60% increase in the
                                              number of people with type 2 diabetes starting dialysis

                                          New patients with ESKD due to diabetes starting on
                                                               dialysis
                                                                (Australia 1983-2014)
                                   1200

                                   1000
     Number of patients per year

                                   800
                                                   Type 2     Type 1
                                   600

                                   400

                                   200

                                     0
                                      1983         1988      1993            1998            2003             2008            2013

15
                                                                       ANZDATA, Annual Reports. Available at www.anzdata.org.au
Diabetes and dialysis
     Diabetes is the cause of kidney failure that is
     largely driving the increase in dialysis patients in
     Australia
                45
                        Diabetes          Gn                 BP
                40      Misc              Uncertain          PCK
                35      Reflux            Analg Nx

                30
     Rate pmp

                25

                20

                15

                10

                 5

                 0
                     1998          2000               2002         2004   2006           2008
16
                                                                          ANZDATA Registry
Diabetic Kidney Disease (DKD)
     • Diabetes causes damage to the kidneys;
       called Diabetic Kidney Disease (DKD) or
       diabetic nephropathy
     • Worsens other complications from
       diabetes such as nerve and eye damage
     • Increases the risk of cardiovascular
       disease
     • Usually has no symptoms until it is well
       advanced

17
Diabetic Kidney Disease (DKD)
     • most frequent cause of kidney failure
       worldwide
     • associated with increased morbidity and
       mortality at all stages of CKD
     • early detection and comprehensive
       management is associated with improved
       outcomes
     • CKD management overlaps entirely with
       diabetes management and cardiovascular
       risk reduction
18
Diabetic Kidney Disease (DKD)
     • 20-40% of patients with Type 2 diabetes develop
       nephropathy, which classically occurs in two stages:
       • Early nephropathy: microalbuminuria and normal to high GFR
       • Overt nephropathy: macroalbuminuria and progressive
         decline in GFR

19
Connecting CKD and diabetes
     The presence of diabetes worsens
     the outcomes in all stages of CKD:
         • CVD outcomes

         • Dialysis survival

         • Post-transplant survival

20
CKD and diabetes, the connection
     Diabetes multiplies the morbidity/mortality event rate in CKD
     US Medicare (5% sample); Age >65, no RRT, followed 2yrs. n
     =1,091,201

                                                             D- CKD-        80%
                            60
                                                             D+ CKD- 17%
                            50
        Events/100 pt/yrs

                                                             D- CKD+ 2.2%
                            40
                                                             D+ CKD+ 1.6%
                            30

                            20

                            10

                            0
                                 ASVD   CHF            RRT                  Death

        ASVD, atherosclerotic vascular disease; CHF, chronic heart failure; RRT, renal
                                    replacement therapy
21
                                                       Foley et al. JASN 16: 489-495, 2005
Case study -
     Peter
     Background
     •   62 years old
     •   Caucasian male
     •   Works full-time in business
         management

     Today
     Peter presents at your general
     practice with an acute cough with
     yellow sputum
     He has previously been seen at
     your practice when he
     accompanied his wife for an annual
     flu vaccination

22
History
                      1 packet per day for 40
        Smoker:       years
                      (40 pack-year history)

        Alcohol:      7-10 drinks per week

        Nutrition:    Follows a “diabetic diet”
                      Type 2 diabetes, diagnosed
        Medical
                      12 months ago after
        conditions:
                      presenting with thirst
                     No regular medications,
        Medications: takes occasional NSAIDS for
                     back pain

23
Case study - Peter
     Today’s visit

      Test                  Result
      Blood pressure        160/90 mmHg
      Weight                102 kg
      BMI                   31 kg/m2
      Waist circumference   110 cm
                            Consistent with bronchitis - no
      Chest findings
                            clinical signs of COPD

24
Case study – Question
      Q1: Is Peter at increased risk of kidney
         disease?
         If so, why?

      Today’s visit
      Peter’s GP found some of his results and
      history concerning. The GP has asked you
      to review Peter’s case further, particularly
      his potential risk for kidney disease.

