PSYCHOLOGY, PSYCHIATRY, IMAGING & BRAIN NEUROSCIENCE SECTION

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Pain Medicine 2018; 19: 50–59
doi: 10.1093/pm/pnx005

PSYCHOLOGY, PSYCHIATRY, IMAGING & BRAIN
NEUROSCIENCE SECTION
Original Research Article
The Association of Post-traumatic and

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Postmigration Stress with Pain and Other
Somatic Symptoms: An Explorative Analysis in
Traumatized Refugees and Asylum Seekers

Naser Morina, PhD,* Alexa Kuenburg, MD,* Ulrich                         Methods. One hundred thirty-four treatment-seek-
Schnyder, MD,* Richard A. Bryant, PhD,† Angela                          ing traumatized refugees (78% male, mean age 5 42
Nickerson, PhD,† and Matthis Schick, MD*                                years) were assessed regarding lifetime traumatic
                                                                        experiences, symptoms of post-traumatic stress,
                                                                        overall pain and somatic symptoms, and postmigra-
*Department of Psychiatry and Psychotherapy,                            tion living difficulties.
University Hospital Zurich, University of Zurich, Zurich,
Switzerland; †School of Psychology, University of New                   Results. An exploratory factor analysis of the 12 so-
South Wales, Sydney, Australia                                          matic symptoms revealed two distinct factors: so-
                                                                        matic symptoms related to bodily dysfunction
Correspondence to: Naser Morina, PhD, Department                        (“weakness”) and somatic symptoms related to in-
of Psychiatry and Psychotherapy, University Hospital,                   creased sympathetic activity (“arousal”). DSM-5
University of Zurich, Culmannstrasse 8, 8091 Zurich,                    PTSD Criteria D “alterations in cognitions and mood”
Switzerland. Tel: þ41-44-255-52-80; Fax: þ41-44-255-                    and E “alterations in arousal and reactivity” were pri-
44-08; E-mail naser.morina@usz.ch.                                      marily related to “weakness,” while PTSD Criterion E
                                                                        “alterations in arousal and reactivity” and postmigra-
Funding sources: This study was partly supported by                     tion living difficulties were associated with “arousal.”
the Parrotia Foundation, the Swiss Federal Office for                   Overall pain was associated primarily with living diffi-
Migration (3a-12-0495), and the Swiss Federal Office                    culties and PTSD Criterion D and Criterion E.
for Health (12.005187). AN was supported by a
National Health and Medical Research Council                            Conclusions. Results indicate that somatic symptoms
Clinical Early Career Fellowship (1037091).                             are of considerable concern among traumatized refu-
                                                                        gees and that different patterns of somatic symptoms
Conflicts of interest: The authors disclose no conflicts                are associated with different clusters of PTSD symp-
of interest.                                                            toms. The findings contribute to the better understand-
                                                                        ing of the symptom presentation of traumatized
                                                                        people who are experiencing somatization and poten-
Abstract                                                                tially inform treatment directions and highlight the im-
                                                                        portance of screening for PTSD in refugees presenting
Objective. Post-traumatic stress disorder (PTSD)                        with pain and somatic symptoms.
and somatic symptoms, such as pain, are fre-
                                                                        Key Words.         Post-traumatic Stress Disorder;
quently seen in refugees. Their relationship is
                                                                        Trauma; Pain; Somatic Symptoms; Postmigration
poorly understood, and the treatment of these co-
                                                                        Living Difficulties; Refugee
morbid conditions can be very challenging. The cur-
rent cross-sectional study examined pain and other
somatic symptoms and their relationship with                            Introduction
trauma history, PTSD symptom clusters, and cur-
rent living difficulties among treatment-seeking                        In the current international context, the number of refu-
refugees.                                                               gees and internally displaced people worldwide is

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V                                                                                                                             50
Trauma and Somatic Symptoms in Traumatized Refugees

increasing dramatically and recently exceeded 65 million     family, which may increase the risk of developing psy-
[1]. By definition, refugees have experienced persecution    chological symptoms [29,30]. Despite numerous studies
and are thus often subject to repeated and severe trau-      attesting to the link between trauma exposure,
matic experiences, including life-threatening situations,    postmigration stressors, and psychological disorders in
torture, and multiple bereavement [2]. Accordingly, high     refugees, there is little evidence on how somatic symp-
rates of trauma-related psychological disorders, includ-     toms in traumatized refugees can be explained and how
ing post-traumatic stress disorder (PTSD), depression,       they interfere with other determinants of refugee mental
and anxiety, have been reported in refugees [3–5].           health. There is little research that has demonstrated
                                                             that postmigration stress is associated with somatization
PTSD is often associated with comorbid conditions, and       and somatoform disorders in refugee and immigrant

