COVID-19 Vaccination Information Session - Leanna Coy, FNP-C - Rinehart Clinic
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COVID-19
Vaccination
Information
Session
Leanna Coy, FNP-C
Why Should I Get Vaccinated?
Protection against COVID-19
Why Should I
Vaccination is safer way to build
Get Vaccinated
protection
for COVID-19?
Prevents from developing more
serious illness if exposed
Vaccinations are an important
tool to help stop the pandemic
COVID-19 Deaths by Age, Oregon, 2020–2021*
What Vaccines are Available?
COVID-19 Vaccines
mRNA Adenovirus Vector Protein Subunit
Pfizer-BioNTech Janssen Novavax
• 2 doses given 3 weeks apart • Single dose • 2 doses 3 weeks apart
• mRNA with lipid nanoparticle • Human adenovirus • Nanoparticle with matrix-M1
• Stored at -70oC • May be stored at 2-8oC adjuvant
• Emergency Use Authorization • Phase III trial ongoing • Phase III trial ongoing
Moderna AstraZeneca
• 2 doses given 4 weeks apart • 2 doses 4 weeks apart
• mRNA with lipid nanoparticle • Chimpanzee adenovirus
• Emergency Use Authorization • Phase III trial ongoing
6
https://www.idsociety.org/multimedia/clinician-calls/cdcidsa-covid-19-clinician-call-ask-the-expert-vaccine-qa-with-cdc
Vaccine Availability in Tillamook County
Dosing and Administration of Moderna
2 injections given 28 days apart
You should NOT receive 2nd dose earlier than recommended
For people age 18 and older
Does not contain live virus
mRNA vaccines are not interchangeable
Avoid other vaccines for a minimum of 14 days before or after receiving the
COVID-19 vaccine
8 https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html. Accessed 2/2/21.
How Does the Vaccine Work?
How mRNA Vaccines Work
(lipid nanoparticle)
Abbasi, J. (2020). "COVID-19 and mRNA Vaccines-First Large Test for a New Approach." JAMA 324(12): 1125-1127.
https://www.idsociety.org/covid-19-real-time-learning-network/vaccines/vaccines-information--faq/. Accessed 1/16/21.
https://www.fda.gov/media/144583/download. Accessed 2/1/21.mRNA Vaccines
Do not contain live virus
mRNA does not enter the nucleus
or modify DNA
mRNA and lipid nanoparticle break
down within hours to days
Spike (S) protein produced by the
body estimated to last a few weeks
You are not immediately protected
against the virusHow Effective Are the Vaccines?
94% effective for Moderna
How Effective 95% effective for Pfizer
Are the 66%effective for Johnson and
Vaccines? Johnson
70% effective for AstraZenicaModerna Vaccine
Early studies show 94% efficacy for preventing symptomatic,
laboratory-confirmed COVID-19 after 2 doses
Follow up data shows detectable antibodies after 119 days
Serious adverse events of 0.6% seen with both vaccinated and
placebo groups
14 Baden, L. R., et al. (2020). "Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine." N Engl J Med.
Widge, A. T., et al. (2021). "Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination." N Engl J Med 384(1): 80-82.Pfizer-BioNTech Vaccine
95% effective in preventing symptomatic, laboratory-
confirmed COVID-19 after 2 doses
Serious adverse events similar with both vaccine and
placebo groups (0.6% and 0.5%)
Polack, F. P., et al. (2020). "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine." N Engl J Med 383(27): 2603-2615.
15Are the Vaccines Safe?
YES!
No short cuts were taken in the process
mRNA has been used in immune response in
animals for more than 30 years
Lipid nanoparticles have been researched in
animal models for years
Prior to the COVID-19 pandemic other mRNA
vaccines were in trialsmRNA Vaccine Safety
Pfizer- Moderna Combined
BioNTech
People vaccinate with 1 or 12,153,536 9,689,497 21,843,033
more doses in U.S.
