Intro to Exercise Stress Testing* - Dr. Sarah Ramer 2021

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Intro to Exercise Stress Testing* - Dr. Sarah Ramer 2021
Intro to Exercise
 Stress Testing*
     Dr. Sarah Ramer
           2021
Intro to Exercise Stress Testing* - Dr. Sarah Ramer 2021
Resources

•   2013 ACC/AHA guideline

•   Dr. Sarah Ramer - sarah.ramer@nshealth.ca
Intro to Exercise Stress Testing* - Dr. Sarah Ramer 2021
Exercise Prescription for Apparently                                                                                                             exercise standa
                     Healthy Individuals . . . . . . . . . . . . . . . . . . . . . . . . . . 907                                                                    fundamentals
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           63 pages to combat
                   Exercise Training Techniques . . . . . . . . . . . . . . . . . . . . 908
                   Behavioral Aspects of Initiating and                                                                                                             American Hea
                     Sustaining an Exercise Program . . . . . . . . . . . . . . . . 911                                                                             Cardiology Fo
               insomnia…..
               The American Heart                 AHA                 Scientific
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           and submit a Disclosure Questionnaire showing all such relationships that might be perceived as
               ThisExercise
                          statement was          Standards approved byfor                  TestingHeart
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               The Gerald
                        American               Heart Association
                                      F. Fletcher,            MD, FAHA, requests                thatA.this
                                                                                      Chair; Philip         document
                                                                                                         Ades,              be cited as follows: Fletcher GF, Ad
                                                                                                                 MD, Co-Chair;
   Paul Kligfield,
           LA, FlegMD,        JL,FAHA,Forman        Co-Chair;
                                                         DE, Gerber      Ross TC,   Arena, PhD, M,
                                                                                         Gulati   PT, Madan
                                                                                                       FAHA; K,  Gary   J. Balady,
                                                                                                                     Rhodes                  MD, FAHA;
                                                                                                                                     J, Thompson                    PD, Williams MA
     Vera Cardiac
           A. Bittner,         MD, MSPH, FAHA;
                           Rehabilitation,                                Lola A. Coke,
                                                              and Prevention                  PhD, ACNS,
                                                                                          Committee            FAHA;
                                                                                                          of the  CouncilJerome   on L.       Fleg, MD;
                                                                                                                                         Clinical           Cardiology, Council
                       Daniel E. Forman, MD, FAHA; Thomas C. Gerber, MD, PhD, FAHA;
           onMartha
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                           Gulati, MD,and            MS,Stroke FAHA;Nursing,              and Council
                                                                               Kushal Madan,      PhD, PT; on Jonathan
                                                                                                               Epidemiology Rhodes,and       MD;   Prevention. Exercise sta
    Paul the    AmericanMD;
           D. Thompson,                 Heart    Mark Association.
                                                             A. Williams,          Circulation   . 2013;128:873–934.
                                                                                      PhD; on behalf     of the American Heart Association
  Exercise, Expert
               Cardiac peer               review ofand
                               Rehabilitation,                  AHA           Scientific
                                                                      Prevention            Statements
                                                                                         Committee   of theisCouncil
                                                                                                                conducted          by theCardiology,
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           development,
     Council    on Nutrition,visit         Physicalhttp://my.americanheart.org/statements
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                     Table of Contents
           Permission-Guidelines_UCM_300404_Article.jsp.                                     Evaluation andA Exercise
                                                                                                              link  toPrescription
                                                                                                                        the              in
                                                                                                                                “Copyright                 Permissions Request
Exercise Testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 874         Patients With CVD. . . . . . . . . . . . . . . . . . . . . . . . . . . 912
               (Circulation.
  Purposes of Exercise      Testing . . .2013;128:873-934.)
                                               . . . . . . . . . . . . . . . . . . 874       Effects of Exercise Training in
  Physiology of©Exercise
                    2013 TestingAmerican     . . . . . .Heart
                                                         . . . . . . .Association,
                                                                       . . . . . . 874     Inc.Patients With CVD. . . . . . . . . . . . . . . . . . . . . . . . . . . 914
  Types of Exercise . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 874   Prognostic Benefits of Exercise in
               Circulation
  Cardiovascular Responses to Exercise is available at http://circ.ahajournals.org      Patients With CVD. . . . . . . . . . . . . . . . . . . . . . . . . . . 914
    in Normal Subjects. . . . . . . . . . . . . . . . . . . . . . . . . . . 874       Targeting Exercise Prescription to
  Exercise Testing Procedures . . . . . . . . . . . . . . . . . . . . . 876             Relevant Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . 915
  Clinical and Cardiopulmonary Responses                                     Downloaded      from
                                                                                    References . . . . . http://circ.ahajournals.org/                     873
                                                                                                         . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 920at   Capital H
What is this?
Look familiar?
On the exam - Paper 1
•   List absolute and relative contraindications to stress testing

•   Complications of Exercise Testing

•   Absolute and Relative Indications for Terminating EST

•   Definition of positive, negative or equivocal ECG changes
    during exercise

•   Definitions of abnormal BP response

•   Prognostic value of exercise stress testing - DUKE Score

•   Exercise prescription

•   Sens/Specificity, pre-test and post-test probabilities
On the exam - Paper 2

•   Report a stress test (graphics provided)

    •   Could be normal or abnormal

•   Clinical stem, stress test given - how to manage?

•   Calculate a Duke score and estimate risk
On the Exam - Oral
•   Clinical scenario where a stress test is ordered.
    Interpret the stress test in front of the examiner and
    develop an appropriate management strategy.