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physical complaints have been found to be among the          groups [31–33]. Literature has shown that patients with
most frequently reported symptoms in individuals with        somatic symptoms have excessively higher rates of
PTSD [6]. Comorbid chronic pain—a prominent mani-            health care utilization and in addition such patients may
festation of somatic symptoms—has been reported in           contribute to increasing cost of health care services
34% to 80% of PTSD patients [7–9], and the frequent          [34]. A better understanding is needed to provide effec-
co-occurrence of PTSD with unexplained somatic               tive treatment for this highly vulnerable population.
symptoms and medical conditions is well documented
[10,11,12]. Particularly high comorbidity rates of PTSD      This exploratory study examines the nature of pain and
and somatic symptoms have been demonstrated in               somatic symptoms, as well as their interaction with
samples of refugees [13,14] and torture survivors [15].      PTSD and postmigration living difficulties (PMLDs), in a
Furthermore, somatization is considered a vital part of      sample of treatment-seeking refugees. On the premise
post-traumatic symptomatology in relation to complex         that pain is associated with elevated stress, we hypoth-
trauma [16].                                                 esized 1) a positive association of PTSD symptoms,
                                                             pain, and somatic symptoms; and 2) due to the explor-
While there is solid evidence with regard to the frequent    ative character of this study, no hypothesis was made
co-occurrence of trauma-related mental and somatic           regarding the exact nature of the association between
health problems, the nature of this relationship is still    PTSD symptoms and level of PMLDs.
poorly understood. Psychological, behavioral, and bio-
logical factors, as well as the complex interactions be-     Methods
tween these factors, serve as possible mechanisms
through which PTSD may be associated with physical           Participants
health [10,17]: Somatic presentations may occur in
PTSD patients as a result of a number of mechanisms,         These data were collected between May 2012 and
including 1) trauma-independent somatic disorders; 2)        August 2013. Participants were refugees or asylum
traumatic injuries and tissue damage sustained in the        seekers who had survived war and/or torture and came
course of the initial traumatic event; 3) somatic condi-     from a variety of refugee backgrounds. At the time of
tions related to the increased allostatic load or to unfa-   the study, they were receiving psychological treatment
vorable health habits associated with PTSD; 4)               for trauma-related health complaints at the outpatient
autonomic, neuroendocrine, and immunologic dysregu-          units for victims of torture and war in either Zurich or
lation resulting from PTSD; 5) genetic and epigenetic        Bern, Switzerland. Inclusion criteria were written in-
predispositions; 6) somatoform disorders, particularly       formed consent, being 18 years or older, and speaking
dissociative or conversion disorders associated with ele-    one of the study languages, that is, German, English,
vated stress levels; 7) somatic intrusions that function     Turkish, Arabic, Farsi, or Tamil. Patients were excluded
as a form of re-experiencing of the trauma; or 8) alexi-     if they were unable to fill in self-report questionnaires, if
thymia or culture-dependent expression of psychological      they were pregnant, if they had a severely impaired dis-
distress [18–22]. So far, several theoretical models,        tress tolerance (for example, severe dissociative symp-
such as the mutual maintenance model [23], the shared        toms), or if they were currently suffering from psychosis
vulnerability model [24], and the fear avoidance model       or were acutely suicidal or a threat to others.
[25], have been suggested to explain the mechanisms
of the co-occurrence of pain and PTSD.                       Based on the inclusion criteria, 152 patients were invited
                                                             to participate in the study and 137 patients (90.1%)
Refugee mental health is becoming an increasingly im-        agreed to participate. After three participants failed to
portant public health concern in hosting societies           attend the assessment, 134 participants were included
[3,26,27]. While evidence-based therapies for PTSD in        in the final sample.
refugees do exist [28], there are no empirically sup-
ported treatments for trauma-related somatic symp-           Measures
toms. In addition, over and above the adverse
psychological and physical effects of trauma, refugees       The measures used in this study have been used across
and asylum seekers are often subjected to a variety of       multiple cultural groups. Accredited translators trans-
postmigration stressors, including unemployment, inse-       lated them into Turkish, Arabic, Farsi, and Tamil. Blind
cure visa status, discrimination, and separation from        back-translation procedures were also implemented

                                                                                                                       51
Morina et al.

[35], with differences between the two translations           with social worker”). The 17 items were rated on a five-
being rectified by independent bilingual individuals expe-    point scale (0 ¼ “not a problem” to 4 ¼ “very serious
rienced in working with health-related questionnaires.        problem”). Items scored at least 2 (“moderately serious
Sociodemographic sample characteristics were as-              problem”) were considered positive responses, yielding
sessed at the beginning of the assessment.                    a total count of living difficulties.

Trauma exposure was measured by combining the
                                                              Procedures
trauma event lists of two standardized questionnaires,
the Harvard Trauma Questionnaire (HTQ) [36], and the
                                                              The ethics committees of the respective Cantons of
Post-traumatic Diagnostic Scale (PDS) [37,38]. This

