THE PHARMACEUTICAL INDUSTRY'S MARATHON - SOLUTIONS FOR GREENER DATA CENTRES
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SOLUTIONS AGILITY LEADER
GRABIT, THE
FOR GREENER ELEMENTARY CYBERSECURITY
DATA CENTRES PARTICLES FRIEND
VACCINES COVID-19
THE PHARMACEUTICAL
INDUSTRY’S MARATHON
THE AGILITY EFFECT MAGAZINE - NUMBER 9 - SPRING 2021
SUMMARY EDITORIAL
AGILITY PICTURE We are living in an era that can be seen as
20 MINUTES TO INSTALL SOLUTIONS FOR GREENER COLD CHAIN: ELECTRIC DELIVERIES conducive to transformation – not just our own,
A MOBILE EMERGENCY DATA CENTRES A STRATEGIC ISSUE FOR IN THE STARTING BLOCKS but that of our clients, partners and suppliers
CARE UNIT 15 THE PHARMACEUTICAL 40 too. It is also an opportunity for us to identify
4 INDUSTRY what really matters and should be safeguarded,
28 and shows our need for collective action.
AGILITY LEADER For four years now, we have been reporting,
AMSTERDAM ACCELERATES
DRIVE TOWARDS BECOMING
EMMANUELLE DUEZ, in The Agility Effect, on examples of
THE FORCE BEHIND transformation and change that characterise
CIRCULAR CITY
“ELEMENTARY PARTICLES” our joint ability to withstand and adapt
6
18 to challenges, whether energy, climate
or more recently health-related.
Against a backdrop of global warming and
scarcity of natural resources, our environmental
THE LAST MILE:
ambition responds to far-reaching expectations.
PRECISION What we want to do is work in partnership
ENGINEERING with our clients to find solutions that lead
30 to the decarbonisation of our economies.
For VINCI Energies, this long-term
THE IMPORTANCE VINCI AND PARISTECH transformation project is central to the plan
OF DATA STORAGE STEP UP THE PACE pursued by our business units and includes
IN THE PHARMACEUTICAL IN APPLIED RESEARCH
AGILITY FOCUS MANUFACTURING SYSTEM 41
a forward-looking growth strategy,
based on hiring talent, acquiring expertise
AN ULTRA-RAPID BATTERY FOR
THE 32
HOW VINCI ENERGIES and integrating businesses that will enable
THE 24 HOURS OF LE MANS PHARMACEUTICAL PROTECTING HEALTH IS IMPROVING ACCESS us to meet these challenges.
9
INDUSTRY’S WITH DIGITISED
TRACEABILITY SYSTEM
TO WATER IN AFRICA
42
It’s by pooling our collective intelligence,
creativity and inventiveness that we’ll find
THE TOWN PLANNER OF MARATHON 34 a more sustainable path.
THE FUTURE WILL NEED
TO BE AN INTEGRATOR FIRST
21 ENERGY STORAGE SYSTEMS
HELP BALANCE THE GRID
AND FOREMOST GRABIT, THE COBOT RAISING 45 I hope you enjoy reading this issue.
VACCINE PRODUCTION
10 CYBERSECURITY AWARENESS
REQUIRES BOTH TECHNICAL
IN FACTORIES
KNOW-HOW AND FLEXIBILITY
BUILDINGS SET TO
22
36 AGILITY OPINIONS Arnaud Grison,
ACCOMMODATE A MIX OF USES Chairman and chief executive officer, VINCI Energies
12 PRIORITISE PREVENTION
TO KEEP YOURSELF AND
YOUR COMPUTER SAFE
46
AGILITY PICTURE
WINE TOURISM
THE CHALLENGES DEVOPS: AGILITY IN MEGACOMPLEX DRIVEN
OF CLEAN ROOMS SOFTWARE ROLLOUTS BY DATA
26 39 48
2 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 3
AGILITY PICTURE
20 MINUTES
TO INSTALL
A MOBILE
EMERGENCY
CARE UNIT
In November 2020, to provide
relief for its emergency department,
which was becoming overloaded
with the influx of patients during
the second wave of Covid-19,
the Centre Hospitalier de la Côte
Basque in Bayonne (Pyrénées-
Atlantiques) introduced a unique
mobile hospital, the Multipurpose
Mobile Unit Europe Occitanie
(UMPEO). Designed in partnership
with Cegelec Défense, this care unit
was installed in just 20 minutes
with all the equipment needed
to treat 10 emergency patients and
8 critical patients simultaneously.
4 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 5
make significant progress by also set to benefit, with productivity Reducing logistics
implementing business models gains expected to lead to the
AMSTERDAM
that promote sustainable solutions. creation of 700 jobs in the building The 2020-2025 strategic plan
Construction and organic waste sector and 1,200 jobs in the food sets out a roadmap for each of
processing were identified as processing industry. the value chains that shape the
possible drivers of the transition. circular economy: food and waste
ACCELERATES DRIVE
The potential benefits of investing streams, consumer goods and
in these two areas have been the built environment. In order to
calculated. The implementation Construction supply a sustainable food system,
TOWARDS BECOMING
of material re-use strategies can
create €85 million of value per year,
and organic the plan promotes short chains and
aims to increase the consumption
while more efficient processing waste processing of regional products by stimulating
of organic waste streams can
identified as drivers circular agriculture and urban
CIRCULAR CITY
deliver €150 million per year, says agriculture. This should result in
the report. Material savings could of the transition a reduction in the environmental
amount to some 900,000 tonnes
per year, in sharp contrast with
towards circularity. impact of logistics.
The city of Amsterdam is playing
the region’s current annual import of its part in the food action plan by
3.9 million tonnes. Employment is purchasing regional products and
The Dutch capital has set
itself a model roadmap
aimed at achieving a fully
circular economy by 2050
by means of controlled
production and consumer
chains.