At least 1 v-safe health 997,042 1,083,174 2,080,216
check in
Pregnancies reported to v- 8,633 6,498 15,131
safe
18 https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-01/06-COVID-Shimabukuro.pdf. Accessed 2/11/21.Common Side Effects Uncommon side effects Low grade fever Immediate allergic Chills reaction Soreness at the High fever injection site Muscle pain Headache Joint pain Slight fatigue Nausea
Reaction Percent for Moderna 1st Pfizer- Pfizer-
Days 0-7 All Vaccines dose BioNTech BioNTech
1st dose 2nd dose
Pain 70.7 70.1 67.7 74.8
Fatigue 33.4 29.7 28.6 50.0
Headache 29.4 26.0 25.6 41.9
Myalgia 22.8 19.6 17.2 41.6
Chills 11.5 9.3 7.0 26.7
Fever 11.4 9.1 7.4 25.2
Swelling 11.0 13.4 6.8 26.7
Joint pain 10.4 8.6 7.1 21.2
Nausea 8.9 7.7 7.0 13.9
20 https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-01/06-COVID-Shimabukuro.pdf. Accessed 2/21/21.Estimated Anaphylaxis
Doses administered Anaphylaxis Reporting rate
cases
Moderna 7,581,429 21 2.8 per million doses
given
Pfizer-BioNTech 9,943,247 50 5.0 per million doses
given
https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-01/06-COVID-Shimabukuro.pdf. Accessed 2/1/21Who Should Not Get the Vaccine?
Underlying Medical Conditions
MAY PROCEED WITH PRECAUTION TO VACCINATION CONTRAINDICATION
VACCINATION TO VACCINATION
Conditions Conditions Conditions
• Immunocompromised • Moderate to severe acute • None
• Pregnancy illness
• Lactation
ACTIONS ACTIONS ACTIONS
• Additional information • Risk assessment • N/A
provided • Potential deferral of
• 15 min observation period vaccination
• 15 min observation period if
vaccinated
23Allergies
MAY PROCEED WITH PRECAUTION TO CONTRAINDICATION TO
VACCINATION VACCINATION VACCINATION
History of allergies unrelated History of immediate allergic • Anaphylaxis after previous mRNA
to mRNA COVID-19 vaccine or reaction to vaccine or COVID-19 vaccine or any of its
components injectable therapy (except ingredients
• Oral medication those related to mRNA COVID- • Immediate allergic reaction of
• Food, pet, insect, venom, 19 vaccines) any severity to previous mRNA
environmental, latex, etc. COVID-19 vaccine or components
• Immediate allergic reaction to
any polysorbate
ACTIONS ACTIONS ACTIONS
• 30 min observation for any • Risk assessment • Do not vaccinate*
history of anaphylaxis • Consider deferring vaccine • Consider referral to allergist
• 15 min observation for any and/or referral to allergist
other reaction • 30 min observation if
vaccinated
24 https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html. Accessed 1/18/21What if I had or think I had COVID-19?
Current or Prior COVID-19 Infection
Vaccination should be delayed until:
Recovered from acute illness AND
Criteria have been met to discontinue isolation
While vaccine supplies remain limited people with documented recent
COVID-19 infection may delay vaccination
26 https://www.cdc.gov/coronavirus/2019-ncov/hcp/disposition-hospitalized-patients.html. Accessed 2/12/21.
https://www.cdc.gov/coronavirus/2019-ncov/hcp/disposition-in-home-patients.html. Accessed 1/18/21.Laboratory Testing
Viral testing to assess for acute infection or serologic testing to assess for prior
infection for purposes of vaccine decision-making is NOT recommended
Cough, shortness of breath, loss of taste/smell, runny nose, sore throat are
NOT consistent with post-vaccination symptoms and could indicate SARS-CoV-2
infection
Quarantine until negative COVID-19 screening
Symptoms such as fever, body aches, fatigue may be related to vaccination
https://www.cdc.gov/coronavirus/2019-ncov/hcp/post-vaccine-considerations-healthcare-personnel.html
27 https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.htmlDo I Need to Wear a Mask After Being Vaccinate?
