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PROGRAM ANNUAL CONGRESS
2021
Immunology
after COVID-19
AUGUST 19 – 20, 2021
Irchel Campus, University of Zurich
Credits
FAMH SGAI SGDV SVVLD VSKT
10 Credits 11 Credits 9 Credits 2 education Recognition to the extent of 0.5 day
SGINF SGMO SGR points for Animal welfare officers / Study
4 Credits 9 Credits 8 Credits directors / Involved persons
www.congress-info.ch/ssai2021
11/202011/2020
C-APROM/CH//0492
ANNUAL CONGRESS
C-APROM/CH//0492
C-APROM/CH/CUVI/0003
2021
C-APROM/CH/CUVI/0003
TABLE OF CONTENTS
Welcome 04
More
Moreflflexibility
exibilityfor
foryour
your Scientific Program 05–12
patients
patientswith
withPID
PID
Chairs and speakers 14–15
Room plan / Exhibition 16
CUVITRU
CUVITRU®®––tailoring
tailoring REIMAGINETHE
REIMAGINE THEWAY
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SCIG
SCIGtreatment
treatment forfor YOU TREAT
YOU TREATHAE
HAE Sponsors / Exhibitors 17
the
theindivitual
indivitualneeds
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of •• SIGNIFICANT
SIGNIFICANTREDUCTION
REDUCTIONININ ATTACKS
ATTACKS
yourpatients
your patients1-3
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OUTOFOF1010PATIENTS
PATIENTSHAD ZERO
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ZERO ATTACKS
Organization 22
References: •• IMPROVEMENT
IMPROVEMENTININQUALITY
QUALITY OFOF
LIFE 1
LIFE1
References:
1. Cuvitru
1. Cuvitru ®
®
, www.swissmedicinfo.ch.
, www.swissmedicinfo.ch. CLINICALLY
CLINICALLYMEANINGFUL
MEANINGFUL IMPROVEMENT
IMPROVEMENT IN IN
2. Borte M, et al. Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globu-
2. Borte M, et al. Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globu- QUALITY OF LIFE WITH TAKHZYRO TM
lin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.
lin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.
Clin Exp Immunol. 2016;187:146–59.
QUALITY OF LIFE WITH TAKHZYRO TM
Clin Exp Immunol. 2016;187:146–59.
3. Suez D. et al, Efficacy, Safety, and Pharmacokinetics of a Novel Human Immune Globulin Subcut- •• 2x
2x AAMONTH
1
3. Suez
aneous,
D. et 20%
aneous,
201620%
al, Effi incacy, Safety,
Patients withand Pharmacokinetics
Primary Immunodeficiency of aDiseases
Novel Humanin North
in Patients with Primary Immunodeficiency Diseases in North America, J Clin Immunol
36:700–712.
Immune
America, Globulin Subcut-
J Clin Immunol MONTH1
ONE SUBCUTANEOUS SELF-INJECTION General information 23
2016 36:700–712. ONE SUBCUTANEOUS SELF-INJECTION
PID = Primary Immune Deficiencies; SCIG = Subcutaneous Immunoglobulin
PID = Primary Immune Deficiencies; SCIG = Subcutaneous Immunoglobulin
CUVITRU Succinct Statement:
CUVITRU Succinct Statement: (SCIg) 200 mg / ml (min. 98 % IgG). I: Substitution therapy for adults, Lanadelumab injection sous-cutanée
C: Human
C: Human
children
immunoglobulin
immunoglobulin
and adolescents(SCIg) (0–18200 mgPrimary
years): / ml (min. 98 % defi
immune IgG). I: Substitution
ciency diseases with therapy
impairedfor antibo-
adults, Reference: Lanadelumab injection sous-cutanée
children and adolescents
dy formation. (0–18 years): Primary
Hypogammaglobulinaemia and immune
recurrentdefi ciencyinfections
bacterial diseasesinwith impaired
patients antibo-
with chronic Reference:
1. Prescribing information TakhzyroTM online available under www.swissmedicinfo.ch
lymphocytic
dy formation. leukaemia (CLL) in whomand
Hypogammaglobulinaemia prophylactic
recurrenttreatment
bacterial with antibiotics
infections has failed
in patients withorchronic
is con- 1. Prescribing information TakhzyroTM online available under www.swissmedicinfo.ch
traindicated.
lymphocytic Hypogammaglobulinaemia
leukaemia (CLL) in whom prophylactic and recurrent bacterial
treatment withinfections
antibiotics in patients
has failed withormultiple
is con- Information professionnelle court: (Lanadelumab). Anticorps IgG1 monoclonal recombi-
myelomaHypogammaglobulinaemia
traindicated. (MM). Hypogammaglobulinaemia in patients
and recurrent before infections
bacterial and after allogeneic
in patients haematopoietic
with multiple nant humain. I:
Information Pour la prévention
professionnelle court:à long terme des crises
(Lanadelumab). de l’angiooedème
Anticorps IgG1 monoclonal héréditaire
recombi-
myelomastem(MM).
cell transplantation (HSCT). D: Dosage
Hypogammaglobulinaemia and dosing
in patients intervals
before depend
and after on the indication
allogeneic haematopoieticas well (AOH) chez lesI:patients
nant humain. Pour la âgés de 12 ans
prévention et plus.
à long termeD: La dose
des recommandée
crises de l’angiooedème est de 300 mg
héréditaire
as trough levels and clinical response. Dosage should be
stem cell transplantation (HSCT). D: Dosage and dosing intervals depend on the indication adjusted to maintain an IgG troughas level
well toutes les 2 semaines. Un intervalle de dose de 300 mg toutes les 4 semaines
(AOH) chez les patients âgés de 12 ans et plus. D: La dose recommandée est de 300 mg est également
(measured
as trough levelsbefore the next
and clinical infusion)Dosage
response. of at least 5–6 gbe
should / Ladjusted
and aim to to be within the
maintain serum
an IgG reference
trough level effi caceles
toutes et 2peut être considéré
semaines. lorsque
Un intervalle le patient
de dose de 300 estmg
bien stable
toutes lesdepuis
4 semainesplus de
est6également
mois
interval for IgG for the appropriate age. For subcutaneous use only.