25
Risk factors for kidney disease
                                                                                                   Peter has 5 of
                                                                                                  the risk factors
      Diabetes                                                                                       for CKD
      Hypertension
     • Established cardiovascular disease
     • Family history of kidney failure
                                                                                                                1 in 3
      Obesity (BMI >30kg/m2)                                                                               Australian
      Smoker                                                                                               adults is at
     • Aboriginal or Torres Strait Islander                                                               increased risk
       origin                                                                                             of CKD due to
                                                                                                             these risk
     • History or acute kidney injury                                                                          factors
      Age over 60 years

                                            RACGP Guidelines for preventive activities in general practice 8 th edition;
26       Chronic Kidney Disease (CKD) Management in General Practice, 3 rd edition. Kidney Health Australia: Melbourne,
                                                                                                                  2015
Case study – Question
       Q1a: What does Peter’s diabetes mean for his
          CKD risk?

     •20-40% of patients with Type 2 diabetes develop
      nephropathy,
      which classically* occurs in 2 stages:
        Early nephropathy - microalbuminuria and
         normal-high GFR
        Overt nephropathy - macroalbuminuria and
         progressive decline in GFR
     * Recent data shows that 33% individuals with diabetes with
       eGFR
Classical stages of diabetic
     kidney disease*
              *Those with Type 2 diabetes may have overt nephropathy at presentation

       GFR                                                                normal

                                                                          normal

Albuminuria

                   0                5               10              15

                             Duration of Diabetes (years)
28
Further reading
     KinD Report 2014

                        www.kidney.org.au

29
Case study – Question
      Q1b: Peter has hypertension. What does
         this mean for his CKD risk?

     • Hypertension is extremely common among those
       with type 2 diabetes, particularly those with DKD

     • Among those with diabetes (and without), those
       with hypertension are 5-8 times as likely to have
       albuminuria

     • Achieving BP control is one of the most effective
       ways to delay the progression of kidney disease

30
Hypertension
     Adequate BP management delays the
     progression of CKD
     (reduces the GFR drop/year)

                                                                 160/90mmHg
     If Peter’s BP was consistently below
      target, his GFR loss per year would
              be reduced by 71%
31
                                            Bakris et al., Am J Kid Disease, 2000
Case study – Question
     Q1c: Peter is obese. What impact does his weight
        have on his risk of CKD?
      • Overweight (BMI 25.1-30) and obese (BMI
        >30) people are 40% and 80% more likely to
        develop CKD compared to normal weight
        individuals1
      • Central obesity appears to be more important
        than generalised
      • Obesity contributes to the development of
        albuminuria and proteinuria
      • Obesity leads to greater difficulty in achieving
        glycaemic control and BP control
32        1 Wang Y et al. Association between obesity and kidney disease: a systematic review and
                                                       meta-analysis. Kidney Int. 2008;73:19-33.
Case study – Question
      Q1d: How does smoking increase Peter’s risk of
           CKD?
     • Among individuals with diabetes, those who
       smoke are more likely to get albuminuria and
       among those with diabetic kidney disease,
       smoking accelerates progression to failure1,2
     • Even among the normal Australian population,
       smoking has been associated with kidney
       damage3

                         [1] Gambaro et al. Diabetes Nutr Metab 2001;14:337.
33                             [2] Orth & Hallan. Clin J Am Soc Nephrol 2007.
                              [3] Briganti et al. Am J Kidney Dis 2002;40:704.
Case study – Question
      Q1e: Does Peter’s occasional NSAID use increase his
           risk of CKD?

