Bellevue Investment Strategies - Review 2020 - Markus Peter, Jean-Pierre Gerber, Loreno Ferrari - Senior Product Specialists - Fund ...

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Bellevue Investment Strategies - Review 2020 - Markus Peter, Jean-Pierre Gerber, Loreno Ferrari - Senior Product Specialists - Fund ...
Bellevue Investment Strategies – Review 2020
Markus Peter, Jean-Pierre Gerber, Loreno Ferrari – Senior Product Specialists

Zurich, January 14th 2021
Bellevue Investment Strategies - Review 2020 - Markus Peter, Jean-Pierre Gerber, Loreno Ferrari - Senior Product Specialists - Fund ...
Agenda

    Economic & market environment
1
    BB Global Macro

    Overview
2
    Absolute & relative performance, peer-comparison

    Healthcare
3
    Investment companies, Luxembourg Funds

    Spezialized growth strategies
4
    BB Entrepreneur Funds, BB African Opportunities

                                                       2
Bellevue Investment Strategies - Review 2020 - Markus Peter, Jean-Pierre Gerber, Loreno Ferrari - Senior Product Specialists - Fund ...
1

Economic & market environment

        BB Global Macro

                                3
Economic & market environment

COVID-19 led to a very sharp short-term downturn in economic activity
comparable to the 2008 financial crisis…

                                                               Sharp decline in the
                                                               ISM Manufacturing
                                                                 Index in Q2 2020

                                                                Subsequent rapid
                                                                    recovery

Source: Bellevue Asset Management, Bloomberg                                       4
Economic & market environment

…the US Federal Reserve responds with an extremely expansive monetary policy
and increases the Fed balance by USD 3,400 billion

                                                                                         USD 3,000 billion
                                                                                       expansion to counter
                                                                                       COVID-19 recession,
                                                                                         USD 3,400 billion
                                                                         +USD 3,400b      since end of QT
                                                              Tapering
                                                                                       Stimulus programs
                                                                                       provide additional
                                                               QE3
                                                                                         support to the
                                                 Operation twist              QT           economy
                                                        QE2
                                                  QE1                +USD 3,400b

                                               TARP

Source: Bellevue Asset Management, Bloomberg                                                             5
Economic & market environment

Healthcare in the perception of many investors as a winner alongside tech
…but this was no longer the case after the sector rotation in the second half of the year

Total return of the GICS-sectors in USD – Year 2020                      Tech leading the way – Energy lagging behind

  Information Technology
                                                                           In H1, cyclical sectors (Energy, Financials, Industrials)
                                                                            significantly underperformed the overall market, while
 Consumer Discretionary                                                     defensive sectors significantly outperformed the
                                                                            overall market
    Communication Svcs
                                                                           The IT sector showed the strongest performance in
                Materials
                                                                            H1, mainly driven by the "stay at home" and "home
             MSCI World                                                     office" requirements imposed by the lockdowns

               Healthcare                                                  The 2nd half of the year was characterized by
                                                                            extremely expansive monetary policies of the major
               Industrials                                                  central banks, economic stimulus programs of
                                                                            important industrialized nations and positive trial
       Consumer Staples
                                                                            results of vaccine developers (Pfizer/Biontech,
                  Utilities                                                 Moderna)

               Financials                                                  Cyclical sectors (Consumer Discretionary, Materials
                                                                            and Industrials) show strong performance in H2
              Real Estate

                  Energy

                          -40% -30% -20% -10% 0% 10% 20% 30% 40% 50%

                              2020    H2 2020     H1 2020

Source: Bellevue Asset Management, data in USD as of December 31, 2020                                                                  6
Economic & market environment

    BB Global Macro ends the year with a positive annual return in a
    volatile market environment

         The drawdown in March was followed by a strong recovery in performance

         The magnitude of the drawdown was primarily due to short-term portfolio management decisions rather than our long-term view
          that a portfolio consisting of 75% government bonds and 25% equities is a very solid, neutral portfolio

         At year-end, the portfolio held 30% equity exposure, 25% in non-government bonds, and 17% in long-term government bonds