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                                                              Zurich and Bern, Switzerland, approved the study (KEK-
combined scale indexes exposure to 23 types of trau-
                                                              ZH-Nr. 2011-0495). A therapist-assisted computer-
matic events associated with the refugee experience
                                                              based assessment tool (MultiCASI) was used to
(i.e., brainwashing, torture, being close to death) and
                                                              implement the self-report measures [48]. In MultiCASI,
traumatic experiences associated with other civilian
                                                              participants can read each item and the range of possi-
trauma (i.e., natural disaster, serious accident, fire, or
                                                              ble responses in their respective mother tongue on a
explosion). A count of the number of types of traumatic
                                                              tablet screen and—in case of illiteracy—can listen to the
events experienced by each participant was computed.
                                                              audio-recorded items/responses. Items are answered
                                                              by touching the screen. A study team member ex-
To measure PTSD symptom severity over the past
                                                              plained the purpose of the study to potential partici-
month, part three of the PDS [37,38] was used. The
                                                              pants, including that the study would be performed
PDS has been used with several refugee groups [39–
                                                              anonymously and would have no influence on their sta-
41]. As data collection for this study was conducted
                                                              tus of residence or asylum procedures. Written informed
prior to publication of the DSM-5 in 2013, the additional
                                                              consent was obtained from all participants. Participants
items included in DSM-5 for the proposed PTSD diag-
                                                              were informed that they were free to withdraw from the
nostic criteria were added to the PDS [42,43].
                                                              study at any time without jeopardizing their ongoing
According to the DSM-5, to meet criteria for PTSD one
                                                              treatment. Participants attended a research assessment
must initially be exposed to a traumatic event (Criterion
                                                              of 60 to 120 minutes’ duration. Assessments were su-
A). PTSD symptoms are then divided into four main cri-
                                                              pervised by a psychiatrist, clinical psychologist, or a
teria: Criterion B: intrusion symptoms; Criterion C: per-
                                                              Master’s-level    student    of     clinical psychology.
sistent avoidance of stimuli associated with the trauma;
                                                              Participants were reimbursed CHF 40 (approximately
Criterion D: negative alterations in cognitions and mood;
                                                              USD 40) for participation.
Criterion E: alterations in arousal and reactivity.
Probable PTSD diagnosis was determined by applying
DSM-5 criteria to symptoms in the PDS [39]. Internal          Data Analysis
consistency for this scale was high (a ¼ 0.94).
                                                              Analyses were conducted using SPSS version 22
Somatic symptoms were measured using the somatiza-            (SPSS-IBM, INC). Exploratory factor analysis (principal
tion subscale of the Symptom Checklist (SCL) [44]. This       components) was used to derive somatization patterns
subscale is a self-report inventory of 12 physical symp-      based on the 12 SCL items. Two factors were retained,
toms with strong autonomic mediation that are often as-       with the criteria for extraction being an eigenvalue equal
sociated with emotional distress. Symptom severity            to or greater than 1. The factors were rotated by the di-
during the last seven days is rated on a five-point Likert    rect oblimin (oblique) function in order to obtain a sim-
scale ranging from 0 ¼ “not at all” to 4 ¼ “extremely.”       pler structure with greater interpretability. Items with a
Items scored as 2 ¼ “moderately” or above are consid-         loading higher than 0.40 on a given factor were consid-
ered positive responses, yielding a total count of so-        ered to contribute substantially to that factor. Only one
matic symptoms. The SCL has been used with                    item failed to load to one of the two factors; for this rea-
individuals from many cultural backgrounds [45]. In the       son, we omitted this item. After deriving these two fac-
current study, internal consistency was set at an             tors, multiple linear regression (using the method
a of 0.89.                                                    stepwise) was utilized to examine the relationship be-
                                                              tween the two somatic symptom factors and pain as
Overall pain over the past four weeks was assessed            outcome variables and age, gender (Step 1), potentially
with a single item on a five-point scale ranging from         traumatic events and current living difficulties (Step 2),
0 ¼ “not at all” to 4 ¼ “extremely.”                          and PTSD core symptom clusters (Step 3) as indepen-
                                                              dent variables. Assumptions for regression analyses
A version of the Postmigration Living Difficulties            were checked in terms of linearity of the relationships
Checklist (PMLDC) [46,47] adapted to the Swiss context        between somatic symptoms and independent variables,
was used to examine the extent to which postmigration         autocorrelation       of      residuals    (Durbin-Watson
challenges had been of concern to the individual over         test ¼ 1.974), and homoscedasticity and normal distribu-
the past 12 months (i.e., “communication difficulties,”       tion of residuals, and all were found to be satisfactory.
“discrimination,” “difficulties in interviews with immigra-   Furthermore, we found no multicollinearity between in-
tion officials,” “difficulties with employment,” “conflict    dependent variables (all VIF < 1.7).

52
Trauma and Somatic Symptoms in Traumatized Refugees

Results                                                       Table 1    Sample characteristics

Participants in this study had a mean age of 42.4 years       Variable
(SD ¼ 9.9), and the sample comprised 78.4% (N ¼ 105)
males. Participants reported having experienced a mean        Male gender, N (%)                           105 (78.4)
of 13.11 (SD ¼ 4.80) types of traumatic events, with          Age, mean (SD), y                             42 (9.9)
over 90% of the sample having experienced torture             Nationality, N (%)
(N ¼ 114, 92.7%) and a mean of 9.77 (SD ¼ 4.2) types            Turkey (with N ¼ 58 being Kurdish)          71 (53.0)
of living difficulties during the last 12 months.               Iran                                        15 (11.2)
Approximately half of the sample (N ¼ 66, 49.3%) had a          Sri Lanka                                   11 (8.2)