(measured before the next infusion) of at least 5–6 g / L and aim to be within the serum reference AI: Known anaphylactic or severe (p.
effiex.
cacen‘aetplus eu être
peut de crise). CI: Hypersensibilité
considéré lorsque le patientau principe actifstable
est bien ou à l’un des excipients.
depuis plus de 6 mois
hypersensitivity reactions to subcutaneous administration of the active substance or to any of the MG&P: Réactions d’hypersensibilité: Comme pour tout anticorps monoclonal, des réactions
interval for IgG for the appropriate age. For subcutaneous use only. AI: Known anaphylactic or severe (p. ex. n‘a plus eu de crise). CI: Hypersensibilité au principe actif ou à l’un des excipients.
excipients. Severe IgA deficiency and history of hypersensitivity to treatments with human immuno- graves peuvent apparaître, p. ex. chute de tension, tachycardie, vertiges, dyspnée, nau-
hypersensitivity reactions to subcutaneous administration of the active substance or to any of the MG&P: Réactions d’hypersensibilité: Comme pour tout anticorps monoclonal, des réactions
globulins. Intravenous or intramuscular administration. PR: If CUVITRU is accidentally administered sées, urticaire et autres symptômes cutanés; Interférence avec les tests de coagulation:
excipients. Severe IgA deficiency and history of hypersensitivity to treatments with human immuno- graves peuvent apparaître, p. ex. chute de tension, tachycardie, vertiges, dyspnée, nau-
into a blood vessel, the patient may develop shock. If severe allergic or anaphylactic reactions are augmentation de aPTT sans changer l‘RNI et pas associée à des évènements hémorragiques
globulins. Intravenous
suspected, or intramuscular
the infusion must be stopped administration.
immediately. PR:IA:
If CUVITRU is accidentally
Administration administered
of immunoglobulin may sées, urticaire
indésirables et autres
anormaux. IA: symptômes
Aucune étude cutanés; Interférence
n’a été réalisée avec les tests
pour enregistrer de coagulation:
les interactions
into ainterfere
blood vessel,
with thethe effipatient
cacy of may develop shock.
live attenuated If severesuch
viral vaccines allergic or anaphylactic
as measles, reactions
rubella, mumps and are
va- augmentation
et les interactionsde aPTT
médiéessanspar
changer
l’enzyme l‘RNI et pas
CYP sontassociée
donc peu à des évènements
probables. EI: trèshémorragiques
fréquent
suspected, the infusion must be stopped immediately. IA: Administration
ricella for a period of at least 6 weeks up to 3 months. AE: Very common (≥10 %): headache (22.1 %), of immunoglobulin may indésirables
(≥1/10): anormaux.
réactions IA: Aucune fréquent
au site d’injection, étude n’a(≥1/100,
été réalisée
ANNUAL CONGRESS
2021
WELCOME FROM THE PRESIDENTS OF PROGRAM – THURSDAY, 19TH OF AUGUST 2021
THE ORGANIZING COMMITTEE
Dear Friends, dear Colleagues,
09:00 – 09:45 h Registration
We are delighted to invite you to the 2021 Annual Congress of the Swiss Society for 09:45– 10:00 h Welcome
Allergology and Immunology (SSAI) that will take place on 19th and 20th of August 2021 at Burkhard Becher, (Zurich, CH)
the Irchel Campus of the University of Zurich.
10:00 – 10:30 h Plenary Lecture 1: Allergy
Chair: Thomas Kündig, (Zurich, CH)
We are happy that the Annual Congress of SSAI is one of the first venues to return to
international scientific exchange, networking with your colleagues and a Novel Insights into Immune Regulation of Allergic Inflammation
celebration of immunology and allergology. for Airway Disease by Allergen Immunotherapy (AIT)
Mohamed Shamji, (London, UK)
Therefore, the theme of our Congress is «Immunology after COVID-19», pushing open the
10:30 – 11:00 h Coffee break
door to exciting new developments in allergology and reflecting on lessons in immunology
of infectious diseases that we have learned from the current pandemic. This will include 11:00 – 12:30 h Symposia 1 a–c
both basic immunology and allergology, diagnostics and new treatment options. We have
assembled three exiting plenary lectures and 12 workshops in which both established and Symposium 1a: Basic Immunology Autoimmunity
young investigators will present their cutting-edge research. We have attracted prominent Chair: Burkhard Becher, (Zurich, CH)
national and international speakers and the meeting will bring together established basic CD8+ T cells as drivers of compartmentalized immune
scientists and clinicians along with young researchers and residents, postdocs and stu- responses in the CNS
dents, who will have many opportunities to present their work at workshops and poster Doron Merkler, (Geneva, CH)
sessions in an attractive setting that will maximize interactions among the participants.
How IL-17 regulates CNS autoimmunity via modulation
We strongly encourage companies, organizations and institutions to sponsor and exhibit of the gut microbiota
at the Congress and to take advantage of the opportunity to interact face-to-face with Ari Waisman, (Mainz, D)
professionals from all over Switzerland to build visibility, to introduce new products and Abstract Talk (OP4): Characterization of autoreactive T cells
services, and give product demonstrations. We count on their presence and support to in Guillain-Barré syndrome.
make this meeting a great event. Daniela Latorre, (Zurich CH)
Abstract Talk (OP3): SLAMF7 and CD38 as Possible New Thera-
We will keep you informed about registration and abstract deadlines, fellowships for
peutic Targets on NK Cells for Systemic Lupus Erythematosus
students, assistants and postdocs, and will update the preliminary program continuously.
Morgane Humbel, (Lausanne CH)
Together with the members of the Local Organizing Committee, we are looking forward Symposium 1b: Clinical Immunology
to welcoming you to Zurich and to an exciting Congress. Allergy
Chair: Peter Schmid-Grendelmeier, (Zurich, CH) /
Peter Jandus, (Geneva, CH)
Presidents of the Organizing Committee
Molecular approaches for allergen-specific immunotherapy
and preventive allergy vaccination
Christian Münz and Burkhard Becher
Rudolf Valenta, (Vienna, AT)
Institute of Experimental Immunology Lung neutrophils: regulators of immune-mediated disorders
University of Zürich Thomas Marichal, (Liège, B)
Abstract Talk (OP14): Cytokine dominance in delayed drug
hypersensitivity correlates with the clinical picture
Daniel Yerly, (Bern CH)
Abstract Talk (OP16): Ligelizumab as add-on therapy for
patients with anti-H1-refractory CSU:Primary results of a
placebo- and active-controlled phase 2b dose-finding study
Nico Janssens, (Basel, CH)
04 > www.congress-info.ch/ssai2021/ 05
ANNUAL CONGRESS
2021
Benlysta is
Designed for Lupus
PROGRAM – THURSDAY, 19TH OF AUGUST 2021
Symposium 1c: Laboratory Diagnostics
Chair: Elsbeth Probst, (Zurich, CH) / Ingmar A.F.M. Heijnen, (Basel, CH)
PID diagnostics in the flow - What is really helpful in a fast
moving world?
Klaus Warnatz, (Freiburg, D)
Sense and Nonsense of Allergy Serology
Michael Horn, (Bern, CH)
Abstract Talk (OP9): Quantification of IL-1 with Electrochemi-
cal Biosensors by Electrochemical Impedance Spectroscopy
(EIS), using Screen Printed Electrodes (SPE).