Five years ago, Amsterdam enacted
a radical change of course by
deciding to swap its traditional
model of linear development for
a circular economy project so as
to avoid fully depleting the Earth’s
resources. The solutions it seeks
to implement involve re-using
materials, especially raw materials.
By minimising waste and relying
on renewable energies, the circular
economy helps meet climate goals,
says the Amsterdam Circular 2020-
2025 Strategy report.
The roadmap is in line with tests
conducted by the city in the
construction sector, which included
building a new neighbourhood in
accordance with circular standards
near Schiphol international airport.
It outlines the measures to be taken
to reduce by half the use of new raw
materials by 2030 and achieve a
fully circular economy by 2050.
This strategic plan is based on
outcomes generated by the City
Circle Scan tool, which pinpointed
sectors in which the city can
6 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 7
AN ULTRA-RAPID
BATTERY FOR THE 24
HOURS OF LE MANS
driving urban agriculture. Among The city of Amsterdam wants to of public spaces and roads. Again, Paul van Schijndel says the brand is
the experiments already under way, lead the way and has set itself the goals included in the report are “Invested in the energy transition and
an initiative devised by residents the goal of cutting its overall specific and measurable: by 2025, in building a sustainable future for all.”
of K-district is seen as a pilot consumption by 20% by 2030. 50% of all building refurbishment “InMotion is also fully committed to
scheme. Locals here have assumed To do this, it is implementing a and maintenance operations this objective,” he adds. “It’s a logical
the responsibility of managing the fully circular procurement process, should follow the principles of partnership – Omexom is keen to
Zuidoost Food Forest, which is used starting with consumables and circular construction. address the challenges of e-mobility
to produce berries, herbs, fruit trees furnishings for city premises. This circular strategy, based on and electrical infrastructure.
and vegetables. Residents can do their bit to the “doughnut” concept (see box), Recharging an electric vehicle needs
reduce consumption by sharing is intended to be scalable. An initial to be as easy as refuelling a car.
In order to improve the collection appliances and equipment, evaluation of the various projects When we achieve that equivalence,
and processing of waste streams, and favouring use over ownership. is due to be carried out in 2021 Omexom is supporting a team of Dutch students in their goal electric mobility will have become
again as part of a drive to reduce In this respect, the city aims to gain insights into what is of entering the famous race with an electric car that can be a reality.” This is not InMotion’s first
wastage, the plan is to process to encourage infrastructure for working and to refine future recharged in two minutes: as fast as filling up a combustion- foray into motor racing. The team
kitchen and garden waste sharing platforms. circular actions. In order to powered vehicle. previously developed the first
separately by 2023. Here too, The third priority of this circular manage the rollout of the circular
the city is playing its part by
“setting the right example”, says
economy model is the built
environment, covering the
economy as effectively as possible,
Amsterdam has developed a
In a circuit motorsport race,
refuelling time is a key element.
electric vehicle. Their team,
InMotion, dreams of creating
“Recharging an
the report, and making residents construction and refurbishment monitoring tool to track raw Quicker is better, with valuable the most innovative racing car in electric vehicle
aware of the importance of
separating uncontaminated waste.
of buildings through to the design materials and assess initiatives. minutes saved. This is true for
a combustion powered car and
the world. The students are using
an innovative technology called
needs to be as easy
It also plans to create waste an electric car alike. But that’s Electric Refuelling, which should as refuelling a car.
collection and re-use sites.
City doughnut
where things get complicated!
Recharging a battery is time-
make recharging their electric
vehicle as fast as refuelling
When we achieve
consuming, and trying to make it a combustion-powered vehicle. that equivalence,
Sharing and repairing Amsterdam’s circular strategy is based on the City Doughnut economic
model, in which the city is represented in a doughnut-shaped diagram.
as fast as filling a fuel tank
represents a real challenge.
According to Paul Van Schijndel,
manager of Omexom Dordrecht,
electric mobility
In terms of consumer goods, Developed by Kate Raworth, a British economist, The Amsterdam City For an idea of the scale of this feat, which is supporting the operation, will have become
residents are being encouraged
to change their consumption and
Doughnut is an evaluative framework which looks at the city from four
perspectives: social, ecological, local and global. The inner ring of
it typically takes an hour to recharge
an electric vehicle, while it only takes
“To achieve this objective,
the team needs to manage
a reality.”
purchasing behaviour with regard the doughnut represents all the basic needs that must be met in order five seconds to refuel an F1 car. the design of the battery pack.”
to products such as electronic to live comfortably: access to drinking water, food, decent housing, Fifty students from Eindhoven bio-ethanol racer in the Netherlands.
equipment, textiles and furniture. sanitation, energy, education, healthcare, as well as the right to income, University of Technology and Fontys With the next car “Fusion”, the team
The aim is to find solutions political voice and gender equality. Those without access to these University of Applied Science in The future of electric mobility raced on Dutch circuits to show what
that extend product lifecycle essentials live in the doughnut’s hole. The outer ring of the doughnut the Netherlands decided to take up a team of young students is capable
and prevent raw materials and represents the planet’s needs. An efficient circular economy is one this challenge by entering Explaining Omexom’s of. With its third creation “Vision”,
other types of waste from being which successfully combines the two rings. the 24 Hours of Le Mans in 2023 (VINCI Energies) involvement with InMotion is anticipating the future
incinerated. with a special race-prepared InMotion and the Dutch students, of electric mobility.