    •   Evaluation of chest pain

    •   Assessment of prognosis

    •   Indication for valve surgery based on symptom
        assessment

    •   Assessment of arrhythmia, long QT, WPW etc.
Case
•   A 44 year old woman is referred for exercise
    stress testing. She reports chest pain, sharp
    stabbing retrosternal lasting a few seconds
    several times per day. No relationship to
    physical activity. She is concerned because of
    a positive family history. She has no other
    cardiac risk factors.
Phase            Stage       Time       Speed   Grade    HR          BP       Comment
Name             Name        in Stage   (mph)   (%)      (bpm)       (mmHg)

                             01:08      1.0     0.0      71          120/80

                            Stress test
PRETEST          STANDING
Exercise         STAGE 1     03:00      1.7     10.0     84          114/80
                 STAGE 2     03:00      2.5     12.0     98          126/76
                 STAGE 3     03:00      3.4     14.0     127         140/76
                 STAGE 4     01:11      4.2     16.0     144
Recovery         1 Minute    01:00      0.0     0.0      171         142/76   00:00 Target heart rate
                                                                              achieved
                 2 Minute    01:00      0.0     0.0      84          150/76
                 3 minute    01:00      0.0     0.0      71
                 4 minute    01:00      0.0     0.0      75          130/70
                 5 MINUTE    00:52      0.0     0.0      72          120/70

The patient exercised according to the BRUCE for 10:11 min:s, achieving a work level of Max.
METS: 12.0. The resting heart rate of 73 bpm rose to a maximal heart rate of 171 bpm. This value
represents 103 % of the maximal, age-predicted heart rate. The resting blood pressure of 120/80
mmHg , rose to a maximum blood pressure of 150/76 mmHg. The exercise test was stopped due to
Target Heart Rate, Dyspnea.

Interpretation

Summary: Resting ECG: Early repolarization abnormality.
Functional Capacity: Class I.
HR Response to Exercise: appropriate.
BP Response to Exercise: normal resting BP - appropriate response.
Chest Pain: none.
Arrhythmias: see comments.
ST Changes: Depression upsloping see comments.
LEPINE, PAUL                                 12-Lead Report
Patient ID: 0011176781         73 bpm            PRETEST                BRUCE
2017/04/20
 9:25:46
                                        Rest
                               120/80 mmHg       STANDING
                                                  00:08
                                                                          0.0 mph
                                                                          0.0 %

I                        aVR                          V1                         V4

II                       aVL                          V2                         V5

III                      aVF                          V3                         V6

GE
CASE V6.73                                   25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(II,V5)
Peak
LEPINE, PAUL                             12-Lead Report (PEAK EXERCISE)
Patient ID: 0011176781         144 bpm       EXERCISE              BRUCE
2017/04/20                                   STAGE 4                 4.2 mph
 9:36:57                                      10:11                 16.0 %

I                        aVR                      V1                         V4

II                       aVL                      V2                         V5

III                      aVF                      V3                         V6

GE
CASE V6.73                               25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(II,V5)
LEPINE, PAUL                             12-Lead Report

                   Recovery 00:15
Patient ID: 0011176781         141 bpm       RECOVERY               BRUCE
2017/04/20                                   1 Minute                 1.5 mph
 9:37:12                                      00:15                   3.1 %

I                        aVR                      V1                         V4

II                       aVL                      V2                         V5

III                      aVF                      V3                         V6

GE
CASE V6.73                               25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(II,V5)
Recovery 2:00
LEPINE, PAUL                                 12-Lead Report
Patient ID: 0011176781         84 bpm            RECOVERY               BRUCE
2017/04/20                     150/76 mmHg       2 Minute                 0.0 mph
 9:38:57                                          02:00                   0.0 %

I                        aVR                          V1                         V4

II                       aVL                          V2                         V5

III                      aVF                          V3                         V6

GE
CASE V6.73                                   25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(II,V5)
LEPINE, PAUL                                                 ID:0011176781             20-APR-2017 09:25:38                                                                                  NSES
                                                                                      GRADED EXERCISE SUMMARY
                  09-JUN-1961 (55 yr)                                  Male           BRUCE                          Total Exercise Time:10:11

                                 Medians Summary
                  Wt:                     Ht:                                         Max HR: 171 bpm 103% of Max Predicted 165 bpm                                                25mm/s
                  Med: Tamsulosin, rosuvastatin                                       Max BP: 150/76                 Maximum Workload: 12.0                                        10mm/mV
                                                                                                                                                                                   150Hz
                                                                                       cc: Dr. Maged Gerges
                  Referred by: DOUGLAS HAYAMI                                          Endpoint was THR and dyspnea
                  Technician:SARAH MCLEAN                                              Functional Class I ( 12 METs)
                  Test ind: Ischemia Evaluation, R/O Arrhyth                           No chest pain
                  Test type: Treadmill Stress                                          Resting EKG shows early repolarization abnormailty. At peak exercsie developed
                                                                                       > 1.5 mm ( beyond baseline) upsloping ST depression
                                                                                       In recovery had 18 second run of SVT at 160 bpm, withusual symptoms
                                                                                       Borderline positives test by EKG with SVT in recovery

                                                                                       Confirmed by MACDONALD, M.D., NANCY (9504) on 4/20/2017 11:33:05 AM

                        BASELINE                                                                                               MAX ST
                                                                                      Lead                                                                                          Lead
EXERCISE STAGE 1                       71 bpm                ST @ 10mm/mV             ST              EXERCISE STAGE 4                      144 bpm           ST @ 10mm/mV          ST
00:00      1.3                                               60ms postJ               Slope           10:11      12.0                                         60ms postJ            Slope