Joana Costa, (Bern CH)
Abstract Talk (OP11): Highly specific and reliable in vitro
diagnostic analysis of memory T and B lymphocytes in a Swiss
cohort of Covid-19 patients
Lester Thoo, (Bern CH)
12:30 – 14:00 h Lunch break with industry exhibit
Superior disease activity reduction 13:00 – 13:45 h Company Symposium
compared to standard therapy alone1 Severe Asthma Satellite Symposium SSAI 2021
Sponsored by GlaxoSmithKline AG
Targeting eosinophilic diseases in real life. Update on treating
severe eosinophilic asthma and EGPA in Europe and Switzerland.
Reduction of disease activity in patients aged 5 years and older (infusion solution) and in patients aged Prof. Dr. med. Jörg D. Leuppi, Head physician Pneumology
18 years and older (subcutaneous injection) respectively with active autoantibody positive systemic lupus Kantonsspital Baselland /Dr. med. Urs Steiner, Leading physician
erythematosus (SLE) who are receiving standard therapy. Belimumab has not been studied in patients Clinic for Immunology Universitätsspital Zürich
with severe active central nervous system lupus or severe active lupus nephritis.1
SYIS Symposium
BENLYSTA powder for making an infusion solution, solution for subcutaneous injection. AI: Belimumab. I: Reduction of disease activity in patients aged 5 years and older (infusion solution) and in patients Introduction of SYIS & presentation of selected abstracts
aged 18 years and older (subcutaneous injection) respectively with active autoantibody positive systemic lupus erythematosus (SLE) who are receiving standard therapy. Belimumab has not been studied in Dr. Daniella Latorre
patients with severe active central nervous system lupus or severe active lupus nephritis. D: Patients ≥ 5 years: Infusion solution: 10 mg/kg on Days 0, 14, 28, and at 4weeks intervals thereafter. I.v.-infusion
over a 1 h period; must not be administered as an i.v. push or bolus. Premedication with an oral antihistamine, with or without an antipyretic, may be administered. Patients should be monitored during and 14:00 – 15:30 h Symposia 2 a–c
for an appropriate period of time after administration. Patients ≥ 18 years: Solution for subcutaneous injection: 200 mg once a week, on the same day of the week (independent of body weight). S.c.-injection
(abdomen or thigh). Suitable training of patient in the technique associated with s.c. injection and the perception of signs and symptoms of hypersensitivity reactions. Switch from i.v.- to s.c.-treatment: first Symposium 2a: Basic Immunology
s.c. dose approx. 2 weeks after the last i.v. dose. General: consider discontinuing treatment if there is no improvement in the control of the disease after 6 months. For elderly patients and patients with renal B cell responses
impairment, dosage adjustment is not recommended. Hepatic impairment: see product information. CI: Hypersensitivity to one of the ingredients. W/P: Infusion-, injection- and hypersensitivity reactions are Chair: Davide Robbiani, (Bellinzona, CH) / Doron Merkler, (Geneva, CH)
possible, which can be severe, or fatal (delay in onset, and recurrence after initial resolution possible). Patients should be made aware of potential risks and signs of such reactions. Increased risk of infection
possible. Presenting neurological symptoms, possibility of progressive multifocal leukoencephalopathy (PML) should be considered. Increased potential risk for development of malignancies. Before treatment Human B cell memory to emerging viruses
with belimumab, the patient’s risk for depression or suicide must be carefully evaluated and the patient must be monitored accordingly during treatment. The physician must be contacted in the event of new Davide Robbiani, (Bellinzona, CH)
or worsening psychiatric symptoms. Application in combination with other B-cell-targeted therapy or cyclophosphamide i.v. was not studied. Live vaccines should not be given for 30 days before or concurrently
with Belimumab. IA: No drug interaction studies have been conducted. Evidence of increased clearance of belimumab i.v. when co-administrated with steroids and ACE inhibitors. P/L: Pregnancy: Belimumab Evolution of human B cell memory to a malaria parasite protein
should only be used if the potential benefit to the mother justifies the potential risk to the foetus. If indicated, women of childbearing age should use adequate contraceptive measures while being treated Hedda Wardemann, (Heidelberg, D)
and for at least four months after the last treatment. Lactation: Safety not verified. In consideration of all aspects it is recommended to consider discontinuing breast-feeding. UE: Very common: Infections,
nausea, diarrhoea. Common: Hypersensitivity-, infusion- and injection-related reaction, pyrexia, (rhino)pharyngitis, bronchitis, cystitis, gastroenteritis viral, pain in extremity, insomnia, depression, migraine, Abstract Talk (OP23): Low-affinity but high-avidity interactions
leukopenia; reactions at the administration site (s.c.-injection). Uncommon: a. o. bradycardia, anaphylactic reaction, angioedema, Suicidal thoughts, suicidal behavior, rash. Store: at + 2 °C to + 8 °C, may offer an explanation for allergen-cross-reactivity
do not freeze. P: Powder for making an infusion solution: 120 mg and 400 mg vial. Solution for subcutaneous injection: Autoinjector 200 mg (1 ml) ×1 and ×4. DC: Vial: A. Autoinjector: B. Last updated: Xinyue Chang, (Bern CH)
September 2020. GlaxoSmithKline AG, 3053 Münchenbuchsee. Detailed information you can find under www.swissmedicinfo.ch. Please report adverse drug reactions under pv.swiss@gsk.com.
Abstract Talk (OP10): Mild COVID-19 elicits early functional
Reference: 1. Fachinformation Benlysta, www.swissmedicinfo.ch. plasmablasts and long-term memory B cells while sustaining
neutralizing antibody titers
Trademarks are owned by or licensed to the GSK group of companies.
Paola Andrea Martinez Murillo, (Geneva CH)
©2021 GSK group of companies or its licensor.
GlaxoSmithKline AG, Talstrasse 3–5, CH-3053 Münchenbuchsee,
Tel. +41 (0)31 862 21 11, Fax +41 (0)31 862 22 00, www.glaxosmithkline.ch 06 > www.congress-info.ch/ssai2021/ 07
PM-CH-BEL-JRNA-210003-06/2021
ANNUAL CONGRESS
2021
CONGRESS DINNER AT THE PROGRAM – THURSDAY, 19TH OF AUGUST 2021
«ZUNFTHAUS ZUR MEISEN»
Symposium 2b: Clinical Immunology
Inflammation
Thursday, 19 august 2021 Chair: Mike Recher, (Basel, CH) / Burkhard Ludewig, (St. Gallen, CH)
Immunological approaches to suppress inflammaging
Cultural activities and hospitality look back on a long tradition in the «Zunfthaus zur
and promote systemic rejuvenation
Meisen». Food and drink are very closely related to the vintners’ guild. In 1757, the guild
Alexander Eggel, (Berne, CH) – Sanofi laureate 2020
for innkeepers, painters and saddlers, founded in 1336, moved into its new guild house at
one of the prime locations in Zurich. Business deals were discussed and political plans The cGAS-STING pathway in health and disease
were concocted. In the evenings, guild members would meet in the guilds’ lounge for a Andrea Ablasser, (Lausanne, CH)
nightcap.
