Ali Shilatifard, Ph.D - Northwestern University
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Ali Shilatifard, Ph.D.
Chairman, Department of Biochemistry and Molecular Genetics
Director, Simpson Querrey Center for Epigenetics
Northwestern University Feinberg School of Medicine
________________________________________________________________________________________________
Searle 6-512, 320 E. Superior Street, Chicago, IL 60611 E-mail: ASH@Northwestern.edu
Family Married to Laura Shilatifard (1995) with four children:
Francesca (1996), Natalie (1997), Joseph (1999), and Anthony (2002)
Citizenship USA
Academic Appointments
2017-present Director, Simpson Querrey Center for Epigenetics, Northwestern University
2014-present Professor of Pediatrics, Department of Pediatrics, Northwestern University,
and Lurie Children’s Hospital
2014-present Robert Francis Furchgott Professor and Chairman, Department of
Biochemistry and Molecular Genetics, Northwestern University School of Medicine
2018-present Editor, Science Advances
2014-2018 Chair of the Editorial Board and Deputy Editor, Science Advances
2015-2017 Senior Editorial Board, Science
2014-2018 Board of Reviewing Editors, eLife
2007-2017 Editor, Molecular and Cellular Biology
2003-2017 Instructor, Cold Spring Harbor Laboratory, Gene Expression Course
2007-2014 Investigator, Stowers Institute for Medical Research
2005-2007 Professor of Biochemistry, SLU-SOM
2002-2007 Associate Scientific Director, Saint Louis University Cancer Center
2002-2005 Associate Professor of Biochemistry with tenure, SLU-SOM
1997-2002 Assistant Professor of Biochemistry, Saint Louis University School of Medicine
1995-1997 Jane Coffin Childs Postdoctoral Fellow, Oklahoma Medical Research Foundation
Education
1992-1994 Ph.D., University of Oklahoma School of Medicine, Department of Biochemistry,
Advisor: Dr. Richard D. Cummings
1990-1992 University of Georgia, Department of Biochemistry and Complex Carbohydrate Research Center
Advisor: Dr. Richard D. Cummings
1986-1990 B.S., Kennesaw State University, Organic Chemistry (ACS Certified)
Scientific Community Responsibilities
• Member of the Scientific Advisory Board (SAB), BBVA Foundation Frontiers in Biomedicine (2017-
present) • Max-Planck Society’s SAB (2014-2019) • Genentech’s Scientific Research Board (SRB) (2014-
present) • Piramal Enterprises Limited, SAB (2014) • Cancer Prevention and Research Institute of Texas
Board of Reviewers (2014-2019) • Keystone Symposia, SAB (2014-present) • Israel Centers of Excellence,
SAB (I-COREs) (2012-2014) • Cell Signaling Technology, SAB (2012-2016) • Deutsche
Forschungsgemeinschaft (DFG) SAB (2012) • Novartis Science Board (2011) • Fox Chase Cancer Center,
Keystone External Advisory Board (2011-2013) • Starr Cancer Consortium, SAB (2011-present) • Member,
Cancer Molecular Pathology (CAMP) study section (2010-2012) • Member of SAB, The Leukemia &
Lymphoma Society (2007-2014) • Chairman, ASBMB Small Meetings Committee (2006-2011) • Member,
Molecular Genetics B (CDF1) study section National Institutes of Health (2003-2007) • Member of the SAB
for Sigma Chemical Company (1998-2004)
1Active Funding
2015-2022 National Cancer Institute, “Mutations of Chromatin and its Modifying Machineries in
Malignancies” R35CA197569 (PI)
2004-2021 National Cancer Institute, “Transcriptional Elongation Control in Development
and Disease” R01CA214035-15 (PI)
2018-2023 National Cancer Institute, “Understanding and targeting wild-type SS18 function and stability
in synovial sarcoma” U54CA231638-01 (PI)
K-, R- and Fellowship Awards Mentored by Shilatifard During the past 5 years
2014-2016 Hans-Martin Herz, Ph.D., Postdoctoral fellow, “Trithorax-related, MLL3 and MLL4 in
enhancer-mediated cancer pathogenesis” K99CA181506
2015-2020 Benjamin D. Singer, M.D., Assistant Professor of Medicine, “Regulatory T Cell UHRF and
DNA methylation in repair of acute lung injury” K08 HL128867
2015-2020 Jae (Jaehyuk) Choi, M.D., Ph.D., Assistant Professor of Dermatology and Biochemistry and
Molecular Genetics, “The role of ZEB1 mutations in cutaneous T Cell” K08CA191019
2015-2018 Andrea Piunti, Ph.D., Postdoctoral Fellow EMBO Long-Term “Mutant histone H3.3 and
Polycomb roles in Diffuse Intrinsic Pontine Gliomas” #ALTF 372-2015
2016-2021 Amanda Saratsis, M.D., Assistant Professor of Neurological Surgery, “Investigation of histone
H3 post-translational modifications in pediatric brainstem glioma” K08NS097624
2016-2017 Andrea Piunti, Ph.D., Postdoctoral Fellow, AIRC-Marie Curie COFUND iCARE “Histone H3
mutant and Polycomb Repressive Complex 2 role in Diffuse Intrinsic Pontine Gliomas” #17912
2016-2021 Edwin R. Smith, Ph.D., “Histone Modifications and transcription elongation in human cancer”
R50CA211428-01
2017-2019 Ryan Rickels, graduate student, “Investigating catalytic and non-catalytic roles for
Trr/COMPASS in regulation of enhancer function during Drosophila development”
F31CA213928
2017-2020 Christie Ching-Lin Sze, graduate student, “Functional Study of Mammalian Set1A/COMPASS
Methyltransferase in Stem Cells and Development” F31CA228149
2017-2022 Kyle Eagen, Ph.D., “Biochemical Basis of Chromatin Folding and Chromosome Condensation”
DP5OD024587
2017-2022 Elizabeth Bartom, Ph.D., “Bioinformatic Analysis of Next Generation Sequencing Data from
Cancer Cells” R50CA221848
2017-2019 Ryan Rickels, graduate student, “Investigating the epigenetics of enhancer function in Cancer”
F99/K00CA222988
22019-2021 Kaixiang Cao, postdoctoral fellow “Exploring novel regulatory mechanisms underlying
enhancer activation and cell fate transition” K99HD094906
2019-2021 Andrea Piunti, postdoctoral fellow “A molecular informed therapy for Diffuse Intrinsic Pontine
Gliomas (DIPG)” K99CA234434
Previous Funding
2004-2016 National Institutes of Health, GM, R01GM069905, “Chromatin Modification by Histone
Ubiquitination” (PI)
2001-2015 National Institutes of Health, and the National Cancer Institute, “Dot 1 Complex, Transcriptional
Elongation Control and Human Cancer” R01CA89455 (PI)
2010-2015 National Institutes of Health, and the National Cancer Institute, “The COMPASS family of H3K4
methylases in development and cancer” R01CA150265 (PI)
1999-2008 American Cancer Society, “Chromosomal translocations and human cancer”
RSG-04-186-GMC (PI)
2001-2006 The Leukemia and Lymphoma Society, “Role of MLL protein in the development of Acute Human
Leukemia” (PI)
1999-2002 The Edward Mallinckrodt Foundation, “Molecular Basis of Acute Human Leukemia”
Editorial Board Responsibilities
