INDICATORS OF MARKERS OF BONE METABOLISM IN PATIENTS WITH GENERALIZED PERIODONTITIS DEPENDING ON BLOOD GROUP
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Archives of the Balkan Medical Union vol. 54, no. 1, pp. 72-77
Copyright © 2019 Balkan Medical Union March 2019
ORIGINAL PAPER
INDICATORS OF MARKERS OF BONE METABOLISM
IN PATIENTS WITH GENERALIZED PERIODONTITIS
DEPENDING ON BLOOD GROUP
Yurii BANDRIVSKY1 , Orysia BANDRIVSKA2, Romam GNID3, Lidia MINKO3,
Maryana SHEVCHUK3
1
„I. Horbachevsky“ Ternopil State Medical University, Department of Child Dentistry, Ternopil, Ukraine
2
„I. Horbachevsky“ Ternopil State Medical University Department of Orthopedic Dentistry, Ternopil,
Ukraine
3
„Danylo Halytsky“ Lviv National Medical University, Department of Therapeutic Dentistry FPGE, Lviv,
Ukraine
Received 2 Dec 2018, corrections received 3 Jan 2019, Accepted 27 Jan 2019
https://doi.org/10.31688/ABMU.2019.54.1.10
ABSTRACT RÉSUMÉ
Introduction. The close relationship of the osteo- Indicateurs des marqueurs du métabolisme osseux
porosis with the periodontal tissue disease is of great chez des patients présentant une périodontite géné-
importance in dentistry, because of the development ralisée d’après l’appartenance à un groupe sanguin
of inflammatory-destructive processes of tooth hold-
ing tissues. A database to individualize the basics of Introduction. La stomatologie revêt une grande im-
metabolism in terms of bone remodeling in patients portance pour ce qui est de la relation entre l’ostéo-
with generalized periodontitis (GP) in connection with porose et la maladie des tissus parodontaux, considé-
AB0-belonging will reveal the fundamental basis of the rée comme un facteur de risque du développement
influence of group-specific features of blood flow and des processus inflammatoires destructeurs des tissus
treatment of generalized periodontitis. qui fixent les dents. L’absence d’une base de données
The aim of the study was to assess the dynamics of permettant d’individualiser le métabolisme primaire
bone remodeling markers in blood and oral liquid of dans les paramètres de remodelage osseux chez les
patients with generalized periodontitis, with different patients atteints de parodontite généralisée (GP) en
blood groups. lien avec l’appartenance à AB0, révélera la base fon-
Material and methods. The clinical and laboratory damentale de l’influence des caractéristiques de la cir-
studies were conducted in 175 patients with general- culation sanguine et du traitement de la parodontite
ized periodontitis (main group) and in 120 persons généralisée.
without somatic and dental diseases (comparison Le but de l’étude était la dynamique des marqueurs
group), who were divided into groups in connection de remodelage osseux dans le sang et le liquide buccal
Address for correspondence: Yurii BANDRIVSKY
Dept. of Child Dentistry, I. Horbachevsky Ternopil State Medical University,
Ternopil, Ukraine
Address: Chekhova 7, Ternopil 46001, Ukraine
Email: bandrivsky.83@gmail.com, phone + 380973047399Archives of the Balkan Medical Union
with AB0-belonging. It was determined the activity of des patients atteints de parodontite généralisée avec
acid and alkaline phosphatase in blood and oral liquid une affiliation différente au groupe sanguin.
of patients, by conventional biochemical methods, and Méthodes. Les études cliniques et de laboratoire ont
levels of osteocalcin and C-end telopeptide by ELISA. été menées chez 175 patients atteints de parodontite gé-
Results. Patients with generalized periodontitis pre- néralisée (groupe principal) et chez 120 personnes sans
sented a significant increase of the markers of bone maladies somatiques ou dentaires (groupe témoin), di-
resorption (acid phosphatase and C-end telopeptides), visées en groupes liés à l’appartenance à AB0. L’activité
while healthy persons presented a reduction of these de la phosphatase acide et alcaline dans le sang et le
parameters of bone formation (osteocalcin and alka- liquide buccal des patients a été déterminée par des
line phosphatase) in blood and oral liquid, regardless méthodes biochimiques classiques et par les taux d’os-
of blood group affiliation. Further, processes of bone téocalcine et de télopeptide C-end par ELISA.