I                       aVR                       V1                     V4                           I                        aVR                 V1                   V4
      0.4 mm              -0.6                         0.7                    0.9                          -0.1                   0.8                   1.1              -0.8
     -0.3 mV/s            -1.5                         0.3                    0.8                           0.1                  -1.3                   0.5                2.4

II                      aVL                       V2                     V5                           II                       aVL                 V2                   V5
      0.8                  0.1                         1.7                    0.7                          -1.6                   0.7                   0.8              -1.3
      0.3                 -0.5                         1.5                    0.5                           1.7                  -0.8                   2.2                1.5

III                     aVF                       V3                     V6                           III                      aVF                 V3                   V6
      0.3                 0.5                          1.4                    0.4                        -1.5                    -1.5                   0.3              -0.9
      0.3                 0.3                          1.4                    0.1                         1.1                     1.5                   2.4                0.8

                                                                                    Confirmed By: NANCY MACDONALD, M.D.                   Date:20-APR-2017

8.0.1       CASE V6.73-0.0                                                                                        SID: 0001644160 EID:9504 EDT: 11:33 20-APR-2017 ORDER:         ACCOUNT: 28714882
With respect to this stress test:

•   A) It’s normal - Negative

•   B) It’s abnormal - Positive

•   C) It’s equivocal - Non-diagnostic

•   D) Holy crap why did I order this stress test?
ECG changes with exercise
                                                   Fletcher et al     Exercise Standards for Testing and Training              885

                                                                                                    Figure 4. Definition of
                                                                                                    ST-segment depression
                                                                                                    changes during exercise.
                                                                                                    Positive standard test
                                                                                                    responses include horizontal
                                                                                                    or downsloping depression
                                                                                                    ≥1.0 mm (0.1 mV), whereas
                                                                                                    upsloping ST depression ≥1.0
                                                                                                    mm is considered equivocal
                                                                                                    (a change that does not
                                                                                                    usefully separate normal from
                                                                                                    abnormal). All ST depression
                                                                                                    1.6 µV/bpm defined as
ischemic disease than in normal subjects.101 At the same time,      abnormal.90,111 Because it is calculated from only upright con-
increasing HR during graded exercise is what influences pro-        trol and peak exercise data, the ST/HR index can be derived
gressive ST-segment depression because it is a major deter-         from tests that are not gently graded. The ST/HR index has
Pearl of wisdom
•   With resting ST depression, further ST
    depression is measured

•   With resting ST elevation due to early
    repolarization, only ST depression related to
    baseline is measured

•   Baseline is P-Q segment as T-P is often too short
    during exercise.
Indications for Exercise
                 Stress testing
-Symptoms suggesting myocardial ischemia
-Acute chest pain in whom acute coronary syndrome (ACS) and
myocardial infarction have been excluded
-Recent ACS treated without coronary angiography
-Known coronary heart disease and change in clinical status
-Prior coronary revascularization
-Valvular heart disease (asymptomatic)
-Newly diagnosed heart failure or cardiomyopathy (compensated)
-Certain cardiac arrhythmias
-An indication for cardiac assessment prior to non-cardiac surgery

•   2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with
    stable ischemic heart disease: Miller TD, Askew JW, Anavekar NS.

•   Noninvasive Stress Testing for Coronary Artery Disease. Heart Fail Clin. 2016 Jan;12(1):65-82.
cardiac output     Absolute and Relative Contraindications to Exercise
V̇o2max divided     Testing
                    Absolute and relative contraindications to exercise testing
             Contraindications to Stress
  as the oxygen
ume (ie, cardiac    balance the risk of the test with the potential benefit of the
                    information derived from the test. Assessment of this balance
e arteriovenous
e arteriovenous
 siological limit
                      Testing
                    requires knowledge of the purpose of the test for the individ-
                    ual subject or patient and what symptom or sign end points
 cardiovascular     will be for the individual test.
 xygen pulse at     Absolute Contraindications
n in the forward
 bout a patient’s   ●   Acute myocardial infarction (MI), within 2 days
 e can be made      ●   Ongoing unstable angina
 peak exercise.     ●   Uncontrolled cardiac arrhythmia with hemodynamic
 ke volume) at          compromise
  size, and sex.    ●   Active endocarditis
ver, by dividing    ●   Symptomatic severe aortic stenosis
 minute) by the     ●   Decompensated heart failure
  influenced by     ●   Acute pulmonary embolism, pulmonary infarction, or deep
uration. Proper         vein thrombosis
hould take into     ●   Acute myocarditis or pericarditis
                    ●   Acute aortic dissection
                    ●   Physical disability that precludes safe and adequate testing
 ages of 15 and
At age 60 years,    Relative Contraindications
 ds of that at 20
d stroke volume) at           compromise
s age, size, and sex.     ●   Active endocarditis
however, by dividing          Symptomatic severe aortic stenosis
               Contraindications to Stress
                          ●

rs per minute) by the     ●   Decompensated heart failure
 lso is influenced by     ●   Acute pulmonary embolism, pulmonary infarction, or deep
 n saturation. Proper         vein thrombosis
ore should take into    Testing
                          ●

                          ●
                              Acute myocarditis or pericarditis
                              Acute aortic dissection
                          ●   Physical disability that precludes safe and adequate testing
 n the ages of 15 and
age. At age 60 years,     Relative Contraindications
 o thirds of that at 20
o2max was observed
                          ●   Known obstructive left main coronary artery stenosis
however, the rate of
                          ●   Moderate to severe aortic stenosis with uncertain relation
  years in individuals        to symptoms
ars in individuals in
                          ●   Tachyarrhythmias with uncontrolled ventricular rates
1.
                          ●   Acquired advanced or complete heart block
                          ●   Hypertrophic obstructive cardiomyopathy with severe rest-
                              ing gradient
n that of men.22 This     ●   Recent stroke or transient ischemic attack
 heir smaller muscle      ●   Mental impairment with limited ability to cooperate
e, and smaller stroke     ●   Resting hypertension with systolic or diastolic blood pres-
ne for each decade is         sures >200/110 mm Hg
rth decade onward.21      ●   Uncorrected medical conditions, such as significant ane-
                              mia, important electrolyte imbalance, and hyperthyroidism
ence on V̇o2max. In
≈12 METs, whereas         Subject Preparation
uch as distance run-      Preparations for exercise testing include the following:
Another case

•   47 year old man complaining of decreased
    exercise tolerance and palpitations with exertion.