     In %           Jan          Feb          Mar          Apr         May          Jun          Jul         Aug          Sep          Okt          Nov         Dez            YTD
     2010                                                   +0.2         +0.2         +0.4         -0.7        +1.2         +0.3         +0.3         +0.5        +1.6             +4.1
     2011              0.1         +0.8         -1.0        +1.5         +0.3         -0.9         +0.8         -6.0         -0.6        +2.3         -1.0        +1.4             -2.5
     2012             +0.8         +0.6         -0.7          0.0         -4.1        +2.4         -0.6        +1.1         +0.6         +1.0         +0.8        +1.4             +3.2
     2013             +0.5         -0.3         -0.8        +3.4          -0.8        -2.8         +2.8        +0.7         +2.7         +2.3         +0.4         -1.4            +6.9
     2014             +2.6         +1.2         -0.2        +0.1         +1.6         +0.3          0.0        +0.9          -0.3        +0.7         +1.5         -0.6            +8.0
     2015             +4.2         +0.8         +2.9         -0.5        +0.4         -2.2         +1.7         -1.1        +0.2         +1.4         -0.3         -1.2            +6.2
     2016              -0.2         0.0         +2.2        +0.5         +0.3         +0.2         +1.7        +0.5          0.0          0.0         -2.3        +1.4             +4.2
     2017              -0.4        +1.3         +0.5        +0.9         +0.2         -0.2         +0.3        +0.3         +0.5         +1.1         -0.4         -0.6            +3.5
     2018              -0.8        -0.6         +0.1        +0.1          -0.4        -0.1         +0.8         -0.9        +0.5         -1.2         +0.4          0.0            -2.2
     2019             +2.6         +0.7         +1.1        +1.1          -1.2        +1.1         +0.3         -1.1        +1.1         +0.1         +1.4        +0.1             +7.4
     2020              -0.7        -2.4         -9.3        +5.9         +2.8         +1.6         -1.3        +1.8          -1.2        -1.2         +6.2        +1.2             +2.7

    Note: Performance of the I-EUR share class
    The subfund is denominated in a currency that may differ than an investor’s base currency, changes in the rate of exchange may have an adverse effect on prices and incomes.
    Performance is shown net of fees and expenses for the relevant share class over the reference period. All performance figures reflect the reinvestment of dividends and do not take
    into account the commissions and costs incurred on the issue and redemption of shares, if any. The reference benchmark of this class is used for performance comparison purposes
    only (dividend reinvested). No benchmark is directly identical to a subfund, thus the performance of a benchmark is not a reliable indicator of future performance of the subfund it is
    compared to. There can be no assurance that a return will be achieved or that a substantial loss of capital will not be incurred.

.   Note II: Pro forma performance of the unregulated fund from September 2008 to March 2010; after administration, management and performance fees                                       7
2

                  Overview

Absolute & relative performance, peer-comparison

                                                   8
Overview

Solid investment performance
Excellent competitiveness, client benefit, stability

                                                                         72% of AuM in 1st or 2nd quartile YTD 2020
  Very competitive
                                                                         82% of AuM in 1st and 2nd quartile over 3 years
  performance of invest-
                                                                         93% of AuM in 1st and 2nd quartile since inception
  ment strategies
                                                                         80% of AuM in 1st quartile since inception

                                                                         79% of AuM beat benchmark YTD 2020
Value generation for
investors (“alpha”) *                        α                           75% of AuM beat benchmark over 3 years
                                                                         84% of AuM beat benchmark since inception

                                                                         16 of 19 lead portfolio managers in charge since date of launch
High continuity and
                                                                         No portfolio manager changes in 2020
stability in portfolio
                                                                         Very low fluctuation rates for >10 years
management
                                                                         Steady recruitment of new investment professionals and young talents

* Outperformance after expenses, based on institutional share classes

Source: Bellevue Group, as at December 31, 2020                                    9
3.1

    Healthcare

Investment companies

                       10
Healthcare

BB Biotech AG
Investing in leading science

                                                                                                      Currency     Share         NAV      NBI

 Strong NAV Outperformance                                                                              CHF       +19.3%        +24.3%   +15.1%

                                                                                                        USD       +30.4%        +35.9%   +25.7%

                                                              With Prof. Dr. Mads Krogsgaard Thomsen, CSO of Novo Nordisk and Dr. Susan
 Two new, renowned members,
                                                               Galbraith, Head of Oncology of AstraZeneca, BB Biotech was able to attract two
 joined the Board of Directors                                 renowned new Board Members
                                                              Due to the COVID-19 pandemic, M&A activity was severely impacted in H1 2020
 Further acquisitions in the portfolio
                                                              In the second half of 2020, with Myokardia (Bristol-Myers Skibb) and Alexion
 of BB Biotech AG                                              (AstraZeneca) two important portfolio positions have been taken over

                                                              USD 47 bn market cap (an investment since Q1 2018)
                                                              Pioneering mRNA based medicines – a broad clinical pipeline
                                                              COVID-19 prophylactic vaccine candidate within only 42 days from sequence
 Moderna receives FDA emergency                                selection
 use authorisation for COVID-19
                                                              Initial dosing of healthy volunteers started in mid March 2020
 vaccine
                                                              Phase III with 30’000 patients – primary efficacy analysis shows vaccine was 94.1%
                                                               effective!
                                                              FDA - Emergency use authorisation as of December 18, 2020

Source: Bellevue Asset Management, as of December 31, 2020                                                                                        11
Healthcare

BB Biotech AG
Portfolio breakdown

Main focus on US small & mid-cap companies that address unmet medical needs, especially in oncology and
infectious diseases