8 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 9
THE TOWN PLANNER OF
THE FUTURE WILL NEED
TO BE AN INTEGRATOR
FIRST AND FOREMOST
Urban development has agency Euroméditerranée, [when land taken is compensated
suddenly become a whole Hugues Parant: “Use patterns for elsewhere] and the increasing
lot more complex due to are of paramount importance in scarcity of land mean that we are
the revolution in use patterns urban planning, and the breadth having to build cities on top of cities.
and the ecological transition. and scope of them is a driver of Land consolidation, new partnerships,
Integrating new features, creativity.” However, the whole decontamination and thermal
competencies and aspirations challenge of urban planning is to rehabilitation of old buildings: it’s
is key to the future of cities. strike increasingly tricky balances: not clear which business models
between the growing autonomy should be actioned.” Urban planning
New use patterns, the explosion of civil society and the legitimacy professions will therefore need to
in digital technology, the green of political decision-making,
transition and the health crisis are all between growth stimulation and of operations require greater to the failure of Google’s Quayside Delivering that extra-special
unprecedented and uncertain factors sustainable consumption, and so on. cooperation between all industry project in Toronto, which promised something
that the urban planning sector is “Planners- stakeholders at the earliest possible to be citizen-led. “Consultation
having to take into account.
Faced with this complex landscape, Introducing new equations
integrators stage of the urbanisation process. is always directed at regulars of
the consultation procedure and
Planners must start finding ways
to meet the major challenges of
how should planners reinvent their must ensure public debate circuit,” confirmed the city of tomorrow, whether by
Building a narrative around
business and promote new skills?
And, going forward, who will deliver
“Clients are everywhere, whether
they are elected officials, employees,
the long-term consultation
Hugues Parant, and holding a public
meeting at 7pm on a weeknight or
developing hybrid private/public
spaces, creating communal
integrated urban development investors or developers, and viability of 9 am at the weekend doesn’t make private spaces, producing
solutions? Cities themselves, public
or private planners, or indeed tech
the financial model for planners is
becoming more and more complex,”
applications.” In ensuring that these stages are
fully anticipated, where does that
any difference. “Consultation needs
to be redesigned as a narrative
reversible buildings, constructing
zero-carbon housing, incorporating
giants? stressed Christophe Lasnier, senior leave public consultation? so that projects are of interest to greenery into main roads and areas
These were some of the questions manager at EY Consulting, which The issue raised some concerns people,” maintained in cities, taking leisure activities
raised on 28 September 2020 oversees the “Panorama de la among participants during the Euroméditerranée CEO. into account or offsetting land
at a conference entitled ville et de l’immobilier” study focus on understanding the later the conference. Not so much about And town planners must be scarcity with densification.
“Urban planning 3.0: who will be (Real Estate & Urban Employment stages of the property value chain the principle itself of consultation warned against the temptation
the integrator for the usage-driven Monitor). The need to master new and how they are financed. Cécile – indeed, the various round- of withdrawing from the process This means that as well as having
city?”, held as part of the Building business models becomes ever Maisonneuve, chief executive of table speakers agreed that in an once decisions have been signed expertise in legal affairs and urban
Beyond Festival by the VINCI group’s more critical as environmental La Fabrique de la Cité, stressed the increasingly usage-driven system, off: “You can’t involve citizens in a development, planners will also
foresight platform Léonard in issues increase, asserted Virginie impact of these new requirements: it’s vital that users are linked to consultation about what their use need to show a powerful ability
partnership with another VINCI Leroy, deputy managing director for “We’ve gone from ‘what do we want urban choices. patterns will look like in the future, to understand, anticipate and
think tank, La Fabrique de la Cité. urban planning and major urban to do?’ to ‘what do we need to do?’” But the terms implemented for then disappear from the scene after integrate. In short, they’ll need
All the experts who attended reached projects, and director of the office Overall, the conference participants public consultations so far have two years. Planners-integrators must that extra-special something,
a common assessment, summed up department at VINCI Immobilier: agreed that the diversity of use clearly produced mixed results. also ensure the long-term viability of insisted the experts atthe
by the CEO of urban development “The concept of ‘no net land take’ patterns and increased complexity Cécile Maisonneuve drew attention applications.” conference.
10 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 11
BUILDINGS
SET TO
ACCOMMODATE
A MIX OF USES
From their lobbies these are the three aspects that
and meeting rooms to underpin any innovation strategy
workstations, smart in the commercial property sector.
buildings are fit for a The strategy is not without risk.
wide range of purposes, Being a large sector, enormous
benefitting regular stakes and investments are
occupants and others involved, and each “false start” can
besides. prove very damaging economically
and environmentally.
The smart building offers an The greatest enemy of innovation
unprecedented opportunity in this case is probably innovation
to observe and test not just itself. With society as a whole
professional practices but also voicing an urgent need for digital
new and future lifestyles. Indeed, sustainability, the temptation
digital tools and data outcomes of promoting an ultra-technical
make it possible to track, measure vision of digital transformation
and analyse the behaviours and should be avoided. The concepts of
practices of building users in real modularity, scalability and flexibility
time and over the long term. must remain both practical and
“Never have players in the property intelligible.
sector had as much information “Working methods are changing,
to feed into a service offering that as are practices, and the smart
meets increasingly complex uses building must reflect these
and needs, as flexibility becomes changes. But the focus must be
more important,” says Philippe on simplicity,” warns Emmanuel
Conus, building solutions director Prod’homme, VINCI Energies
and innovation director at project director for the fit-out of
VINCI Energies. the VINCI group’s future head
Flexibility, scalability, modularity: office, L’Archipel.