Abstract Talk (OP17): Investigation of the PI3K-dependent
inflammation in chronic inflammatory pulmonary disease
he most important events, however, were the guild meetings frequently accompanied
T
Jeremy Yeoh, (Bern CH)
by a rich meal.
Abstract Talk (OP22): Alveolar macrophages strictly rely on
In Zurich, the guilds had attained a position hardly found anywhere else. GM-CSF from alveolar epithelial type 2 cells after birth and
They were the pillars of the city-state. The government was made up of their masters, throughout adulthood
and guild members handled a large part of the administrative work. Julia Gschwend, (Zurich CH)
Symposium 2c: Clinical Immunology
Immune regulation
Chair: Werner Held, (Lausanne, CH) / Daniel Legler, (Thurgau, CH)
COSTS SCHEDULE Shielding immune cells for targeted immunotherapy
Lukas Jeker, (Basel, CH)
SSAI Members, Non-members CHF 120.00 18.30 h Rhythms in adaptive immune responses
Reception at the Uni Irchel Christoph Scheiermann, (Geneva, CH)
Assistant Doctors, Students CHF 90.00
Abstract Talk (OP5): c-Maf expression induces memory-like
19.15 h features in mouse and human ILC2 enforcing their type 2
Bustransfer to the restaurant functional identity
Sara Trabanelli, (Geneva CH)
«Zunfthaus zur Meisen»
Abstract Talk (OP7): CD85k Contributes to Regulatory T Cell
19.30 h Function in Chronic Viral Infection
Congress Dinner at the Anna Estrada Brull, (Zurich CH)
«Zunfthaus zur Meisen» 15:30 – 16:00 h Coffee break
16:00 – 17:00 h Poster session with presenters present at
23.00 h even numbered posters
Individual return 17:00 – 18:30 h SSAI General Assembly
18:30 – 19:15 h Evening Reception
19:30 – 23:00 h Congress Dinner
08 > www.congress-info.ch/ssai2021/ 09
ANNUAL CONGRESS
2021
PROGRAM – FRIDAY, 20TH OF AUGUST 2021 PROGRAM – FRIDAY, 20TH OF AUGUST 2021
08:30 – 09:00 h Registration Symposium 3c: Clinical Immunology
Novel biologics in immunotherapy
09:00 – 09:30 h Plenary Lecture 2: Cancer immunotherapy Chair: Thomas Hauser, (Zurich, CH) / Onur Boyman, (Zurich, CH)
Chair: Daniel Speiser, (Lausanne, CH)
Mitochondria dynamics tailor T cell anti-tumor immunity
T cell receptor gene therapy Ping-Chih Ho, (Lausanne, CH)
Thomas Blankenstein, (Berlin, D)
Immunotherapy with Gene Engineered T Cells
09:30 – 10:00 h Coffee break Hans Stauss, (London, UK)
10:00 – 11:30 h Symposia 3 a–c Abstract Talk (OP1): Development of a compartment locked
IL-12 version with increased tissue retention and minimal
Symposium 3a: Clinical Immunology peripheral exposure for local glioblastoma therapy
Vaccination Linda Schellhammer, (Schlieren CH)
Chair: Martin Bachmann, (Bern, CH) / Steve Pascolo, (Zurich, CH)
Abstract Talk (OP6): Anti-CD20 rituximab IgG1, IgG3 and IgG4
Preclinical development of vaccine candidates against COVID-19 but not IgG2 subclass differentially trigger Ca2+ mobilization
Martin Bachmann, (Bern, CH) and cytotoxicity in human NK cells
YF17D-based vaccines against COVID-19 and other Marta Freitas Monteiro, (Geneva CH)
emerging infections 11:30 – 13:15 h Lunch break with industry exhibit
Kai Dallmeier, (Leuven, BE)
12:15 - 13:00 h Company Symposium
Abstract Talk (OP2): HLA-DRB1*04 associated chronic Sponsored by Novartis Pharma Schweiz AG
inflammation and extracellular matrix-specific autoimmunity
following inadvertent periarticular influenza vaccination Familial mediterranean fever (FMF) - behind the scene
Julia R. Hirsiger, (Basel CH) More than just fever: diagnosis and standard treatment of FMF/
How to treat patients with FMF and amyloidosis
Abstract Talk (OP24): PD-L1 Incorporation within HIV Virions
Dr. med. Tatjana Welzel, University Children’s Hospital Basel
Contribute to Functionally Impair T-Follicular Helper Cells
(UKBB), Switzerland / Prof. Dr. med. Norbert Blank, University
Olivia Munoz, (Lausanne CH)
Hospital Heidelberg, Germany
Symposium 3b: Clinical Immunology
13:15 – 14:45 h Symposia 4 a–c
Lindenmann symposium for innate immunity
Chair: Otto Haller, (Zurich, CH) / Stéphanie Hugues, (Geneva, CH) Symposium 4a: Basic Immunology
NK cell-mediated recognition of virus-infected cells Zinkernagel symposium on anti-viral immunology
Marcus Altfeld, (Hamburg, D) Chair: Manfred Kopf, (Zurich, CH) / Annette Oxenius, (Zurich, CH)
Stroma-macrophage interactions Mechanisms of CD8 T cell immunity and pathology
Marc Bajenoff, (Marseille, F) Dietmar Zehn, (Freising, D)
Abstract Talk (OP8): Autophagy proteins in the restriction of Functional biology of hepatic CD8+ T cells
Kaposi’s Sarcoma-Associated Herpesvirus Entry Matteo Iannacone, (Milan, I)
Katarina Schmidt, (Zurich CH) Abstract Talk (OP13): Human tissue resident memory T cells
Abstract Talk (OP18): Multisystem Inflammation and arise during Epstein Barr virus infection in a humanized mouse
Susceptibility to Viral infections in Human ZNFX1 Deficiency model
Stefano Vavassori, (Zurich CH) Daniel Kirchmeier, (Zurich CH)
Abstract Talk (OP15): Viral Infections License CD4+ T Cells for
Antigen-Independent Recruitment and Activation
Nima Yassini, (Zurich CH)
10 > www.congress-info.ch/ssai2021/ 11
ANNUAL CONGRESS
2021
PROGRAM – FRIDAY, 20TH OF AUGUST 2021 SYMPOSIUM
Symposium 4b: Basic Immunology
Tumor immunology SYMPOSIUM | PROGRAM
Chair: Pedro Romero, (Lausanne, CH) / Mitchell Levesque, (Zurich, CH)
Targeting Regulatory T Cells in Cancer: Means and Mechanism
FAMILIAL MEDITERRANEAN FEVER (FMF) –
Sergio Quezada, (London, UK) BEHIND THE SCENE
Immunoregulation and the tumor microenvironment
Pamela Ohashi, (Toronto, CA) TIME: 12:15–13:00
Abstract Talk (OP20): Isocitrate dehydrogenase 2 inhibition in-
duces memory CD8+ T cells with enhanced antitumor function
WELCOME
Alison Jaccard, (Epalinges CH)
MORE THAN JUST FEVER: DIAGNOSIS AND STANDARD
Abstract Talk (OP21): Bedside formulation of a personalized
multi-neoantigen vaccine against mammary carcinoma
TREATMENT OF FMF
Mona Mohsen, (Bern CH) Dr. med. Tatjana Welzel, University Children’s Hospital Basel (UKBB), Switzerland
Symposium 4c: Clinical Immunology
HOW TO TREAT PATIENTS WITH FMF AND AMYLOIDOSIS
Microbiota
Professor Dr. med. Norbert Blank, University Hospital Heidelberg, Germany
Chair: Wolf-Dietrich Hardt, (Zurich, CH) / Emma Slack, (Zurich, CH)
The diversity and specialty of intestine mucosal antibody
Q&A AND TAKE-HOME MESSAGE
responses
Andrew Macpherson, (Berne, CH)
Gut microbiota mediated regulation of neuroinflammation
Gurumoorthy Krishnamoorthy, (Martinsried, D)
Abstract Talk (OP12): Epithelium-autonomous NAIP/NLRC4 Severe Asthma Satellite Symposium SSAI 2021
prevents TNF-driven inflammatory destruction of the gut Targeting eosinophilic diseases in real life.