• Editor, Science Advances (2018-present)
• Deputy Editor and Chair of the Editorial Board, Science Advances (2014-2018)
• Senior Editorial Board, Science (2015-2017)
• Board of Reviewing Editors, eLife (2014-2018)
• Editor, Molecular and Cellular Biology (2007-2017)
• Editorial Board, Epigenetics and Chromatin (2008-present)
• Editorial Board member, Journal of Biological Chemistry, (2002-07)
• Ad hoc reviewer for Science, Cell, Molecular Cell, Nature, Nature CB, Nature SMB, Genes and
Development, and the Proceedings of the National Academy of Sciences USA
Honors
2016 Elected Fellow of the American Association for the Advancement of Sciences (AAAS)
2016 Martin E. and Gertrude G. Walder Award for Research Excellence
2016 Keynote Lecturer, ASBMB Symposium on Chromatin and Transcription, Snow Bird, Utah
2015 Keynote Lecturer, European Association for Cancer Research Symposium, Berlin, Germany
2015 Keynote Lecturer for the 2015 meeting of The Genetics Society of Korea, Seoul, Korea
2014 Keynote Lecturer, Oslo Epigenetics Meeting, Oslo, Norway
2013 Keynote Lecturer, Dutch Biochemical Society Symposium on Chromatin
2013 Keynote Lecturer, The Israeli Society for Developmental Biology
2013 Distinguished Lecturer, Cancer Science Institute of Singapore
2011 Keynote Lecturer, Spetses Summer School on Chromatin & Systems Biology
2011 Keynote Lecturer, Centre for Molecular Medicine, University of BC, Vancouver
2007 Innovation Award, Academy of Science, St. Louis
2006 ASBMB-AMGEN Award
2006 American Cancer Society Award of Excellence
2006 Selected as Leukemia & Lymphoma Society Stohlman Scholar
2002 Recipient of the Sword of the American Cancer Society
2001-2006 Scholar of the Leukemia and the Lymphoma Society
1995-1997 Jane Coffin Childs Postdoctoral Fellow
3Invited Seminar Presentations (2001-Present)
2020
Plenary Lecturer, Annual Research Symposium - University of Nebraska Medical Center, Omaha, NE
Host: Punita Dhawan
Max Perutz Labs, Center for Medical Biochemistry, PhD Training Program on Tissue Homeostasis in Health
and Disease, SFB-HIT Lectureship Vienna, Austria
Host: Karl Kuchler
Southeast University, Nanjing, China
Host: Chengqi Lin
Keystone Symposia on Gene Regulation: From Mechanisms to Disease/Cancer Epigenetics: New Mechanisms
and Therapeutic Opportunities, Keystone, CO
Advances in Diagnostics and Therapeutics Session of the AACR Annual Meeting, San Diego, CA
Fusion meeting on Epigenetic Pathways and Human Disease, Crete Greece
Symposium on Epigenetics and Disease, Cambridge, UK
Gordon Research Conference on Chromatin Structure & Function, Castelldefels, Spain
Cold Spring Harbor Course on Chromatin Gene Expression, Cold Spring Harbor, NY
2nd Fusion conference on Epigenetics, Nassau, Bahamas
EMBL Meeting on Transcription and Chromatin, Heidelberg, Germany
Epigenetics and Epigenomics in Health and Disease Brussels, Belgium
Cold Spring Harbor Laboratory meeting on Epigenetics & Chromatin, Cold Spring Harbor, NY
Forbeck Forum on Targeted Therapies in Pediatric Cancers La Jolla, CA
Epigenetic mechanisms of aging and cancer, FASEB Portugal
ASBMB Symposium on Transcriptional Regulation: Chromatin and RNA polymerase II, Snowbird, UT
Frontiers in Cancer Science 2020 Conference, Singapore
Fourth Biennial Miami Epigenetics and Cancer Symposium, Miami, FL
6th Max Planck Freiburg Epigenetics Meeting, Max Planck Institute of Immunobiology and Epigenetics in
Freiburg, Germany
Vencer el Cancer conference on Epigenetics and Cancer, Madrid, Spain
42019
Keynote speaker, Cell Symposium on Transcription and Developmental Biology, Chicago, IL
Keynote speaker, Third International Epigenome Conference, Shanghai
Keynote speaker, University of Kansas Medical Center Invite Hosted Student in Cancer Biology Society
Keynote speaker, Southern Illinois University Annual Trainee Research Symposium
Host: The Graduate Student Organization
2019 Visiting Professor of Lerner Research Institute at Cleveland Clinic
Host: Michelle Longworth
“Leaders in the Field” Seminar Series, UCLA Jonsson Comprehensive Cancer Center,
Hosts: Michael Teitell and Siavash Kurdistani
University of Massachusetts, Worcester, MA
Host: Michael Green
The University of Toronto, Laboratory for Structural Genomics
Host: Cheryl H. Arrowsmith
Medical University of South Carolina, Department of Biochemistry and Molecular Biology
Host: Philip Howe
American Association for Cancer Research Annual Meeting, Atlanta, Ga
Suddath Symposium on Epigenetics and Cancer, Georgia Institute of Technology
European Society of Human Genetics 2019 Symposium "Regulatory Landscapes" in Gothenburg, Sweden
GRC conference on Epithelial differentiation, Newry, ME
Cold Spring Harbor Laboratory Gene Expression Course, Cold Spring Harbor, NY
Cold Spring Harbor Laboratory, Mechanisms of Eukaryotic Transcription, Cold Spring Harbor, NY
H2020 ITN project proposal “ChromDesign - Chromatin and Design”, University of Copenhagen
Forbeck Forum focused on DIPG, Lake Geneva, WI
14th Asia Epigenome /3rd Taipei Epigenetics and Chromatin Meeting, Academia Sinica, Taipei, Taiwan
2019 National Institute of Health Chromatin Symposium, Bethesda, MD
Organizer, Outstanding Investigator Award annual meeting, National Cancer Institute, Bethesda, MD
Organizer, Nature/Chicago Science 2019: Epigenetics and Genome Editing, Northwestern University
52018
The University of Texas Southwestern Medical Center at Dallas, Department of Molecular Biology
Hosts: Eric Olson and Sean Morrison
Albert Einstein College of Medicine, Cancer Center Distinguished Lecture series
Host: Amit Verma
Oregon Health & Science University, Basic and Translational Sciences Seminar Series co-hosted by the
Department of Cell, Developmental & Cancer Biology and the Knight Cancer Institute
Hosts: Lisa M. Coussens, Sudarshan Anand, and Amanda Lund
Beckman Research Institute of City of Hope, Symposium on New Insights into Genetic and Environmental
Factors
Host: Xiaochun Yu
University of Florida Health Cancer Center Seminar Series
Host: John Licht
New Frontiers in Cancer Research Seminars, Sanford Burnham Institute, San Diego, CA
Host: Peter Adams
Indo-US conference Symposium on Transcription, Chromatin structure, DNA repair and Genomic instability
Bangalore, India
FASEB Meeting on Chromatin and Epigenetics, Florence, Italy
Gordon Conference on Chromatin Structure & Function Newry, Maine
EMBL Transcription and Chromatin meeting Heidelberg, Germany
Cold Spring Harbor Laboratory Meeting on Chromatin and Epigenetics, Cold Spring Harbor, NY
Epigenetic workshop, Barcelona, Spain