                      Probably not
     • Chronic use of NSAIDs have not been proven
       to lead to CKD in humans
     • NSAID ingestion can aggravate underlying
       kidney disease and hypertension and  risk
       of vascular events
     • NSAIDs should be avoided in this setting

34
Case study – Question
       Q1f: Will Peter’s chest infection contribute
           to his likelihood of CKD?
                          No
     • Chest infection by itself has no relationship to
       CKD
     • Recurrent chest infections are more common
       in smokers
     • With his history of smoking Peter is highly
       likely to develop COPD in the future

35
CVD risk
 Australian Absolute Cardiovascular Disease Risk
 Calculator

     **Peter is at increased risk of kidney disease and
     therefore also at risk of having a cardiovascular event.
36               www.cvdcheck.org.au
CVD risk
     anyone with…
         • eGFR < 45 mL/min/1.73m2 or persistent
            proteinuria
         • Diabetes and microalbuminuria
         • Diabetes and age > 60 years
         • Established cardiovascular disease
         • Familial hypercholesterolemia or total cholesterol above
            7.5
         • Severe hypertension
           – Systolic 180 mmHg or greater
           – Diastolic 110 mmHg or greater

     is already at the highest risk of a cardiovascular
                             event,
           therefore the calculator should not be used
37
      Guidelines for the management of Absolute cardiovascular disease risk: National Vascular Prevention Alliance.
Cardiovascular risk reduction in
 CKD
     • CKD is one of the most potent known risk factors
       for cardiovascular disease
     • It is essential to clinically determine the risk of
       CKD before using the Australian absolute
       cardiovascular risk tool (www.cvdcheck.org.au )
       to accurately calculate cardiovascular risk
     • Individuals with CKD have a 2-3 fold greater risk
       of cardiac death than individuals without CKD
     • People with CKD are at least 20 times more
       likely to die from cardiovascular disease than
       survive to need dialysis or transplant

38
Chronic Kidney Disease (CKD) Management in General Practice, 3rd edition. Kidney Health Australia: Melbourne, 2015
Resources
     Guidelines for the assessment and management
     of Absolute Cardiovascular Disease Risk
     National Vascular Disease Prevention Alliance

                                    Available at
                                                     www.cvdcheck.org.au

39
Checking for kidney damage
      Q2: What test results would you use as
         evidence of kidney damage?

     Peter is at increased risk of kidney disease and you
     decide to test him for evidence of kidney damage.
       ?   urine dipstick for blood and protein
       ?   spot urine albumin/creatinine ratio (ACR)
       ?   24 hour urine protein
       ?   serum creatinine
       ?   eGFR
       ?   renal ultrasound (kidney outline and size)

40
Checking for kidney damage

      ? urine dipstick for blood and protein
       spot urine albumin/creatinine ratio
        (ACR)
      ? 24 hour urine protein
       serum creatinine
       eGFR
      ? renal ultrasound (kidney outline and size)

41
Urine albumin /creatinine ratio
     (ACR)
        •     The preferred urine test in all diabetics is to look for microalbuminuria
        •     This is best tested by a urine albumin:creatinine ratio (ACR)
        •     Preferably 1st morning void but a random sample can also be used

     ACR result                  Test results range   Recommended follow -up
                                 Females 25
                                                      (to quantify protein excretion)
                                 mg/mmol
42
                                                                   NHMRC Guidelines 2009
Glomerular filtration rate
     • Glomerular filtration rate (GFR) best measure of
       kidney function
     • Can be estimated (eGFR) from serum creatinine
     • eGFR automatically provided by pathology
       laboratories when a creatinine is ordered (for adults
       over 18 yrs)
     • Reported as an actual numerical value or >
       90mL/min/1.73m2
     • eGFR is accurate at values  60 mL/min/1.73m2
     • Creatinine alone will commonly under-estimate the
       degree of reduction in kidney function, particularly in
       small elderly women
                                    Australasian Proteinuria Consensus Group, 2012
43
                                     Chudleigh et al, Diabetes Care 2007;30:300-5.
Comparing creatinine and
     eGFR
     Serum creatinine

                                                             CKD 1 & 2
                                        CKD 3b CKD 3a
                                CKD 4

                        CKD 5

                        0              30         60       90                  120
                                                GFR mL/min
                            Dialysis                             Albuminuria

