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FCF Fox Corporate Finance | FCF Life Sciences
Life Sciences Venture Capital Monitor
May 2020                                                                              Antibody

Part of FCF Life Sciences Research Series       Strategic Financing Advisory in Life Sciences
Agenda

F C F L i f e S c i e nc e s O v e r v i ew

                                              2
Overview

Overview                                                                                              Service Portfolio                     Facts and Figures

       Focus on Biotechnology, MedTech and HealthTech                                                                                                                                                  Over                  Over
                                                                                                                                               Life Sciences                     Life Sciences
                                                                                                                      Management                  Team of                                           100 years              EUR 2bn
FCF advises innovative companies on arranging, structuring and placing                                                                                                             Advisory        in aggregated        Life Sciences
                                                                                                                      Presentation                    ~10
equity and debt transactions in a holistic financing strategy approach.                                                                                                             Board          Life Sciences         transaction
                                                                                                        Integrated                           based in Munich
Together with its industry advisors, FCF Life Sciences provides valuable                                                                                                                             experience             volume1
                                                                                                         Financial
support on the strategic positioning of its clients                                                      Modeling
                                                                                                                          Post-                       Over                                                                    4
                                                                                                                                                                                     Access to
       Strategic Financing Advisory                                                                                    Transaction                        80                                         Leading             regularly
                                                                                                                         Support                                                      > 1000
                                                                                                                                              completed Life                                        EIB advisor        published Life
                                                                                                                                                                                  international
FCF advises with its dedicated Life Sciences team on the following                                      Investor                                 Sciences                                            in Europe           Sciences
                                                                                                                                                                                    investors
transaction types:                                                                                      Screening                              transactions1                                                              reports
                                                                                                                                           1 comprising   Professionals and Advisory Board
                                                                                                                       Investor / IB
                            Venture Capital                Venture Debt                                                 Roadshow
                                  +                             +
                                                                                                                                            Life Sciences Research Series
                             Growth Equity                                                                 Due
                                                                                                         Diligence
                                                                                                         Support                            Venture Capital Monitor                               Public Equity Monitor
                                                                                                                      Equity & Debt                                      is     a    monthly                       is the most detailed
       Life Sciences Team                                                                                              Fundraising
                                                                                                                                                                         published overview                        analysis           of
                                                                                                        Financing                                                        of venture capital                        European     publicly
                                                                                                         Strategy                                                                                                  listed   companies,
                                                                                                                                                                         transactions of Life
                                                                                                         Advisory
                                                                                                                                                                         Sciences companies                        from     the     Life
                                                                                                                        Closing                                                                                    Sciences sectors
Dr. Holger Bengs        Prof. Dr.             Elijah Falk          Arno Fuchs    Dr. Alexandra Goll
                                                                                                                       Assistance
  Founder & CEO       Horst Domdey              Analyst                CEO            Former
 BCNP Consultants   Co-Founder of Medigene                                         General Partner
                                                                                    TVM Capital
                                                                                                        Term Sheet
                     & board member BioM                                                                                                    Venture Capital Report                                IPO Report
                                                                                                        Negotiation
                                                                                                                                                                         analyses the latest                       examines        recent
                                                                                                                          IPO
                                                                                                                        Execution                                        Venture       Capital                     IPO trends in the
                                                                                                                         Support                                         funding activities in                     Life Sciences sector,
                                                                                                           Life
                                                                                                         Science                                                         the Life Sciences                         with a strong focus
    Yasmin            Claus Schalper          Dr. Mathias           Sebastian      Enno Spillner        Advisory                                                         sector in Europe                          on the comparison
   Herrmann          Co-Founder & former        Schott               Sommer          CFO Evotec           Board       (extract from
     Analyst          CFO Pieris Pharma         Director             Associate                                        service portfolio)                                 and the US                                of European and US
                                                                                                                                                                                                                   characteristics