epithelial barrier in Salmonella-infected mice Update on treating severe eosinophilic asthma and EGPA in
Stefan Fattinger, (Zurich CH)
Europe and Switzerland.
Abstract Talk (OP19): Aryl hydrocarbon receptor (AhR)
signaling in the host response directed against the skin Thursday 19th of August 2021, 13:00 - 13:45
commensal yeast Malassezia during health and disease
Eduardo Gushiken Ibañez, (Zurich CH) Prof. Dr. med. Jörg D. Leuppi
14:45 – 15:15 h Coffee break
Head physician Pneumology
Kantonsspital Baselland
15:15 – 16:15 h Poster session with presenters present at
odd numbered posters
Dr. med. Urs Steiner
16:15 – 17:00 h Plenary Lecture 3: Anti-viral Immunity
Chair: Christian Münz, (Zurich, CH)
Leading physician Clinic for Immunology
Universitätsspital Zürich
Antibody-mediated neutralization of SARS-CoV-2
Florian Klein, (Cologne, D) Looking forward to meet you in
Ab 17:00 h person on our Stand n°10!
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Awarding of the Brunello Wüthrich Poster Prices,
the Biotest Poster Prices and the ACTERIA Oral Prices
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12 > www.congress-info.ch/ssai2021/ 13
ANNUAL CONGRESS
2021
CHAIRS AND SPEAKERS CHAIRS AND SPEAKERS
Ablasser Andrea, Prof. Dr. med., Lausanne, CH Ludewig Burkhard, Prof. Dr., St.Gallen, CH
Altfeld Marcus, Prof. Dr., Hamburg, D Macpherson Andrew, Prof. Dr. med., Bern, CH
Bachmann Martin, Prof. Dr., Bern, CH Marichal Thomas, Liège, BE
Bajénoff Marc, PhD, Marseille, F Merkler Doron, Genève ,CH
Becher Burkhard, Prof. Dr., Zurich, CH Münz Christian, Prof. Dr. med., Zürich, CH
Blankenstein Thomas, Prof. Dr., Berlin, D Ohashi Pamela, PhD, Toronto, CA
Boyman Onur, Prof. Dr. med., Zürich, CH Oxenius Annette, Prof. Dr., Zürich, CH
Dallmeier Kai, PhD (Dr. rer. nat.), Leuven, BE Pascolo Steve, PD Dr., Schlieren, CH
Eggel Alexander, PD Dr., Bern, CH Probst Elsbeth, Dr. med. Dr. phil., Zürich, CH
Haller Otto, Prof. Dr. med., Zürich, CH Quezada Sergio A., Prof. PhD, London, GB
Hardt Wolf-Dietrich, Prof. Dr., Zürich, CH Recher Mike, Prof., Basel, CH
Hauser Thomas, Dr. med., Zürich, CH Robbiani Davide, Dr. med., Bellinzona, CH
Heijnen Ingmar A.F.M., Dr., Basel, CH Romero Pedro, Epalinges, CH
Held Werner, Epalinges, CH Sallusto Federica, Prof. Dr., Zürich, CH
Ho Ping-Chih, Prof., Epalinges, CH Scheiermann Christoph, Prof., Genève, CH
Horn Michael P., Dr. phil. nat., Bern, CH Schmid-Grendelmeier Peter, Prof. Dr. med., Zürich, CH
Hugues Stéphanie, Prof., Genève, CH Shamji Mohamed, Dr., London, GB
Iannacone Matteo, Prof. Dr. med., Milano, I Slack Emma, Prof. Dr., Zürich, CH
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Jeker Lukas, Prof. Dr., Basel, CH Stauss Hans, Prof., London, CH
Klein Florian, Univ.-Prof. Dr., Köln, D Valenta Rudolf, Dr. med., Vienna, A
Kopf Manfred, Prof. Dr., Zürich, D Waisman Ari, Univ-Prof. Dr., Mainz, D
Krishnamoorthy Gurumoorthy, Dr., Martinsried, D Wardemann Hedda, Prof. Dr., Heidelberg, D
Kündig Thomas, Prof. Dr. med., Zürich, CH Warnatz Klaus, Prof. Dr. med., Freiburg, D
Legler Daniel, Prof. Dr., Kreuzlingen, CH Zehn Dietmar, Prof. Dr. med., Freising, D
Levesque Mitchell, Prof., Schlieren, CH
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More flexibility for your
patients with PID
SAVE THE DATE!
24th Course: Allergy and Immunology Update (AIU)
28–30 January 2022
CUVITRU® – tailoring SCIG treatment for
C-APROM/CH/CUVI/0003 11/2020
the individual needs of your patients1-3
References:
1. Cuvitru®, www.swissmedicinfo.ch.
2. Borte M, et al. Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies. Clin Exp Immunol. 2016;187:146–59.
3. Suez D. et al, Efficacy, Safety, and Pharmacokinetics of a Novel Human Immune Globulin Subcutaneous, 20% in Patients with Primary Immunodeficiency Diseases in North America, J Clin Immunol 2016 36:700–712.