•   No cardiac risk factors.
Name             Name        in Stage   (mph)   (%)      (bpm)     (mmHg)

PRETEST          STANDING    09:37      1.0     0.0      85        134/74
Exercise         STAGE 1     03:00      1.7     10.0     91        150/74
                 STAGE 2     03:00      2.5     12.0     112       156/66
                 STAGE 3     03:00      3.4     14.0     146       172/60

Recovery
                 STAGE 4

                 STAGE 5

                 1 Minute
                             03:00

                             02:16

                             01:00
                                          EST
                                        4.2

                                        4.8

                                        0.0
                                                16.0

                                                18.0

                                                0.0
                                                         153

                                                         187

                                                         137
                                                                   172/60
                                                                            09:45 Target heart rate
                                                                            achieved
                                                                            13:05 breathing getting
                                                                            laboured

                 2 Minute    01:00      0.0     0.0      122
                 3 minute    01:00      0.0     0.0      113
                 4 minute    01:00      0.0     0.0      110
                 5 MINUTE    00:36      0.0     0.0      109

The patient exercised according to the BRUCE for 14:15 min:s, achieving a work level of Max.
METS: 17.2. The resting heart rate of 72 bpm rose to a maximal heart rate of 187 bpm. This value
represents 106 % of the maximal, age-predicted heart rate. The resting blood pressure of 134/74
mmHg , rose to a maximum blood pressure of 172/60 mmHg. The exercise test was stopped due to
Dyspnea.

Interpretation

Conclusions

cc: Dr. Farah Kapur
SIMMONS, GREGORY
Patient ID: 0010647048
25.07.2016
 9:43:25am
                               76 bpm
                                     Rest
                               134/74 mmHg
                                                 PRETEST
                                                 STANDING
                                                  00:58
                                                                        BRUCE
                                                                          0.0 mph
                                                                          0.0 %

I                        aVR                          V1                         V4

II                       aVL                          V2                         V5

III                      aVF                          V3                         V6

V1

GE
CASE V6.61                                   25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.3 HR(II,V4)
Peak
SIMMONS, GREGORY
Patient ID: 0010647048         151 bpm       RECOVERY               BRUCE
25.07.2016                                   1 Minute                 0.0 mph
10:07:06am                                    00:48                   0.0 %

I                        aVR                      V1                         V4

II                       aVL                      V2                         V5

III                      aVF                      V3                         V6

V1

GE
CASE V6.61                               25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.3 HR(V3,V4)
Peak (continued - cardiologist
                  becoming anxious)
SIMMONS, GREGORY
Patient ID: 0010647048         157 bpm       RECOVERY               BRUCE
25.07.2016                                   2 Minute                 0.0 mph
10:07:20am                                    01:02                   0.0 %

I                        aVR                      V1                         V4

II                       aVL                      V2                         V5

III                      aVF                      V3                         V6

V1

GE
CASE V6.61                               25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.3 HR(V3,V4)
SIMMONS, GREGORY
Patient ID: 0010647048
25.07.2016
10:10:40am
                               Recovery
                               111 bpm       RECOVERY
                                             5 Minute
                                              04:22
                                                                    BRUCE
                                                                      0.0 mph
                                                                      0.0 %

I                        aVR                      V1                         V4

II                       aVL                      V2                         V5

III                      aVF                      V3                         V6

V1

GE
CASE V6.61                               25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.3 HR(V1,II)
SIMMONS, GREGORY                                            ID:0010647048             25-JUL-2016 09:42:27                                                                                 NSES

                                                                       Medians
                                                                                     GRADED EXERCISE SUMMARY
                  15-FEB-1972 (44 yr)                                 Male           BRUCE                          Total Exercise Time:14:15
                  Wt:                      Ht:                                       Max HR: 187 bpm 106% of Max Predicted 176 bpm                                               25mm/s
                  Med: NIL                                                           Max BP: 172/60                 Maximum Workload: 17.2                                       10mm/mV
                                                                                                                                                                                 150Hz
                                                                                      cc: Dr. Farah Kapur
                  Referred by: RATIKA PARKASH
                  Technician:LINDA BOURBONNAIS                                        A stress echo was performed.
                  Test ind: Screening for CAD                                         Non-diagnostic stress test.
                  Test type: Stress Echo                                              Wide complex tachycardia noted.
                                                                                      See echo report.

