Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft

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Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
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The Science Magazine of the Max Planck Society 2.2015

Light
COGNITION              COMMUNICATION     EARTH SYSTEM         RELIGION
Dreams Bring Lucidity Secret Code        … and now for        A Crucial Question
to Our Thinking       in a Laser Pulse   tomorrow’s climate   for the Nation State
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
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Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
ON LOCATION
Photo: MPI for Chemical Ecology/Anna Schroll

                                               Eternal Summer
                                               Even on cloudy days, the sun shines in the greenhouse of the Max Planck Institute for Chemical Ecology: 520
                                               high-pressure lamps with assimilation sodium vapor bulbs ensure that the plants have sufficient light and that the
                                               spectral distribution is right for photosynthesis. To simulate uniform irradiation, the lamps move back and forth
                                               automatically on tracks. The air conditioning is also computer controlled: temperatures remain at summer levels –
                                               but not too high – all year round.
                                                    Half of the 474-square-meter cultivation floor is usually sown with coyote tobacco (Nicotiana attenuata), a
                                               species of wild tobacco and the institute’s most important model plant. Along with rapeseed and pea plants and
                                               poplars, the greenhouse also boasts some more exotic inhabitants: pest-resistant bananas, noni trees and carnivo-
                                               rous pitcher plants. The latter are the main focus of interest for researcher Ayufu Yilamujiang. He studies the exact
                                               composition of the digestive fluid with which the plant digests the trapped insects.
                                                    Carnivorous plants grow in low-nutrient soils and obtain additional nutrition from their animal prey, mainly
                                               insects. To this end, they have developed special trapping and digestive mechanisms. In the case of the pitcher plant,
                                               sweet nectar lures the insects to the edge of the pitcher, which is basically formed from reshaped leaves.
                                                    The animals slip off the edge of the pitcher and fall into the digestive fluid. The pitcher plants also find the
                                               occasional prey in the greenhouse, as parasites or beneficial organisms used to combat these – ichneumon wasps,
                                               for instance – occasionally fall victim to them. For experiments carried out under controlled conditions, the scien-
                                               tists feed the pitcher plants with fruit flies.

                                                                                                                                               2 | 15 MaxPlanckResearch   3
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
Contents

                                                                                                  Complicated: Jens Hjörleifur

18 LIGHT                                                                                 46       Bárðarson focuses on, among other
                                                                                                  things, topological insulators.

18 Tweezers Made of Light                                                                PERSPECTIVES
     Many biomolecules move through cells like microscopic machines.
                                                                                         06   Cooperation Worth Celebrating
     Often, however, it isn’t known what forces these molecules
     generate or how fast the molecules act or move. That’s why Stephan                  06   Green Light for Research Projects

                                                                                                                                      Cover: iStockphoto – merrymoonmary; photos this page: Thorsten Naeser (large image), Sven Doering
     Grill from the Max Planck Institute of Molecular Cell Biology and                   07   The Max Planck Society Researches
     Genetics in Dresden decided to specialize in measuring molecular                         Its Own History
     forces. He uses optical tweezers to pull gently on DNA strands and                  07   Max Planck Spinoff Finds Buyer
     to study proteins.                                                                       with Deep Pockets
                                                                                         08    “It’s not surprising that the fear
24 The Making of a Quantum Movie
                                                                                              was palpable”
     Until even just a few years ago, no camera was fast enough to film
                                                                                         09   New Internet Presence for
     the movements of electrons. Ferenc Krausz, Director of the Max
                                                                                              max-wissen.de
     Planck Institute of Quantum Optics in Garching, and his team can
     now do this using new techniques, creating the basis for optimizing                 09   On the Net
     processes in chemistry and electronics.

32 Between Spotlight and Shadow                                                          VIEWPOINT
     The main figures in Caravaggio’s paintings seem to be sitting                       10   Peace – Europe’s Polyphonic
     in a spotlight. There were numerous legends surrounding the                              Promise
     painter and his lighting techniques. Sybille Ebert-Schifferer,                           In view of the challenges to
     Director at the Bibliotheca Hertziana in Rome, wants to demystify                        peace and security in Europe,
     Caravaggio’s image.                                                                      it’s time for EU member states
                                                                                              to take joint action.