PID = Primary Immune Deficiencies; SCIG = Subcutaneous Immunoglobulin
CUVITRU Succinct Statement:
C: Human immunoglobulin (SCIg) 200 mg / ml (min. 98 % IgG). I: Substitution therapy for adults, children and adolescents (0–18 years): Primary immune deficiency diseases with impaired antibody formation. Hypogammaglobulinaemia and recurrent
bacterial infections in patients with chronic lymphocytic leukaemia (CLL) in whom prophylactic treatment with antibiotics has failed or is contraindicated. Hypogammaglobulinaemia and recurrent bacterial infections in patients with multiple myeloma
(MM). Hypogammaglobulinaemia in patients before and after allogeneic haematopoietic stem cell transplantation (HSCT). D: Dosage and dosing intervals depend on the indication as well as trough levels and clinical response. Dosage should be
adjusted to maintain an IgG trough level (measured before the next infusion) of at least 5–6 g / L and aim to be within the serum reference interval for IgG for the appropriate age. For subcutaneous use only. AI: Known anaphylactic or severe hyper-
sensitivity reactions to subcutaneous administration of the active substance or to any of the excipients. Severe IgA deficiency and history of hypersensitivity to treatments with human immunoglobulins. Intravenous or intramuscular administration.
PR: If CUVITRU is accidentally administered into a blood vessel, the patient may develop shock. If severe allergic or anaphylactic reactions are suspected, the infusion must be stopped immediately. IA: Administration of immunoglobulin may interfere
with the efficacy of live attenuated viral vaccines such as measles, rubella, mumps and varicella for a period of at least 6 weeks up to 3 months. AE: Very common (≥10 %): headache (22.1 %), diarrhoea (16.4 %), nausea (11.5 %), fatigue (10.7 %), local
reaction at injection site (32.0 %) including erythema (14.8 %) and pain (20.5 %). Rarely, human immunoglobulins may cause a drop in blood pressure with an anaphylactic reaction, even in patients who have previously tolerated treatment with normal
human immunoglobulin well. Patients with anti-IgA antibodies should be treated with special caution. P: Pack sizes: 5 ml, 10 ml, 20 ml, 40 ml and 50 ml. Dispensing category B. Reimbursed by health insurers. Marketing authorisation holder: Takeda
Pharma AG, 8152 Opfikon. For further information: see product information (www.swissmedicinfo.ch). C-APROM/CH/CUVI/0002 09/2020
Takeda Pharma AG | Thurgauerstrasse 130 | 8152 Glattpark (Opfikon)
18 > www.congress-info.ch/ssai2021/ 193 INDIKATIONEN
2 SIGNALWEGE*
1 DUPIXENT®
Mittelschwere bis schwere
PRIX atopische Dermatitis1
Biotest Switzerland and the Swiss Society for Allergology and Immunology (SSAI)
GALIEN announce the
SUISSE
2021 Schweres Asthma1
BIOTEST AWARD 2021
on Understanding and making use of naturally occurring
antibodies
Schwere CRSwNP1
The award of CHF 10’000.– is sponsored by Biotest Switzerland
DUPIXENT zielgerichtet gegen die Typ-2-Inflammation
® 1,2
Naturally occurring antibodies are often involved in autoimmune, inflammatory and
allergic disorders, infections, cancer and transplant rejections. Such antibodies can
CRSwNP = chronische Rhinosinusitis mit Nasenpolypen. * Blockade der Signalwege der Interleukine IL-4 und IL-13.
1 DUPIXENT® Fachinformation, Stand der Information: Dezember 2020. www.swissmedicinfo.ch. promote disease or can be beneficial for patients. Treatment with human plasma
2 Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016; 15(1): 35–50. products is increasingly helpful, although the mechanisms are not always clear.
Dupixent® Lösung zur subkutanen Injektion. Jede Spritze bzw. jeder Fertigpen enthält 200 mg Dupilumab in 1,14 ml Lösung (175 mg/ml) oder 300 mg
Dupilumab in 2 ml (150 mg/ml). W: Dupilumab (aus gentechnisch veränderten Zellen des chinesischen Hamsters). I: Dupixent ist angezeigt zur Behand- This award will be given to a scientific basic or clinical study that improves the
lung von mittelschwerer bis schwerer atopischer Dermatitis (AD) bei erwachsenen Patienten und Jugendlichen ab 12 Jahren, wenn eine Therapie mit
verschreibungspflichtigen topischen Medikamenten keine angemessene Krankheitskontrolle ermöglicht oder nicht empfohlen wird. Dupixent kann understanding of disease mechanisms involving naturally occurring antibodies and
mit oder ohne topische Kortikosteroide angewendet werden. Dupixent ist als Zusatz zur Erhaltungstherapie bei Erwachsenen und Jugendlichen ab 12 therapies with human plasma products.
Jahren bei schwerem Asthma indiziert, gekennzeichnet durch folgende Kriterien: *Eosinophilenzahl im Blut ≥ 0,15 g/l (entspricht ≥ 150 Zellen/μl), un-
zureichende Asthmakontrolle und mindestens 1 schwere Exazerbation in den vorausgegangenen 12 Monaten, trotz inhalativen Kortikosteroiden und
langwirksamen Bronchodilatatoren; *oder Notwendigkeit zur dauerhaften Behandlung mit systemischen Kortikosteroiden. Dupixent ist indiziert als
Add-on-Therapie mit intranasalen Kortikosteroiden von Erwachsenen mit schwerer CRSwNP, die mit systemischen Kortikosteroiden und/oder chirurgi- Applicants are asked to provide a cover letter (max 1 page) and the manuscript
schem Eingriff nicht ausreichend kontrolliert werden kann. Dosierung: Für atopische Dermatitis: bei Erwachsenen: Anfangsdosis von 600 mg als subku- of their work. All documents should be assembled to one single PDF file, fully
tane Injektion (2 Injektionen zu je 300 mg), danach 300 mg als s.c. Injektion Q2W. Bei Jugendlichen zwischen 12 bis 17 Jahren: < 60 kg: Anfangsdosis von
400 mg (2 Injektionen zu je 200 mg), danach 200 mg als s.c. Injektion Q2W. Jugendliche ≥ 60 kg und darüber: Anfangsdosis von 600 mg als subkutane searchable (i.e. generated electronically, not by scanning).