12 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 13
System interoperability and precedence over 4 or 6-person more than a manual one.”
equipment scalability will mean bench desks. Meeting rooms, fitted Today, modular smart building
SOLUTIONS
nothing without seamless user out with web conferencing systems design is more about adapting
experiences. There is no longer any or touchscreens to support a range to diverse practices rather than
place for gadgets or unnecessary of working practices, will need to transforming the structure itself
features. Even if, or rather have moveable partitions to create (except in workspaces, where
FOR GREENER DATA
especially if, it is modular, more or less space depending on partitions, workstations and
the smart building first and the number of participants. Here equipment are moved around).
foremost serves those who But the next step could well
CENTRES
“experience” it – and this involve making the smart building
encompasses everything from itself modular (see box).
the access to the building and
workstations to meeting rooms. “Having a mix of activities and
Take the lobby. This is an area people under one roof is not only
which, being modular, is no “Working methods becoming possible but integral
longer reserved for visitors but
accommodates a variety of uses,
are changing, to a building that meets urban
specifications, with the concept of
for example allowing employees as are practices, openness to the city and its streets,
from a company housed in the
building to meet for an informal
and the smart shops and stations built into
the design,” says Philippe Conus.
supporting increased use while at
the same time limiting the impact
catch-up. Workspaces must building must The L’Archipel project in Nanterre on the environment?
achieve a subtle balance between
openness and customisation.
reflect these (to the west of Paris) for example,
which will open its doors to
To bring energy consumption
under control, data centres must
“It’s about playing around cleverly changes. occupants and visitors in 2021, is work on their equipment and
with wall partitions – whether
their quantity, shape or material –
But the focus must part of a wider complex consisting
of 74,000 m² of office buildings,
processes.
while using sensors and analysing be on simplicity.” 90 terraces (intended for eating Power generation sources must
occupancy data to anticipate out, meeting people, working or also be diversified, with renewables
space planning requirements and relaxing), and a hotel and shops incorporated into the mix.
make adjustments transparent covering 1,500 m². Designed Spectacular progress has
for occupants,” highlights as a set of interconnected and already been made in terms of
Prod’homme. interdependent islands linked IT equipment, which has helped
Workspace design must also by walkways, this permeable limit energy costs. “Between
incorporate new health and too, points out Prod’homme, it’s development provides connections 2010 and 2018, the consumption
well-being metrics, since physical essential that equipment is easy with the surrounding town and of a computing server was
distancing rules are now applicable to use: “Experience has shown, transport network. It will be a reduced fourfold and that of a
in all public environments. for instance, that an automatic modular building in an increasingly storage server ninefold,” stresses
Individual workstations will take moveable wall will be used much mobile and adaptive city. Tissandier. “Overall, computing
volume increased more than
fivefold over the period, and the
Data centres, which form the cornerstone of network amount of electricity used actually
Are modular structures in the pipeline? infrastructure, consume a huge amount of energy. But there only rose by 6%.”
are several ways they can reduce their environmental footprint.
So are we likely to see a convergence between smart a juxtaposition of modules that could be reconfigured Infrastructure has also been
and modular in terms of the structure itself? Google and converted based on need. Although Google Data centres are central to digital “With European commitments upgraded. And consumption has
promised just this with its Quayside project in Toronto. eventually abandoned the project in May 2020, transformation. They house IT on greenhouse gas emissions been optimised thanks to better
Built on 12 acres of port wastelands, the smart officially due to “unprecedented economic uncertainty” equipment (server racks) that is at the top of the agenda, it’s vital management of cooling processes
neighbourhood project, managed by Alphabet group stemming from the covid-19 pandemic, a gap has used to store, process and protect that we monitor the issue closely,” and increasingly sophisticated
subsidiary Sidewalks Labs, was intended to blend opened up. data. Sustained growth in says Aymeric Tissandier, Building equipment. “What we’ve noticed
connectivity and modularity. The project included In France, players from the construction sector grouped the generation and use of digital Solutions director at VINCI Energies as an installer is that data centres
dynamic streets, comprising slabs fitted with LED within the Smart Buildings Alliance recently participated data both by homes and and director of France Datacenter, are one of the most high-tech
lights that could be easily removed and swapped to in a call for projects issued by the French Ministry for businesses calls for ever greater an association bringing together sectors,” adds Tissandier.
install interchangeable street furniture; ground floors the Armed Forces involving easily and rapidly replicable storage capacity and optimised stakeholders from the data centre This is true of new-build projects
of buildings equipped with prewired modules ready to patient care solutions. They proposed delivering within data management systems. ecosystem, which has adopted as well as of many replacement
house cafes, markets, libraries and community spaces; a 6-week period re-usable timber modules, comprising This growth makes a similar the EU Code of Conduct on Data or retrofit projects, which are
and buildings constructed with mass timber and around 15 intensive care rooms and associated facilities. explosion in energy consumption Centre Energy Efficiency. using next-generation, more
a legitimate concern. So what is the best way of energy-efficient equipment.
14 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 15
Optimising consumption Fluid dynamics and PUE
and developing renewables
Furthermore, energy efficiency
Data centre operators have every improvements can be made at
reason to invest in initiatives to the operation stage by working
optimise energy consumption, on cold and hot airflow within
not least financial reasons since the server room. The layout in
energy is a data centre’s biggest the room can be rearranged to
area of expenditure (49%), according separate airflow with panels by
to the Association technique positioning the server racks in
énergie environnement (ATEE), such a way that the hot aisle is
an environmental association that contained and that hot and cold
air does not mix.
VINCI Facilities offers a fluid
dynamics simulation tool for use
in data centres. “The tool helps
reallocate servers and spread out
The VINCI energy use more effectively,”
Facilities fluid points out Thomas Felgines, project
manager at the VINCI Facilities Data
dynamics Center & Télécom business unit.
simulation tool Following an audit phase,
VINCI Facilities sets up
“helps reallocate a monitoring system that uses
servers and spread sensors to collect data and
thus identify ways to reduce
out energy consumption.
use more During the subsequent
recommendation phase, an expert
effectively.” proposes server room layout
changes, and suggests what
equipment should be replaced
and what adjustments made.