1      Strong focus remains on high                             2 Strong focus on new                           3 Mid-cap companies offer ideal
       unmet needs                                                 technologies                                   risk/reward profiles
                          0.2%
                                                                                                                                    2.9%
                      4.9%                                                      7.2%                                         5.9%          6.5%
              7.7%
                                                                         8.2%
                                       38.2%
       8.2%
                                                                                              46.6%
                                                                16.2%                                           30.6%
    14.0%

                                                                                                                                                       53.9%

                                                                           21.6%
                      26.6%

                                                             Small Molecule            RNA
    Orphan Diseases                 Oncology
                                                                                                                        > 30 bn                   5 bn - 30 bn
    Neurological Diseases           Others                   Antibody                  Gene- and cell therapy           1 bn - 5 bn               500 mn - 1 bn
    Cardiovascular Diseases         Metabolic Diseases                                                                  < 500 mn
    Infectious Diseases                                      Protein

Note: Portfolio breakdown as of September 30, 2020, in % of securities                                                                                            12
Healthcare

BB Healthcare Trust
Investing in the rapidly evolving healthcare paradigm

                                                                                                                                           MSCI World
                                                                                                       Currency      Share        NAV
                                                                                                                                           Healthcare
 Strong outperformance of Share
                                                                                                         GBP        +29.1%      +25.7%       +10.3%
 and NAV
                                                                                                         USD        +32.9%      +29.3%       +13.5%

                                                              Re-invention of the entire healthcare system is necessary to meet the requirements
                                                               of the 21st century population in a cost-effective manner. (e.g. strong increase in
 Investing in the rapidly evolving                             chronic diseases)
 healthcare paradigm                                          Portfolio is highly operationally geared to areas that would benefit from an inevitably
                                                               changing healthcare paradigm (e.g. digitalization)
 Inclusion in the FTSE 250                                    The management team currently overweight's the sub-sectors biotech, life science
                                                               tools and diagnostic, the strongest underweight is in pharma
                                                              BB Healthcare Trust was included in the FTSE 250 Index as of June 19, 2020

                                                              CareDx, provides products, drugs, testing services for transplant patients. Surprised
                                                               with very strong Q3 2020 revenue numbers
 CareDx, Teladoc, Pacific Biosciences                         Teladoc: telemedicine provider offering the perfect business model during the
 und Genmark with strong                                       pandemic. Acquisition of Livongo creates the potential to evolve into a fully
                                                               integrated “virtual-care-provider”
 performance contributions
                                                              Genmark: specialises in “point-of-care” diagnostics for the diagnosis of pathogens
                                                               in respiratory, gastrointestinal and blood infections (sepsis). Develops and
                                                               distributes COVID-19 tests

Source: Bellevue Asset Management, as of December 31, 2020                                                                                            13
Healthcare

BB Healthcare Trust
Diversified but at the same time concentrated Healthcare Portfolio which offers a high active share

                                                                                   MSCI World Healthcare

     Holding                       Subsektor                 %      Holding                  Subsektor             %
     Bristol Myers Squibb          Pharma                    7.1%   Johnson & Johnson        Pharma                6.2%

     Hill-Rom Holding              Medtech                   6.0%   UnitedHealth             Dienstleistungen      5.0%

     Vertex                        Biotech                   6.0%   Roche                    Pharma                3.7%

     Anthem                        Dienstleistungen          5.9%   Novartis                 Pharma                3.2%

     Jazz                          Speicialty Pharma         5.4%   Pfizer                   Pharma                3.1%

     Insmed                        Biotech                   5.1%   Merck & Co               Pharma                3.0%

     GW Pharmaceuticals            Speicialty Pharma         5.0%   Abbott Lab.              Medtech               2.9%

     Alnylam                       Biotech                   4.7%   Thermo Fisher Scient.    Life Sciences Tools   2.8%

     Humana                        Dienstleistungen          4.1%   AbbVie                   Pharma                2.8%

     Amgen                         Biotech                   3.7%   Medtronic                Medtech               2.4%

Source: Bellevue Asset Management, as of December 31, 2020                                                                14
3.2

  Healthcare

Luxembourg Funds

                   15
Healthcare

Bellevue Healthcare Strategies with strong performance in a challenging
environment

Peformance BB Healthcare strategies in % (USD)
December 31, 2019 – December 31, 2020

                                                              MSCI World Healthcare TR (USD):+13.5%                                  +68.4%

                                                                                                                                     +50.7%
                                                                                                                                     +45.0%

                                                                                                                                     +29.2%
                                                                                                                                     +27.9%
                                                                                                                                     +23.9%
                                                                                                                                     +16.6%

Source: Bloomberg, Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share classes. Past performance is not a reliable indicator of future results and can be misleading            16
Healthcare

US elective procedures have been negatively impacted by the Corona
pandemic but have recovered from April lows