Cold Spring Harbor Laboratory Gene Expression Course, Cold Spring Harbor, NY
CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA
Medical Epigenetics Symposium, Freiburg, Germany
William Guy Forbeck Research Foundation Symposium on Epigenetic Therapy, Lake Geneva, WI
39th Lorne Genome Conference, Victoria, Australia
University of Miami Cancer Epigenetics Symposium, Miami Beach, FL
Fusion Conference on “Epigenetics: from mechanisms to disease” Cancun, Mexico
62017
Peter MacCallum Cancer Center, Melbourne, Australia
Host: Ricky Johnstone
CRG, Institute Seminar Series, Barcelona, Spain
Host: Luciano Di Croce
National Cancer Institute Center for Cancer Research Grand Round
Host: Tom Misteli
Columbia University Irvine Cancer Center, Distinguished Seminar Series Lecturer
Host: Jean Gautier
Memorial Sloan Kettering, Epigenetic Center Annual Retreat Research Symposium, New York, NY
Host: Ross Levine
Emil J Freireich Leukemia Hematology Grand Rounds MD Anderson Medical Center, Houston, TX
Host: Farhad Ravandi
Distinguished Lecture at the German Cancer Research Center (DKFZ) Heidelberg, Germany
Host: Darjus Tschaharganeh
Cornell University Medical Center, Department of Pathology, New York, NY
Host: Jessica Tyler
Marquette University Department of Biology, Milwaukee, WI
Host: Graduate Students
Institute for Cellular and Molecular Biology, A*STAR Singapore
Host: Chengqi Lin
Northwestern University School of Medicine, Department of Rheumatology Grand Rounds, Chicago, IL
Host: Calvin R. Brown
Stanley Manne Children's Research Center, Chicago, IL
Host: Jhumku D. Kohtz
Institut de recherches cliniques de Montréal
Host: François Robert
Wistar Symposium on “Epigenetics and Disease”
Host: Paul Lieberman
Keystone Symposia on Epigenetics and Human Disease, Seattle, WA
Banbury Center conference on “Enhancers and Enhanceropathies”, Cold Spring Harbor, NY
Genome Architecture in Cell Fate & Disease Gordon Conference, Hong Kong Univ. Science/Technology
7Cold Spring Harbor Laboratory course on Chromatin, Epigenetics and Gene Expression
American Association for Cancer Research 2017 Annual Meeting, Washington DC
8th Barossa Signaling meeting, Adelaide, Australia
ASIP 2017 Annual Meeting at Experimental Biology, Chicago, IL
NIEHS/NIH Symposium on Stem Cells & Epigenetics, National Institutes of Health
Abcam Annual Meeting on Epigenetic Regulatory Pathways, Seoul, Korea
Mechanisms of Eukaryotic Transcription, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
University of Georgia, Department of Biochemistry, Athens, Ga
2016
Boehringer Ingelheim, Department of New Therapeutic Concept Discovery, Vienna, Austria
Host: Manfred Koegl
St. Jude Children’s Research Hospital Annual Biomedical Symposium, Memphis, TN
Host: Charles Mullighan and Martine Roussel
Genentech, San Francisco, CA
Host: Andrew Chan
Baylor College of Medicine, Houston, TX
Host: Bert O’Malley
University of Texas, Institute for Cellular and Molecular Biology, Austin, Tx
Host: Blerta Xhemalce
Northwestern University, Department of Molecular Biosciences, Evanston, IL
Host: Jason Brickner
Texas Woman’s University, Department of Biology, Dallas, TX
Host: Christopher Brower
University of Nebraska Medical Center, Department of Biochemistry and Molecular Biology
Host: Kelly Miguel Trujillo
IRCM distinguished lecture series, Montreal, Canada
Host: François Robert
Deutsche Forschungsgemeinschaft, Germany
Host: Beate Oftadeh
Northwestern University School of Medicine, Department of Cell and Molecular Biology, Chicago, IL
Host: Dileep Varma
8University of Illinois, Department of Pharmacology, Chicago, IL
4th Max Planck Society Freiburg Epigenetics Meeting, Freiburg, Germany
Keynote Lecturer, ASBMB Symposium on Transcriptional Regulation by Chromatin and RNA Polymerase II,
Snowbird, UT
Cell Symposia: Transcriptional Regulation in Development and Disease, Chicago, IL
Keystone Symposia on Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases, Santa Fe,
New Mexico
Cold Spring Harbor Laboratory Meeting on Epigenetics and Chromatin, Cold Spring Harbor, NY
Keystone Symposia on Chromatin and Epigenetics, British Columbia, Canada
Society for Developmental Biology, Epigenetics in plant and animal development, Boston, MA
CSHL, Chromatin, Epigenetics and Gene Expression course, Cold Spring Harbor, NY
Keystone Symposia on Nuclear Receptors/Metabolism, Transcription and Disease, Snowbird, Utah
2016 Midwest Chromatin and Epigenetics Meeting (MCEM) Grand Rapids, MI
Cold Spring Harbor Asia meeting on “Chromatin, Epigenetics and Transcription” Cold Spring Harbor, NY
Annual Meeting of the American Association for Cancer Research, New Orleans, LA.
Miami Epigenetic Symposium, Miami, FL
Co-organizer, Keystone Symposia on Non-coding RNAs/Enhancer Malfunction in Cancer, Santa Fe, New
Mexico
Co-organizer, EMBL Transcription and Chromatin meeting, Heidelberg, Germany
2015
Yale University School of Medicine, Department of Pathology
Host: Qin Yan
Harvard Medical School and ABCAM Cancer Epigenetics meeting
Host: Johnathan Whetstine
University of Pennsylvania, Children’s Hospital of Philadelphia
Host: Carolyn A. Felix
University of Chicago School of Medicine
Host: Yingming Zhao
9Washington University School of Medicine, Department of Genetics
Host: Todd E. Druley
The Van Andel Institute
Host: Peter Jones
University of Ottawa Cancer Center Distinguish Lecture Series
Host: Jeff Dilworth
Genentech Lecture Series
Host: Bob Yauch
University of Colorado, Department of Chemistry and Biochemistry, Boulder Colorado
Host: James Goodrich
Tumor Cell Biology Lecture series, Northwestern University School of Medicine
Host: Leonidas Platanias
MD Anderson and ABCAM Epigenetics Meeting
Host: Sharon Dent
University of Wisconsin, McArdle Laboratory for Cancer Research, Cancer Biology Seminar
Host: Wei Xu
University of Chicago, IL, Department of Molecular Biology
Host: Max Frolov
Cincinnati Children’s Hospital, Cincinnati, Ohio
Host: Harinder Singh
Texas Women University Lecture Series in Biochemistry
Host: Christopher Brower
Loyola University Chicago, Oncology Research Institute Lecture Series
Host: Nancy J. Zeleznik-Le
Genentech 2015 SRB Meeting
Cold Spring Harbor Laboratory Gene Expression Course
Cold Spring Harbor Laboratory, Mechanisms of Eukaryotic Transcription meeting
Barcelona 4D-Cell Fate/Epigenetics meeting, Barcelona, Spain
Keystone Symposium on Epigenetics and Cancer, Keystone Colorado
2015 Midwest Yeast Meeting
Abcam Chromatin Meeting, Grand Cayman Island
