Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals

Insect nicotinic acetylcholine receptor agonists as flea
              adulticides in small animals
                Vo D.T., Hsu W.H., Abu-Basha E.A., Martin R.J.
 Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA
50011, United States; Department of Internal Diseases and Pharmacology, Faculty of Animal Science and
Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Viet Nam; Department of Veterinary Basic
 Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan

Abstract: Fleas are significant ectoparasites of small animals. They can be a severe irritant to animals and
serve as a vector for a number of infectious diseases. In this article, we discuss the pharmacological
characteristics of four insect nicotinic acetylcholine receptor (nAChR) agonists used as flea adulticides in
dogs and cats, which include three neonicotinoids (imidacloprid, nitenpyram, and dinotefuran) and a
macrocyclic lactone (spinosad). Insect nAChR agonists are one of the most important classes of insecticides,
which are used to control sucking insects on both plants and animals. These novel compounds provide a new
approach for practitioners to safely and effectively eliminate adult fleas. © 2010 Blackwell Publishing Ltd.
Index Keywords: advantage; advantix; capstar; comfortis; dinotefuran; imidacloprid; nicotinic agent;
nicotinic receptor; nicotinic receptor alpha4beta2; nitenpyram; unclassified drug; vectra 3d; cat; controlled
study; dog; Drosophila melanogaster; drug absorption; drug elimination; drug metabolism; drug structure;
environmental impact; female; flea infestation; male; maximum plasma concentration; nonhuman; plasma
half life; priority journal; protein domain; protein phosphorylation; protein structure; rat; review; time to
maximum plasma concentration; Animals; Cats; Dogs; Drug Combinations; Guanidines; Imidazoles; Insect
Vectors; Insecticides; Macrolides; Nicotinic Agonists; Nitro Compounds; Pyridines; Siphonaptera;
Animalia; Canis familiaris; Hexapoda; Siphonaptera (fleas)

Year: 2010
Source title: Journal of Veterinary Pharmacology and Therapeutics
Volume: 33
Issue: 4
Page : 315-322
Link: Scorpus Link
Chemicals/CAS: imidacloprid, 138261-41-3; Drug Combinations; Guanidines; Imidazoles; Insecticides;
Macrolides; Nicotinic Agonists; Nitro Compounds; Pyridines; dinotefuran, 165252-70-0; imidacloprid,
105827-78-9; nitenpyram; spinosad
Tradenames: advantage, Bayer, United States; advantix; capstar, Novartis; comfortis, Lilly; vectra 3d
Manufacturers: Bayer, United States; Lilly; Novartis
Correspondence Address: Vo, D. T.; Department of Biomedical Sciences, College of Veterinary Medicine,
Iowa State University, Ames, IA 50011, United States
ISSN: 1407783
CODEN: JVPTD

DOI: 10.1111/j.1365-2885.2010.01160.x
PubMed ID: 20646191
Language of Original Document: English
Abbreviated Source Title: Journal of Veterinary Pharmacology and Therapeutics
Document Type: Review
Source: Scopus
Authors with affiliations:
1. Vo, D.T., Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011,
     United States, Department of Internal Diseases and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Nong
     Lam University, Ho Chi Minh City, Viet Nam
2. Hsu, W.H., Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011,
     United States
3. Abu-Basha, E.A., Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Jordan University of Science and
     Technology, Irbid, Jordan
4. Martin, R.J., Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011,
     United States
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