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probable diagnosis of PTSD according to the DSM-5               Bosnia                                       6 (4.5)
criteria. Further sociodemographic and sample charac-           Iraq                                         6 (4.5)
teristics are presented in Table 1.                             Afghanistan                                  5 (3.7)
                                                                Others (i.e., Algeria, Bangladesh,          20 (14.9)
An exploratory factor analysis of the 12 SCL items re-          Ethiopia, Congo, Kosovo, Lebanon,
vealed two distinct factors of somatic complaints. A fac-       Liberia, Libya, Somalia, Syria, Tunesia)
tor-loading matrix is shown in Table 2. The first factor,
                                                              Years of education, N (%)
with five items, was labeled “weakness” as it presented
                                                                Less than 4                                 18 (10.4)
high loadings of items referring to weakness, soreness,
                                                                4–8                                         25 (18.7)
or heaviness symptoms and accounted for 45.7% of
                                                                8–12                                        39 (29.1)
the variance. For this factor, the internal consistency
was set at an a of 0.85. The second factor comprised            12þ                                         49 (36.6)
six items and was characterized by high loadings of so-       Employment status, N (%)
matic symptoms predominantly associated with sympa-             Full time                                    9 (6.79)
thetic hyperactivation, such as chest pain or shortness         Part time                                   17 (12.6)
of breath, and was labeled “arousal.” This factor ex-           Unemployed                                  82 (61.2)
plained 10.3% of the variance, and the internal consis-         Retired/homemaker                           23 (17.1)
tency was set at an a of 0.81. The item “hot or cold          Duration of stay in Switzerland (SD), y     9.01 (6.67)
spells” did not load on either factor.                        No. of experienced trauma types, mean      13.23 (4.54)
                                                                (SD)
The results of the correlation analyses are shown in          Probable PTSD diagnosis, N (%)                66 (49.3%)
Table 3. Multiple regression analyses revealed that only      Number of somatic symptoms, mean (SD)        7.3 (3.5)
symptoms of the PTSD Criterion D “alterations in cogni-       Symptom scores, mean (SD)
tions and mood” and Criterion E “alterations in arousal         PTSD symptoms (range ¼ 0–60)              33.2 (13.8)
and reactivity” symptoms were independently associ-                PTSD Criterion B (range ¼ 0–15)         9.2 (4.0)
ated with the “weakness” factor, accounting for 36% of             PTSD Criterion C (range ¼ 0–6)          3.4 (1.9)
the variance, while the “arousal” factor was associated            PTSD Criterion D (range ¼ 0–21)        10.9 (5.3)
with female gender, the PTSD Criterion E “alterations in           PTSD Criterion E (range ¼ 0–18)         9.9 (4.5)
arousal reactivity,” and the postmigration living difficul-
                                                                Somatic symptoms
ties, accounting for 32% of the variance (see Table 4).
                                                                   “Weakness” (range ¼ 0–4)                2.1 (0.9)
Overall pain was associated with age, female gender,
                                                                   “Arousal” (range ¼ 0–4)                 1.7 (0.8)
living difficulties, and both PTSD Criteria D and E.
                                                                   Overall pain (range ¼ 0–4)              2.3 (1.2)

Discussion

This exploratory cross-sectional study examined the fac-      PTSD symptom clusters as well as PMLD, with the
tor structure of somatic symptoms (as assessed with           highest correlations emerging with Criterion D (“negative
the SCL) and the relationship of somatic symptoms and         alterations in cognitions and mood”) and Criterion E (“al-
pain with PTSD symptom clusters and postmigration liv-        terations in arousal and reactivity”). However, while the
ing difficulties in a clinical sample of severely trauma-     “weakness” factor showed slightly higher correlations
tized refugees.                                               with PTSD symptoms, “arousal” was more strongly re-
                                                              lated to PMLD. Regression analysis revealed that, when
An exploratory factor analysis revealed two distinct fac-     controlling for all variables simultaneously, while both
tors of somatic complaints: Factor one included physical      factors related to Criterion E, the “weakness” factor was
perceptions in terms of bodily dysfunction and was re-        additionally related to PTSD Criterion D and the
ferred to as “weakness,” whereas factor two included          “arousal” factor related to PMLD. Overall pain was re-
somatic symptoms predominantly associated with sym-           lated to PMLD and both PTSD CRITERIA D and E.
pathetic hyperactivation and was referred to as
“arousal.” Correlation analyses revealed that both fac-       While the relationship between traumatic experiences,
tors and overall pain were significantly related to all       PTSD, and somatic complaints is well documented, this

                                                                                                                     53
Morina et al.

Table 2 Summary of the factor loadings for the                    function that has been observed in PTSD [49].
somatization items of SCL (N ¼ 134)                               Conversely, potentially life-threatening somatic symp-
                                                                  toms such as shortness of breath or chest pain may re-
Factor loadings                                                   sult in increased sympathetic activation, often
                                                                  accompanied by secondary symptoms such as hyper-
                              Factor 1              Factor 2      ventilation, dizziness, muscular hypertension, and ten-
Item                          “weakness”            “arousal”     sion headache [50,51]. Dizziness has been noted in
                                                                  prior traumatized populations, especially those from
Soreness of                        0.925                  0.118   non-Western backgrounds; for example, dizziness has
  muscles                                                         been found to be a prominent complaint in a study on