                                                                                         FOCUS
                                                                                         18   Tweezers Made of Light
ON THE COVER Light is our lifeblood, the inspiration for artists, and an indispensable
tool in science and technology. Reason enough for UNESCO to declare 2015 the Inter-      24   The Making of a Quantum Movie
national Year of Light. The image shows light in optical fibers.                         32   Between Spotlight and Shadow

4   MaxPlanckResearch 2 | 15
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
Concealed: Magnetic resonance                    Encrypted: The quantum                       Swirled: Ocean currents such as

                                                                                    52       imaging makes visible which brain
                                                                                             regions are active in lucid dreamers.   60       information receiver that can’t
                                                                                                                                              be tapped unnoticed.               68        the Gulf Stream play a major role
                                                                                                                                                                                           in the climate.

                                                                                    SPECTRUM                                         BIOLOGY & MEDICINE                          CULTURE & SOCIETY
                                                                                    40   Listen Carefully                            52   Dreams Bring Lucidity to               76   A Crucial Question for the
                                                                                    40   Mars – The Blue and Red Planet                   Our Thinking                                Nation State
                                                                                    41   Nature’s Medicine Cabinet                        “I think, therefore I am” – René            While Islam is still perceived by
                                                                                                                                          Descartes’ thinking gave him the            many as the greatest impediment to
                                                                                    41   Food in Tubes
                                                                                                                                          certainty that he did, in fact,             integration in European immigration
                                                                                    41   By Computers, for Computers                      exist. Lucid dreamers are able to           societies, scientists have come up
                                                                                    42   World Record in Color                            reflect on their own thoughts               with a more differentiated approach.
                                                                                    42   Ceres – A Mysterious World                       even during sleep.
Photos: David Ausserhofer, Axel Griesch, DKRZ – Michael Böttinger (left to right)

                                                                                    43   Babies Learn while Snoozing
                                                                                                                                                                                 REGULAR FEATURES
                                                                                    43   Poison Sprays Return to Haunt Us
                                                                                                                                     MATERIAL & TECHNOLOGY
                                                                                    44   Language Roots on the Steppe                                                            03   On Location
                                                                                    44   Solving the Puzzle of Nova Vul 1670         60   Secret Code in a Laser Pulse           16   Post from – London, England
                                                                                    45   Using Nuclear Spin to Study                      Quantum cryptography aims to                Immediate Inspiration
                                                                                         Individual Proteins                              protect data transmissions against     82   Flashback
                                                                                                                                          eavesdropping. This is what                 Strawberry Fields Forever
                                                                                    45   Customized Carbon
                                                                                                                                          researchers from the Max Planck
                                                                                    45   Learning with All the Senses                                                            84   Community
                                                                                                                                          Institute for the Science of Light
                                                                                                                                                                                 84   “A Win-Win Situation”
                                                                                                                                          are working on.
                                                                                                                                                                                 85   New Content Leads to New Horizons
                                                                                    PHYSICS & ASTRONOMY                                                                          86   50 Million Euros for Junior Scientists
                                                                                                                                     ENVIRONMENT & CLIMATE                       87   Research Establishments
                                                                                    46   Player in a Magical World
                                                                                                                                                                                 87   Imprint
                                                                                         Personal Portrait:                          68   … and now for tomorrow’s climate
                                                                                         Jens Hjörleifur Bárðarson                        Researchers want to predict what
                                                                                                                                          the Earth’s climate will be like
                                                                                                                                          10 or 15 years from now, and in this
                                                                                                                                          way also explain why, since 1998,
                                                                                                                                          the Earth has been heating up more
                                                                                                                                          slowly than models predict.

                                                                                                                                                                                                  2 | 15 MaxPlanckResearch     5
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
PERSPECTIVES

                                                                                                                                         Photos: Amac Garbe/MPG (top), MPI for Molecular Cell Biology and Genetics, Katrin Boes, Max-Planck-Campus/Tübingen, fotostudio arlene knipper, private collection, MPI for Human Cognitive and Brain Sciences, private collection (bottom, from left to right)
Cooperation Worth Celebrating
Science celebrates 50 years of German-Israeli relations

                                                      Half a century has passed since Germany and Israel established diplo-
                                                      matic relations. To mark this anniversary, scientists from both coun-
                                                      tries, the presidents of leading research organizations, and political
                                                      guests met in Israel for a two-day celebration. The event was co-orga-
                                                      nized by the Minerva Stiftung, a subsidiary of the Max Planck Society
                                                      that is financed by the Federal Ministry of Education and Research and
                                                      that has been promoting scientific cooperation between the two coun-
                                                      tries since 1964. “I firmly believe that nobody could have predicted
                                                      such a development 50 years ago,” said Max Planck President Martin
                                                      Stratmann, stressing that “in view of our particular history, promoting
                                                      mutual understanding remains an important task.”
                                                          The high point of the celebrations was a scientific symposium held
                                                      at the Weizmann Institute of Science in Rehovot and officially launched
                                                      by the German Federal Minister of Education and Research, Johanna
                                                      Wanka. The Minister also inaugurated two new Minerva Research Cen-
                                                      ters, bringing the total to 23 of these centers of excellence in Israel.
                                                      “The Minerva Centers are the jewel in the crown of German-Israeli sci-
                                                      entific relations. They have also become an important feature of the
                                                      Israeli research landscape,” said Johanna Wanka.