                                                                                                                                                                                                                                        3
Executive Summary

The FCF Life
                                  FCF Life Sciences Venture Capital Monitor                                                Recipients
Sciences Venture
Capital Monitor is a     is a monthly published overview of biotechnology, pharmaceutical,      The FCF Life Sciences Venture Capital Monitor targets the following
monthly published        medical technology and healthcare technology companies,                recipients:
overview focusing on     displaying venture capital financing trends in the European life             ▪ Corporates / Executives  ▪ Venture capital investors
the venture capital      science industry                                                             ▪ Institutional investors  ▪ Family Offices / High-
financing                                                                                             ▪ Private equity investors     net-worth individuals
environment in the                                                                                                               ▪ Advisors
biotechnology,                                          Scope
pharmaceutical,
medical technology       The selection of companies is based on the following criteria:                                    Availability
and healthcare
technology               ▪ Focus on transactions with European headquartered life science       The FCF Life Sciences Venture Capital Monitor is available on FCF’s
segments, and can           companies and available deal volume                                 website at “https://www.fcf.de/de/research/life-science-research“
be used as a quick       ▪ Companies operating in the biotechnology, pharmaceutical,
reference for               medical technology, healthcare technology, services or other life                                  Data
investors, corporates       science related sectors
and professionals                                                                               All input data is provided by Pitchbook or GlobalData and is not
                         ▪ The therapeutics sector is further divided into the following        independently verified by FCF. Ratio and multiple calculations are
                            indications: Oncology, Cardiovascular, Central Nervous System,      driven based on the input data available. For additional information
                            Gastrointestinal,     Hematological,    Infectious   Diseases,      and disclaimer, please refer to the last page
More advanced,              Immunology, Metabolic, Ophthalmology, Rare Diseases,
detailed and / or           Respiratory, Diversified and Others
customized reports
are available upon
request                    To recommend colleagues or fellow investors to be added to the       If you have questions, comments or ideas, please do not hesitate
                             mailing list, kindly send an email with the respective contact                               to contact us
                                                       information

                                                                                                                                                                       4
Agenda

V e n t ur e C a p i t a l T r a n s a c t i ons
May 2020

                                                   5
European Venture Capital Transactions in Life Sciences
                                                                    May 2020

                                                                                                                                                                                                                                                     Deal  Total
                                                                                                                                                                         Vertical -                                                                Volume Raised
Overview (YTD)                                                                                                          # Date          Company       HQ    Subsector    Indication / Stage Company Description                           Series   (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)
                                                                                                                                                                                            Developer of a health management
  6,000                                                                                                                                                                  Self-Care /                                                                              The company raised $301.83 million of venture funding in the form of convertible debt
                                                                                                                        1   28-05-20 LumiraDx         GBR HealthTech                        software designed to transform patient           -      278     555
                                                                                                                                                                         On market                                                                                on May 28, 2020.
  5,000                                                                                                                                                                                     care.
  4,000                                        3,027
  3,000
  2,000
                                                                                                                                                                         Orthodontics
  1,000                                                                                                2020                                                                                 Provider of orthodontics solutions intended
                                                                                                                        2   28-05-20 PlusDental       DEU MedTech        solutions /                                                         -       32     42    The company raised EUR 32 million of venture funding on May 28, 2020.
                                                                                                       2019                                                                                 for the healthcare industry.
       0                                                                                                                                                                 Developing
                 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
                         Financing Volume (May 2020): EUR 791m

Subsectors                                                   Indications1
                                                                                                                                                                         3D printing system
                 Healthcare
                                                                                                                                                                         for industrial and
                  Services                                                                                                                                                                  Developer of a 3D printing system created
                                                                                                                        3   28-05-20 Kumovis          DEU MedTech        medical                                                             A       4       5    The company raised EUR 3.6 million of Series A venture on May 28, 2020.
     MedTech                                                                                                                                                                                for industrial and medical applications.
                                                                                                           Oncology                                                      applications /
                                                                 Others
                          4%                                                                                                                                             On market
                  14%                                                                           25%
                                                                              28%
                            EUR                                                           EUR