10Co-organizer, FASEB Transcription, Chromatin and Epigenetics Meeting, Palm Beach, Florida
Keynote Lecturer, European Association for Cancer Research - Basic Epigenetic Mechanisms in Cancer,
Berlin, Germany
Keynote Lecturer for the 2015 meeting of The Genetics Society of Korea, Seoul, Korea
2014
Institute Curie, Section de recherché, Paris
Host: Allison Bardin
Ottawa Hospital Research Institute
Host: Jeffrey Dilworth
University of Pennsylvania Symposium on Epigenetics and Cancer
Host: Kenneth Zaret
Genentech
Host: Vishva Dixit
The University of Tokyo, Institute of Molecular and Cellular Biosciences
Host: Katsuhiko Shirahige
National Institute of Biological Sciences, Beijing, China
Host: Bing Zhu
Saint Louis University Cancer Center, St. Louis, MO
Host: Joel Eissenberg
MD Anderson Cancer Center, Department of Biochemistry and Molecular Biology
Host: Min Gyu Lee
The 9th 3R (Replication, Recombination and Repair) symposium, Gotemba, Japan
Gordon Conference on Chromatin Structure and Function, Waltham, MA
Oslo Epigenetics Symposium, Oslo, Norway
American Association for Cancer Research, annual meeting, San Diego, CA
Keystone Symposium on Chromatin Mechanisms and Cell Physiology, Oberstdorf, Germany
Recent sightings in the epigenetic landscape: A symposium celebrating Danny Reinberg’s 60th birthday
celebration, NYU, NY
Lamarck, Landmarks and Landscapes: frontiers in epigenetics, Institute Pasteur, Paris
ASBMB Symposium on Transcriptional Regulation: Chromatin and RNA Polymerase II, UT
11Cold Spring Harbor Laboratory meeting on Chromatin and Epigenetics, Cold Spring Harbor, NY
Co-organizer, EMBL Transcription Meeting, Heidelberg, Germany
2013
Celebration of Watson’s 60th Anniversary of Double Helix, Cold Spring Harbor Laboratory, NY
Keynote Speaker, Dutch Biochemical Society Symposium on Chromatin and Disease, Netherlands
Keynote Speaker, The Israeli Society for Developmental Biology, Eilat, Israel
Keynote Speaker, Mayo Clinic Epigenetics to Practice Conference, Rochester, MN
Harvard SOM and the Dana-Farber Cancer Institute, Seminars in Oncology lecture
Host: Thomas Look
UCSF Helen Diller Family Comprehensive Cancer Center
Host: David Toczyski
Live Webinar on “Why histone modifications matter in health and disease” with Jay Bradner
Host: Nature Methods and Nature Biotechnology
Columbia University Medical Center, NY
Host: Adolfo Ferrando and Laura Pasqualucci
Piramal HealthCare Limited, Mumbai, India
University of Michigan, Department of Pathology
Host: Greg Dressle
Mayo Clinic, Rochester, MN
Host: Zhiguo Zhang
Institute of Molecular and Cell Biology (IMCB), A*STAR
Host: Wanjin Hong, Executive Director A*STAR
Cancer Science Institute of Singapore
Host: Daniel G. Tenen and Fu Xin-Yuan
University at Buffalo (SUNY), Buffalo, NY
Host: Steve Fliesler
University of Texas Southwestern Medical Center at Dallas, Cecil H. and Ida Green Center
Host: W. Lee Kraus
Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Host: Hodaka Fujii
12Director's Lecturer, University of New Mexico Cancer Center, Albuquerque, NM
Host: Cheryl Willman and Mary Ann Osley
University of Illinois, Department of Cell and Developmental Biology, Urbana-Champaign
Host: Supriya G. Prasanth
6th Biennial Workshop on Clinical Translation of Epigenetics in Cancer Therapy, Asheville, NC
EMBO Conference on Chromatin and Epigenetics, Heidelberg, Germany
TRR81 symposium: “Chromatin Changes in Differentiation and Malignancies” The Netherlands
2013 FASEB Conference, “Transcription, Chromatin and Epigenetics" Nassau, Bahamas
Global Technology Community, 3rd Cancer Epigenetics Conference, San Francisco, CA
Abcam Chromatin Meeting, Grand Cayman Island
Lorne Genome Conference, Lorne Australia
Cold Spring Harbor Conference, "Mechanisms of Eukaryotic Transcription"
Third AACR International Conference on Frontiers in Basic Cancer Research, Maryland
Sanford-Burnham Medical Research Institute 35th Annual Symposium, “Epigenetics: Developments and
Disease” San Diego, CA
Organizer, Keystone Symposium on Epigenetic Marks and Cancer Drugs, Santa Fe, NM
2012
Stanford University Medical Center, Department of Genetics, Stanford, CA
Host: Anne Brunet
Fred Hutchinson Cancer Research Center, Clinical Research Division Seminar Series
Host: Irv Bernstein
St. Jude Children’s Research Hospital, Memphis, TN
Host: James Downing
Institute for Advanced Study, Princeton University, Princeton, NJ
Host: Arnold Levine
Rutgers, The State University of New Jersey Dept. Molecular Biology & Biochemistry
Host: Thomas Kusch
Cold Spring Harbor Laboratory, Lab-wide seminar series
Host: Chris Vakoc
Banbury Center of Cold Spring Harbor Laboratory meeting on Transcription and Cancer
Hosts: Jim Watson and Rick Young
13The Gladstone Institutes/UCSF, San Francisco, CA
Host: The Graduate Students
Bristol-Myers Squibb, Department of Oncology
Host: Susan Wee
University of Virginia School of Medicine, Charlottesville, VA
Host: Dan Burke
University of Pennsylvania Cancer Center
Host: Shelley Berger
Keynote Lecturer, Annual Retreat, Molecular Oncology Program, University of Colorado Cancer Center
Host: Joaquin Espinosa
University of Montreal School of Medicine, Montreal, Quebec, Canada
Host: Dindial Ramotar
Cell Signaling Technology, Danvers, MA
Host: Christopher Fry
Twenty-Seventh Aspen Cancer Conference, Aspen, Colorado
Sanford|Burnham Medical Research Institute at Lake Nona, Florida
Max-Planck Institute’s Epigenetics Meeting, Freiburg, Germany
CSH-Asia meeting on "Epigenetics, Chromatin, and Transcription" Suzhou, China
XIX. Wilsede Meeting “Modern Trends in Human Leukemia and Cancer,” Hamburg Germany
Cold Spring Harbor Laboratory Epigenetics Meeting
Chromatin Gordon Research Conference, Il Ciocco, Italy
Keystone Symposia on Epigenomics/Chromatin Dynamics, Keystone, Colorado
Keystone Symposium on Eukaryotic Transcription, Snowbird, Utah
EMBO Conference on Gene Transcription in Yeast, St. Feliu de Guixols, Spain
FASEB Transcriptional Regulation During Growth, Differentiation, and Development, Snowmass, Colorado
Co-organizer, ASBMB Transcription/Chromatin meeting, Snowbird, Utah
Co-organizer, EMBL Transcription meeting, Heidelberg, Germany
142011
The Salk Institute
Host: Inder Verma
Rockefeller University
Host: Alexander Tarakhovsky
Genentech, Inc.
Host: Vishva Dixit
Ipsen Foundation Symposium on “Epigenetics and Cancer” Walvis Bay, Namibia
Keynote Lecturer, Spetses Summer School on Chromatin & Systems Biology, Spetses Island, Greece
Keynote Lecturer, Centre for Molecular Medicine and Therapeutics Symposium, University of British
Columbia, Vancouver, B. C.