                                                     In his speech at the anniversary celebrations, Max Planck President Stratmann
                                                     emphasized the unifying nature of science: “People from different countries
                                                     can meet on neutral ground, so to speak, in scientific institutions.” This was
                                                     also the basis for German-Israeli scientific relations, which have existed now
                                                     for more than 55 years.

Green Light for Research Projects
Max Planck scientists attract EU millions for their projects

The 328 junior scientists awarded          institutes also competed successfully          in their applications for the funding of
Starting Grants by the European Re-        for ERC Consolidator Grants. The               projects with partners from Bulgaria,
search Council (ERC) last December         Teaming funding line is a new element          Poland and Cyprus.
include 17 Max Planck scientists. The      of the “Horizon 2020” EU Research
funding of up to two million euros al-     Framework Programme, which links               The Max Planck scientists recently awarded
located to the 17 Max Planck research-     renowned research institutions with            Consolidator Grants (from left): Jochen Rink
ers is intended to help them with the      institutes in regions that perform less        and Jan Huisken (molecular cytology and
                                                                                          genetics), Birte Höcker (developmental
development of independent scientif-       strongly in the area of research. The
                                                                                          biology), Sönke Zaehle (biogeochemistry),
ic careers in the period immediately       Max Planck Society played a key role           Mikael Simons (experimental medicine),
following their doctoral studies. A fur-   in the design of this instrument. Four         Jonas Obleser (cognitive and neurosciences)
ther seven scientists from Max Planck      Max Planck institutes were successful          and Henrik Beuther (astronomy).

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Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
PERSPECTIVES

                        The Max Planck Society Researches Its Own History
                        Seven-year program focuses on the organization’s development

                        Over the next seven years, a research
                        program at the Max Planck Institute for
                        the History of Science will examine the
                        development of the Max Planck Soci-
                        ety from its foundation in 1948 to the
                        end of Hubert Markl’s presidency in
                        2002. The program is intended to in-
                        vestigate the organization’s dynamics
                        and research successes, as well as its sci-
                        entific dead ends, which, however, of-
                        ten proved productive in the final anal-
                        ysis. The program will also concentrate
                        on critical topics like the ethical limits
                        of research, the dual-use problem and
                        external influences. Building on the
                        studies on the Kaiser Wilhelm Society
                        during the National Socialist period,
                        the scientists also intend to take a fresh
                        look at how the Max Planck Society
                        dealt with the misconduct of its prede-
                        cessor organization.
                            The research program, whose par-
                        ticipants include renowned external            The history of the Max Planck Society began in 1948. The inaugural meeting took place in the
                                                                       canteen of the Institute for Aerodynamic Testing (Aerodynamische Versuchsanstalt) in Göttingen.
                        scholars, aims to comprehensively re-
                        construct the past and classify it in
                        terms of the relevant historical con-          stitution’s research and development              view to its position in science, society
                        texts. Based on the example of several         mutually influenced each other. The fo-           and politics. The research program will
                        inter-institutional topics, the historians     cus here is on the changes of the Max             be supervised by an international sci-
                        wish to concretely examine how the in-         Planck Society through time with a                entific advisory board.

                           Max Planck Spinoff Finds Buyer with Deep Pockets
                           US concern Baxter takes over biotech company SuppreMol

                           How the knowledge gained through ba-         pany, which has 20 employees, made it so       agency supported the development of
                           sic research stimulates the economy was      attractive that US pharmaceutical con-         SuppreMol, particularly in the company’s
                           demonstrated by the sale of SuppreMol        cern Baxter was willing to pay over 200        pre-spinoff and early phase. The fact that
                           GmbH in March: Established in 2002 by        million euros for it.                          SuppreMol succeeded in attracting a
                           scientists working with Nobel laureate           “This was one of the biggest transac-      strong owner like Baxter for the expen-
                           Robert Huber from the Max Planck Insti-      tions in the sector, which has been expe-      sive clinical development and market
                           tute of Biochemistry in Martinsried, the     riencing funding difficulties, particularly    preparation of its drugs has been warm-
Photo: Amac Garbe/MPG

                           biotech company carries out research on      in Germany, for years,” says Ulrich Mahr,      ly welcomed. The Max Planck Society and
                           innovative drugs for the treatment of au-    a member of the management team of             the Max Planck Institute will also benefit
                           toimmune diseases such as multiple scle-     Max -Planck-Innovation GmbH. The Max           from the sale and stand to receive sums
                           rosis. The advances achieved by the com-     Planck Society’s technology transfer           in the lower single-digit million range.