Weekly YoY-growth of elective procedures in the US

                       Jan                    Feb               Mar               Apr              Mai            Jun              Jul            Aug                   Sep           Oct               Nov

                                                                                                                                                                                                                     40%

                                                                                                                                                                  19%
                                                                                                                             13%
                                                                                                                                                                                                                     20%

                                   0%         0% 0%             0%
                                                                                                                                                                                                                     0%
                                        -1%           -1% -1%
                             -3%
                                                                                                                                                                          -6% -7% -7% -5% -5% -7% -6%
Year over year %

                   -6% -6%
                                                                                                                                                            -8%
                                                                                                                                         -10%-9%-11%-10%-9%
                                                                                                                                     -12%
                                                                                                                      -14%-14%                                                                      -15%             -20%
                                                                                                                                 -16%                                                                   -17%
                                                                                                                  -18%
                                                                                                              -23%                                                                                            -24%
                                                                                                          -27%                                                      -28%
                                                                                                      -34%                                                                                                           -40%
                                                                     -43%
                                                                                                   -46%

                                                                                                                                                                                                                     -60%
                                                                                               -60%

                                                                                            -77%                                                                                                                     -80%
                                                                        -81%
                                                                                        -84%
                                                                            -86%
                                                                                -88%-87%
                                                                                                                                                                                                                     -100%
                   1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46
                                                                                                                  week
Past performance is not a reliable indicator of future results and can be misleading
Source: IQVIA, Bellevue Asset Management, as of November 30, 2020                                                                                                                                                         17
Healthcare

BB Adamant Medtech & Services
Performance – Stability – Diversification

                                                                                                                          MSCI World HC      MSCI World
 Fund outperforms broader                                                                                     Fund
                                                                                                                         Equip. & Supplies   Healthcare
 healthcare markets despite a
                                                                                                             +16.6%           +23.9%          +13.5%
 challenging environment

                                                                     Demand is basically non-cyclical: health problems must be solved (e.g. heart
 COVID-19 affects the fundamental                                     issues, broken bones, glucose measurement and insulin injections)
 factors of Medtech & Services only
                                                                     Certain elective procedures are deferred (e.g. hip and knee implants) as hospital
 in the short-term                                                    capacity has been used for COVID-19 patients, and will result in pent-up demand

                                                                   We expect a complete normalization of elective medical procedures

                                                                   Normalization of investor focus: Fundamental data such as acceleration of
 Positive outlook for 2021                                          organic sales growth, new products & services and clinical data are back in the
                                                                    spotlight
 Further innovations about to be                                   Further innovations will be introduced in 2021 and we expect many new products
 introduced                                                         and services to fuel sales growth, such as Dexcom G7, the Hugo robotic surgery
                                                                    system and MitraClip

                                                                   Managed Care will benefit from the elimination of the Health Insurance Fee (HIF)

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share class                                                                                                                18
Healthcare

BB Adamant Digital Health
Making the healthcare system more efficient with digital health

                                                                                                                                Fund         Nasdaq 100
 Stellar performance, even strongly
 outperforming Nasdaq 100                                                                                                      +68.4%          +48.9%

                                                                     Digitization in healthcare is urgently needed and inevitable
                                                                     The coronavirus crisis has neutralized the natural reflex among the relevant
COVID-19 crisis has accelerated                                       stakeholders – patients, doctors, hospital administrators and payers – to reject such
the Digital Health Investment Case                                    change…
                                                                     …and even prompted some of them to actively support and invest in digital tools
                                                                      and solutions

                                                                   Telemedicine specialists and many other companies have made as much progress
                                                                    in 2020 as they would have normally made in three or four years
 Digital Health Investment Case
                                                                   The growing acceptance of digital solutions in the wake of the pandemic has pushed
 becomes more predictable and even                                  up the potential growth trajectory of the Digital Health Investment Case
 more attractive
                                                                   The strong growth momentum and non-cyclical demand suggest 2021 will be
                                                                    another pleasing year for Digital Health stocks

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share class                                                                                                                19
Healthcare

BB Adamant Digital Health
The fund has participated in 11 Initial Public Offerings (IPOs) in the course of 2020

Portfolio entries through IPOs                                                                                   M&A and transactions
                                                      Placed            Current           Per-                                       Date Ann-                    Per-
Company            Date              Issue price      (mn)              price             formance               Company             ouncement        Transaction formance

                     01/30/2020             $14.00             $282            $43.65             212%                                                 Sale of
                                                                                                                                                                              *89%
                                                                                                                                       07/17/2020      Passport to
                                                                                                                                                                             **77%
                     06/12/2020             $16.50             $256            $23.10              40%                                                 Molina

                     06/19/2020             $16.00             $256            $14.00             -13%
                                                                                                                                                       $18.5bn
                                                                                                                                                                              *9%
                     07/14/2020             $21.00             $914            $13.66             -35%                                 08/05/2020      takeover by
                                                                                                                                                                           **458%
                                                                                                                                                       Teladoc
                     07/01/2020             $22.00             $254            $43.50              98%