Columbia University, Department of Biology
Host: James Manley
Co-organizer with Vytas Bankaitis, Gordon Conference on "Signal Transduction Within The Nucleus"
Ventura, CA
Institute Jacques Monod, Paris, France
Host: Catherine Dargemont
University of Glasgow, Institute of Cancer Science, Scotland
Host: Adam West
University of Virginia School of Medicine, Department of Biochemistry
Host: Dan Burke
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
Host: Olivier Pourquie, Laszlo Tora
Promega Corporation, Madison, WI
Host: Martin Rosenberg and Danette Hartzell
Institute Curie, Section de recherché, Paris
Host: Genevieve Almouzni
Cold Spring Harbor Laboratory, Mechanisms of Eukaryotic Transcription Meeting, Cold Spring Harbor, NY
Medical College of Georgia, Augusta, Georgia
Host: Dorothy Tuan
Novartis Science Board, China Novartis Institute, Shanghai, China
William Guy Forbeck Research Foundation Symposium on Epigenetics, Hilton Head Island, SC
15Keystone Symposia on Histone Code: Fact or Fiction? Midway, Utah
International Society for Experimental Hematology - 40th Annual Scientific Meeting, Vancouver, BC
University of Pennsylvania Cancer Epigenetics Symposium
Transcriptional Mechanisms, and Systems Biology, Michigan State University, MI
Symposium on Chromatin changes in differentiation and malignancies, Giessen, Germany
FASEB Conference on Hematologic Malignancies, Saxtons River VT
Starr Cancer Consortium Retreat, Cold Spring Harbor, NY
Salk Institute Cell Cycle Meeting, San Diego, CA
1st Canadian Conference on Epigenetics, Ontario, Canada
Penn State Summer Symposium on "Chromatin and Epigenetic Regulation of Transcription"
University Park, PA
Abcam Chromatin Meeting, Aruba
FASEB Conference on Epigenetics, Chromatin, and Transcription, Snowmass, CO
The H Foundation Symposium for Basic Sciences, Northwestern University, Chicago, IL
2010
Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA Lecturer for the Seminars in Oncology
series
Host: Alan D. D'Andrea
University of California San Diego, Department of Cellular and Molecular Medicine, CA
Host: Bing Ren and Xiang-dong Fu
Department of Physiological Chemistry, University Medical Centre Utrecht, Netherlands
The Oktoberfest-Lecture, Department of Molecular Biology, Ludwig Maximilians Universitat, München,
Germany
Host: Peter Becker
Keynote address at University of Kansas Cancer Center
Host: Kapil Bhalla
The Netherlands Cancer Institute, Amsterdam, Netherlands
Host: Reuven Agami & Fred van Leeuwen
Université Libre de Bruxelles, Belgium
Host: François Fuks
16UNC Lineberger Comprehensive Cancer Center
Host: Bernard Weissman
Institute of Molecular and Cell Biology (IMCB), Singapore
Host: Ernesto Guccione
The Netherlands Cancer Institute, Amsterdam, Netherlands
Host: The graduate students
Department of Genetics and Microbiology, University of Pavia, Italy
Host: Andrea Mattevi
University of Michigan, Symposium on Epigenetics
Host: Raymond Trievel
5th Ubiqiutin Conference, MD Anderson Cancer Center, Houston, TX
Keystone Symposium " Dynamics of Eukaryotic Transcription during Development," Big Sky, Montana
FASEB Yeast Chromosome Structure, Replication and Segregation Conference, Carefree, Arizona
Epigenetic/Chromatin session for the Chilean Cell Biology Society, Santiago, Chile
Chromatin Modifications Session for 2010 ASBMB Annual Meeting, Anaheim, CA
Chromatin Gordon Research Conference, Bryant University, RI
Co-organizer with Jerry Workman, "Epigenetics in Drosophila: Mechanisms and Regulations" sponsored by
the Stowers Institute for Medical Research
Organizer, ASBMB sponsored meeting on Transcription and Chromatin, Lake Tahoe, CA
2009
Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, MA
Host: Johnathan R. Whetstine
New York University School of Medicine, Frontiers in Pharmacology seminars, New York, NY
Host: Herbert Samuels
Columbia University College of Physicians & Surgeons Department of Biochemistry and Molecular
Biophysics, New York, NY
Host: Alla Grishok
University of California, San Francisco, Department of Biochemistry.
Host: Nevan Krogan
The Wistar Institute
Host: Ramin Shiekhattar
17University of Florida, Department of Biochemistry and Molecular Biology, Gainesville, FL
Host: Suming Huang
University of Massachusetts Medical School, Department of Biochemistry and Molecular Pharmacology
Worcester, MA
Host: The Graduate Student Association
The FibroGen, Inc., San Francisco, CA
Host: David Liu
University of Texas, Department of Chemistry and Biochemistry, Arlington, Texas
Host: S. Mandal
Opening Lecture for the new Center for Gene Regulation, Pennsylvania State University
Host: Joseph Reese/Frank Pugh
Fox Chase Cancer Center
Host: Jonathan Chernoff
EMBL Conference on Chromatin and Epigenetics, Heidelberg, Germany
Naito Symposium on Transcriptional Control and RNA, Sapporo Japan
Co-organizer, Gordon Research Conference, Signal Transduction within the Nucleus, Four Points Sheraton
Harbortown Ventura, CA
4th Biennial Workshop on the Clinical Translation of Epigenetics in Cancer Therapy Coral Gables, Florida
American Association for Cancer Research Basic Science/Clinical Interface: Pathways to Progress” Denver,
Colorado
4th Annual HBGS Symposium, Helsinki, Finland
Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways, Waterville Valley, New
Hampshire
50th Advances in Enzyme Regulation Symposium, University of Bologna, Italy
Epigenetics: Regulating the Genome in Development and Disease, American Society of Nephrology, San
Diego, CA
Abcam Chromatin, Structure and Function Conference, Costa Rica
2008
Max-Planck Institute for Biochemistry, Munich, Germany
Host: The graduate students
Max-Planck-Institute for Immunobiology, Freiburg, Germany
Host: Robert Schneider
18Children's Mercy Hospitals, Department of Pediatrics, Kansas City, MO
Host: Alan S Gamis
University of Kansas Medical Center, Department of Pathology, Kansas City, KS
Host: Patrick Fields
Distinguished Alumni Lecture, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Host: The graduate students
AACR Special Conference: Ubiquitin and Cancer, San Diego, CA
Epley Institute for Research, University of Nebraska Medical Center, Omaha, NE
Host: Angie Rizzino
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Host: Asifa Akhtar
Lecturer in the Stohlman Scholar Symposium of the Leukemia and Lymphoma Society Kansas City, MO
Host: Danesh Moazed
Fourth International Conference on Ubiquitin, Ubiquitin-Like Proteins, and Cancer, Houston, TX
51st Annual Meeting & Conference of the Canadian Society of Biochemistry, Molecular and Cellular
Biology"Epigenetics and Chromatin Dynamics" Banff, Alberta, CA
8th European Molecular Biology Laboratory (EMBL) Transcription Meeting, Heidelberg, Germany
A meeting on Post-translational Modifications & Chromatin, Gurdon Institute,
Cambridge, UK
NIH/NIDDK Symposium “Dynamic Epigenome and homeostatic regulations in health and disease” Bethesda,
MD
Gordon Conference on Chromatin Structure and Function, Barga, Italy
Midwest yeast meeting, Northwestern University, Evanston, IL
FASEB Conference on Transcriptional Regulation during Cell Growth, Differentiation, and Development
Snowmass Village, CO
MSU Summer Symposium on Transcriptional Regulation/Systems in Biology, Lansing, MI
Co-chair, Dynamic Epigenome and Homeostaic Regulations, National Institute of Health
Organizer, ASBMB sponsored meeting on Transcription and Chromatin, Lake Tahoe, CA
Co-organizer with Leanne Weidemann and Jay Hess, Stowers Institute meeting on MLL, Kansas City, MO
Organizer with Shelley Berger and Ramin Shiekhattar, Banbury Meeting on Epigenetics, Cold Spring Harbor,
NY
192007
Beckman Research Institute of City of Hope, Duarte, CA
Host: The Graduate Students
Max Planck Institute for Molecular Genetics, Berlin, Germany
Host: Ann Ehrenhofer-Murray
Department of Biochemistry, University of Georgia, Athens, GA
Host: Biochemistry Graduate Students Association
Department of Biochemistry, Washington State University, Pullman, WA
Host: John Wyrick
Washington University School of Medicine, Radiation Oncology, St. Louis MO
Host: Tej Pandita
Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS
Host: Joseph D. Fontes
Burnham Institute for Medical Research, La Jolla, CA
Host: Ze’ev Ronai
Department of Biochemistry, Tufts University School of Medicine, Boston, MA
Host: Ananda Roy
Department of Biochemistry, University of Alabama, Birmingham, AL
Host: Hengbin Wang
Medical Collage of Georgia, Center for Cancer Research, Augusta, GA.
Host: Douglas Miller
Gordon Conference on Signal Transduction within the Nucleus Ventura, CA
Frontiers in Epigenetics and Chromatin Signaling, Toronto, Canada
Opening Lecturer 21st Symposium of the Protein Society, Boston, MA
Annual Symposium of the Centre for Genomic Regulation, Genomic Regulation: Executing the Code,
Barcelona, Spain
Penn State Summer Symposium on chromatin research, Penn State University, University Park, PA
2nd Meeting on Chromatin: Assembly and Inheritance of Functional States, München, Germany
4th Abcam meeting on Chromatin Structure and Function, Antigua
202006
Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, MA
Host: The students/postdoctoral fellows of MGH Cancer Center
Department of Pharmacology and Cancer Biology, Duke University Medical Center Durham, NC
Host: Dennis Thiele
Department of Molecular Oncology, University of Chicago, Chicago, IL
Host: Stephen Kron
Department of Pharmacology, University of Wisconsin, Madison, WI
Host: Randal Tibbetts
Department of Molecular Genetics, Boston University School of Medicine Boston, MA
Host: Vassilis Zannis
Oncology Research Program, Amgen Inc. Thousand Oaks, CA
Host: Rick Kandall
Department of Biomedical Sciences, Florida State University Medical Center
Tallahassee, FL.