                                                                                                                                           2 | 15 MaxPlanckResearch      7
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
PERSPECTIVES

“It’s not surprising that the fear was palpable”
Anita Schroven from the Max Planck Institute for Social Anthropology is still helping to manage
the Ebola crisis in West Africa

                                                  Where do you get your information from?          things that the locals didn’t understand and
                                                  I am in contact with acquaintances involved      presenting a risk scenario that didn’t en-
                                                  in field research, and follow reports on the     courage cooperation – especially as there
                                                  radio and Internet. I also maintain contact      were huge information campaigns convey-
                                                  with experts in the field – anthropologists      ing the message that there is no cure or
                                                  and other social scientists involved in fight-   treatment for Ebola.
                                                  ing the Ebola outbreak and working with
                                                  the WHO, Médecins Sans Frontières, the           But people realized that this approach
                                                  Red Cross and the UN mission, as well as the     wouldn’t achieve the desired results –
                                                  network to which I belong. We debate spe-        or did they?
Anita Schroven                                    cialist issues and can pass on research find-    Yes, first of all, the communication was im-
                                                  ings about local practices.                      proved. Instead of sending representatives
When field researchers aren’t out in the                                                           from central government, local dignitaries
field, they have no problem participating in      You carried out research in Guinea on ideas      were involved. Village elders, religious lead-
the unfolding events from their desks at          and practices of state and statehood in the      ers and leaders from the initiation societ-
home thanks to technology. Anita Schrov-          local context. Are there links between this      ies lend greater legitimacy to such process-
en, an academic staff member in the “Inte-        and Ebola?                                       es. Secondly, consistent use was made of
gration and Conflict along the Upper Guin-        The question as to the extent to which the       the media; discussion forums in which peo-
ea Coast (West Africa)” research group, is in     population can trust state structures aris-      ple could participate by cell phone were
contact with Guinea. She lived in the West        es in Guinea, in particular. This has a lot to   transmitted on the radio. Moreover, it was
African country for one year. As is the case      do with the history of the country, which        essential to ensure that the information is
in neighboring Sierra Leone and Liberia,          gained independence in 1958 but was then         available in the local languages.
the threat of new Ebola infections hasn’t         governed by two dictators for 50 years. The
been entirely eliminated there.                   political arena has become increasingly          Was at least the initial medical position clear?
                                                  ethnicized in recent years. The president’s      Even among researchers, there was and is
Out of sight, out of mind: Ms. Schroven, how      group is accused of profiting more than          no consensus: How reliably can the knowl-
should we see the current situation in West       others from the state mining revenue.            edge gained from earlier outbreaks be ap-
Africa from our European perspective?             There’s a lot of distrust.                       plied? How different are the situations in
Anita Schroven: The good news is coming                                                            the individual countries? Just one example:
from Liberia at the moment: there have            Naturally, this is disastrous in the context     in Liberia, they changed the recommenda-
been no new cases of Ebola there since            of Ebola.                                        tion for sexual contact for Ebola survivors
March 22. Given that the incubation period        The population perceives government in-          from 90 days of abstinence and now advise
for the disease is 21 days, this gives us cause   tervention as negative, as it is often asso-     people to use condoms until there is great-
for hope. To be on the safe side, the World       ciated with violence and corruption. Mea-        er clarity on the issue. But people sit up and
Health Organization (WHO) has decreed             sures carried out in the areas of infrastruc-    take notice when different information is
that, for a country to be declared Ebola-         ture, education and healthcare tend to be        suddenly in circulation. They assume, for
free, a period of 42 days must pass since the     ascribed to international aid. The idea of       example, that their own government wants
last case tested negative twice. Although         civil society is still a recent one in Guinea.   to harm them.
the number of new Ebola cases is falling in
Sierra Leone, people are still contracting        But comprehensive external aid was rapidly       What’s next for your research?
the disease and the transmission routes           required for Ebola. How was that managed?        We’re planning a conference in Halle in Oc-
aren’t yet known. The number of new Ebo-          That was a major challenge for all three         tober, where the current field research will
la patients in Guinea is stagnating.              countries. People were used to internation-      be linked with theories concerning knowl-
                                                  al intervention in Sierra Leone and Liberia,     edge production and translation. We want
So, we can’t say that the Ebola outbreak is       as both countries had been subject to UN         to know which information was available
coming to an end?                                 mandates after the civil wars there. At that     where and what kind of knowledge was
No, unfortunately not. This isn’t the percep-     time, refugee aid was provided to people         disseminated, as the degree of knowledge
                                                                                                                                                      Photo: Private collection