The expert also sets out a target
PUE (Power Usage Effectiveness),
promotes energy management. the ratio between the total amount
This energy doesn’t just power the of energy used by the data centre
servers, it also ventilates and cools (IT, ventilation, cooling, lighting)
them. Indeed, all of the electricity and the total amount of energy
consumed by IT equipment is drawn by the IT and network
converted to heat, which needs equipment.
to be removed. Furthermore, the This energy performance indicator
demand for green power from major can vary by a factor of two.
clients means data centres get the At Equinix, the PUE ranges
best of both worlds: optimising between 1.1 and 1.3, whereas in
energy use while also incorporating “data centres that focus more on
renewables into their solutions. security than energy use, it can
At Equinix, the world’s largest data reach 2.5,” says Aymeric Tissandier.
centre and colocation provider, The closer the PUE is to 1,
“renewable sources account for the more energy efficient the data
90% of global energy use,” stresses centre is. Considering that
Régis Castagné, the company’s the average PUE is 1.8 and that
managing director for France. This is 12.5% of data centres have a PUE
achieved, in particular, by generating equal to or higher than 2.5, there
renewable energy in California is still work to be done in helping
and buying green energy through digital transition players
renewable energy certificates. to transition to renewable energy.
16 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 17
AGILITY LEADER
EMMANUELLE
DUEZ,
THE FORCE
BEHIND
“ELEMENTARY
PARTICLES”
Consultant Emmanuelle Duez and her firm The Boson Project
argue that corporate transformation relies first and foremost
on employee autonomy and empowerment.
“As the practice of working from the second isolation. The way to
home during the health crisis respond to these issues is to focus
became widespread, we sometimes on management excellence, and by
overlooked the fact that offices that I mean the ability to care for
also provided a forum for social others in the company.”
justice, enabling each employee She continues: “Unfortunately, I think
to enjoy good working conditions.” most businesses failed to grasp the
Founder in 2012 of The Boson extent to which the role of managers
Project, a consulting firm that would be crucial in getting human
supports business transformation, capital engaged again at the end of
Emmanuelle Duez highlights the crisis.”
the impact of office closures on Together with her team of
employees. consultants, called “Bosons” in
“There are two main risks related to reference to the elementary particles
the period we’re living through at of the same name that serve as
the moment,” she adds. the “glue” holding matter together,
“The first is disengagement, and Emmanuelle Duez aims to “create
18 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 19the conditions in which human
potential can be fully expressed,
AGILITY FOCUS
both individually and collectively.”
In order to pave the way for
the cultural and organisational
transformation of the company
of the future, “we must have the
courage to open Pandora’s box,
involving those most directly
concerned – in other words
employees. Rather than presenting
a risk, this ensures the sustainability
of ongoing changes,” she says.
THE
Looking for impact
At 34, Emmanuelle Duez already has
PHARMACEUTICAL
the self-assurance of an old hand Innovation Hub, a unit dedicated to executives and say to them: if you’re
in the corporate world. This bothers breakthrough innovation at Naval not convinced by parity for ethical
some people. “Once when I was Group. “This collaboration with reasons, you should adapt your
speaking at a conference about the the Navy has given The Boson organisational systems anyway for
INDUSTRY’S
report we’re currently working on, a Project a very practical dimension,” economic reasons and also to attract
man in the audience, who doubted she states today. and retain talent.”
my legitimacy to talk about the issue Emmanuelle Duez has a talent for
so confidently, asked the speaker turning adversity into advantage.
MARATHON
sitting next to me, an admiral in An entrepreneur at heart, she found Workspace is key to human
charge of staff in the French Navy, her calling purely by chance: “When excellence
I was young, I wanted to be a profiler.
That’s why I studied criminal law. In the current crisis, this capacity
I took a course to become a lawyer to recognise the changes taking
“Businesses or magistrate, but in the end place, especially among younger
must not delay I decided I wanted to save the world.
So I moved from the bench to a
generations, makes The Boson
Project a popular think-tank.
in giving serious business school, ESSEC, completing The firm has been working since
consideration as to an apprenticeship, with a view to
setting up an entrepreneurial project
2016 on human resource issues
relating to spatial changes in the
The battle against Covid-19 has entered a decisive phase. With the first vaccines
what justification that would have an impact on workplace (refitting and relocation now available as a result of international research carried out in record time,
extensive vaccination campaigns have been launched in several countries.
there is for people people’s lives.”
It was by creating the WoMen’Up
specifically). Emmanuelle Duez
urges businesses to quickly give Manufacturers in the sector have shown great adaptability in this race against time.
to leave home to association in 2011, as part of “serious consideration as to what Pharmaceutical companies have had to reconcile speed with safety and compliance requirements
go and work in ESSEC’s Leadership and Diversity
Chair, that she discovered her flair
justification there is for people
to leave home to go and work in
across the whole vaccine manufacturing chain. At all stages of this exceptional process,
VINCI Energies business units have contributed their respective areas of expertise by adapting
the office.” for entrepreneurship. “Being involved the office.” to the specific characteristics of vaccine production. Their involvement, whether in setting up
in entrepreneurial activities is She believes that reinventing
nothing less than a way to express workspace is a must. “As far as or refurbishing production lines, fitting out clean rooms, managing the cold chain,
what he thought. My co-speaker my personality,” she confides. development projects are concerned, delivering digital product traceability, storing data or increasing the robustness
give him a real dressing-down. The WoMen’Up project, whose it’s vital to be able to sensitively of the supply chain, has helped make this major global challenge possible.
Following the episode, the admiral motto is “Women and young reflect an organisation’s human
and I struck up a friendship.” people: facing the same struggle and strategic requirements in
This friendship led Emmanuelle in business!” and which focuses on its workspace and to help staff CONTENTS. Vaccine production requires both technical know-how and flexibility, p.22…
Duez to become a Navy reservist management subjects related to embrace these projects so that The challenges of clean rooms, p.26…
in 2014, “a wonderful opportunity gender diversity in big corporations, rather than being an inconvenience
to build bridges between the civilian has opened up many doors for her. they are an opportunity for Cold chain: a strategic issue for the pharmaceutical industry, p.28…
and military worlds.” For almost “It provides leverage for engagement. The human aspect The last mile: precision engineering, p.30…
two years, she has even been an management practices in business, of spatial transformation should The importance of data storage in the pharmaceutical manufacturing system, p.32…
external member of the Naval allowing you to go and see senior not be overlooked.” Protecting health with digitised traceability system, p.34...