                                       Normal Serum Creatinine level
44
                                       Actual Serum Creatinine level
Screening for CKD
     Indications for                                       Recommended                                             1 in 3
                                                                                              Frequency
     assessment*                                            assessments                                          Australia
     Diabetes
                                                                                                                 n adults
                                                        Urine ACR, eGFR, blood                                      is at
     Hypertension
                                                                  pressure                                      increased
     Established cardiovascular
     disease**                                                                                                    risk of
     Family history of kidney                       If urine ACR positive repeat twice                           CKD due
                                                                                                Every 1-2
     failure                                          over 3 months (preferably first
                                                              morning void)                       years†
                                                                                                                 to these
     Obesity (BMI ≥30 kg/m2)                                                                                         risk
                                                       If eGFR < 60mL/min/1.73m2
     Smoker                                                    repeat within                                      factors
     Aboriginal or Torres Strait                                  7 days

     Islander origin aged ≥ 30
     years‡
     History of acute kidney injury                              See recommendations in booklet
     *Whilst being aged 60 years of age or over is considered to be a risk factor for CKD, in the absence of other risk factors it
     is not necessary to routinely assess these individuals for kidney disease.
     **Established cardiovascular disease is defined as a previous diagnosis of coronary heart disease, cerebrovascular disease
     or peripheral vascular disease.
     † Annually for individuals with diabetes or hypertension.
     ‡ Refer to booklet for more details regarding recommendations for testing in Aboriginal and Torres Strait Islander peoples.
45   Chronic Kidney Disease (CKD) Management in General Practice, 3rd edition. Kidney Health Australia: Melbourne,
                                                                                                             2015
Kidney Health Check

                       Kidney Health Check

          Blood Test                           Urine Test                           BP Check

                                             Albumin /
               eGFR                       Creatinine Ratio                      Blood pressure
                                                                                      maintain
          calculated from                      (ACR)                             consistently below
         serum creatinine                        check for                            BP goal
                                                albuminuria

        CKD screening should be undertaken as a part of every
          chronic disease & cardiovascular risk assessment
46       Chronic Kidney Disease (CKD) Management in General Practice, 3rd edition. Kidney Health Australia:
                                                                                          Melbourne, 2015
Case study - Peter
     You identify Peter as being at increased risk for CKD
     and request he be recalled for further tests.

     Peter's test results show the following:

     Test               Result
     Creatinine         135 µmol/L
     eGFR               46 mL/min/1.73m2
     Urine ACR          44 mg/mmol (macroalbuminuria)
     HbA1c              9.6% / 81 mmol/mol
     Blood pressure     160/90 mmHg

47
Case study - Peter
     Q3: What can be done to improve Peter’s
        control of his diabetes?
     Good glycaemic control slows progression
     of kidney failure*
       • Prescribe exercise and diet
       • 44% of patients are on a sulphonylurea
       • Metformin okay to use in reduced doses when eGFR
         is between 30 and 60 mL/min - avoid use if GFR
         below 30 mL/min, due to risk of acidosis
       • Consider referral to endocrinologist and diabetes
         education centre

                 See Diabetes Australia website for
                 guidelines: www.diabetes.com.au

48
                                       *UKPDS. Lancet 1998;352:837-53
Drug therapy recommendations
     for non-insulin hypoglycaemic drug therapy for
     patients with stages 3b – 5 CKD
     CLASS                        CKD                                Complications
                                  Reduce dose
     Biguanide (Metformin)        Contraindicated GFR                Lactic acidosis
Drug class target sites
                                    Pancreas
     Liver                          -cell dysfunction
     Hepatic glucose
     overproduction

                                                 Sulphonylureas
                                                 Meglitinides            Muscle and fat
                                                 GLP-1 analogs           Insulin resistance
              Biguanide                          DPP 4 inhibitors
              TZDs

                                       ↓Glucose level

 Kidney
 Renal glucose                                                        Biguanides
                                                                      TZDs
 transport

                       SGLT2
                       Inhibitors                        -Glucosidase inhibitors

                                     Gut
50                                   Glucose absorption
Case study – Peter
     Q4: What can be implemented to reduce Peter’s
     blood pressure?

     a) Lifestyle modification?
     b) Medications? ACE-inhibitor, ARB or
        other drugs? Other?
     c) Do more tests?
     d) Refer on to an endocrinologist,
        nephrologist?