Host: Akash Gunjan
Department of Biochemistry, Penn State University, University Park, PA
Host: David Gilmour
Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine
Cleveland Clinic Foundation Cleveland, OH
Host: Paul DiCorleto
Department of Biochemistry, M. D. Anderson Cancer Center, Houston, TX
Host: William Klein
Department of Biochemistry, University of Rochester Medical Center, Rochester, NY
Host: Mike Bulger
Stowers Institute for Medical Research, Kansas City, MO
Host: Robb Krumlauf
Herman B Wells Lecturer, Indiana University School of Medicine, Indianapolis, IN
Host: David Skalnik
National Cancer Institute, Laboratory of Receptor Biology and Gene Expression
Host: Tom Misteli/Gordon Hager
Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY
Host: Stewart Shuman
21Department of Biochemistry, University of California in Los Angeles (UCLA),
Los Angeles, CA. Host: Steven Smale
Amgen Lecturer, Annual Meeting of the American Society for Biochemistry and Molecular Biology, National Meeting
in conjunction with FASEB, San Francisco, CA
Third International Conference: Ubiquitin, Ubiquitin-like proteins, and Cancer, MD Anderson Cancer Center,
Houston, TX
American Society for Biochemistry and Molecular Biology, National Meeting in conjunction with FASEB, San
Francisco, CA
United Kingdom Chromatin Meeting, Manchester, UK
7th European Molecular Biology Laboratory (EMBL) Transcription Meeting, Heidelberg, Germany
Gene Expression Course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Speaker and Session Chair, Gordon Conference on Chromatin Structure and Function, Barga, Italy
Abcam Chromatin Meeting, Punta Canca, Dominican Republic
Organizer, ASBMB sponsored meeting on Transcription and Chromatin, Kiawah Island,
Charleston, SC
2005
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
Host: Bradley Cairns
Department of Biochemistry, University of Illinois, Chicago, IL
Host: Maxim Frolov
Department of Pharmacology, Washington University School of Medicine, St. Louis, MO
Host: Kerry Kornfeld
Department of Biochemistry, Southern Illinois University Medical Center, Carbondale, IL
Host: Sukesh Bhaumik
Gene Expression Course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Host: The Gene Expression Course
Department of Molecular Microbiology, Saint Louis University Medical Center, St. Louis, MO
Host: John Tavis
The Kaplan Lecture, Department of Biochemistry, University of Kentucky, Lexington, KY
Host: The graduate students
Department of Biochemistry and Molecular Genetics, Charlottesville, VA
Host: Patrick Grant
22Department of Biochemistry, Emory University School of Medicine, Atlanta, GA
Host: Danny Reines
Department of Biochemistry, Michigan State University, East Lansing, MI
Host: David Arnosti
Johns Hopkins University, Department of Molecular Genetics, Baltimore, MD
Host: Jef Boeke
Department of Pathology, University of Michigan, Ann Arbor, MI
Host: Jay Hess
Symposium on Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD
Cold Spring Harbor Laboratory, Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor, NY
University of Virginia, Symposium on Chromatin and Transcription, Charlottesville, VA
Gordon Conference on The Molecular and Genetic Basis of Cell Proliferation, New London, NH
Alan Kaplan Minisymposium on Transcription and Cancer, University of Kentucky
Speaker and Session Chair, Abcam Chromatin Meeting, Nassau, Bahamas
Cold Spring Harbor meeting on Transcription, CSH, NY
Organizer, Abcam sponsored Meeting on Chromatin and Cancer, St. Louis, MO
Speaker and Session Chair, Keystone Symposium on Chromatin, Snowbird, UT
2004
Department of Pathology and Medicine, Yale University School of Medicine, New Haven, CT
Host: Archibald Perkins
The Abramson Cancer Center, The University of Pennsylvania
Host: Jay Hess
Department of Biochemistry, University of Missouri, Columbia, MO
Host: Susan Deutscher
Department of Biochemistry, University of California Santa Cruz, Santa Cruz, CA
Host: Grant Hartzog
Mount Sinai School of Medicine, Derald H. Ruttenburg Cancer Center, New York, NY
Host: Ze’ev Ronai
Department of Cell Biology, University of Texas, Southwestern Medical Center, Dallas, TX
Host: Kim Orth
23Gene Expression Course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
UCLA Cancer Center, Los Angeles, CA
Host: Steven Smale
Organizer, ASBMB sponsored meeting on Chromatin and RNA Polymerase II in Transcriptional Regulation,
Granlibakken, Lake Tahoe, CA
Gordon Research Conference on Chromatin Structure & Function, Tilton, NH
Abramson Cancer Center, the Hematological Malignancies Conference,
University of Pennsylvania
Transcription section of the annual ASBMB Meeting in Boston, MA
The Second International Conference, Ubiquitin, Ubiquitin-like proteins, and Cancer, MD Anderson Cancer Center
Session Chair, AbCam Organized Meeting on Chromatin Structure and Function, Cancun, Mexico
AbCam Organized Meeting on Chromatin Structure and Function, Cancun, Mexico
FASEB sponsored Meeting on Transcription, Saxton River, VT
Stohlman Scholar Symposium for the Annual Leukemia & Lymphoma Society, Denver, CO
2003
Department of Cancer Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Host: Andrea McClatchey
Department of Biochemistry, Laval University and University of Quebec, Quebec, Canada
Host: Jacques Cote
Department of Biochemistry, University of California in Los Angeles (UCLA),
Los Angeles, CA. Host: Michael Carey and Steven Smale
Department of Radiation Oncology, Washington University, St. Louis, MO
Host:Tej Pandita
Gene Expression Course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Host: The Gene Expression Course
Department of Biophysics and Physiology, University of Iowa, Iowa City, IA
Host: Scott Moye-Rowley
Department of Biochemistry, University of Arkansas School of Medicine, Little Rock, AR
Host: Wayne Wahls
National Cancer Institute, Bethesda, MD
Host: Rohinton Kamakaka
International Genomic Proteomic Conference, Fargo, ND
24Cold Spring Harbor Course in Eukaryotic Gene Expression
Marie Curie Institute, Oxted, London
Cold Spring Harbor Laboratory, Mechanisms of Eukaryotic Transcription Meeting, Cold Spring Harbor, NY
American Society of Biochemistry and Molecular Biology national meeting in
San Diego, CA
Gordon Research Conference on Molecular and Genetic Basis of Cell Proliferation
Keystone Meeting on Chromatin and Transcription, Santa Fe, NM
2002
The Institute for Cellular and Molecular Biology, The University of Texas at Austin,
Austin, TX. Host: Alan Lambowitz
The Best Institute, The University of Toronto School of Medicine, Toronto, Canada
Host: Nevan Krogan
Keynote Lecturer for the American Cancer Society Fundraiser, St. Louis, MO
Host: ACS Heartland Chapter
Section of DNA Biology, National Cancer Institute, Bethesda, MD
Host: David Levens
Wistar Institute, University of Pennsylvania, Philadelphia, PA
Host: Ramin Shiekhattar
University of Colorado, Department of Biochemistry, Denver, CO
Host: Biochemistry Students
University of California, Irvine Department of Medicine, Irvine, CA
Host: Rainer Brachmann
Co-Organizer of the ASBMB "Satellite Meeting" on Transcriptional Regulatory Mechanisms
2001
Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, CT
Host: Joan and Tom Steitz
Department of Biochemistry, Pennsylvania State University, State College, PA.