20 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 21AGILITY FOCUS
VACCINE PRODUCTION
REQUIRES BOTH
TECHNICAL KNOW-HOW
AND FLEXIBILITY
The standards and constraints The country is the central hub have available for the works, the
imposed on pharmaceutical around which the continent’s life engineering phase is continuously
production facilities are sciences industry turns. being challenged, sometimes to
currently stronger than ever, VINCI Energies has several business the very last minute. That requires
as the race for vaccines units there, supporting the main constant proactive communication
against Covid-19 reaches players in the market. with the customer.”
full speed. For the major In November 2020, Actemium
pharma players and Leuven, Actemium Herentals and Actemium had previously been part
the VINCI Energies business Hooyberghs HVAC won the order of an even larger project from 2016
units supporting them, for a vaccine production line for to 2018: the overhaul of an entire
this exacting environment coronaviruses (clean & black utilities vaccine installation near Brussels.
has become an exercise in networks, manufacturing and “We built the whole factory with
responsiveness and agility. installation of cleaning and filtration the help of nine VINCI Energies
units, integration of production business units from Belgium and and flexibility. “On the Sanofi site Actemium provides technical
The Covid-19 pandemic and equipment, etc.). France,” says Jan Meeuwesen, in Val-de-Reuil, having three of our assistance in EIA (electrical systems,
the race for vaccines have increased “With this project, the challenge Client Manager Life Sciences at business units: Nassandres (experts instrumentation and automation) “The challenge
the pressure on the pharmaceutical
industry worldwide to an
is to build a distribution system
where most of the loops have to
Actemium Herentals. “This called
for huge flexibility, especially
in specialist machinery), Grand
Couronne (electrical systems
to the site. “Our assignments
concern the installation and
is to build
unprecedented level. Things are remain completely sterile, with all given the very short timescales: and instrumentation) and Le Havre management of ‘tray turners’ a distribution
particularly intense in the production
sector, an area where VINCI Energies
the required qualifications, within
a very short time frame – rather
by definition, the automation
component always comes at
Process Control (industrial IT)
working together enables us to
(machines that turn the egg trays at
the exit from vaccine lines to expel
system that remains
business units are in the front line, than the usual two-and-a-half the end of the chain.” manage and equip much of the the shells and send them to waste completely sterile,
with their real-world solutions
helping vaccine manufacturers
years, we barely had a year,”
explains Bart Groeninckx.
complex, but we also remain highly
responsive, with all three business
processing), robotised production
cells, vial transfer from the filling
and all within
to start up their production lines The Actemium Leuven Business Being close to customers units located less than an hour from machine outlets to the freeze dryers, a very short time
in a reduced time frame. Europe,
in terms of vaccine production,
Unit Manager also highlights
the agility this project called In Normandy, Actemium is adding
the site,” explains Ghislain Brière,
Business Unit Manager of Actemium
and egg conveyor systems from
the Ovopharm plant to the Sanofi
frame.”
means Belgium. for: “Given the reduced time we proximity to its assets of reciprocity Le Havre Process Control. Pasteur site,” says Ghislain Brière.
22 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 23But the Val-de-Reuil site is also around teams of professionals
a worldwide distribution centre, with in-depth knowledge of
exporting vaccines made by Sanofi pharmaceutical processes thanks
in France to 190 countries, to their dual grounding in chemistry
with 900 million doses of vaccine and pharmacy.
shipped every year. “Our experts have a thorough
“Within the framework of this understanding of the FDA (Food
materials handling activity, and Drug Administration) standard
we handle all the industrial IT that regulates manufacturing
maintenance. Our expertise with processes in the market, which is
the digital command-and-control extremely stringent,” says the director
system is key, as the site is fully of development. “One of our
automated. We also recently business units also operates a
completed the same assignment maintenance contract for the whole
for the site extension project due Marcy L’Etoile site, from production
for completion in 2023,” adds to R&D.”
Ghislain Brière, who, for that project,
was able to mobilise a technical
support team whose members
have between 15 and 30 years’
experience in this field.
More than 30 years’ experience “Our experts
VINCI Energies’ expertise in
have a thorough
the pharmaceutical market, and understanding
the vaccine market in particular,
is the fruit of lengthy experience,
of the FDA standard
just like that acquired by Actemium that regulates
over the last 30-plus years working
in partnership with the Sanofi
manufacturing
group. Its long collaboration with processes in
the Sanofi Marcy-L’Etoile site near
Lyon is a prime example.
the market,
For the largest vaccine production which is extremely
site in Europe, which exports its
product to 150 countries worldwide,
stringent.”
Actemium business units have
assembled a wide range of expertise.
The starting point was in the area
of production equipment. “We are
established right across the vaccine
production chain, but it’s primarily
in the harvesting and purification Last but not least, according to
stages that we apply our most Jean-Pierre Nemoz, is Actemium’s
sophisticated expertise, with special ability to offer custom-made
stainless-steel tanks made by our solutions. “It’s largely thanks to this
highly qualified boilermakers and agility that we we’ve been in talks
pipe fitters,” explains Jean-Pierre with Sanofi to take part in their EVF
Nemoz, Director of Development (Evolutive Vaccine Facility) project
at VINCI Energies France Industrie in Neuville-sur-Saône, a new type
Centre Est Méditerranée. of flexible unit housing several
Actemium also has considerable production modules that allow
expertise in the field of equipment production of three or four vaccines
automation management, with simultaneously according to
its different business units built their seasonality.”