                      3,027m          54%      Biotech /                                1,655m
               28%                             Pharma                         5%
                                                           Genetic                               18%        Central                                                      Sound technology Developer of a sound technology designed                                The company raised EUR 2.3 million of Series A venture on May 28, 2020. The
                                                           Disorders               9%                       Nervous     4   28-05-20 IntendiMe        ITA   HealthTech   application /    to help deaf people detect objects and             A       2       3    funding will be used by the startup to enter the market, increase R&D activities, and
                                                                                         15%                System
HealthTech
                                                                 Gastro-
                                                                                                                                                                         On market        sounds.                                                                 hire more team members.
                                                                 intestinal
                                                                                    Immunology

Top Company Origins                                          Top Investor Origins                                                                           Healthcare
                                                                                                                                                                         Digital health     Operator of a digital health company                                  The company raised EUR 45 million of Series C venture on May 27, 2020. The funds
                                                                                                                        5   27-05-20 Doktor.se        SWE                platform /         intended to streamline and create better         C       45     83    will be used for expanding its digital operations and physical clinics to meet growing
                                                                                                                                                            Services
        Others                                                                                                                                                           On market          access to Swedish healthcare.                                         demand, and to lay the groundwork for international expansion.
                                                              Others
                    21%                                                        25%

                            EUR       39%                                                 EUR    43%
               8%
                      3,027m                                                  5%        3,027m                                                                                              Developer of glycan targeted carbohydrate-
                                                                                                                                                                                                                                                                  The company raised GBP 4 million of venture funding on May 27, 2020. The funds will
                 8%                                                           8%                                                                            Biotech /    Oncology /         binding modules intended to focus on the
                                                                                                                        6   27-05-20 Pneumagen        GBR                                                                                    -       5       6    be used for the clinical development of Neumifil for the prevention and treatment of
                      12%                                                           8%                                                                      Pharma       Pre-clinic         treatment of respiratory tract infections
                               12%                                                        11%                                                                                                                                                                     COVID-19.
                                                                                                                                                                                            (RTIs) and cancer.

Top 5 Deals                                                 Top 5 Investors
                                      Deal                                                         # of        Deal
 # Company                  HQ       Volume   Series         # Investor                    HQ     Deals       Volume2
                                                                                                                                                                         Central Nervous    Developer of gene therapies designed for                              The company raised $222.7 million of Series A venture on May 26, 2020. The funds
                                                                                                                                       Arvelle              Biotech /
                                                                                                                        7   26-05-20                  CHE                System /           the treatment of partial-onset seizures in       A      205     205   will be used to continue to expand the company's operations across Europe, including
                                                                                                                                       Therapeutics         Pharma
 1 LumiraDx                           278       -            1 Bpifrance                              13        28                                                       In filing          adult patients.                                                       key country-by-country hires in preparation of the European launch of cenobamate.
   Arvelle                                                       High-Tech
 2                                    205       A            2                                         7         7
   Therapeutics                                                  Gründerfonds
   Oxford
                                                                 BioInnovation
 3 Nanopore                           186       -            3                                         6         4
                                                                 Institute (BII)                                                                                                                                                                                  The company raised GBP 49 million of Series C venture funding on May 26, 2020. The
   Technologies                                                                                                                                                                             Developer of automated drug discovery
                                                                                                                                                            Biotech /    Other /                                                                                  funds will be used by the company to expand its existing portfolio and pipeline, by
                                                             4 Investiere                              5         9      8   26-05-20 Exscientia       GBR                                   technologies intended to improve the             C       56     97
 4 AM-Pharma                          163       -                                                                                                           Pharma       On market                                                                                launching new projects, progressing advanced projects to the clinic, and expanding AI
                                                                                                                                                                                            medicine development process.
                                                                                                                                                                                                                                                                  biology as part of its full-stack capabilities.
 5 Immunocore                         154       B            5 Almi Invest                             5         1