Host: David Gilmour
Department of Biochemistry, Michigan State University, East Lansing, MI
Host: Zack Burton
25Department of Biochemistry, The Best Institute and the University of Toronto, Toronto, Canada
Host: Al Edwards
The Stowers Institute for Medical Research, Kansas City, MO
Host: Joan Conaway
Keynote Lecturer for Annual American Cancer Society Employee Meeting, Kansas City, KS
Host: ACS Heartland chapter
ASBMB National Meeting Orlando, FL
Keystone Symposia on Mechanisms of Eukaryotic Transcriptional Regulation
26Publications (selected from over 200 manuscripts)
Wang, L., and Shilatifard, A. (2019) UTX mutations in human cancer. Cancer Cell 35,168-176.
Zhao, Z., and Shilatifard, A. (2019) Epigenetic modifications of histones in cancer. Genome Bio. 20, 245.
Pan, J., McKenzie, Z. M., D'Avino, A. R., Mashtalir, N., Lareau, C. A., St Pierre, R., Wang, L., Shilatifard
A., Kadoch C. (2019) The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex
identity and catalytic activity-independent genomic targeting Nature Genetics 51, 618-626
Piunti, A., Smith, E. R., Morgan, M.A.J., Ugarenko, M., Khaltyan, N., Helmin, K.A., Ryan, C.A., Murray,
D.C., Rickels, R.A., Yilmaz, B.D., Rendleman, E.J., Savas, J.N., Singer, B.D., Bulun, S.E., Shilatifard A.
(2019) CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of
Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 5, eaax2887
Zhao, Z., Wang, L., Volk, A. G., Birch, N. W., Stoltz, K. L., Bartom, E. T., Marshall, S. A., Rendleman, E. J.,
Nestler, C. M., Shilati, J., Schiltz, G. E., Crispino, J. D., and Shilatifard, A. (2019) Regulation of
MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical
therapy of leukemia. Genes Dev 33, 61-74
Zhao, Z., Wang, L., Bartom, E., Marshall, S., Rendleman, E., Ryan, C., Shilati, A., Savas, J., Chandel, N.,
Shilatifard, A. (2019) β-Catenin/Tcf7l2-dependent transcriptional regulation of GLUT1 gene expression by
Zic family proteins in colon cancer. Sci Adv. 5, eaax0698
Liang, K., Smith, K. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A.,
Murray, D. C., Wang, L., Ozark, P. A., Mishra, R. K., Hashizume, R., Schiltz, G. E., and Shilatifard, A.
(2018) Targeting processive transcription elongation through SEC disruption for Myc cancer therapy.
Cell 175, 766-779
Qu, Q., Takahashi, Y. H., Yang, Y., Hu, H., Zhang, Y., Brunzelle, J. S., Couture, J. F., Shilatifard, A*.,
Skiniotis, G*. (2018) Structure and Conformational Dynamics of a COMPASS Histone H3K4
Methyltransferase Complex. Cell 174,1117-1126
*Co-corresponding authors
Wang, L., Zhao, Z., Ozark, P. A, Fantini, D., Marshall, S. A, Rendleman, E. J., Cozzolino, K. A., Louis, N.,
He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K, Smith, E. R., Ntziachristos, P., Savas, J. N., Zou,
L., Hashizume, R., Meeks, J. J., and Shilatifard A. (2018) Resetting the epigenetic balance of Polycomb and
COMPASS function at enhancers for cancer therapy. Nature Medicine 2018 Jun;24(6):758.
Cao, K., Collings, C. K., Morgan, M. A., Marshall, S. A., Rendleman, E. J., Ozark, P. A., Smith, E.R.,
Shilatifard, A. (2018) An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and
pluripotency transition in embryonic stem cells. Science Adv. Jan 31;4(1): eaap8747
Liang, K.., Volk A. G., Haug, J. S., Marshall, S. A., Woodfin, A. R., Bartom, E. T., Gilmore, J. M., Florens,
L., Washburn, M. P., Sullivan, K, D., Espinosa, J, M., Cannova, J., Zhang, J., Smith, E, R., Crispino, J. D.,
and Shilatifard, A. (2017) Therapeutic targeting of MLL degradation pathways in MLL-rearranged
leukemia. Cell 168, 59-72.
27Chen, F. X., Xie, P., Collings, C. K., Cao K., Aoi, Y., Marshall, S. A., Rendleman, E. J., Ugarenko, M.,
Ozark, P. A., Zhang, A., Shiekhattar, R., Smith, E. R., Zhang, M. Q., and Shilatifard, A. (2017) PAF1
Regulation of Promoter-Proximal Pause-Release via Enhancer Activation. Science 357,1294-1298.
Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E.
J., Ma, Q., Takahashi, Y. H., Woodfin, A. R., Misharin, A. V., Abshiru, N. A., Lulla, R. R., Saratsis, A. M.,
Kelleher, N. L., James, D. A., and Shilatifard, A. (2017) Heterotypic nucleosome associated BET
bromodomain proteins and Polycomb as therapeutic targets in diffuse intrinsic pontine gliomas.
Nature Medicine 23, 493-500.
Rickels, R., Herz, H-M Sze, C. C., Cao, K., Morgan, M. A., Collings, C. K., Gause, M., Takahashi, Y-H.,
Wang, L., Rendleman, E. J., Marshall, S. A., Krueger, A., Bartom, E. T., Piunti, A., Smith, E., Abshiru, N.
A., Kelleher, N. L., Dorsett, D., and Shilatifard, A. (2017) Histone H3K4 monomethylation catalyzed by
Trr/COMPASS-like at enhancers is dispensable for development and viability. Nature Genetics 49, 1647-
1653.
Hu, D., Gao, X., Cao, K., Morgan, M, A., Mas, G., Smith, E. R., Volk, A. G., Bartom, E. T., Crispino, J, D.,
Di Croce, L., and Shilatifard, A. (2107) Not All H3K4 methylations are Created Equal: Mll2/COMPASS
Dependency in Primordial Germ Cell Specification. Mol Cell 65, 460-475.
Wang L., Collings C. K., Zhao Z., Cozzolino K. A., Ma Q., Liang K., Marshall S. A., Sze C. C., Hashizume
R., Savas J. N., and Shilatifard A. (2017) A cytoplasmic COMPASS is necessary for cell survival and triple-
negative breast cancer pathogenesis by regulating metabolism. Genes Dev 31, 2056-2066.
Morgan M. A. J., Rickels R. A., Collings C. K., He X., Cao K., Herz H. M., Cozzolino K. A., Abshiru N. A.,
Marshall S. A., Rendleman E. J., Sze C. C., Piunti A., Kelleher N. L., Savas J. N., and Shilatifard A. (2017)
A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Genes Dev
31, 2003-2014.
Sze C. C., Cao K., Collings C. K., Marshall S. A., Rendleman E. J., Ozark P. A., Chen F. X., Morgan M. A.,
Wang L., and Shilatifard A. (2017) Histone H3K4 methylation-dependent and -independent functions of
Set1A/COMPASS in embryonic stem cell self-renewal and differentiation. Genes Dev 31, 1732-1737.
Cao K, Collings C. K., Marshall S. A., Morgan M. A., Rendleman E. J., Wang L., Sze C. C., Sun T., Bartom
E. T., and Shilatifard A. (2017) SET1A/COMPASS and shadow enhancers in the regulation of homeotic
gene expression. Genes Dev 31, 787-801.
Piunti, A., and Shilatifard, A. (2016) Epigenetic Balance of Gene Expression by Polycomb and COMPASS
Families. Science 352, 6290.
Rickels, R., Hu, D., Collings, C., Piunti, A., Woodfin, A., Mohan, M., Herz, H-M., Kvon, E., and
Shilatifard, A. (2016) An Evolutionary epigenetic mark of polycomb response elements implemented
by Trx/MLL/COMPASS. Mol Cell, 63(2):318-28.