24 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 25AGILITY FOCUS
THE CHALLENGES
OF CLEAN ROOMS
Controlling the concentration G+H Innenausbau and its clean a hermetic sliding door. The former,
of airborne particles and fire room business unit located in fully sealed with silicone without
safety in these rooms designed Ludwigshafen, Germany. wet joints, comes with a range
for research or industrial With almost 40 years’ experience of suitable installation solutions
production is particularly in clean room construction, for lighting, ventilation casings, etc.
crucial during a health crisis. this business employs 20 people The latter is equipped with a
VINCI Energies business units dedicated to creating these special specially shaped silicone seal
have developed valuable rooms. In the 1970s, it developed and offers increased soundproofing.
know-how in this area. the first metal clean room wall Exporting chiefly to Switzerland and
with a flush-mounted window for Turkey, G+H is one of Germany’s
Enclosed spaces with a controlled the pharmaceutical industry. market leaders for clean rooms.
atmosphere to avoid any “One of the projects we’ve managed
contamination of the ambient was the redevelopment in 2018
air, clean rooms are essential to “These of a large existing installation
researching and manufacturing
medicines and vaccines. Outside air,
rooms require for the Bayer group,” says Thomas
Fuchs. restrictions,” says Cyrille Harand, generates, and thus the cost of for the installation’s remote-
paint, coatings, and particles from the installation Business Unit Manager of Uxello storing and treating it, by a similar control system (for triggering,
on-site equipment or cleaning
products are just some of the many
of highly technical, Bespoke fire safety
Risques Spéciaux, which is installing
the fire protection system in
amount. Second, this system is as
effective as traditional equipment,
maintenance, locking down), and
also when making parts for passing
sources of air pollution affecting extremely clean the German Boehringer Ingelheim if not more so. Essentially, the finer through the walls, and with all
clean rooms. In addition to the
quality of their ventilation systems,
and flat surfaces Installing fire protection systems
in the tightly protected spaces
group’s future antigen production
facility and laboratory in Jonage,
the water droplets, which are forced
out under high pressure, the better
the equipment made from 316L
stainless steel to give it
these installations require a wealth of with very fine that are clean rooms is a feat in near Lyon. they absorb heat.” the smoothness needed for
precautions in terms of construction,
fire safety and maintenance. Naturally,
joints.” itself. The teams of researchers
and technicians working in these
The challenge posed by this P4-level
site, where extremely hazardous
the industrial cleaning process.”
In another first, for Boehringer
expertise in these areas is in great areas are handling viruses and agents are handled, is all the greater ... And ad-hoc certification Ingelheim’s future P4 centre in
demand during the present health “These rooms require other active substances that require because the group and the Technip Jonage, Uxello Risques Spéciaux
crisis. the installation of highly technical, special fire suppression and water design office preferred a water On such an unusual worksite, was able to manage the whole
extremely clean and flat surfaces treatment systems. mist system. This is a first for this business unit specialising certification process for this
with very fine joints,” explains “The water used obviously needs a pharmaceutical laboratory in France. in fire safety had to adapt and installation without mist – which
Special techniques Thomas Fuchs, Division Manager to be extremely clean and is filtered “There are two advantages with show its agility. “We’re having does not yet comply with any
and materials at VINCI Energies Deutschland to 10 microns. But the rooms this system,” explains Cyrille to customise at every stage of established rules. “We turned to
Building Solutions. themselves also have to be fully Harand. “First, it needs, on average, the project,” says the head of a notified body based in Austria,
VINCI Energies counts several firms G+H Innenausbau offers two sealed. Running pipework and five times less water than a sprinkler Uxello Risques Spéciaux. “This was where the equipment we installed in
with expertise in this area among its noteworthy innovations in this area: nozzles through the walls system. As a result, it reduces certainly the case when designing Jonage is made,” the Business Unit
business units. One such is the Vario Access ceiling and is therefore subject to serious the waste water the fire system the programmable equipment Manager explains.
26 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 27AGILITY FOCUS the freezers that will store
the Covid-19 vaccine supply for
enlarged with six containers in 2020
and will be expanded in 2021 with a
services,” says Xavier Delattre,
Business Unit Manager of CEF
Europe. Wireless sensors also monitor 2,000-cubic-metre storage building Industrie Picardie. “In addition
the vaccines’ temperature while they at temperatures below -50 °C. to our permanent maintenance
are transported internally on dry ice in “We are currently [December 2020] provision, we offer an atypical
cooled container boxes. testing new containers specially service, with a mixed yearly visit
Roderick Nijffels, Client Manager at designed to store Covid vaccines, where our own technicians attend
COLD CHAIN:
Actemium Herentals, explains that to connect them to the IMS system,” together with the manufacturers
“More than 1,300 wired sensors says Henk Coolen, Project Engineer of the machinery installed on site,
will be installed in the freezers, and Automation at Actemium Herentals. who have perfect knowledge of how
A STRATEGIC ISSUE FOR
40 wireless sensors in the cooled “The storage building is under their equipment ages.”
containers, to monitor temperature construction to be fully operational
in real time. The wireless sensors
were tested in a Proof of Concept for
before April.”
“The high quality
THE PHARMACEUTICAL
use in a large warehouse filled with of pharmaceutical
metal racks and freezers, with very
positive results. Besides the vaccine
Long-term confidence
products means
that the cold chain
INDUSTRY
storage, our EMS (Environmental In France, CEF Industrie Picardie,
Monitoring System) solution is
also used to monitor temperature,
a VINCI Energies Réseau Froid
business unit, has been working
must be guaranteed
pressure, humidity and particulates in tandem with the Sanofi at all times.”
in the clean rooms where the drugs group for more than 15 years
are manufactured.” on the Compiègne site, where it He continues, “This enables
handles preventative and curative us to improve our predictive
Another pharmaceutical company maintenance of the water chillers, maintenance, while our teams
entrusted Actemium with the creation cold stores for raw materials and acquire new knowledge. Alongside
in 2018, and expansion in 2020, of finished products, and climatic these maintenance projects,
the IMS (Information Management chambers for storing samples. CEF also provides new equipment
From production to transport down to -80 °C or even -100 °C. explains the VINCI Energies expert. System) monitoring solution for its “Our relationship of confidence that combines energy efficiency
and storage, cold chain The problem isn’t the technology, “That’s why the cold storage facilities vaccine freezer facility. The facility was with Sanofi is based on our bespoke with clean refrigeration fluids.”
management is an absolute but having the financial capacity are all self-sufficient, with double
priority for drug and vaccine to implement it.” or even triple redundancy to avoid
manufacturers. In France The costs can be two or three times failures. Temperature recorders
and across Europe, higher for ultra-low-temperature are also installed, often equipped
VINCI Energies business installations compared with standard with an alarm system. It takes four
units are applying their cold storage. Michel Lecarpentier to six visits per year to maintain this
solutions to secure the cold explains that “The additional cost refrigeration equipment, compared
chain. is due to the design requirements, with two to three as standard in
plus the specific class of climatic the food industry.”