                     07/16/2020             $22.00             $205            $89.41             306%                                                 $3.3bn
                                                                                                                                                                               *9%
                                                                                                                                       12/21/2020      takeover by
                                                                                                                                                                             **24%
                                                                                                                                                       Gainwell
                     09/14/2020             $27.00             $278            $56.84             111%

                     09/17/2020             $18.00             $853            $25.33              41%           *Since announcement to year-end or date of transaction respectively
                                                                                                                 **Performance full-year 2020

                     10/15/2020             $18.00             $163            $44.82             149%

                     12/03/2020             $19.00             $201            $56.14             195%

                     12/08/2020         HK$70.58        HK$30,997         HK$150.00               113%

Source: Bellevue Asset Management, as per December 31, 2020
Past performance is not a reliable indicator of future results and can be misleading. The performance of a benchmark shall not be indicative of past or future
performance of any Sub- Fund. Holdings and allocations are subject to change. Any reference to a specific company or security does not constitute a
recommendation to buy, sell, hold or directly invest in the company or securities.                                                                                                20
Healthcare

Our global healthcare strategies both outperformed in 2020
BB Adamant Healthcare Strategy & BB Adamant Sustainable Healthcare

                  Correction                                                  Rebound                                                     Full year
                 31.12.2019 – 23.03.2020                                   23.03.2020 – 31.12.2020                                     31.12.2019 – 31.12.2020

        Funds outperforming its benchmark and                  Global equity market outperforms healthcare,               Strong absolute and relative return of the funds
          global equities (MSCI World Index)                funds with an outperformance against benchmark                compared to benchmark and MSCI World Index

110%                                                    180%                                                           130%

                                                                                                                       120%
100%                                                    160%
                                                                                                                       110%

 90%                                                    140%
                                                                                                                       100%

                                                                                                                       90%
 80%                                                    120%

                                                                                                                       80%
 70%                                                    100%
                                                                                                                       70%

 60%                                                     80%                                                           60%
   Dec-19            Jan-20                Feb-20          Mar-20            Jun-20           Sep-20          Dec-20     Dec-19      Mar-20       Jun-20         Sep-20      Dec-20

       BB Adamant Healthcare Strategy (Lux) I-USD                 BB Adamant Healthcare Strategy (Lux) I-USD                  BB Adamant Healthcare Strategy (Lux) I-USD
       BB Adamant Sustainable Healthcare (Lux) I-USD              BB Adamant Sustainable Healthcare (Lux) I-USD               BB Adamant Sustainable Healthcare (Lux) I-USD
       MSCI World Healthcare Net                                  MSCI World Healthcare Net                                   MSCI World Healthcare Net
       MSCI World Net                                             MSCI World Net                                              MSCI World Net

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share class                                                                                                                                    21
Healthcare

Our global healthcare strategies outperform
40 holdings, four regions, off-benchmark, ESG integration vs. holistic ESG-approach

                                                                                                                             Fund          Benchmark

 Both funds clearly outperform the                                                                                          +27.9%
 MSCI World Healthcare Index                                                                                                                 +13.5%
                                                                                                                            +29.2%

 1    Underweight Pharma                                           Diversification pays off again – clearly positive performance contributions from
                                                                    different sub-sectors, e.g. biotech and life science tools & services
                                                                   Healthcare in emerging markets, led by China, with compelling performance in
 2    Underweight US                                                2020
                                                                   Negative performance contributions from underweight in large & mega caps more
 3    Mid cap focus                                                 than offset thanks to exposure to innovative mid caps

                                                                     EBITDA-Margin                   Sales Growth                    Active Share
 Characteristics support                                            ____________                   ____________                  ____________
 attractiveness of both portfolios
 and underline our active approach
                                                                        ~28%                        ~14-17%                           ~80%

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share class                                                                                                             22
Healthcare

Healthcare in Asia and Emerging Markets
Innovation and digitization generate sustainable growth

                                                                                                                                                Local Equity
                                                                                                                      Fund       Benchmark
                                                                                                                                                  Market

 Very competitive performance                                                                                        +45.0%        +32.8%        +19.7%*
 of both investment strategies
                                                                                                                     +50.7%        +52.8%        +18.3%**

                                                                  *MSCI AC Daily TR Net Asia Pacific USD Index **MSCI Emerging Markets Net TR USD Index

                                                                     With JD Health and Ali Health, all digital health subsidiaries of major Chinese tech
                                                                      companies are now listed at the stock exchange (incl. Ping An)
                                                                     "Facebook for Doctors" M3 in Japan with first-ever drug co-development, focus on
 Digitization in Asia is progressing                                  clinical development (IP and revenue share) and use of proprietary digital marketing
                                                                      after launch
                                                                     Indian hospital chain Apollo Hospitals successfully established its own
                                                                      telemedicine app