Hu D, Shilatifard A. (2016) Epigenetics of hematopoiesis and hematological malignancies.
Genes Dev. 30, 2021-2041.
Sze CC, Shilatifard A. (2016) MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer
Function and Cancer. Cold Spring Harb Perspect Med.
28Chen, F., Woodfin, A. R., Gardini, A., Rickels, R., Marshall, S. A., Smith, E. R., Shiekhattar, R., and
Shilatifard, A. (2015). PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II.
Cell, 62,1003-1015
Zhu, J., Sammons, M. A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-Awar, R,
Katona, B. W., Shilatifard, A., Huang, J., Hua, X., Arrowsmith, C. H., Berger, S. L. (2015) Gain-of-function
p53 mutants co-opt chromatin pathways to drive cancer growth. Nature 525, 206-211
Ortega-Molina, A., Boss, I. W., Canela, A., Pan, H., Jiang, Y., Zhao, C., Jiang, M., Hu, D., Agirre, X.,
Niesvizky, I., Lee, J. E., Chen, H. T., Ennishi, D., Scott, D. W., Mottok, A., Hother, C., Liu, S., Cao, X. J.,
Tam, W., Shaknovich, R., Garcia, B. A., Gascoyne, R. D., Ge, K., Shilatifard, A., Elemento, O.,
Nussenzweig, A., Melnick, A. M., Wendel. H. G. The histone lysine methyltransferase KMT2D sustains a
gene expression program that represses B cell lymphoma development. Nature Medicine 21,1199-208.
Liang, K., Woodfin, A. R., Slaughter, B. D., Unruh, J. R., Box, A. C., Rickels, R. D., Gao, X., Haug, J. S.,
Jaspersen, S. J., and Shilatifard, A. (2015) Mitotic Transcriptional Activation: The Clearance of Actively
Engaged Pol II Via Transcriptional Elongation Control in Mitosis. Mol Cell, 60, 435-445.
De Kumar, B., Parrish, M.E., Slaughter, B.D., Unruh, J.R., Gogol, M., Seidel, C., Paulson, A., Li, H.,
Gaudenz, K., Peak, A., McDowell, W., Fleharty, B., Ahn, Y., Lin, C., Smith, E., Shilatifard, A., Krumlauf,
R. (2015) Analysis of dynamic changes in retinoid induced transcription and epigenetic profiles of murine
Hox clusters in ES cells. Genome Res. 8, 1229-1243.
Luo, Z., Gao, X., Lin, C., Smith, E.R., Marshall, S., Swanson, S.K., Florens, L., Washburn, M.P.,
Shilatifard, A. (2015) Zic2 Is an Enhancer-Binding Factor Required for Embryonic Stem Cell Specification.
Mol Cell 57, 685–694.
Morgan, M.A., Shilatifard, A. (2015) Chromatin Signature of Cancer. Genes Dev. 29, 238-249.
Zhang, P., Chaturvedi, C.P., Tremblay, V., Cramet, M., Brunzelle, J.S., Skiniotis, G., Brand, M., Shilatifard,
A., Couture, J.F. (2015) A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Genes
Dev. 29, 123-128.
Chen, F., Gao, X., Shilatifard, A. (2015) Stably paused genes revealed through inhibition of transcription
initiation by the TFIIH inhibitor triptolide. Genes Dev. 29, 39-47
Liang, K., Gao, X., Gilmore, J.M., Florens, L., Washburn, M.P., Smith, E., Shilatifard, A. (2015)
Characterization of human CDK12 and CDK13 complexes in CTD phosphorylation, gene transcription and
RNA processing. Mol Cell Biol.
Herz, H-M., Morgan, M.A., Gao, X., Jackson, J., Rickels, R., Swanson, S. K., Florens, L., Washburn, M. P.,
Eissenberg, J. C., and Shilatifard, A. (2014) Histone H3 Lysine-to-methionine mutants as a paradigm to
study chromatin signaling Science 354, 1065-1070.
Herz, H-M., Hu, D., and Shilatifard, A. (2014) Enhancer Malfunction in Cancer. Mol Cell 53, 859-866.
Smith, E., and Shilatifard, A. (2014) Enhancer Biology and Enhanceropathies. Nature SMB
21, 210-219.
29Thornton, J., Westfield, G. H., Takahashi, Y-H., Cook, M., Gao, X., Woodfin, A. R., Lee, J-S., Morgan, M.
A., Jackson, J., Smith, E. R., Couture, J-F.,Skiniotis, G.,and Shilatifard, A. (2014) Context Dependency of
Set1/COMPASS Mediated H3 Lysine 4 Trimethylation. Genes Dev. 28,115-120.
Cheng, J., Blum, R., Bowman, C., Hu, D., Shilatifard, A., Shen, S., and Dynlacht, B. D. (2014) A Role for
H3K4 Monomethylation in Gene Repression and Partitioning of Chromatin Readers. Mol Cell 53, 979-992.
Gardini, A., Baillat, D., Cesaroni, M., Hu, D., Marinis, J. M., Wagner, E. J., Lazar, M. A., Shilatifard, A.,
and Shiekhattar, R. (2014) Integrator regulates transcriptional initiation and pause release following
activation. Mol Cell 56, 128–139.
Hu, D., Garruss, A. S., Gao, X., Morgan, M.A., Cook, M., Smith, E., and Shilatifard, A. (2013) The Mll2, a
master regulator of promoter bivalency in embryonic stem cells. Nature SMB 20, 1093-1097.
Hu, D., Smith, E. R., Garruss, A. S., Mohaghegh, N., Varberg, J. M., Lin, C., Jackson, J., Gao, X., Saraf, A.,
Florens, L., Washburn, M. P., Eissenberg, J. C., and Shilatifard, A. (2013) Multiple roles for Little
Elongation Complex in initiation and elongation phases of snRNA gene transcription. Mol Cell 51, 493-505.
Rickels, R., and Shilatifard, A. (2013) A Histone Modifier’s Ill-Gotten Copy Gains. Cell 154, 477-479.
Morgan, M.A., and Shilatifard, A. (2013) (Poly)Combing the pediatric cancer genome for answers. Science
30, 823-824.
Tarayrah, L., Herz, H. M., Shilatifard, A., and Chen, X (2013) Histone demethylase dUTX antagonizes
JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.
Development 140, 1014-1023.
Hu, D., Gao, X., Morgan, M.A., Herz, H.M., Smith, E.R., and Shilatifard, A. (2013). The MLL3/MLL4
branch of the COMPASS family is a major H3K4 monomethylase at enhancers. Mol Cell Biol 33, 4745-
4754.
Morgan, M. A., and Shilatifard, A. (2013) Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-
like complexes in development and disease. Mol. Cell. Bio. 33,1698-1701.
Smith, E., and Shilatifard, A (2013) Transcriptional checkpoint control in development and disease. Genes
and Dev. 27, 1079-1088.
Lin, C., Garruss, A.S., Luo, Z., Guo, F., Shilatifard, A. (2013) The RNA polymerase II elongation factor
Ell3 marks enhancers in embryonic stem cells and primes future gene activation. Cell 152, 144-56.
Herz, H-M., Mohan, M., Garruss, A.S., Takahashi, Y-H., Mickey, K., Voets, O., Verrijzer, C.P., and
Shilatifard, A. (2012) Enhancer-associated H3K4 mono-methylation by Drosophila Trithorax-
related/COMPASS, the Drosophila homolog of Mll3/Mll4 complexes Genes Dev. 26, 2604-20.
Luo, Z., Lin, C., and Shilatifard A. (2012) The Super Elongation Complex (SEC) family in transcriptional
control. Nature Rev Mol Cell Bio 13, 543-547.
Shilatifard, A. (2012). The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in
Development and Disease Pathogenesis. Ann. Rev. Biochem. 81, 65-95.
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