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Numbness or tin-                   0.813                  0.251   traumatized Cambodians [51]. We also note that the
  gling in part of                                                items in the “arousal” factor overlap with those of panic
  the body                                                        attacks; panic disorder is frequently comorbid with
Pains in lower                     0.726                  0.356   PTSD [52], and it is possible that many of the refugees
  back                                                            in this sample had comorbid panic disorder. This possi-
Heavy feeling in                   0.719                  0.263   bility cannot be clarified because comorbid disorders
  your arms or                                                    were not assessed.
  legs
Feeling weak in                    0.691                  0.200   With regard to the “weakness” factor, a recent meta-
  parts of your                                                   analysis found traumatic experiences to be associated
  body                                                            with an increased prevalence of functional somatic syn-
                                                                  dromes (FSS), including fibromyalgia, chronic widespread
Trouble getting                  0.156                   0.829
                                                                  pain, and chronic fatigue syndrome [53]. Individuals re-
  your breath
                                                                  porting exposure to trauma had 2.7 times higher odds of
Pains in heart or                  0.082                  0.747
                                                                  having FSS. Combat exposure and PTSD had the stron-
  chest
                                                                  gest association with FSS. FSS typically accompanies
Faintness or                       0.060                  0.698   complaints included in the “weakness” factor. Apart from
  dizziness                                                       sympathetic activation, the association of the “weakness”
Headaches                          0.135                  0.602   factor and overall pain with the PTSD CRITERION of
Nausea or upset                    0.213                  0.588   “negative alterations in cognitions and mood” is notable
  stomach                                                         and points to other potential mechanisms; for example, it
Lump in your                       0.350                  0.490   is possible that the “weakness” symptoms may be asso-
  throat                                                          ciated with fatigue overreported in dysphoric states that
Hot or cold spells                 0.397                0.339     is incorporated in Criterion D.
Variance, %                       45.7                 10.3
Internal                       a ¼ 0.85             a ¼ 0.81      Somatic Symptoms and PMLD
  consistency
                                                                  The association of somatic complaints (i.e., somatization
Factor loadings higher than 0.40 are presented in bold.           symptoms and pain) with postmigration living difficulties
                                                                  has attracted little research attention to date. While
                                                                  PMLDs have repeatedly been identified to be related to
                                                                  mental health problems in refugees over and above
is one of the very first studies to examine distinct clus-        trauma exposure [32,46,54–56], this is one of the first
ters of somatic symptoms and pain, their association              studies to our knowledge to show an association with
with different PTSD clusters, and their association with          regard to physical health complaints. The association of
PMLD. Our findings suggest a model of triangular rela-            PMLD with the PTSD Criterion E and the “arousal” fac-
tion between the three elements: post-traumatic stress,           tor and pain suggests a shared basis in terms of an ele-
postmigration living difficulties, and somatic symptoms.          vated stress level, in analogy to the above-cited
Though by virtue of the cross-sectional study design the          neurobiological and cognitive models. Again, it remains
causal direction of the respective associations remains           unclear whether PMLDs result in stress and stress-
unclear, some subpatterns can be distinguished.                   associated somatic complaints, or if PTSD and somatic
                                                                  complaints would rather map into PMLD due to func-
Somatic Symptoms and PTSD                                         tional impairment, or a combination of both.

The relationship between the “arousal” factor of somatic          Apart from nonspecific elevated stress levels resulting
symptoms and PTSD Criterion E is not surprising. PTSD             from PMLD, another hypothesis for the relationship be-
models have suggested that the relationship between               tween somatic symptoms and PMLD is social rejection,
pain and PTSD, particularly the arousal symptoms (i.e.,           in terms of social pain. Social rejection might be particu-
hypervigilance, exaggerated startle response), is a func-         larly perceived by refugees, who, after their displace-
tion of sympathetic hyperactivation (or diminished para-          ment, are confronted with often adverse social
sympathetic activation) and the altered HPA-axis                  environments in hosting societies. In an experimental

54
Trauma and Somatic Symptoms in Traumatized Refugees

Table 3 Pearson’s correlation of somatization symptoms and overall pain with potentially traumatic
events, PTSD symptom criteria and living difficulties (N ¼ 134)

                          1             2             3            4            5             6             7             8

1   “Weakness”
2   “Arousal”             0.634**
3   Overall pain          0.658**       0.630**
4   PTE                   0.208*        0.193*        0.120

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5   PTSD Criterion   B    0.349**       0.329**       0.278*       0.159
6   PTSD Criterion   C    0.241**       0.233**       0.227*       0.179*       0.428**
7   PTSD Criterion   D    0.439**       0.392**       0.385*       0.161        0.450**       0.501**
8   PTSD Criterion   E    0.572**       0.511**       0.434*       0.300**      0.480**       0.441**       0.532**
9   PMLD                  0.296**       0.340**       0.261*       0.201*       0.233**       0.221*        0.260**       0.267**

Criterion B ¼ intrusion symptoms; Criterion C ¼ persistent avoidance of stimuli associated with the trauma; Criterion D ¼ negative
alterations in cognitions and mood; Criterion E ¼ alterations in arousal and reactivity; PMLD ¼ postmigration living difficulties;
PTE ¼ potentially traumatic events; PTSD ¼ post-traumatic stress disorder.
*
Morina et al.

Table 4 Summary of the multiple regression analyses of somatization factors and overall pain, age,
gender, trauma, PTSD symptom criteria, and living difficulties (N ¼ 134)

Outcome         Independent                                                                                                 Adjusted
variable        variable               B           SEB       b          T           P        F          P         R2        R2

“Weakness”                                                                                   10.313     0.000     0.398       0.359
                Age                     0.014      0.007      0.139      1.960      0.052
                Gender                  0.067      0.166      0.028      0.400      0.690