                                                                                      Confirmed by RAMER, M.D., SARAH (10381) on 8/9/2016 10:35:11 AM

                        BASELINE                                                                                          MAX ST
                                                                                     Lead                                                                                         Lead
EXERCISE STAGE 1                        83 bpm              ST @ 10mm/mV             ST             EXERCISE STAGE 3                   141 bpm           ST @ 10mm/mV             ST
00:00      1.7                                              60ms postJ               Slope          8:50       10.1                    172/60            60ms postJ               Slope

I                       aVR                      V1                     V4                          I                     aVR                   V1                 V4
      0.5 mm              -0.8                     0.7                       0.7                         -1.4               -0.3                 -5.2                    0.6
      0.4 mV/s            -1.0                    -0.2                       0.5                         -0.5              -11.5                 -9.8                   11.4

II                      aVL                      V2                     V5                          II                    aVL                   V2                 V5
      1.1                 -0.1                     0.1                       0.7                          2.1               -2.4                  -3.5                   1.0
      0.7                  0.1                    -0.1                       0.5                         17.3               -9.6                 -12.6                  11.6

III                     aVF                      V3                     V6                          III                   aVF                   V3                 V6
      0.7                 0.9                         0.6                    0.6                          3.5               2.8                   0.1                    1.5
      0.1                 0.5                         0.3                    0.5                         17.8              17.5                  10.4                   11.7

                                                                                   Confirmed By: SARAH RAMER, M.D.                   Date:09-AUG-2016

8.0.1       CASE V6.61-0.0                                                                                  SID: 0001283363 EID:10381 EDT: 10:35 09-AUG-2016 ORDER:            ACCOUNT: 27750333
What happened here and how
 are you going to report it?
ure with a risk of        suggest that the ventilatory threshold has been exceeded.
  be certain that the
                           Angina Characteristics and Scale
Good communica-
 tory.
                    Complications of Stress
   the test, and writ-
                           Levels of anginal discomfort in those with known or suspected
                           CAD are also excellent subjective end points. Whether typi-
                           cal angina occurs with exercise or is the reason for termina-
   ensuring that the
d that exercise test-      Testing
                           tion of the test is an important observation in evaluation of the
                           exercise test, and it is an important factor in calculation of the
  cise testing should      Duke Treadmill Score.63
nel with sufficient
bility to recognize
 tion on the ECG.43        Table 1.     Complications Secondary to Exercise Testing
 uring a test can be       Cardiac            Bradyarrhythmias
 bject being tested.                          Tachyarrhythmias
 or physician’s des-
                                              Acute coronary syndromes
 uestions about the
                                              Heart failure
 physical examina-
performed immedi-                             Hypotension, syncope, and shock
 gned to a properly                           Death (rare; frequency estimated at 1 per
   assistant, or exer-                          10 000 tests, perhaps less)
apparently healthy         Noncardiac         Musculoskeletal trauma
 e with stable chest                          Soft-tissue injury
   permit additional       Miscellaneous      Severe fatigue (malaise), sometimes persisting for
nel.43 Possibly with                            days; dizziness; body aches; delayed feelings of illness
 y individuals (eg,          Reproduced with permission from Fletcher et al.1 © 2001 American Heart
uld be immediately         Association, Inc.

m http://circ.ahajournals.org/ at Capital Health on May 27, 2015
20                                             to near-baseline values. Eve
                Reprinted from Borg219 with permission of the          at peak exercise, postexercis
              publisher. Copyright ©1982, the American College of      an abnormal electrocardiogr

Indications to Stop a Stress
              Sports Medicine.

     Indications for Termination of Exercise Testing
                                                                       during the recovery period. M
                                                                       trophysiological abnormaliti
                                                                       exercise can persist for minu
     The decision to terminate exercise is an important function of
            Test
     test supervision that is generally determined by the purpose
     of testing in individual subjects. Symptom-limited testing is
                                                                       pressure should continue du
                                                                       responses could occur, partic
                                                                       mias also might be present in
     desirable for general evaluation, but this recommendation
     could be modified in several situations.58                        Management of Pacemaker
                                                                       Exercise testing can be used
     Absolute Indications                                              implanted pacemakers and o
                                                                       of tracking function that can
     ●   ST-segment elevation (>1.0 mm) in leads without preexist-
                                                                       with implanted defibrillators
         ing Q waves because of prior MI (other than aVR, aVL,
                                                                       alone, firing function should
         and V1)
                                                                       maximum testing if the thres
     ●   Drop in systolic blood pressure >10 mm Hg, despite an
                                                                       exercise. In the presence of a v
         increase in workload, when accompanied by any other evi-
                                                                       cannot be evaluated for isch
         dence of ischemia
                                                                       “pacemaker memory” could
     ●   Moderate-to-severe angina
                                                                       that can mimic ischemia when
     ●   Central nervous system symptoms (eg, ataxia, dizziness,
                                                                       to examine the underlying ele
         near syncope)
     ●   Signs of poor perfusion (cyanosis or pallor)
     ●   Sustained ventricular tachycardia (VT) or other arrhythmia,
                                                                       Clinical and Cardiopulm
         including second- or third-degree atrioventricular (AV)
                                                                       Exercise
         block, that interferes with normal maintenance of cardiac     Clinical Responses
         output during exercise
                                                                       Symptoms
     ●   Technical difficulties in monitoring the ECG or systolic
                                                                       Assessment of perceived sym
         blood pressure
                                                                       of the exercise test. Sympto
     ●   The subject’s request to stop
                                                                       separate quantification of d
     Relative Indications                                              exertion. Scales for each of
●   Signs of poor perfusion (cyanosis or pallor)
                     ●   Sustained ventricular tachycardia (VT) or other arrhythmia,
                                                                                            Clinical and Cardi
                                                                                            Exercise
                Indications to Stop a Stress
                         including second- or third-degree atrioventricular (AV)
                         block, that interferes with normal maintenance of cardiac
                         output during exercise
                                                                                            Clinical Responses
                                                                                            Symptoms
                     ●