51
Hypertension in diabetes
      Lifestyle approaches are the first
      consideration in all people with diabetes
      and high blood pressure - the key
      elements are:
      SNAP - smoking, nutrition, alcohol, physical activity
       • Stop smoking
       • A low salt diet
       • A reduction in his alcohol intake
       • An exercise program
       • A low calorie diet to reduce his BMI

52
                     For more details General Practice Management of Type 2 diabetes 2014/15
Lifestyle effects on BP
     Modification Recommendation
     Weight                                                                              4.4mmHg (for 5.1kg
                                   BMI 18-24.9 kg/m2
     reduction                                                                           weight lost)
     Dietary                       Reduce dietary sodium intake 4-7mmHg (for
     sodium                        to no more than 2.4g sodium reduction by 6g in
     restriction                   (or 6g salt)                 daily salt intake)
                                                                                         5.5-11.4mmHg (5.5
                                   Fruit, vegies, low saturated                          for normotensives
     DASH diet
                                   and total fat                                         11.4 for
                                                                                         hypertensives)
     Physical                      Aerobic activity for 30-
                                                                                         5mmHg
     activity                      60mins/day, 3-5 days/week
     Moderate                                                                            3mmHg (for 67%
                                   No more than 2 drinks per
     alcohol                                                                             reduction from
                                   day (men) or 1 drink per day
     consumption                   (women)                                               baseline of 3-6
     only                                                                                drinks per day)
53   Tiberio MFrisoli et al Beyond salt; lifestyle modifications and blood pressure: European Heart Journal (2011) 32,
                                                                              3081–3087 doi:10.1093/eurheartj/ehr379
Hypertension in Diabetes
      Medications may be needed to
      lower blood pressure to target
      levels
      • The preferred anti-hypertensive
        agents in diabetes are an ACE-
        inhibitor or ARB
      • These agents may also slow
        progression of CKD
      • Any other anti-hypertensive
        agent that lowers blood pressure
        will improve the patient’s disease
54
        progression
Case study - Peter
       Peter has stage 3b CKD with macroalbuminuria and
      diabetes, so at high risk of a CVD event automatically
          and his blood pressure should be maintained
                 consistently below 130/80mmHg
     Flag with his GP to consider:
     • Starting a clinical action plan
     • Lifestyle modification
     • Pharmacotherapy to treat his hypertension
     • Monitor 6-12 weekly until sufficient
        improvement

                                       Maintain BP consistently
      People with....
                                          BELOW (mmHg)
      Albuminuria
Orange Clinical Action Plan

                             eGFR 30-59 mL/min/1.73m2 with microalbuminuria
                                   OR eGFR 30-44 mL/min/1.73m2 with
                                           normoalbuminuria
                          Goals of management
                          • Investigations to determine underlying cause
                          • Reduce progression of kidney disease
                          • Assessment of Absolute Cardiovascular Risk
                          • Avoidance of nephrotoxic medications or volume
                            depletion
                          • Early detection and management of complications
                          • Adjustment of medication doses to levels appropriate
                            for kidney function
                          • Appropriate referral to a nephrologist when indicated

56
Chronic Kidney Disease (CKD) Management in General Practice, 3rd edition. Kidney Health Australia: Melbourne, 2015
Orange Clinical Action Plan

                          Frequency of
                                                         3 to 6 months
                          monitoring
                          Clinical                       Blood pressure
                          assessment                     Weight