Source: PitchBook as of 08.06.2020; FCF Equity Research; GlobalData
Note: All volumes in EURm; financing rounds without deal values are excluded                                                                                                                                                                                                                                                                               6
1Only includes biotechnology and pharmaceutical deals; 2 Proportional attribution of deal values to investors participating in a transaction (transaction volume / # investors by financing round)
European Venture Capital Transactions in Life Sciences
                                                                    May 2020

                                                                                                                                                                                                                                                           Deal  Total
                                                                                                                                                                             Vertical -                                                                  Volume Raised
Overview (YTD)                                                                                                          # Date           Company          HQ    Subsector    Indication / Stage Company Description                             Series   (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)
                                                                                                                                                                             Point-of-care      Developer of an automated point-of-care                                The company raised EUR 16.3 million of Series B venture on May 26, 2020. The
  6,000
                                                                                                                        9    26-05-20 Spindiag            DEU MedTech        screening system / system designed to offer a sustainable             B       16     21   funding raised will be used to enable the market launch of the innovative Rhonda
  5,000                                                                                                                                                                      On market          platform for diagnosing infectious diseases.                           diagnostic platform for the detection of the SARS-CoV-2 virus.
  4,000                                        3,027
  3,000
  2,000
                                                                                                                                                                             Central Nervous    Developer of drugs intended to treat
  1,000                                                                                                2020                             Accure                  Biotech /
                                                                                                                        10   26-05-20                     ESP                System /           diseases related to the Central Nervous            A       8       8   The company raised EUR 7.6 million of Series A venture funding on May 26, 2020.
                                                                                                       2019                             Therapeutics            Pharma
       0                                                                                                                                                                     Phase I            System (CNS).
                 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
                         Financing Volume (May 2020): EUR 791m

Subsectors                                                   Indications1
                 Healthcare                                                                                                                                                                                                                                            The company raised EUR 2.3 million of Series A venture funding on May 25, 2020.
                  Services                                                                                                                                      Biotech /    Oncology /         Operator of biopharmaceutical company                                  The funds will be used to advance the preclinical development of TL-532: Tollys will
                                                                                                                        11   25-05-20 Tollys              FRA                                                                                      A       2       6
     MedTech                                                                                                                                                    Pharma       On market          intended to cure cancer-related disease.                               notably use the funding to produce TL-532 and to launch the regulatory safety studies
                                                                                                           Oncology                                                                                                                                                    required before clinical trials in bladder cancer planned by the end 2021 / early 2022.
                                                                 Others
                          4%
                  14%                                                                           25%
                                                                              28%
                            EUR                                                           EUR

                      3,027m          54%      Biotech /                                1,655m
               28%                             Pharma                         5%
                                                           Genetic                               18%        Central                                                          Central Nervous    Operator of a biotechnology company                                    The company raised CHF 2 million of angel on May 25, 2020. The funds will be used
                                                                                   9%                       Nervous                                             Biotech /
                                                           Disorders                                                    12   25-05-20 GliaPharm           CHE                System /           intended to develop new approaches to              -       2       2   to advance its drug development program and generate key preclinical data for the
                                                                                         15%                System                                              Pharma
HealthTech
                                                                 Gastro-
                                                                                                                                                                             Discovery          treat neurological diseases.                                           next anticipated round of financing.
                                                                 intestinal
                                                                                    Immunology

Top Company Origins                                          Top Investor Origins                                                                               Healthcare
                                                                                                                                                                             Cloud-based IoT    Provider of a cloud-based IoT service
                                                                                                                        13   22-05-20 Tellu               NOR                service /          designed to innovate smart solutions for           -       4       4   The company raised NOK 40 million of venture on May 22, 2020.
                                                                                                                                                                Services
        Others                                                                                                                                                               On market          eHealth and personnel safety.
                                                              Others
                    21%                                                        25%

