INSIGHT Outstanding performance for routine GC GC
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INSIGHT ™ Outstanding performance for routine GC×GC
INSIGHT
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Robust modulator for repeatable, affordable multi-dimensional GC
••••••••••••••••••••••••••••••••••
INSIGHT™, the new flow
modulator from SepSolve
Analytical, overcomes the
practical and performance ••••••••••••••
Compact design is easily
difficulties experienced with mounted within the oven of any
commercial GC.
other modulator designs for
GC×GC. ••••••••••••••••••••••••••••••••••
Reverse fill/flush dynamics
provide increased peak capacity
and improved peak symmetry
With cryogen-free operation and compared to other flow
outstanding peak capacity, modulators.
INSIGHT for the first time allows •••••••••••••••••••••••••••
Innovative design ensures the
routine GC laboratories to widest possible volatility range
(C1 to C60) , and the flexibility to
benefit from the full power of perform heart-cutting, splitting
for parallel detection,
GC×GC peak separation. backflushing and critical
component peak compression.
Take your GC analysis into a ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••
‘Filling’ and ‘flushing’ of a sample
new dimension with INSIGHT loop means low running costs
and none of the logistical issues
flow modulation. associated with liquid cryogen.
Why choose flow modulation?
Flow modulation simply involves using differential carrier gas flows to ‘fill’ Tackling a wider range of samples
and ‘flush’ a sample loop. In contrast to thermal modulation, this means:
Flow modulation does not suffer from the same
►► Low running costs for routine GC×GC. volatility restrictions as thermal modulation, because it
►► None of the logistical issues associated with liquid cryogen. does not rely on trapping analytes using a cold jet.
Analytes as volatile as methane can be modulated
►► Improved repeatability.
efficiently without any need for liquid cryogen.
►► Elimination of volatility restrictions.
Dichloromethane •
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Delivering the confidence required for routine applications ••
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The valve-based INSIGHT allows identical configurations to be installed across Isopropanol • • • • • • • • • •
••••••
multiple instruments, unlike in thermal devices, where small variations in column
position can have a large impact on results. ••••
••••
••• ••••
Acetone • ••••
Day 1 Day 2 Day 3
0.09%
0.09%
2.53%
3.42%
0.24%
0.27%
2.19%
0.74%
0.21%
Second-dimension retention time (s)
5
First-dimension retention time (min)
60
2
••••••••••••••
Peak abundance (× 10 8 counts)
0.56%
0.54%
0.43%
4.13%
3.19%
0.98%
0.58%
0.39%
2.89%
0.69%
0.00%
0.33%
0.23%
0.61%
50
0.13%
4
0.38%
0.61%
0.51%
0.00%
0.26%
0.15%
2.09%
3.35%
3.71%
0.00%
0.30%
40
0.12%
3
2.97%
4.53%
3.14%
0.00%
0.37%
30
0.17%
1
2
3.06%
2.42%
2.10%
•••••
20
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1 ••
10 ••
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•• n-Hexane
0 0 0 ••
••
•
ne
ne
ne
ne
ne
ne
ne
e
e
e
ne
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in
in
in
Diethyl ether
an
an
an
al
ca
al
ca
ca
al
ca
ca
ca
ca
ca
ca
ec
ec
ec
tr
tr
••••
tr
de
de
de
de
De
De
De
de
de
lte
lte
lte
ad
ad
ad
••••
Do
Do
Do
ra
ra
ra
••••
hy
hy
ct
hy
ct
ct
t
t
t
Te
••••
Te
Te
O
O
O
et
et
et
••••
M
M
M
But-1-ene
6-
6-
6-
2 tR
1 tR
Excellent repeatability of retention times is aided by the use of a dedicated EPC for each column.
The charts show
The next generation of flow modulators
INSIGHT, as a reverse fill/flush device, offers superior Improved peak capacity
performance to first-generation forward fill/flush flow
Reverse fill/flush dynamics provide narrower peaks in the second
modulators. As well as its operational simplicity, minimal
dimension than previous generations of flow modulators, leading to
breakthrough allows sharp, symmetrical peaks, while an
improved sensitivity and greater peak capacity.
interchangeable collection channel provides greater
flexibility in method development.
INSIGHT
2
provides narrow
Abundance (× 10 5 counts)
Reverse fill/flush operation peaks (
Another level of information with parallel detection
Using parallel detection by MS and FID
TOF MS
is the ideal way of achieving qualitative 4
and quantitative analyses in a single
run. While this can be troublesome to 3
configure in thermally-modulated
(s)
R
2t
systems, optimal alignment of 2
retention times can easily be achieved
with INSIGHT. 1
FID
Keeping fragrance labs ahead of the 4
regulations
3
Hundreds of similar terpenes, diverse
(s)
R
2t
sample types and complex matrices make
2
monitoring allergens in cosmetics a
challenging prospect. INSIGHT keeps labs
ahead of the regulations, by providing the 1
10 20 30 40 50 60
•••••••••
separation required for confident 1t
R (min)
identification and quantitation of an
extended suite of allergens.
•
6
Fast and simple
cross-validation for FID ••
••••• TOF MS
a suite of fragrance
Abundance (counts)
••
4 ••
allergens, analysed
•••
by parallel-detection
GC×GC, is possible 2
due to excellent
retention time
alignment between 0
FID and TOF MS. 39.0 39.1 39.2 39.3
1t (min)
R
Dual-channel configuration for enhanced productivity
The compact design of INSIGHT enables two devices to be installed within the same GC oven. This
allows the simultaneous analysis of two samples using dual injection – optimising lab productivity.
Injector 2
Injector 1
FID 2
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FID 1 ••••
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Use of two INSIGHT modulators in a dual-channel
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configuration immediately doubles productivity,
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resulting in a swift return on investment. This is
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illustrated for environmental monitoring of total
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Modulator 2 petroleum hydrocarbons (TPH) using the ‘stencil’
•••••
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Modulator 1
feature in SepSolve’s ChromSpace software.
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Sample 1 Sample 2
From niche to mainstream...
It is commonly said that flow modulators are difficult to use – but this is no longer the case,
and the appeal of GC×GC is broadening as a result. With tools and advice from SepSolve,
analysts the world over are finally able to incorporate GC×GC into routine workflows.
Simple method development Bespoke training packages
INSIGHT can be retrofitted to most popular GCs, with the field kit containing Our specialists can offer customised training, so that you
everything you need to get started. An easy-to-use flow calculator is included to can make the most of your modulator from the moment
simplify method development, for beginners and experts alike. it is installed, whatever your application area:
►► Environmental
►► Petrochemical
►► Food/beverage aromas
►► Fragrances
Simplify your GC×GC method
development by using the flow
calculator that comes as part of ►► Defence and forensic
the INSIGHT software package.
D0007_3_060717
INSIGHT™ is a trademark of SepSolve Analytical.
About SepSolve Analytical
SepSolve Analytical is dedicated to helping analysts select the best equipment
for GC and GC×GC analysis.
The wide range of products offered include SepSolve’s application experience is extensive,
SepSolve’s INSIGHT™ flow modulator for placing it in an excellent position to advise on
GC×GC, and sample preparation equipment, getting the best from an analysis – in
robotic autosamplers, thermal desorbers and everything from environmental monitoring to
mass spectrometers with novel soft EI petrochemical analysis and food aroma
capability from leading manufacturers profiling.
including GL Sciences, CTC Analytics and
Markes International.
SepSolve Analytical Ltd
T: +44 (0)1733 669222 (UK) +1 888-379-383 (US)
E: hello@sepsolve.com
www.sepsolve.com
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