Injektion (2 Injektionen zu je 300 mg), danach 300 mg als s.c. Injektion Q2W. Für Asthma: für Erwachsene und Jugendliche ≥12 Jahre: *für Patienten mit
schwerem Asthma, das mit inhalativen Kortikosteroiden und langwirksamen Bronchodilatatoren behandelt wird: Anfangsdosis von 400 mg (2 Injektio-
nen zu je 200 mg), danach 200 mg als s.c. Injektion Q2W. *Bei schwerem Asthma, das mit oralen Kortikosteroiden behandelt wird, oder schwerem Asth-
ma in Verbindung mit mittlerer oder schwerer atopischer Dermatitis, je nach genehmigter Indikation, Anfangsdosis von 600 mg als subkutane Injektion The award will be attributed to first and last author(s). They will be invited to
(2 Injektionen zu je 300 mg), danach 300 mg als s.c. Injektion Q2W. Für CRSwNP: empfohlene Dosierung von Dupilumab für Erwachsene: Anfangsdosis present their study at the 24th Allergy Immunology Update Meeting taking place
von 300 mg, danach 300 mg alle zwei Wochen. Leichte bis mittelschwere Niereninsuffizienz: gleiche Dosierung. KI: Überempfindlichkeit gegen Wirk-
stoff oder einen Hilfsstoff. VM: Enthält Natrium (< 1 mmol/Dosis). Überempfindlichkeitsreaktionen: Bei allgemeiner systemischer Überempfindlichkeit from 28 – 30 January 2022.
(akut oder verzögert) Anwendung von Dupixent sofort beenden und eine geeignete Behandlung einleiten. Hypereosinophilie: Bei Asthmapatienten,
die am Entwicklungsprogramm teilgenommen haben, wurden Fälle von Pneumopathien durch Eosinophilen und Fälle von Vaskulitis in Zusammenhang
mit eosinophiler Granulomatose mit Polyangitis berichtet. Das Auftreten von Hautläsionen wegen Vaskulitis, einer Verschlimmerung der Lungensymp-
tome, von Herzkomplikationen und/oder einer Neuropathie bei Patienten mit Hypereosinophilie sollten dem Arzt/der Ärztin Anlass zur Sorge bereiten.
Helminthose: Vorbestehende Helminthose vor Therapie mit Dupixent behandeln, bei Infektion während der Behandlung und Nichtansprechen auf Hel- The application deadline is the 30 September 2021
MAT-CH-2101249-V1-06/2021
minthosebehandlung Dupixent aussetzen bis Infektion abgeklungen ist. Bei Patienten mit AD: Konjunktivitis und Keratitis: Patienten darauf hinweisen,
dass sie das Auftreten oder eine Verschlimmerung von Augensymptomen dem Arzt / der Ärztin mitteilen sollten. Patienten mit Asthma: Anpassung der for sending your application to
Asthma-Behandlung nicht ohne vorherige Absprache mit Arzt / Ärztin, nach dem Absetzen der Behandlung diese Patienten sorgfältig überwachen. IA:
Anwendung von Lebendimpfstoffen vermeiden. NW: Reaktionen an der Injektionsstelle; Konjunktivitis, okularer Juckreiz Blepharitis, oraler Herpes, Eo-
sinophilie, Kopfschmerzen, Arthralgien, Schlafstörungen, Gastritis. P: Dupixent 300 mg, Injektionslösung in einer Fertigspritze mit Sicherheitssystem: Jolanda Trachsel
Packung mit 2 Fertigspritzen. Dupixent 300 mg, Injektionslösung im Fertigpen: Packung mit 2 Fertigpens. Dupixent 200 mg, Injektionslösung in einer
Fertigspritze mit Sicherheitssystem: Packung mit 2 Fertigspritzen. Dupixent 200 mg, Injektionslösung im Fertigpen: Packung mit 2 Fertigpens. AK: B. ZI: General Manager SSAI
sanofi -aventis (schweiz) ag, 1214 Vernier/GE (für weitere Informationen vgl. http://www.swissmedicinfo.ch/). Stand der Information: Dezember 2020
email to: office@ssai.ch.
Sanofi und Regeneron arbeiten gemeinsam an einem globalen Produktentwicklungsprogramm und an der Vermarktung von DUPIXENT®
Zulassungsinhaberin: sanofi -aventis (schweiz) ag · 3, route de Montfleury · 1214 Vernier
20 > www.congress-info.ch/ssai2021/ 21ANNUAL CONGRESS
2021
ORGANIZATION GENERAL INFORMATION
Venue
Irchel Campus, University Zurich, Winterthurerstrasse 190, 8057 Zürich,
> www.uzh.ch/cmsssl/de/about/info/sites/irchel.html
Presidents of the Organizing Committee Congress language
Christian Münz English (no simultaneous translation)
University of Zurich
Mail: muenzc@immunology.uzh.ch Registration
You can now benefit from early enrollment fees and register online:
Burkhard Becher > www.congress-info.ch/ssai2021/registration
University of Zurich
Mail: becher@immunology.uzh.ch Registration fee
1 day pass 2 day pass
Local Organizing Committee
Until June 15, From June 16, Until June 15, From June 16,
Thomas Hauser, IZZ Immunologie-Zentrum Zurich
2021 2021 2021 2021
Manfred Kopf, ETH Zurich
Annette Oxenius, ETH Zurich SSAI Members CHF 250.00 CHF 300.00 CHF 400.00 CHF 450.00
Elsbeth Probst, University Hospital Zurich Non-members CHF 300.00 CHF 350.00 CHF 450.00 CHF 500.00
Peter Schmid-Grendelmeier, University Hospital Zurich Assistants/Students CHF 120.00 CHF 150.00 CHF 220.00 CHF 250.00
Scientific Advisory Committee
Credits
Cezmi A. Akdis, SIAF Swiss Institute of Allergy and Asthma Research Davos
Martin Bachmann, Inselspital University Hospital Berne FAMH SGAI SGDV
Ingmar A.F.M. Heijnen, University Hospital Basel 10 Credits 11 Credits 9 Credits
Werner Held, University of Lausanne
SGINF SGMO SGR
Stéphanie Hugues, University of Geneva
Peter Jandus, University of Geneva 4 Credits 9 Credits 8 Credits
Daniel Legler, BITg Biotechnology Institute Thurgau at University of Konstanz
Burkhard Ludewig, Cantonal Hospital St. Gallen
Doron Merkler, University of Geneva SVVLD VSKT
Mike Recher, University Hospital Basel 2 education Recognition to the extent of 0.5 day for Animal
Davide Robbiani, IRB Institute for Research in Biomedicine Bellinzona points welfare officers / Study directors / Involved persons
Pedro Romero, University of Lausanne
Federica Sallusto, ETH Zurich
Daniel E. Speiser, University of Lausanne
Administrative Organization
Medworld AG, Andrea Studer / Selina Poletti
Sennweidstrasse 46, 6312 Steinhausen
Phone: +41 41 748 23 00, Fax: +41 41 748 23 11
E-Mail: registration@medworld.ch
> www.medworld.ch
22 > www.congress-info.ch/ssai2021/ 23JETZT
KASSEN-
ZULÄSSIG.