Continue Current Recommendations to
Prevent the Spread of COVID-19
Wear a mask
Stay at least six feet away from others
Avoid crowds
Wash hands with soap and water for 20 seconds or using hand sanitizer with at
least 60% alcohol
Follow CDC travel guidance
Follow quarantine guidelines after exposure to COVID-19
Follow any workplace guidelinesWill the Vaccine Prevent Me from Infecting Others?
Will the Vaccine Prevent Me from Infecting Others?
We don’t know
Clinical trials did not measure if vaccine decreases risk of infecting others
Immune response triggered by the vaccine may reduce the amount of virus
in your body
More research is neededWhen Can I Get Vaccinated?
https://covid.cdc.gov/covid-data-tracker/#vaccinations. Accessed 2/14/2021.
Vaccine doses administered in Oregon
ALL LOCATIONS TILLAMOOK COUNTY
Series in Progress 286,767 1,903
Fully Vaccinated 189,061 585
Total People 475,828 2,488
34
https://public.tableau.com/profile/oregon.health.authority.covid.19#!/vizhome/OregonCOVID-
19VaccinationTrends/OregonStatewideVaccinationTrends. Accessed 2/14/2021.COVID-19 Vaccination Phases
December 13 Group 1A
• Health care personnel
• First responders
• Long-term care facility residents and staff
January 25 • Childcare providers
• Early learning educators
• K-12 educators and staff
February 8 • People age 80 and older
February 15 • People age 75 and older
February 22 • People age 70 and older
March 1 • People age 65 and older
To be determined • 1B: Front-line essential workers
• 1C: Other essential workers
• 2: All othersFederal Retail Pharmacy Program
The program is beginning this week in Oregon.
Locations in 27 of Oregon’s 36 counties
103 Safeway/Albertson’s locations, 13 Costco Locations, and 11 Health Mart
(independent affiliate) pharmacies.
Each site is currently only scheduled to receive 100 doses per week
Costco: costco.com/covid-vaccine.html
Safeway/Albertsons: safeway.com/pharmacy/covid-19.htmlFrontline Essential Workers Food and agriculture Manufacturing U.S. Postal Service workers Public transit workers Grocery store workers
Other Essential Workers Transportation and logistics Food service Shelter and housing Finance Information technology and communication Energy Media Legal Engineers Water and wastewater Grocery store workers
What About the Children?
Vaccines for children?
Pfizer is already approved for 16-18, so
their study looks at 12-15
Moderna is looking at 12-18 year old
individuals
AstraZenica will have two study groups of
12-18 and 6-11 year old individuals
Johnson and Johnson will start trials in
children six weeks after EUA approval.
40
https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-first-participants-dosed-phase-23-study-covidWhat to Know Before You Go
Know Before You Go
Make sure the site you plan to go is accepting individuals in your group
Check to see if you need an appointment
Wear a mask that covers your mouth and nose
There is not cost for the vaccine
You should receive a vaccination card that tells you when to get your second
dose
Get the 2nd dose from the same site you received your first dose
Use OHA’s vaccine information tool to sign up for a mass vaccination event:
covidvaccine.oregon.gov
Online Vaccine Form for Rinehart Clinic:
https://www.facebook.com/RinehartClinic/posts/3744708415584772Take-Home Points
COVID-19 mRNA vaccines do not contain live virus and do not alter DNA
No underlying medical conditions are contraindications to vaccination
Be patient
Continue to practice social distancing, masking, and hand washing
Online Vaccine Form for Rinehart Clinic - People (65+) can sign up if they are
interested in getting the vaccine:
https://www.facebook.com/RinehartClinic/posts/3744708415584772
Go to covidvaccine.oregon.gov to sign up for notifications
43Questions?
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