                            EUR       39%                                                 EUR    43%
               8%
                      3,027m                                                  5%        3,027m
                                                                                                                                                                                                Developer of clinical trial systems designed
                 8%                                                           8%                                                        Bio-Images Drug         Biotech /    Other /
                                                                                                                        14   22-05-20                     GBR                                   to activate and accelerate product                 -
European Venture Capital Transactions in Life Sciences
                                                                    May 2020

                                                                                                                                                                                                                                                              Deal  Total
                                                                                                                                                                              Vertical -                                                                    Volume Raised
Overview (YTD)                                                                                                          # Date           Company           HQ    Subsector    Indication / Stage Company Description                               Series   (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)
                                                                                                                                                                              Metabolic
  6,000                                                                                                                                                          Biotech /                         Developer of proprietary drug formulas                                 The company raised PLN 7 million of venture funding on May 20, 2020. The funds will
                                                                                                                        17   20-05-20 Biotts               POL                Disorders /                                                             -       2       2
                                                                                                                                                                 Pharma                            intended for anti-diabetes therapies.                                  be used for development, team building and patent protection.
  5,000                                                                                                                                                                       Pre-clinic
  4,000                                        3,027
  3,000
  2,000
                                                                                                                                                                                                   Operator of a medtech company intended
  1,000                                                                                                2020                             Sarissa                               Biosensors /         to develop novel biosensors for use in                                 The company raised GBP 1.2 million of venture funding on May 20, 2020, putting the
                                                                                                                        18   20-05-20                      GBR MedTech                                                                                -       1       5
                                                                                                       2019                             Biomedical                            Developing           Point-of-Care in-vitro diagnostic (PoC IVD)                            company's pre-money valuation at GBP 2.99 million.
       0                                                                                                                                                                                           applications.
                 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
                         Financing Volume (May 2020): EUR 791m

Subsectors                                                   Indications1
                 Healthcare
                                                                                                                                                                              Elderly care
                  Services                                                                                                                                       Healthcare                        Provider of elderly care services intended                             The company raised EUR 350,000 of venture funding on May 20, 2020. The funding
                                                                                                                        19   20-05-20 Time for You Care GBR                   services /                                                              -
European Venture Capital Transactions in Life Sciences
                                                                    May 2020

                                                                                                                                                                                                                                                         Deal  Total
                                                                                                                                                                          Vertical -                                                                   Volume Raised
Overview (YTD)                                                                                                          # Date         Company         HQ    Subsector    Indication / Stage Company Description                              Series   (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                        Medical
                                                                                                                                                                          technology devices Developer of medical technology devices
  6,000
                                                                                                                        25   12-05-20 AorticLab        ITA   MedTech      to treat aortic valve designed to treat patients suffering from        -
European Venture Capital Transactions in Life Sciences
                                                                    May 2020

                                                                                                                                                                                                                                                     Deal  Total
                                                                                                                                                                         Vertical -                                                                Volume Raised
Overview (YTD)                                                                                                          # Date           Company       HQ    Subsector   Indication / Stage Company Description                           Series   (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                                           Developer of implantable bio-artificial
                                                                                                                                                                         Bio-artificial
  6,000                                                                                                                                                                                      medical devices designed to enhance drug                            The company raised EUR 1.8 million of venture funding on May 4, 2020. The funds will
                                                                                                                        33   04-05-20 Defymed          FRA   MedTech     medical devices /                                                   -       2      16
                                                                                                                                                                                             delivery systems for diverse therapeutic                            be used to launch the clinical phase of ExOlin.
  5,000                                                                                                                                                                  On market
                                                                                                                                                                                             applications.
  4,000                                        3,027
  3,000
  2,000                                                                                                                                                                                     Developer of an end-to-end digital platform                          The company raised GBP 700,000 of venture funding on May 4, 2020, putting the
                                                                                                                                                                         End-to-end digital
  1,000                                                                                                2020                             Bond Digital                                        that enhances lateral flow tests and                                 company's pre-money valuation at GBP 4.3 million. The funds will be used to develop
                                                                                                                        34   04-05-20                  GBR HealthTech    platform /                                                          -
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