                     ●
                            Test
                         Technical difficulties in monitoring the ECG or systolic
                         blood pressure
                         The subject’s request to stop
                                                                                            Assessment of perceiv
                                                                                            of the exercise test. S
                                                                                            separate quantificatio
                     Relative Indications                                                   exertion. Scales for ea
                                                                                            the present statement
                     ●   Marked ST displacement (horizontal or downsloping of >2            symptoms induced by
                         mm, measured 60 to 80 ms after the J point [the end of the         and are even more p
                         QRS complex]) in a patient with suspected ischemia                 depression.67 Exercise
                     ●   Drop in systolic blood pressure >10 mm Hg (persistently            a worse prognosis th
2013                     below baseline) despite an increase in workload, in the            important to obtain fro
                         absence of other evidence of ischemia                              perceived symptoms d
                     ●   Increasing chest pain                                              patient considers to be
Perceived            ●   Fatigue, shortness of Downloaded
                                                 breath, wheezing,   leg cramps, or
                                                            from http://circ.ahajournals.org/ at Capital Health on
                         claudication
                     ●   Arrhythmias other than sustained VT, including multifocal
                         ectopy, ventricular triplets, supraventricular tachycardia,
                         and bradyarrhythmias that have the potential to become
 Very, very light        more complex or to interfere with hemodynamic stability
                     ●   Exaggerated hypertensive response (systolic blood pressure
 Very light              >250 mm Hg or diastolic blood pressure >115 mm Hg)
                     ●   Development of bundle-branch block that cannot immedi-
 Fairly light            ately be distinguished from VT
Another case
•   54 year old man with exertional chest pain.

•   Restrosternal pressure ‘like somebody sitting on
    chest’

•   Relieved with Rest

•   CRF = high cholesterol and pos family history
Exercise Test Summary
Phase            Stage         Time       Speed    Grade        HR      BP       Comment
Name             Name          in Stage   (mph)    (%)          (bpm)   (mmHg)

                                                EST
PRETEST          STANDING      05:43      1.0      0.0          63      130/80
Exercise         STAGE 1       03:00      1.7      10.0         100     164/82
                 STAGE 2       01:39      2.5      12.0         112     160/84   03:04 chest discomfort
                                                                                 starting into right shoulder
                                                                                 04:16 Chest Discomfort
                                                                                 Increasing 3/10
Recovery         1 Minute      01:00      0.0      0.0          83      158/84   00:55 discomforrt easing
                 2 Minute      01:00      0.0      0.0          63      158/84
                 3 minute      01:00      0.0      0.0          62
                 4 minute      00:55      0.0      0.0          61      148/80   03:37 chest and right
                                                                                 shoulder discomfort gone

The patient exercised according to the BRUCE for 04:39 min:s, achieving a work level of Max.
METS: 6.5. The resting heart rate of 60 bpm rose to a maximal heart rate of 112 bpm. This value
represents 66 % of the maximal, age-predicted heart rate. The resting blood pressure of 130/80 mmHg
, rose to a maximum blood pressure of 164/82 mmHg. The exercise test was stopped due to usual
chest, right shoulder discomfort increasing.

Interpretation

Summary: Functional Capacity: Class II.
Chest Pain: limiting.
ST Changes: Depression horizontal.
Overall Impression: Positive stress test typical of ischemia.

Conclusions
SOKOLIC, VALERIANO                           12-Lead Report

                                        Rest
Patient ID: 0006354559         60 bpm            PRETEST                BRUCE
2017/04/13                     130/80 mmHg       STANDING                 0.0 mph
13:50:57                                          00:06                   0.0 %

I                        aVR                          V1                         V4

II                       aVL                          V2                         V5

III                      aVF                          V3                         V6

GE
CASE V6.73                                   25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(V2,II)
SOKOLIC, VALERIANO                           12-Lead Report (PEAK EXERCISE)

                                       Peak
Patient ID: 0006354559         112 bpm           EXERCISE              BRUCE
2017/04/13                     160/84 mmHg       STAGE 2                 2.5 mph
14:01:12                                          04:39                 12.0 %

I                        aVR                          V1                         V4

II                       aVL                          V2                         V5

III                      aVF                          V3                         V6

GE
CASE V6.73                                   25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(V2,II)
Recovery 00:15
SOKOLIC, VALERIANO                       12-Lead Report
Patient ID: 0006354559         107 bpm       RECOVERY               BRUCE
2017/04/13                                   1 Minute                 1.5 mph
14:01:27                                      00:15                   0.0 %

I                        aVR                      V1                         V4

II                       aVL                      V2                         V5

III                      aVF                      V3                         V6

GE
CASE V6.73                               25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(V2,II)
Recovery 2:00
SOKOLIC, VALERIANO                           12-Lead Report
Patient ID: 0006354559         63 bpm            RECOVERY               BRUCE
2017/04/13                     158/84 mmHg       2 Minute                 0.0 mph
14:03:12                                          02:00                   0.0 %

I                        aVR                          V1                         V4

II                       aVL                          V2                         V5

III                      aVF                          V3                         V6

GE
CASE V6.73                                   25mm/s    10mm/mV   60Hz   0.01Hz   FRF+   HEART V5.4 HR(V2,II)
SOKOLIC, VALERIANO                                        ID:0006354559             13-APR-2017 13:50:51                                                                                  NSES
                                                                                   GRADED EXERCISE SUMMARY

                             Medians Summary
                  03-FEB-1966 (51 yr)                               Male            BRUCE                           Total Exercise Time:4:39
                  Wt:                    0lb                                        Max HR: 112 bpm 66% of Max Predicted 169 bpm                                                25mm/s
                  Med: TECTA, rosuvastatin                                          Max BP: 164/82                  Maximum Workload: 6.5                                       10mm/mV
                                                                                                                                                                                150Hz
                                                                                    cc: Dr. Shalini Veerassamy
                  Referred by: GENEVIEVE MORTERA                                    Functional Class 2
                  Technician:LINDA BOURBONNAIS                                      Normal heart rate response
                  Test ind: Screening for CAD                                       Normal blood pressure response
                  Test type: Treadmill Stress                                       No chest pain
                                                                                    Significant ST depression
                                                                                    Positive test for ischemia