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                Trauma                  0.007      0.016      0.032      0.427      0.670
                Living difficulties     0.033      0.017      0.144      1.937      0.055
                PTSD Criterion B        0.150      0.245      0.052      0.613      0.541
                PTSD Criterion C       0.203      0.178     0.097     1.141      0.256
                PTSD Criterion D        0.438      0.187      0.213      2.344      0.021
                PTSD Criterion E        0.881      0.184      0.434      4.783      0.000
“Arousal”                                                                                      8.843    0.000     0.361       0.321
                Age                     0.011      0.006      0.124      1.694      0.093
                Gender                  0.313      0.150      0.153      2.087      0.039
                Trauma                  0.008      0.014      0.045      0.591      0.556
                Living difficulties     0.044      0.016      0.215      2.819      0.006
                PTSD Criterion B        0.186      0.221      0.073      0.844      0.401
                PTSD Criterion C       0.131      0.160     0.071     0.816      0.416
                PTSD Criterion D        0.272      0.168      0.151      1.618      0.108
                PTSD Criterion E        0.640      0.166      0.360      3.861      0.000
Overall pain                                                                                   7.285    0.000     0.322       0.277
                Age                     0.023      0.009      0.206      2.771      0.008
                Gender                  0.553      0.204      0.206      2.708      0.008
                Trauma                  0.002      0.020      0.007      0.088      0.930
                Living difficulties     0.043      0.021      0.159      2.010      0.047
                PTSD Criterion B        0.142      0.300      0.043      0.472      0.638
                PTSD Criterion C       0.086      0.222     0.036     0.387      0.699
                PTSD Criterion D        0.512      0.230      0.217      2.231      0.028
                PTSD Criterion E        0.646      0.226      0.277      2.857      0.005

Criterion B ¼ intrusion symptoms; Criterion C ¼ persistent avoidance of stimuli associated with the trauma; Criterion D ¼ negative
alterations in cognitions and mood; Criterion E ¼ alterations in arousal and reactivity; Gender ¼ 1: male, 2: female; Living difficul-
ties ¼ count of postmigration living difficulties; PTSD ¼ post-traumatic stress disorder; Trauma ¼ count of experienced potentially
traumatic events.

Future research should include longitudinal studies con-              involved in the conception of the study, in the analysis
ducting multivariate analyses with larger sample sizes in             and interpretation of the data, and in the drafting of the
order to investigate indicators and causal factors, in                manuscript. RB was involved in the conception of the
which the two factors “weakness” and “arousal” are                    study, in the analysis and interpretation of the data, and
related to aspects of trauma experience and                           in the drafting of the manuscript. AN was involved in the
postmigration living difficulties.                                    conception and design of the study, the analysis and in-
                                                                      terpretation of the data, and the drafting of the manu-
                                                                      script. MS was involved in the design of the study, the
Authors’ Contributions                                                acquisition, analysis and interpretation of the data, and
                                                                      the drafting of the manuscript. NM and AK contributed
Naser Morina and Alexa Kuenburg contributed equally                   equally to this manuscript. All authors read and ap-
to this article.                                                      proved the final manuscript.

NM was involved in the conception and design of the
study, the acquisition, analysis, and interpretation of the
data, and the drafting of the manuscript. He is account-              References
able for all aspects of the work. AK was involved in the               1 UNHCR. Global trends UNHCR 2015. 2016.
acquisition, analysis, and interpretation of the data and                Available at: http://www.unhcr.org/576408cd7.pdf
the drafting and the revision of the manuscript. US was                  (accessed August 20, 2016).

56
Trauma and Somatic Symptoms in Traumatized Refugees

 2 Hollifield M, Warner TD, Nityamo L, et al. Measuring       Examination of comorbidity with anxiety and depres-
   trauma and health status in refugees: A critical re-       sion. J Trauma Stress 2002;15(5):415–21.
   view. J Am Med Assoc 2002;288(5):611–21.
                                                           15 Carlsson JM, Olsen DR, Mortensen EL, Kastrup M.
 3 Fazel M, Wheeler J, Danesh J. Prevalence of serious        Mental health and health-related quality of life: A 10-
   mental disorder in 7000 refugees resettled in west-        year follow-up of tortured refugees. J Nerv Ment Dis
   ern countries: A systematic review. Lancet 2005;365        2006;194(10):725–31.
   (9467):1309–14.
                                                           16 Aragona M, Catino E, Pucci D, et al. The relation-
 4 Johnson H, Thompson A. The development and                 ship between somatization and posttraumatic symp-

                                                                                                                        Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020
   maintenance of post-traumatic stress disorder              toms among immigrants receiving primary care
   (PTSD) in civilian adult survivors of war trauma and       services. J Trauma Stress 2010;23(5):615–22.
   torture: A review. Clin Psychol Rev 2008;28:36–47.
                                                           17 Rohlof HG, Knipscheer JW, Kleber RJ. Somatization
 5 Heeren M, Mueller J, Ehlert U, et al. Mental health        in refugees: A review. Soc Psychiatry Psychiatr
   of asylum seekers: A cross-sectional study of psy-         Epidemiol 2014;49(11):1793–804.
   chiatric disorders. BMC Psychiatry 2012;12:114.
                                                           18 Schnurr PP, Green BL. Trauma and health: Physical
 6 McFarlane AC, Atchison M, Rafalowicz E, Papay P.           health consequences of exposure to extreme stress.
   Physical symptoms in post-traumatic stress disor-          Washington,     DC:    American      Psychological
   der. J Psychosom Res 1994;38(7):715–26.                    Association; 2004.