                                                         Urine ACR
                                                         eGFR
                                                         Biochemical profile including urea, creatinine,
                                                           electrolytes
                                                         HbA1c (for people with diabetes)
                          Laboratory                     Fasting lipids
                          assessment                     Full blood count
                                                         Calcium and phosphate
                                                         Parathyroid hormone (6-12 monthly if eGFR
Orange Clinical Action Plan
                              eGFR 30-59 mL/min/1.73m2 with
                              microalbuminuria OR eGFR 30-44
                            mL/min/1.73m2 with normoalbuminuria

                   It is also important to consider…

                  •    Absolute Cardiovascular Risk Assessment
                       (www.cvdcheck.org.au)
                  •    Lifestyle modification
                  •    Blood pressure reduction
                  •    Lipid lowering treatments
                  •    Glycaemic control

58   Chronic Kidney Disease (CKD) Management in General Practice, 3rd edition. Kidney Health Australia:
                                                                                      Melbourne, 2015
Screening and assessments
     Screening - search* for patients at risk and invite patients for a
     health check
     Health Assessments (Items 701, 703, 705, 707, 715)
        Screen those at risk            Assessments   Health Checks

                                                        A type 2 diabetes risk
          Diabetes                       701            evaluation for people aged
          Family history of kidney                      40-49 years (inclusive) with a
                                         703            high risk of developing type
          failure
                                                        2 diabetes as determined by
          Established CVD                705            the Australian Type 2
                                                        Diabetes Risk Assessment
          High blood pressure            707            Tool – once every 3 years to
                                                        eligible patients
          Obese (BMI >30kg/m2            715            A health assessment for
                                                        people aged 45-49 years
          Smoker                                        (inclusive) who are at risk of
                                                        developing chronic disease –
          Aboriginal or Torres Strait                   once only to an eligible
          Islander origin                               patient
     For more information visit www.mbsonline.gov.au
     *Use data management tools such as ‘PEN CAT’ to help find patients at risk
59
Annual diabetes cycle of care
 Item 2517
                             At least once every 12
     Twice every 12 months                            Every 12 months               Once every 2 years
                             months

                                                                                       Comprehensive eye
       Weight                  Total Cholesterol        Self Care education
                                                                                       examination
       Height                  Triglycerides            Diet
       BMI                     HDL-C                    Physical activity
       BP                      HbA1c                    Smoking evaluation
       Feet examination        Microalbuminuria         Medication Review
                               eGFR

     For more information visit www.mbsonline.gov.au
60
                                                      Diabetes Management in General Practice 14/15
Chronic disease management
     Medicare Australia has provided remuneration for
     chronic disease management by the following item
     numbers:
       GP Management Plan                               Other Items

         Items 721, 729 & 732                             Items 723, 10997, 10986

         For patient and GP management of chronic         Item 715 for Aboriginal and Torres Strait
         disease                                          Islander Health Assessments
         Incorporates patients goals, needs,              Involves collaboration with other health
         achievements and references to resources         professionals in patient care

         Electronic templates for specific conditions
         are available

         CKD template available at
         www.kidney.org.au/health-professionals

61
Monitoring and support
     Item 10997 / 10986
     For provision of monitoring and support to people with a chronic disease by a
     practice nurse or registered Aboriginal Health Worker, on behalf of a GP.
     Available for people who have a GPMP / TCA at a maximum of 5 services can be
     claimed per patient per calendar year. With 15 services available to Aboriginal
     or Torres Strait Islanders with a Health Assessment.

     The item may be used to provide:
        • Checks on clinical progress - eGFRs, ACR, BP
        • Monitoring medication compliance - BP medication(s)
        • Self management advice - personal goals
        • Collection of information to support GP reviews of care
           plans

     For more information visit www.mbsonline.gov.au

62
Resources
     CKD patient fact sheets
      Available along with more kidney health fact
              sheets at www.kidney.org.au

63
Case study – Peter
     Q5: Who could you involve in Peter’s
         management through a Team Care
         Arrangement?