                        BASELINE                                                                                            MAX ST
                                                                                   Lead                                                                                          Lead
EXERCISE STAGE 1                     63 bpm               ST @ 10mm/mV             ST              EXERCISE STAGE 2                      112 bpm           ST @ 10mm/mV          ST
00:00      1.7                                            60ms postJ               Slope           4:39       6.5                        160/84            60ms postJ            Slope

I                       aVR                    V1                     V4                           I                        aVR                 V1                   V4
      0.1 mm              -0.3                      0.3                    0.2                          -0.5                   1.3                   1.3              -1.0
      0.1 mV/s            -0.7                      0.0                    0.2                           0.2                  -0.0                   0.5                0.1

II                      aVL                    V2                     V5                           II                       aVL                 V2                   V5
      0.3                 0.1                       0.8                    0.2                          -2.1                  0.6                    1.2              -1.6
      0.1                 0.1                       0.5                    0.1                          -0.3                  0.3                    1.2              -0.4

III                     aVF                    V3                     V6                           III                      aVF                 V3                   V6
      0.2                  0.3                      0.6                    0.3                        -1.6                    -1.9                   0.2              -1.4
     -0.2                 -0.1                      0.5                    0.0                        -0.6                    -0.5                   1.0              -0.4

                                                                                 Unconfirmed                                           Date:13-APR-2017

8.0.1       CASE V6.73-0.0                                                                                     SID: 0000542668 EID:9100 EDT: 15:21 13-APR-2017 ORDER:         ACCOUNT: 28597681
Stress test interpretation
What is his Duke Score and
         what is the risk?
•   Exercise time (minutes on Bruce) - 5 x (max ST
    depression in mm) - 4 x (angina index)

•   0 = no angina

•   1 = non-limiting

•   2 = limiting
Exercise Test Summary
Phase
SOKOLIC,         Stage
         VALERIANO                          Time ID:0006354559
                                                      Speed           Grade 13-APR-2017
                                                                                 HR          BP
                                                                                        13:50:51     Comment                                                                              NSES
Name                    Name                in Stage  (mph)           (%) GRADED (bpm)       (mmHg)
                                                                                    EXERCISE SUMMARY

                                                       Duke Score
PRETEST           03-FEB-1966 (51 yr)
                        STANDING             05:43     1.0   Male     0.0      BRUCE63           130/80        Total Exercise Time:4:39
                  Wt: STAGE 1            0lb 03:00                             Max HR: 112 bpm 66% of Max Predicted 169 bpm                                                     25mm/s
Exercise                                               1.7            10.0          100          164/82                                                                         10mm/mV
                  Med: TECTA, rosuvastatin                                     Max BP: 164/82                  Maximum Workload: 6.5
                        STAGE 2              01:39     2.5            12.0           112              160/84     03:04 chest discomfort                                         150Hz
                                                                               cc: Dr. Shalini Veerassamy        starting into right shoulder
                  Referred by: GENEVIEVE MORTERA                               Functional Class 2                04:16 Chest Discomfort
                  Technician:LINDA BOURBONNAIS                                 Normal heart rate response        Increasing 3/10
Recovery          Test ind: Screening for CAD 01:00
                         1 Minute                      0.0            0.0      Normal83blood pressure   response 00:55 discomforrt easing
                                                                                                     158/84
                  Test type: Treadmill Stress                                  No chest pain
                        2 Minute            01:00      0.0            0.0            63 ST depression
                                                                               Significant           158/84
                        3 minute            01:00      0.0            0.0            62
                                                                               Positive test for ischemia
                        4 minute            00:55      0.0            0.0            61              148/80      03:37 chest and right
                                                                                                                 shoulder discomfort gone

 The patient exercised
                  BASELINEaccording to the BRUCE for 04:39 min:s, achieving a work MAX       levelSTof Max.
                                                               Lead                                                                                                              Lead
 METS: STAGE
EXERCISE  6.5. The
                1   resting heart
                             63 bpmrate ofST
                                           60@bpm    rose to a ST
                                               10mm/mV          maximal heart  rate of
                                                                          EXERCISE     1122 bpm. This 112
                                                                                    STAGE               value
                                                                                                           bpm                                             ST @ 10mm/mV          ST
00:00       1.7                           60ms postJ           Slope      4:39        6.5              160/84                                              60ms postJ            Slope
 represents 66 % of the maximal, age-predicted heart rate. The resting blood pressure of 130/80 mmHg
 , rose to a maximum blood pressure of 164/82 mmHg. The exercise test was stopped due to usual
 chest, right shoulder discomfort increasing.
I                       aVR                 V1                V4                               I                        aVR                     V1                   V4
Interpretation
  0.1 mm                  -0.3                   0.3                0.2                             -0.5                   1.3                       1.3              -1.0
      0.1 mV/s            -0.7                   0.0                0.2                              0.2                  -0.0                       0.5                0.1

 Summary: Functional Capacity: Class II.
 Chest Pain: limiting.
 ST Changes: Depression horizontal.
II              aVL              V2                 V5                                         II                       aVL                     V2                   V5
 Overall
   0.3   Impression:
                  0.1 Positive stress
                                    0.8 test typical of0.2ischemia.                                 -2.1                  0.6                        1.2              -1.6
      0.1                    0.1                 0.5                0.1                             -0.3                  0.3                        1.2              -0.4