 7 Otis JD, Keane TM, Kerns RD. An examination of          19 Schnurr PP, Jankowski MK. Physical health and
   the relationship between chronic pain and post-            post-traumatic stress disorder: Review and synthe-
   traumatic stress disorder. J Rehabil Res Dev 2003;         sis. Semin Clin Neuropsychiatry 1999;4(4):295–304.
   40(5):397–405.
                                                           20 Rytwinski NK, Avena JS, Echiverri-Cohen AM,
 8 Villano CL, Rosenblum A, Magura S, et al.                  Zoellner LA, Feeny NC. The relationships between
   Prevalence and correlates of posttraumatic stress          posttraumatic stress disorder severity, depression
   disorder and chronic severe pain in psychiatric out-       severity and physical health. J Health Psychol 2014;
   patients. J Rehabil Res Dev 2007;44(2):167–78.             19(4):509–20.

 9 Norman SB, Stein MB, Dimsdale JE, Hoyt DB. Pain         21 Pietrzak RH, Goldstein RB, Southwick SM, Grant
   in the aftermath of trauma is a risk factor for post-      BF. Physical health conditions associated with post-
   traumatic stress disorder. Psychol Med 2008;38             traumatic stress disorder in U.S. older adults:
   (4):533–42.                                                Results from wave 2 of the National Epidemiologic
                                                              Survey on Alcohol and Related Conditions. J Am
10 Gupta MA. Review of somatic symptoms in post-              Geriatr Soc 2012;60(2):296–303.
   traumatic stress disorder. Int Rev Psychiatry 2013;
   25(1):86–99.                                            22 Benyamini Y, Solomon Z. Combat stress reactions,
                                                              posttraumatic stress disorder, cumulative life stress,
11 Pacella ML, Hruska B, Delahanty DL. The physical           and physical health among Israeli veterans twenty
   health consequences of PTSD and PTSD symp-                 years after exposure to combat. Soc Sci Med (1982)
   toms: A meta-analytic review. J Anxiety Disord             2005;61(6):1267–77.
   2013;27(1):33–46.
                                                           23 Sharp TJ, Harvey AG. Chronic pain and posttrau-
12 Taycan O, Sar V, Celik C, Erdogan-Taycan S.                matic stress disorder: Mutual maintenance? Clin
   Trauma-related psychiatric comorbidity of somatiza-        Psychol Rev 2001;21(6):857–77.
   tion disorder among women in eastern Turkey.
   Comprehensive Psychiatry 2014;55(8):1837–46.            24 Asmundson GJ, Coons MJ, Taylor S, Katz J. PTSD
                                                              and the experience of pain: Research and clinical
13 Teodorescu DS, Heir T, Siqveland J, et al. Chronic         implications of shared vulnerability and mutual main-
   pain in multi-traumatized outpatients with a refugee       tenance models. Can J Psychiatry 2002;47
   background resettled in Norway: A cross-sectional          (10):930–7.
   study. BMC Psychol 2015;3(1):7.
                                                           25 Norton PJ, Asmundson GJG. Amending the fear-
14 van Ommeren M, Sharma B, Sharma GK, et al. The             avoidance model of chronci pain: What is the role of
   relationship between somatic and PTSD symptoms             physiological arousal? Behavior Therapy 2003;34
   among Bhutanese refugee torture survivors:                 (1):17–30.

                                                                                                                  57
Morina et al.

26 Harris MF, Telfer BL. The health needs of asylum         38 Foa EB, Cashman L, Jaycox L, Perry K. The valida-
   seekers living in the community. Med J Aust 2001;           tion of a self-report measure of posttraumatic stress
   175(11–12):589–92.                                          disorder: The Posttraumatic Diagnostic Scale.
                                                               Psychol Assessment 1997;9(4):445–51.
27 Maier T, Schmidt M, Mueller J. Mental health and
   healthcare utilisation in adult asylum seekers. Swiss    39 Schnyder U, Müller J, Morina N, et al. Comparison
   Med Wkly 2010;140:w13110.                                   of DSM-5 and DSM-IV Diagnostic Criteria for
                                                               Posttraumatic Stress Disorder in Traumatized
28 Jongedijk RA. Narrative exposure therapy: An                Refugees. J Trauma Stress 2015;28(4):267–74.
   evidence-based treatment for multiple and complex

                                                                                                                          Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020
   trauma. Eur J Psychotraumatol 2014;5:26522.              40 Vinson GA, Chang Z. PTSD symptom structure
                                                               among West African war trauma survivors living in
29 Porter M, Haslam N. Predisplacement and postdis-            African refugee camps: A factor-analytic investiga-
   placement factors associated with mental health of          tion. J Trauma Stress 2012;25(2):226–31.
   refugees and internally displaced persons: A meta-
   analysis. JAMA 2005;294(5):602–12.                       41 Onyut LP, Neuner F, Ertl V, et al. Trauma, poverty
                                                               and mental health among Somali and Rwandese
30 Li SS, Liddell BJ, Nickerson A. The relationship be-        refugees living in an African refugee settlement—An
   tween post-migration stress and psychological dis-          epidemiological study. Confl Health 2009;3:6.
   orders in refugees and asylum seekers. Curr
   Psychiatry Rep 2016;18(9):82.                            42 American Psychiatric Association. DSM-5: G 05
                                                               posttraumatic stress disorder. 2010. Available at:
31 Aragona M, Pucci D, Carrer S, et al. The role of            http://www.dsm5.org/ProposedRevisions/Pages/pro
   post-migration living difficulties on somatization          posedrevision.aspx?rid¼165. (accessed November
   among first-generation immigrants visited in a pri-         7, 2011)
   mary care service. Ann IST Super Sanita 2011;47
   (2):207–13.                                              43 Friedman MJ, Resick PA, Bryant RA, Brewin CR.
                                                               Considering PTSD for DSM-5. Depress Anxiety
32 Laban CJ, Gernaat HB, Komproe IH, Schreuders                2011;28(9):750–69.
   BA, De Jong JT. Impact of a long asylum procedure
   on the prevalence of psychiatric disorders in Iraqi      44 Derogatis LR. SCL-90-R: Administration, Scoring
   asylum seekers in The Netherlands. J Nerv Ment Dis          and Procedure Manual - I. Baltimore, MD: John
   2004;192(12):843–51.                                        Hopkins; 1977.