resorption in blood and oral liquid were examined Les résultats. Il est établi que, chez les patients atteints
in patients with GP, carriers of O(I) and A(II) blood de parodontite généralisée, on a examiné une augmen-
groups. It was noted that the process of bone forma- tation significative des valeurs des marqueurs de la
tion for these levels of osteocalcin and alkaline phos- résorption osseuse (phosphatase acide et télopeptides
phatase were significantly lower in patients with GP, in C-end) dans le contexte de la réduction de ces para-
O(I) and B(III) blood groups. mètres de formation liés aux valeurs chez les personnes
Conclusions. The results of the study showed that in en bonne santé, quelle que soit leur appartenance à un
patients with GP there is an imbalance in the process- groupe sanguin. Ainsi, des processus plus importants
es of bone remodeling, regardless of AB0-belonging. de résorption osseuse dans le sang et le liquide buccal
The study of the composition and functions, not only ont été examinés chez des patients atteints de GP, de
of blood, but also of saliva, can find high regulatory porteurs de groupes de sang O (I) et A (II). Ainsi, il est
and trophic potential of this biological environment à noter que le processus de formation osseuse de ces
and the diversity of its protective and compensatory taux d’ostéocalcine et de phosphatase alcaline était si-
features. gnificativement plus faible chez les patients atteints de
GP, porteurs de groupes de sang O (I) et B(III).
Keywords: generalized periodontitis, AB0-belonging, Conclusions. Les résultats des études menées ont
bone tissue, markers of bone metabolism. montré que les processus de remodelage osseux sont
déséquilibrés chez les patients atteints de GP, indépen-
Abbreviations damment de leur appartenance à AB0. L’étude de la
GP = generalized periodontitis composition et des fonctions du sang, mais aussi de
TRACP = acid phosphatase tartrate la salive, permet de mettre en évidence un potentiel
BSALP = alkaline phosphatase régulateur et trophique élevé pour cet environnement
P1CP = C-terminal telopeptides biologique et la diversité de ses caractéristiques protec-
OC = osteocalcin trices et compensatrices.
Mots-clés: parodontite généralisée, appartenance
AB0, tissu osseux, marqueurs du métabolisme osseux.
INTRODUCTION periodontal disease and consider it as a risk factor
for the occurrence of periodontal disease. Age-related
One of the main problems of modern dentistry bone tissue repair, a violation of bone metabolism,
are periodontal tissue diseases, because of their sig- accelerates the resorption of the alveolar process,
nificant prevalence among people of different ages, causing the deterioration of the flow of generalized
the lack of pre nosological diagnostic methods and periodontitis (GP)11-13.
effective methods of prevention and treatment1-4. At the same time, there is practically no database
Generalized periodontal diseases are characterized for the individualization of the molecular basis of me-
by the progression of the inflammatory-destructive tabolism in some parameters, one of which is blood
processes, which with age leads to the complete de- group genetically determined14. The study of bone
struction of the tooth-holding apparatus and the pre- remodeling data in patients with generalized peri-
mature loss of teeth 5-8. As a result of impaired bone odontitis, in connection with AB0-affiliation, would
metabolism of the alveolar process, its resorption is increase the effectiveness of evaluating the results of
accelerated, which is caused by the action of both lo- bone metabolism markers, for a new approach, in
cal regulatory and systemic causes3,9,10. Recent stud- connection with the influence of group-specific blood
ies underlined the relationship of osteoporosis with on the course of generalized periodontitis15-17.
March 2019 / 73Indicators of markers of bone metabolism in patients with generalized periodontitis… – BANDRIVSKY et al
In the literature, there is interest for the compo- RESULTS
sition and functions not only of the blood, but also
of oral fluid, in order to reveal the high regulatory We have found that the serum activity of
and trophic potential of this biological environment TRACP-lysosomal enzyme, which hydrolyzes phos-
and the diversity of its protective and compensatory phoric monoesters in an acidic environment11,25, in
properties18-20. practically healthy individuals of the control group,
was on average 36.68% lower than in patients with
generalized periodontitis (3.19±0.09 ng/mL versus
THE OBJECTIVE OF THE STUDY was to evaluate the dy-
4.36±0.09 ng/mL, respectively, pArchives of the Balkan Medical Union
Figure 1. Dynamics of bone metabolism markers depending on blood group.
GP was: by 29.02%, pIndicators of markers of bone metabolism in patients with generalized periodontitis… – BANDRIVSKY et al
Figure 2. Dynamics of markers of bone metabolism in the oral fluid
in patients of study groups depending on the blood group.
CONCLUSIONS 8. Shiau HJ, Reynolds MA. Sex differences in destructive
periodontal disease: a systematic review. J Periodontol.
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„The authors declare no conflict of interest regarding in patients with generic osteoporosis symptoms. Annales
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Periodontol. 1972;43:240-255.
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Helsinki Declaration of 1975, as revised in 2008(5), as of destructive periodontal diseases. Periodontology. 1994;
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