                                                                     Private healthcare sector enjoys increasing demand (lack of quality in public sector
                                                                      resources)
 Ongoing consolidation in Brazil                                     Hapvida and Notre Dame have gained policyholders despite recession
                                                                     Both companies have also taken advantage of the "opportunity" of the poor
                                                                      economic situation and acquired numerous private providers

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share class                                                                                                                   23
Healthcare

Healthcare in Asia and Emerging Markets
Innovation in China – similar situation to the late 80s/early 90s in the US

                                                                            Over 50 IPOs in 2020 in the Chinese healthcare sector alone
                                                                            Progress in biotech company pipelines across the board
                                                                            First successful steps by Chinese biotechs abroad (e.g. Beigene)
 Innovation in China
                                                                            Wuxi Biologics has established itself as a leading global R&D platform in the wake
                                                                             of COVID-19
                                                                            Commercial success of biotech companies in China (e.g., Innovent, Zai Lab)

Source: Bellevue Asset Management, Zai Lab
Any reference to a particular company or security does not constitute a recommendation to buy, sell, hold or invest directly in the company or security       24
Healthcare

BB Adamant Biotech
Focused (40–50 holdings), global and mid cap-oriented approach

                                                                                                                                   Fund              NBI
 Strong absolute performance,
 slightly behind benchmark                                                                                                        +23.9%           +26.4%

                                                                      mRNA-vaccine with Pfizer
                                                                                                                                      Antiviral medication
                                                                                                      Antibody therapy                Remdesivir
 At peak up to about 35% portfolio                                                                    (Casirivimab & Imdevimab)
 exposure to COVID-19

                                                                       mRNA-1273-vaccine              Competitor of               Diagnostics & sequencing
                                                                                                      Moderna/BioNtec

                                                                         New, promising therapeutic indications in immuno-oncology, liver diseases as well
                                                                          as rare diseases

 Favorable outlook for the biotech                                       Political perception changes, added value of medicines becomes visible
 sector over the next 12 - 18 months
                                                                         Biotech sector with sustained, strong sales and earnings growth

                                                                         Valuations, especially compared to pharma, are attractive

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-USD share class, list of company examples is not exhaustive                                                                        25
4
       Spezialized growth strategies

BB Entrepreneur Funds, BB African Opportunities

                                                  26
Specialized growth strategies

BB Entrepreneur Funds - performance overview
Strong performance in 2020

BB Entrepreneur Funds – Switzerland                               BB Entrepreneur Funds – Europe
(Performance FY 2020 indexed, in CHF)                             (Performance FY 2020 indexed, in EUR)

130%                                                              130%

120%                                                              120%

110%                                                              110%

100%                                                              100%

 90%                                                              90%

 80%                                                              80%

 70%                                                              70%

 60%                                                              60%

                      BB Entrepreneur Switzerland I-CHF                               BB Entrepreneur Europe I-EUR
                      BB Entrepreneur Swiss Small & Mid I-CHF                         BB Entrepreneur Europe Small I-EUR
                      SPI                                                             Stoxx Europe 600
                      SPI Extra                                                       MSCI Europe Small ex UK Small

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of the I-CHF and I-EUR share classes                                                                     27
Specialized growth strategies

BB Entrepreneur Funds (I) – „Shockwave“
Solid balance sheets – the best medicine

                                                                                 Performance in EUR resp. CHF                Fund          Benchmark

                                                                                                                             16.3%           11.7%
 Strong absolute returns
                                                                                                                             1.9%            -2.0%
 Highly competitive vis-a-vis
 benchmarks and peer groups                                                                                                  20.4%            8.1%

                                                                                                                             18.3%            3.8%
                                                                   (available for distribution in Switzerland only)

                                                                   Markets collapse by one fifth (SPI) to one third (Europe Stoxx 600 and MSCI Europe
                                                                    Small ex UK) until mid of March
                                                                   Advantageous Entrepreneur stocks due to their lower debt quota and less pressure
                                                                    for dividend cuts
                                                                   Technology and Healthcare proved supportive throughout all portfolios, particularly
                                                                    both small and small&mid cap funds outperformed their benchmarks due to IT OW
Phase I – COVID-19 shockwave
31.12.19 – 18.3.2020
                                                                             +21.5%                             -6.8%       +4.2%

                                                                   Stock specific events with positive contributions, e.g. Isra Vision (M&A), +23.0%
                                                                   Increased focus on IT and Healthcare, reduction of cyclicals (e.g. automotive
                                                                    suppliers) – purchase of CEWE, Huber+Suhner and increasing weight LEM, Logitech
Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of I-EUR and I-CHF share classes                                                                                                      28
Specialized growth strategies