33 Schweitzer R, Melville F, Steel Z, Lacherez P.           45 Derogatis LR, Unger, R. (2010). Symptom Checklist-
   Trauma, post-migration living difficulties, and social      90-Revised The Corsini Encyclopedia of Psychology:
   support as predictors of psychological adjustment in        John Wiley & Sons, Inc.
   resettled Sudanese refugees. Aust N Z J Psychiatry
   2006;40(2):179–87.                                       46 Silove D, Sinnerbrink I, Field A, Manicavasagar V, Steel
                                                               Z. Anxiety, depression and PTSD in asylum-seekers:
34 Landa A, Bossis AP, Boylan LS, Wong PS. Beyond              Associations with pre-migration trauma and post-
   the unexplainable pain: Relational world of patients        migration stressors. Br J Psychiatry 1997;170(4):351–7.
   with somatization syndromes. J Nerv Ment Dis
   2012;200(5):413–22.                                      47 Steel Z, Silove D, Bird K, McGorry P, Mohan P.
                                                               Pathways from war trauma to posttraumatic stress
35 Bontempo R. Translation fidelity of psychological           symptoms among Tamil asylum seekers, refugees,
   scales: An item response theory analysis of an              and immigrants. J Trauma Stress 1999;12(3):421–35.
   individualism-collectivism scale. J   Cross-Cult
   Psychol 1993;24:149–66.                                  48 Knaevelsrud C, Müller J. Multilingual Computer-
                                                               Assisted Self-Interview (MultiCASI) System for
36 Mollica RF, Caspi-Yavin Y, Bollini P, et al. The            Psychiatric Diagnostic of Migrants (Version 1.0).
   Harvard Trauma Questionnaire. Validating a cross-           Heidelberg: Springer; 2007.
   cultural instrument for measuring torture, trauma,
   and posttraumatic stress disorder in Indochinese         49 Yehuda R. Advances in understanding neuroendo-
   refugees. J Nerv Ment Dis 1992;180(2):111–6.                crine alterations in PTSD and their therapeutic impli-
                                                               cations. Ann N Y Acad Sci 2006;1071(1):137–66.
37 Foa EB. Posttraumatic Diagnostic Scale Manual.
   Minneapolis, MN: National Computer Systems;              50 Liedl A, O’Donnell M, Creamer M, et al. Support for
   1996.                                                       the mutual maintenance of pain and post-traumatic

58
Trauma and Somatic Symptoms in Traumatized Refugees

   stress disorder symptoms. Psychol Med 2010;40              literature and implications for the Canadian con-
   (7):1215–23.                                               text—Part A. Soc Work Public Health 2012;27
                                                              (4):330–44.
51 Hinton DE, Kredlow MA, Pich V, Bui E, Hofmann
   SG. The relationship of PTSD to key somatic com-        55 Nickerson A, Steel Z, Bryant RA, Brooks R, Silove
   plaints and cultural syndromes among Cambodian             D. Change in visa status amongst Mandaean refu-
   refugees attending a psychiatric clinic: The               gees: Relationship to psychological symptoms and
   Cambodian Somatic Symptom and Syndrome                     living difficulties. Psychiatry Res 2011;187(1–
   Inventory (CSSI). Transcult Psychiatry 2013;50             2):267–74.

                                                                                                                     Downloaded from https://academic.oup.com/painmedicine/article-abstract/19/1/50/3062387 by guest on 11 February 2020
   (3):347–70.
                                                           56 Ryan DA, Benson CA, Dooley BA. Psychological
52 Cougle JR, Feldner MT, Keough ME, Hawkins KA,              distress and the asylum process: A longitudinal
   Fitch KE. Comorbid panic attacks among individuals         study of forced migrants in Ireland. J Nerv Ment Dis
   with posttraumatic stress disorder: Associations with      2008;196(1):37–45.
   traumatic event exposure history, symptoms, and
   impairment. J Anxiety Disord 2010;24(2):183–8.          57 Eisenberger NI. The pain of social disconnection:
                                                              Examining the shared neural underpinnings of physi-
53 Afari N, Ahumada SM, Wright LJ, et al.                     cal and social pain. Nat Rev Neurosci 2012;13
   Psychological trauma and functional somatic syn-           (6):421–34.
   dromes: A systematic review and meta-analysis.
   Psychosom Med 2014;76(1):2–11.                          58 Iffland B, Sansen LM, Catani C, Neuner F. Rapid
                                                              heartbeat, but dry palms: Reactions of heart rate
54 Brabant Z, Raynault M-F. Health situation of mi-           and skin conductance levels to social rejection.
   grants with precarious status: Review of the               Front Psychol 2014;5:956.

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