Conclusions

III                     aVF                 V3                V6                               III                      aVF                     V3                   V6
     0.2                   0.3                   0.6                0.3                           -1.6                    -1.9                       0.2              -1.4
    -0.2                  -0.1                   0.5                0.0                           -0.6                    -0.5                       1.0              -0.4

                                                                            Unconfirmed                                            Date:13-APR-2017

8.0.1       CASE V6.73-0.0                                                                                 SID: 0000542668 EID:9100 EDT: 15:21 13-APR-2017 ORDER:             ACCOUNT: 28597681
Duke Score

•   4 - 5 (2) - 4 (2) = -14

•   High Risk
Elements of a report
•   Patient name

•   Referring provider

•   Indication for test

•   Date performed

•   Protocol performed

•   Duration of exercise
Elements of a report
•   Baseline and Max HR, BP Workload.

•   Description of abnormal HR or BP response

•   Symptoms - when and what. Specifically mention presence or
    absence of chest pain.

•   Reason for Stopping

•   ECG changes - baseline, peak, and when significant

•   Arrhythmias - rest and stress

•   Comparison to age matched controls
Summary
•   “Positive”, “Negative” or “Equivocal”

•   “Normal”, “Abnormal” or “Non-diagnostic”

•   For detection of ischemia a reasonable RPP
    must be achieved. (10th percentile 25,000, 90th
    40,000)

•   THR = 85% max age predicted (220-age)
Weight: 0 lb                                               Race: --

    Study Date: 13-Apr-2017                                    Referring Physician: GENEVIEVE MORTERA
    Test Type: Treadmill Stress                                Attending Physician: TECH CLINIC
    Protocol: BRUCE                                            Technician: LINDA BOURBONNAIS

    Medications:
    TECTA , rosuvastatin

    Medical History:
                                              Report
    Reason for Exercise Test:
    Screening for CAD
•   Mr. Bob Smith
    Exercise Test Summary

•   Referred by: Dr. S. Ramer
    Phase
    Name
                       Stage
                       Name
                                   Time
                                   in Stage
                                              Speed
                                              (mph)
                                                       Grade
                                                       (%)
                                                                     HR
                                                                     (bpm)
                                                                             BP
                                                                             (mmHg)
                                                                                      Comment

    PRETEST            STANDING    05:43      1.0      0.0           63      130/80
    Exercise           STAGE 1     03:00      1.7      10.0          100     164/82
•   Indication: Exertional chest pain, ? ischemia
                       STAGE 2     01:39      2.5      12.0          112     160/84   03:04 chest discomfort
                                                                                      starting into right shoulder
                                                                                      04:16 Chest Discomfort
                                                                                      Increasing 3/10
    Recovery           1 Minute    01:00      0.0      0.0           83      158/84   00:55 discomforrt easing
•   Date: April 24, 2020
                       2 Minute
                       3 minute
                       4 minute
                                   01:00
                                   01:00
                                   00:55
                                              0.0
                                              0.0
                                              0.0
                                                       0.0
                                                       0.0
                                                       0.0
                                                                     63
                                                                     62
                                                                     61
                                                                             158/84

                                                                             148/80   03:37 chest and right
                                                                                      shoulder discomfort gone

    The patient exercised according to the BRUCE for 04:39 min:s, achieving a work level of Max.
    METS: 6.5. The resting heart rate of 60 bpm rose to a maximal heart rate of 112 bpm. This value
    represents 66 % of the maximal, age-predicted heart rate. The resting blood pressure of 130/80 mmHg
    , rose to a maximum blood pressure of 164/82 mmHg. The exercise test was stopped due to usual
    chest, right shoulder discomfort increasing.

    Interpretation

    Summary: Functional Capacity: Class II.
    Chest Pain: limiting.
    ST Changes: Depression horizontal.
    Overall Impression: Positive stress test typical of ischemia.
Report
•   Decreased exercise capacity (FC II) with endpoint of chest
    discomfort. Usual CP developed at 4:30 at a HR of 100 beats per
    minute.

•   Blunted HR response to exercise - target HR not achieved

•   BP response to exercise - normal resting BP, normal BP response
    to exercise

•   Arrhythmias - none

•   ECG changes - Normal resting ECG. Diagnostic ST depression at
    4 minutes in the protocol. At peak exercise there is 2 mm ST
    segment depression, downsloping.
Summary

•   Positive Stress test, typical of ischemia at a FCII
    workload.

•   High risk based on a Duke score of -14.
Important definitions
Normal HR response to
            exercise

•   Increase of 10 beats per min per MET

•   Expect less if beta blocked

•   Chronotropic incompetence can cause
    symptoms and correlates with poorer prognosis.
Abnormal BP response to
          exercise
•   Hypertensive increase in SBP >60 for men, >50
    for women or increase to above the 90th
    percentile (>210 in men and >190 in women).
    DBP increase >10 mmHg or absolute value
    >90mmHg.

•   Blunted = an increase of less than 20-25 mmHg.

•   Hypotensive = drops below resting value or
    rises initially and then drops by >/= 10 mmHg.
Oral Scenario

•   A 62 year old man presents for outpatient
    exercise stress testing for evaluation of chest
    pain. His resting ECG is normal. After 4 minutes
    on a Bruce Protocol he develops 2 mm of ST
    elevation in the anterior leads associated with
    his usual chest pain (retrosternal heaviness).
How to Manage this Patient?
Summary

•   Exercise stress testing is ‘bread and butter’
    cardiology.

•   There will be stress testing on your exam - could
    be in any section of the exam.

•   Know your Duke Score!
Thank you!
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