64
Multidisciplinary Care Team
       May include, but is not limited to:
                                                               Community Health
         Exercise                        Family Members /       -weight and diet
                          Dietitian                                                   Nephrologist
       Physiologist                            carers           programs specific
                                                               to local community

      Optometrist/
                       Endocrinologist   Diabetes Specialist      Renal Nurse       Nurse Practitioner
     Ophthalmologist

                                                                    Vascular/
       Pharmacist        Podiatrist        Social Worker                               Cardiologist
                                                               Transplant Surgeon

     *N.B not all listed here are eligible for TCA inclusion.

65
Peter's management

     Q6: What will you review at Peter’s next visit
       and when?

      The recommended period for a GPMP review
      is every 3-6 months.

66
Management reviews
     History                 Examination     Investigation                 Review

       SNAP                    Weight          HbA1c                          Goals
       Patient’s record of
                               Waist circ.     Intercurrent illnesses
       home testing
       Foot symptoms           Height
                               BP

67
                                              Diabetes Management in General Practice 14/15
Nurse role in CKD
     Reduce the impact of CKD
     Screen for risks               Manage disease                Monitor patient progress

                                      Using care plans and item
       Using Kidney Health Check                                    Using item numbers
                                      numbers
       Diabetes                       Promote self management       Adherence to treatment

       Hypertension                   Diabetes                      Nephrotoxic medications
       Cardiovascular using
       Absolute CVD Risk              Hypertension
       Calculator*
                                      CKD
       Other CKD risk factors
       Using health checks & item     Symptoms
       numbers

     *Refer to slide 36

68
Summary
     Optimal management of DKD
     • Everyone with diabetes should have a kidney health
       check every year
     • Targets of therapy and management change in those
       with DKD e.g. blood pressure, glycaemia etc.
     • Major role for practice nurse in coordinating a
       multidisciplinary approach
     • Kidney disease is an integral part of chronic disease
       management
     • Overlap with diabetes management and CVD risk
       reduction
     • Encourage self management

         Potential to halve the number of
69    patients presenting with kidney failure
Resources
     CKD management in General Practice
     2015 guidelines handbook

                          Available   www.kidney.org.au/
                             at       health-professionals

70
Resources
                                    Rated a
     CKD-GO! Phone App          ‘must have’ App
                                   by Medical
                                    Observer

                             Available on
                         iTunes and Google
                           Play app stores
                     All the best bits of the
                     ‘CKD Management in
                   General Practice’ handbook
                      now in a handy app!
71
Resources
     My Kidneys, My Health Handbook & App
     Free resource for patients newly diagnosed with early
     stage CKD

                           App available on
                          iTunes and Google
                            Play app stores

      Hardcopy books available
           to order visit
72     www.kidney.org.au
Factsheet

                                             Urinary tract infections

     Resources                               How to look after your kidneys

     Healthshare fact sheets
                                             Kidney Health Check up

                                             GP only – Chronic Kidney Disease

      Chronic Kidney Disease fact sheets     All about Chronic Kidney Disease

       for patients. Available for Medical   Looking after yourself with CKD

      Director and Best Practice software    Kidney stones

                                             Kidney transplant

                                             Peritoneal dialysis

                                             Consent and kidney tests

                                             Kidney health tests

                                             Kidney cysts

                                             Access for dialysis

                                             Kidney cancer

                                             Treating kidney disease

                                             Homes haemodialysis

                                             Haemodialysis

                                             Life with a single kidney

                                             All about GFR
73
Resources
     Kidney Health Information Service

         Free call information service for people living with /
                       affected by kidney disease

     Kidney Community…
          Members receive a monthly newsletter from KHA allowing you to access:
     •   Information and invitations to KHA's education and support activities
     •   Updates on medical research in kidney disease
     •   Information on advocacy opportunities and government relations issues
     •   Information on community and corporate events held by Kidney Health Australia

                      To join the kidney community, email
                           community@kidney.org.au
74
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