On 8 December 2020, the first chamber installed, and of course, Another unique feature of
injection of the Pfizer-BioNTech the higher energy consumption the pharmaceutical market is a highly
vaccine against Covid-19 was given at these low temperatures.” demanding sanitary environment,
to a 91-year-old British patient. often with a controlled atmosphere
That was just one of 800,000 doses requiring sophisticated filtration
being stored in a secret warehouse at Regulatory storage thresholds systems and a restricted
a temperature of -70 °C. The vaccine, manufacturing environment.
created jointly by the American The various types of drugs and The various business units in
manufacturer and a German vaccines require extremely precise VINCI Energies’ Réseau Froid
startup, is a reminder of how crucial and regulated storage thresholds: network are specialists in securing
management of the entire cold chain controlled temperature (below +25 °C), the cold chain, well versed in handling
(production, transport and storage) temperature-sensitive products (+2 °C these elements.
is to the pharmaceutical industry. to +8 °C), negative temperature
But, behind the headlines, says (-20 °C to -40 °C) and ultra-low
Michel Lecarpentier, Director temperature (-70 °C and below). Highly advanced expertise
of Réseau Froid Development at “The high quality of pharmaceutical
VINCI Energies, “Cold at very low products means that the cold chain In Belgium, Actemium Herentals
temperatures is now straightforward must be guaranteed at all times,” has installed a system to monitor
28 THE AGILITY EFFECT MAGAZINE NUMBER 9 - SPRING 2021 29AGILITY FOCUS
THE LAST MILE:
PRECISION
ENGINEERING
Distribution is the final link An IT system with no margin The company, specialised in ICT
in the medicine and vaccine for error services and solutions, is also
chain. Business intelligence responsible for all the Windows
and always-on systems At the core of this well-oiled and Linux systems operating on
are key to ultra-refined machine, the IT system is a key an Intel x86 (CPU architecture)
logistics. A look at the case component. Having worked with server base.
of Axians, which manages Phoenix Group in Germany for more “The applications running on
information systems for than 15 years, the VINCI Energies these systems are extremely
Phoenix, one of Europe’s ICT brand Axians signed a contract diverse. There are at least twenty
largest pharmaceutical in autumn 2015 to operate different business intelligence
distributors. the distributor's IBM Power server technologies used mainly by retail
infrastructure. customers or logistics companies companies, distribution centres Axians also provides consulting the consequences of which could
Phoenix Group is Germany’s “The customer’s most important like Phoenix. This is extremely and pharmacies, some of which services to users at Phoenix to be dramatic for the healthcare
largest distributor of prescription applications and processes, such important for making quick are equipped with clean rooms systems of the countries
and over-the-counter medicines as the SAP architecture, run on decisions on medicine orders,” and intensive refrigeration concerned, Axians has technicians
to pharmacies, doctors and this IBM Power infrastructure,” says Zoran Olujic. systems, are on the front line on duty at all times, including
healthcare facilities. Its mission: says Jacques Diaz, CEO of Axians Axians therefore has an obligation preparing the new vaccines ready “We must weekends.
to distribute hundreds of millions
of healthcare products every year.
Germany, “And we manage this not
only in Germany, but across all their
to ensure that these systems can
be used 24 hours a day, seven days
to be used in vaccination centres.
Phoenix’s information services
be able to adapt “Another challenge is the threat
from cybercriminals. We must
Established in 27 European markets.” a week, 365 days a year. are essential to this arrangement, to the different be able to adapt to the different
countries with 161 distribution
centres, the group also holds a
In particular, Axians ensures that
the IBM Power server platforms
“This allows Phoenix continuous
access to their performance
ensuring that the ordering
and distribution systems of
infrastructure infrastructure operations
requirements in different
monopoly for the provision of work with the Unix and Linux indicators, for example by pharmacies perform well. “Our operations countries. For example, if Norway
medicines in Scandinavia.
In addition Phoenix runs about
operating systems. “We also
manage the whole IBM backup
displaying statistics and estimated
stock levels.”
task is to keep the IT environment
operational. With the backup
requirements imposes specific rules on how to
perform a backup to avoid attacks
2,700 own pharmacies. environment: everything under infrastructure, for example, we’re in different occurring as a result, we have
Its strategic position at the end
what used to be known as ‘Tivoli
Storage Manager’, since renamed Continuously trialling new
always introducing technical
innovations and optimisation
countries.” to implement them,” says Zoran
Olujic, who has also the expertise
of the pharmaceutical sector’s ‘Spectrum Project’ [IBM’s storage innovations options. We extensively test of his colleagues at Axians IT
distribution chain is crucial: management application],” innovations from our IT supplier Security to draw upon. This is an
the slightest failure on the group’s explains Zoran Olujic, Business Unit As part of the ongoing campaign partners and implement them if enable them to access data and important issue for Axians, which
part could threaten the entire Manager Managed & Cloud Services to vaccinate against Covid-19 they are useful for Phoenix,” says information more quickly. counts Phoenix as one of its
healthcare system. Factory at Axians Germany. in Europe, pharmaceutical Jacques Diaz. To mitigate any server failure, largest customers.
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