Internal Medicine Research Administration: February 13, 2018 Update UU Drug Discovery Core Offers Two New Services: CRISPR Screening and Viral ...

Internal Medicine Research Administration: February 13, 2018 Update

UU Drug Discovery Core Offers Two New Services: CRISPR Screening and Viral Production
The Drug Discovery Core is pleased to announce a new service for genome-scale CRISPR-Cas9 screening. The Core uses a
human Crispr pooled sgRNA library targeting over 19000 genes. The service includes lentivirus transduction of the library
into cells, screening with treatment, and collection of genomic DNA for next generation sequencing and data
analysis. The Core will assist investigators with bioinformatics analysis and followup validation.

The Core also starts the service of production of small/large scale viral (lentivirus, adenovirus, adeno-associated virus)
packaging, titrations, concentrations and transductions of cells of interest. The Core can provide viruses expressing
marker protein (GFP) for use in testing viral expression in different cell types and organs. For CRISPR screening, the Core
can provide lenti-Cas9 and lentivirus delivery of Cas9 and sgRNA. Labs that have not yet obtained BSL-2 plus approval
from EHS can perform some experiments in the Core facility with training and supervision by Core staff. Other service
details can be found at our website: http://cores.utah.edu/drug-discovery/

REMINDERS
                          Precision Medicine Symposium
                          Frontiers in Precision Medicine III – Will Personalized Medicine Improve
                          Population Health?
                          Friday, March 16th, 8:00 a.m. to 6:30 pm, HSEB 1730

                          For full details, including agenda, please visit the Symposium website.

This event is free and open to the public. To register, please RSVP at
https://events.r20.constantcontact.com/register/eventReg?oeidk=a07eezuqv4v8358082b&oseq=&c=&ch

                                        Center on Aging 2018 Pilot Grant Program
                                        Due: Friday, March 16th
                                        Maximum Budget: $20,000

                                         This annual pilot grant program promotes the development of aging research at
the University of Utah. The goal of the program is to encourage new investigator career development, attract established
investigators to aging research, and stimulate interdisciplinary research collaborations – ultimately leading to new
externally funded research.

Submissions from a wide range of disciplines--from basic biology, clinical sciences, and the social and behavioral aspects
of aging--are encouraged. Priority is given to supporting applications from individuals who are new to aging research and
from two or more investigators who are establishing a new interdisciplinary research collaboration in an aging-related
interest area. Budget limit $20,000.

Principal investigators must have a career or tenure line University of Utah faculty appointment. For more details about
the program and/or submission process, see Center on Aging Pilot Grant Program or contact Heather Podolan at 801-
213-4156.

Registration for the May 18 – 20, 2018 Research Education Grant Writing Academy is now open!

Attendance is highly limited! For additional information see this GWA Information Sheet. Contact Research
Education at 801-587-3958 or sam.ma@hsc.utah.edu and corrie.harris@hsc.utah.edu with any questions.

NIH to Launch Genome Editing Research Program
In order to advance the use of recent gene technologies, such as CRISPR/Cas9, to treat or prevent genetic diseases, the
NIH is planning to grant $190 million over the next six years through a new Somatic Cell Genome Editing program,
funded by the NIH Common Fund. NIH's research priorities include developing better genetic tools and better tests for
safety and efficacy. The program will begin early this year, after NIH funds become available in an approved FY18
budget.

Trailblazer Prize for Clinician-Scientists
The Foundation for the NIH (FNIH) opened nominations for the inaugural Trailblazer Prize for Clinician-Scientists. The
prize recognizes early career clinician scientists, which includes MDs, DOs, and other clinician scientists. The $10,000
prize recognizes early career clinician-scientists in the United States whose work has the potential to or has led to
innovations in patient care. Through the Trailblazer Prize, the FNIH celebrates the transformational work of clinician-
scientists, whose research translates basic scientific observations into new paradigm-shifting approaches for diagnosing,
preventing, treating or curing disease and disability. Nominations will be accepted through Friday, March 30, 2018 at 1
PM EDT.

NIH Funding Opportunities
For all active NIH funding opportunity announcements (FOAs), please visit: NIH Funding Opportunities.

ARCHIVED RESEARCH ADMINISTRATION UPDATES
Past and present updates are published online here for quick reference.

IM RESEARCH ADMINISTRATION CONTACTS
Chris LaSalle          Director                                christine.lasalle@hsc.utah.edu   585-2734
Scott Low              Associate Director,                     scott.low@hsc.utah.edu           585-1380
                          Clinical Research Compliance
Masha Boguslavsky      Research Compliance Education           masha.boguslavsky@hsc.utah.edu   585-5363
Sally Bradstreet       Clinical Research Coordinator           sally.bradstreet@hsc.utah.edu    581-4684
Jennifer Hammond       Research Manager                        jennifer.hammond@hsc.utah.edu    581-6526
Ashley Kapron          Special Projects Manager                ashley.kapron@hsc.utah.edu       585-2084
Kris Larrabee          Grants and Contracts Manager            kris.larrabee@hsc.utah.edu       585-7655
Jessica Little         Research Manager                        Jessica.little@hsc.utah.edu      581-3694
Heather Parkin         Senior Grants and Contracts Officer     heather.parkin@hsc.utah.edu      585-7090
Mary Jane Tinnes       Clinical Research Coordinator           maryjane.tinnes@hsc.utah.edu     585-2254