BB Entrepreneur Funds (II) – „Rebound“
Solid balance sheets - the best medicine

                                                                   Recovery thanks to global support measures – e.g. EU Recovery Fund and
                                                                    stimulus package of EUR 750 bn
                                                                   Partly positive surprises regarding profitability of industrials for Q2/2020, 70% of
                                                                    companies reported better than expected results for Q3
Phase II – Rebound in Q2 with                                      BB Entrepreneur Funds strongly recovered and returned between 30% to 40%
stagnation during Summer /                                         Selective increase of «fallen angels» in cyclicals (e.g. Moeller Maersk, Swatch,
Breakout of second wave of                                          Arbonia), further addition of IT stocks (e.g. Software-One, VAT, Atea) and other
infections                                                          positions (e.g. Husqvarna); partial profit taking in healthcare
                                                                   On a special note: participation in the IPO Knaus Tabbert (camping cars), Mediaset
                                                                    Espana (consolidation), Pierer Mobility (e-bikes, e-motorcycles); takeover of Sunrise by
                                                                    Liberty; reduction of Partners Group following its inclusion in the SMI Index

                                                                   Positive COVID-19 vaccine studies triggered market rally in Nov/Dec
                                                                   US Presidential elections and BREXIT agreement supported geopolitical
                                                                    stability/visibility
                                                                   Rotation from quality/growth into value/cyclicals
 Phase III – Announcement of
                                                                   Year-end rally of BB Entrepreneur Funds between 16% and 21%
 COVID-19 vaccines
                                                                  Outlook 2021
 Outlook 2021                                                      Innovation, new consumer trends, technology and recovery of value stocks
                                                                   Rebound in GDP growth, the unwinding of pent-up demand in consumer spending and
                                                                    corporate investments and proactive fiscal policies being the pillar of recovery
                                                                   Digitalisation and ESG as structural growth themes

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of I-EUR and I-CHF share classes                                                                                                     29
Specialized growth strategies

BB African Opportunities
Structural growth opportunities in emerging African frontier markets

                                                                                   Performance in EUR                         Fund       DJ African Titans
 Underperformance due to focus on
 resilience and liquidity                                                                                                    -14.3%           -6.5%

                                                                   Investments only in countries with no currency risks and with functional FX
                                                                    markets => Nigeria does not form part
                                                                   Tactical increase in gold mining stocks (very liquid and positive momentum)
 High resistance of portfolio stocks
                                                                   Egypt and Morocco possess sufficient economic buffers and external funding
                                                                    sources (e.g. IMF, intl. Bond markets) to address balance of payment risks
                                                                   Focus on companies with high resilience to crises, strong competitive positions, well
                                                                    managed balance sheets and clear strategic plans – core positions with DivY of 10%

                                                                   Egypt – exhibiting by far the most attractive valuations amongst EM/FM (P/E <
                                                                    8x) – notwithstanding a normalisation of economic activities
                                                                   Return to economic growth and interest rate cuts may lead to a substantial re-
                                                                    rating of local equity markets
 Positioned for a recovery in our                                  Economic recovery of the EU later in 2021 may prove a strong driver for Morocco,
 core markets                                                       the EU being Morocco’s most important trading partner incl. tourism)
                                                                   Morocco and Egypt are sufficiently industrialized so as to become key trading /
                                                                    manufacturing hubs to link Africa with the rest of the World
                                                                   Increase of tactical exposure in South Africa (access to global risk liquidity)
                                                                   Yet no engagement in Nigeria (unorthodox monetary policy bears high risks)

Source: Bellevue Asset Management, data as of December 31, 2020
Note: Performance of I-EUR share class                                                                                                                  30
Bellevue Asset Management – Outlook for 2021

                Long-term superior growth prospects – independent from COVID-19 –
Healthcare      owing to structural trends, additional diversification potential in case of
                dampened global GDP growth

                High resilience thanks to solid balance sheets and innovations; global
Entrepreneurs
                market leaders in their niches, increased focus on sustainability

                «Wildcard» on emerging markets recovery, Africa with highly
Africa
                attractive valuations, liquidity and resistance to crisis in the spotlight

                «Weatherproof» strategy under all market conditions, attractive return
Global Macro
                perspectives at limited volatility risk

                  Thank you for your confidence –
                  successful investments in 2021!
                                                                                             31
Contact

   Bellevue Asset Management AG
   Seestrasse 16
   CH-8700 Küsnacht

   Tel.     +41 44 267 67 00
   Fax      +41 44 267 67 01
   E-mail   info@bellevue.ch
   www.bellevue.ch