1 Tablette
täglich1
NEUE ORALTHERAPIE
für mittelschwere bis schwere
atopische Dermatitis1
Wenn topische Therapie
alleine nicht mehr ausreicht1
Schnelle Verbesserung
von Juckreiz und Schlafqualität2
Anhaltende Verbesserung der Hautläsionen3
Günstiges Verträglichkeitsprofil
mit Langzeiterfahrung aus RA#,4,5
Olumiant® – Einfach.* Schnell. Mehr erreichen.**,1,2
# Sicherheitaussagen aus der RA können nicht für die AD interpretiert werden. Kombinationstherapie mit konventionellen krankheitsmodifizierenden Antirheumatika
(DMARDs, disease-modifying anti-rheumatic drugs) einschliesslich Methotrexat (MTX) bei erwachsenen Patienten mit mittelschwerer bis schwerer aktiver
rheumatoider Arthritis, die auf eine Behandlung mit einem oder mehreren DMARDs unzureichend angesprochen haben oder diese nicht vertragen haben. Monotherapie
bei Unverträglichkeit gegenüber MTX oder wenn eine Behandlung mit MTX nicht angebracht ist. Die Wirksamkeit alleine oder mit MTX wurde in zuvor unbehandelten
Patienten nachgewiesen. * Eine Tablette täglich. Olumiant® kann unabhängig von Mahlzeiten und zu jeder Tageszeit eingenommen werden. ** Als mit topischer Therapie
allein. AD = Atopische Dermatitis; JAK = Janus Kinase; RA = Rheumatoide Arthritis.
1. Fachinformation Olumiant®, www.swissmedicinfo.ch. 2. Reich K, et al. Efficacy and Safety of Baricitinib Combined With Topical Corticosteroids for Treatment of Moderate
to Severe Atopic Dermatitis: A Randomized Clinical Trial. JAMA Dermatol. 2020 Dec 1;156(12):1333-1343. 3. Silverberg JI et al. Long-term efficacy of baricitinib in patients
with moderate-to-severe atopic dermatitis enrolled in the phase 3 long-term extension study BREEZE-AD3. Abstract D3T03.4D; European Academy of Dermatology and
Venereology (EADV Virtual); 29-31 October 2020. 4. Bieber T, et al. Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials.
J Eur Acad Dermatol Venereol. 2021 Feb;35(2):476-485. 5. Genovese MC et al. Safety profile of baricitinib for the treatment of rheumatoid arthritis over a median of 3 years of
treatment: an updated integrated safety analysis. Lancet Rheumatol. 2020; 2: e347-e357. DOI:10.1016/S2665-9913(20)30032-1.
Olumiant® (baricitinib) Filmtabletten. I: Rheumatoide Arthritis: Kombinationstherapie mit konventionellen DMARDs einschliesslich Methotrexat (MTX) bei erwachsenen Patienten mit
mittelschwerer bis schwerer aktiver rheumatoider Arthritis, die auf eine Behandlung mit einem oder mehreren DMARDs unzureichend angesprochen haben oder diese nicht vertragen haben.
Monotherapie bei Unverträglichkeit gegenüber MTX oder wenn eine Behandlung mit MTX nicht angebracht ist. Die Wirksamkeit alleine oder mit MTX wurde in zuvor unbehandelten Patienten
nachgewiesen. Atopische Dermatitis: Behandlung erwachsener Patienten mit mittelschwerer bis schwerer atopischer Dermatitis, wenn eine Therapie mit topischen Medikamenten keine angemessene
Krankheitskontrolle ermöglicht oder nicht empfohlen wird. TD: Rheumatoide Arthritis: 4 mg einmal täglich. Bei Patienten ≥ 75 Jahren und für Patienten mit chronischen oder wiederkehrenden
Infektionen ist möglicherweise eine Anfangsdosis von 2 mg angemessen. Für Patienten, die unter 4 mg einmal täglich eine anhaltende Kontrolle der Krankheitsaktivität erreicht haben, kann eine
Erhaltungsdosis mit 2 mg ausreichend sein. Atopische Dermatitis: Initiale Dosis 4 mg einmal täglich. Bei Patienten mit chronischen oder wiederkehrenden Infektionen ist die Anfangsdosis 2 mg. Falls
nach 8-wöchiger Behandlung keine Besserung eintritt, soll das Arzneimittel abgesetzt werden. Bei Patienten, die mit 4 mg täglich eine anhaltende Kontrolle über die Krankheitsaktivität erreicht
haben, soll die Dosierung auf 2 mg täglich reduziert werden. Spezielle Anweisungen: Die empfohlene Dosis beträgt 2 mg einmal täglich bei Patienten, die Probenecid anwenden, und bei Patienten
mit einer geschätzten glomerulären Filtrationsrate zwischen 30 und 60 ml/min/1,73 m2. KI: Überempfindlichkeit gegenüber dem Wirkstoff oder einem der Hilfstoffe. W/V: Nicht anwenden und/
oder Therapie absetzen im Falle von: aktiver systemischer Infektion, chronischen oder rekurrierenden Infektionen oder schwerwiegender oder opportunistischer Infektion in der Vorgeschichte,
Virusreaktivierung (z. B. Herpes zoster, Hepatitis B/C), aktiver Tuberkulose, absoluter Neutrophilenzahl < 1 謁 10 9 Zellen/l, absoluter Lymphozytenzahl < 0,5 謁 109 Zellen/l, Hämoglobinwert
< 8 g/dl), schwerer Einschränkung der Nieren- oder Leberfunktion, tiefer Venenthrombose/Lungenembolie, schwerer allergischer oder anaphylaktischer Reaktion. Lipidparameter überwachen. Vor Beginn
der Behandlung, Impfstatus aktualisieren. Bei Patienten mit (oder mit erhöhtem Risiko für) Divertikulitis mit Vorsicht anwenden. IA: OAT3-Inhibitoren (Probenecid). Sch/S: Während der Schwangerschaft
nicht anwenden, es sei denn, es ist eindeutig erforderlich. Während der Behandlung nicht stillen. UAW: Sehr häufig: Infektionen der oberen Atemwege, erhöhtes LDL-Cholesterin ≥
3,36 mmol/l. Häufig: Herpes zoster, Herpes simplex, Infektion der Harnwege, Thrombozytose > 600 謁 109 Zellen/l, Kopfschmerzen, Übelkeit, Bauchschmerzen, erhöhte ALT ≥ 3 謁
ULN, Hautausschlag, Akne, erhöhte Kreatinphosphokinase > 5 謁 ULN. Andere schwere UAW (gelegentlich): Neutropenie < 1 謁 109 Zellen/l, Divertikulitis, Schwellung des Gesichts,
Urtikaria, tiefe Venenthrombose, Lungenembolie. P: Olumiant 2 mg und 4 mg, 28 Filmtabletten. Abgabekategorie B. Kassenzulässig. Weitere Informationen finden Sie unter www.
swissmedicinfo.ch. Eli Lilly (Suisse) SA, ch. des Coquelicots 16, CP 580, 1214 Vernier (GE). V 02-2021 PP-BA-CH-0302/04.2021You can also read