                                  32
Disclaimer
This marketing communication relates to Bellevue Funds (Lux) (hereinafter the “Fund”), an investment company with variable capital “société à capital variable” (SICAV) under the
current version of the Law of the Grand Duchy of Luxembourg of 10 August 1915 on commercial companies (“Law of 1915”) and is authorized under Part I of the Law of 17
December 2010 relating to undertakings for collective investment (“Law of 2010”) as an undertaking for collective investment (UCITS). The Funds are a subfund of Bellevue Funds
(Lux). This marketing communication is issued by Bellevue Asset Management AG, which is an authorized asset manager subject to the supervision of the Swiss Financial Market
Supervisory Authority (FINMA) and acts as an Investment Manager of the Fund. The Prospectus, statutes, the annual and half-yearly report, the share prices and further information
about the Fund can be obtained free of charge in English and German from the management company of the Fund, Bellevue Asset Management AG, Seestrasse 16, CH-8700
Küsnacht, from the representative, paying, facilities and information agents mentioned below or online at www.bellevue.ch. The Key Investor Information documents are available
free of charge in the languages of the countries of distribution at www.fundinfo.com. This document is neither directed to, nor intended for distribution or use by, any person or entity
who is a citizen or resident of any locality, state, country or jurisdiction where such distribution, publication, availability or use would be contrary to law or regulation. It is particularly
not intended for US persons, as defined under Regulation S of the U.S. Securities Act of 1933, as amended. The information and data presented in this document are not to be
considered as an offer to buy, sell or subscribe to any securities or financial instruments. The information, opinions and estimates contained in this document reflect a judgment at
the original date of release and are subject to change without notice. This information pays no regard to the specific or future investment objectives, financial or tax situation or
particular needs of any specific recipient and in particular tax treatment depends on individual circumstances and may be subject to change. This document is not to be relied upon
in substitution for the exercise of independent judgment. Before making any investment decision, investors are recommended to ascertain if this investment is suitable for them in the
light of their financial knowledge and experience, investment goals and financial situation, or to obtain specific advice from an industry professional. The details and opinions
contained in this document are not to be considered as recommendation or investment advice. Every investment involves risk, especially with regard to fluctuations in value and
return, and investors‘ capital may be at risk. If the currency of a financial product is different from your reference currency, the return can increase or decrease as a result of currency
fluctuations. Past performance is no indicator for the current or future performance. The performance data are calculated without taking account of commissions and costs that result
from subscriptions and redemptions. Commissions and costs have a negative impact on performance. For more information about the associated costs, please refer to the related
costs and fees section of the prospectus. Any benchmarks/indices cited herein are provided for information purposes only. No benchmark/index is directly comparable to the
investment objectives, strategy or universe of the subfund. The performance of a benchmark shall not be indicative of past or future performance of the subfund. Financial
transactions should only be undertaken after having carefully studied the current valid prospectus and are only valid on the basis of the latest version of the prospectus and available
annual and half-yearly reports. Please take note of the risk factors.

Countries of distribution and local representatives
The Bellevue Funds (Lux) is registered and admitted for public distribution in AT, DE, LU, ES, UK and CH. Austria: Paying and information agent: ERSTE BANK der
oesterreichischen Sparkassen AG, Am Belvedere 1, A-1100 Vienna. Germany: Information agent: ACOLIN Europe GmbH, Reichenaustrasse 11a-c, D-78467 Konstanz. Spain:
Representative: atl Capital, Calle de Montalbán 9, ES-28014 Madrid - CNMV under the number 938. UK: The Bellevue Funds (Lux) SICAV is recognised for public offering and
distribution in the United Kingdom. Facilities agent: Financial Express Limited, 3rd Floor, Hollywood House, Church Street East, Woking, Surrey GU21 6HJ. Switzerland: The
Bellevue Funds (Lux) SICAV is registered for public offering and distribution in Switzerland with the Swiss Financial Market Supervisory Authority. Representative agent in
Switzerland: ACOLIN Fund Services AG, Leutschenbachstrasse 50, CH-8050 Zurich. Paying agent in Switzerland: DZ PRIVATBANK (Schweiz) AG, Münsterhof 12, P.O. Box, CH-
8022 Zurich. You can obtain the sales prospectus, Key Investor Information Document (“KIID”), statutes and the current annual and half-yearly reports, the current share prices and
further information about the fund free of charge in German from the management company Bellevue Asset Management AG, Seestrasse 16, CH-8700 Küsnacht, the representative
agent in Switzerland or online at www.bellevue.ch. In respect of the units distributed in or from Switzerland, the place of performance and jurisdiction is at the registered office of the
representative agent.

Prospectus, Key Investor Information Document („KIID“), fund contract as well as the annual and semi-annual reports of the BB securities fund under Swiss law are available free of
charge from: Switzerland: PMG Fonds Management AG, Sihlstrasse 95, CH-8001 Zurich or Bellevue Asset Management AG, Seestrasse 16, CH-8700 Küsnacht.

This material is not intended as an offer or solicitation for the purchase or sale of shares of BB Biotech AG. This material may not be distributed within the United States or any other
country where it may violate applicable law.

Copyright©2021 Bellevue Asset Management, Inc. All rights reserved.
                                                                                                                                                                                               33
The most important terms are explained in the glossary at www.bellevue.ch/en/glossary
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