tion on site either. People are able to move      from neighboring countries in Guinea at          fragmentation is very high. The complexity
freely between the three countries. The           the expense of the local population. So it       of knowledge generation and translation
border controls don’t prevent this, but they      isn’t surprising that the reservations and       alone can explain why, despite the informa-
are having an impact on trade. Food prices        fear were palpable when people wearing           tion available from earlier Ebola outbreaks,
are increasing and this is contributing to        astronaut suits arrived, accompanied by          it wasn’t possible to prevent an epidemic of
an increase in hunger in the region.              people from the ministry of health, saying       the current scale.     Interview: Susanne Beer

8   MaxPlanckResearch 2 | 15
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
PERSPECTIVES

             New Internet Presence for max-wissen.de
             Relaunch of the successful German-language website for students and teachers now online

             To mark its tenth anniversary, the German-language web-              popular destination for both teachers and students. Here,
             site max-wissen.de has a completely new look. In addition            they can access information about current research topics
             to the traditional “MAX-Heft” dossiers, the very latest in-          and obtain more in-depth information than in standard
             formation, images, and now also high-quality videos can              school textbooks. The material presented on max-wissen.
             be found there on fascinating topics from research, such as          de makes the everyday lives and activities of scientists more
             plant immunity, stem cells, climate change and biomateri-            transparent: How do researchers obtain their results? What
             als. The Max Planck Society launched the knowledge por-              methods do they use?
             tal in 2005 with the help of funding from the Stifterverband             The website has supplemented the published MAX se-
             für die Deutsche Wissenschaft. Since then, it has become a           ries, BIOMAX, GEOMAX and TECHMAX, since the late
                                                                                                         1990s. The number of orders re-
                                                                                                         ceived for these dossiers show that
                                                                                                         far in excess of 100,000 students
                                                                                                         work on content from the Max
                                                                                                         Planck Society every year. The infor-
                                                                                                         mation contained in the dossiers
                                                                                                         has even found its way into the Abi-
                                                                                                         tur, the German school-leaving ex-
                                                                                                         amination, in some federal states.

                                                                                                             Animations, video clips, the MAX series,
                                                                                                             background information and teaching
                                                                                                             support material: the max-wissen.de
                                                                                                             teacher’s portal offers up-to-date,
                                                                                                             informative and fascinating material for
                                                                                                             school classes free of charge.

                    On the Net

                    Our City                                    Observing Apes on the PC                     The Art of Packaging in the Cell
                    The German-American youth portal            Welcome to Africa! Primate researchers       We are more than the sum of our genes.
                    “Step into German” of the Goethe Insti-     from the Max Planck Institute for Evolu-     Environmental factors can affect our
                    tut familiarizes young people with mu-      tionary Anthropology built camera traps      chromosomes. This alters the tightness
                    sic, film and soccer in Germany, as well    in 14 African countries to record thou-      of the DNA packaging – and this dic-
                    as the German language. In the new se-      sands of film sequences. The recordings      tates, in turn, whether a particular gene
                    ries “Our City,” members of the band        must now be evaluated. Since April 22,       can be read or not. As our new film Epi-
                    Tonbandgerät present Hamburg and ex-        the public can view the material on the      genetics – Packaging Art in the Cell shows,
                    plain where they spend their free time,     new citizen science platform “Chimp &        the environment can shape our charac-
                    what they like to eat and where they go     See” and in this way help the primatolo-     teristics over generations in this way.
                    shopping. This whets the appetite for a     gists with their work. It is sometimes       https://youtu.be/86H4olxRx7E
                    visit to the Hanseatic city and may even    the case that there is nothing to see for
                    trigger a desire to study and live there.   quite a while. Then, a warthog may
                    www.goethe.de/ins/us/saf/prj/stg/           suddenly appear on the screen before a
                    enindex.htm                                 group of chimpanzees engages in some
Photo: MPG

                                                                leisurely grooming in front of the camera.
                                                                www.chimpandsee.org

                                                                                                                            2 | 15 MaxPlanckResearch    9
Light - The Science Magazine of the Max Planck Society 2.2015 - Dreams Bring Lucidity to Our Thinking - Max-Planck-Gesellschaft
VIEWPOINT_Foreign Affairs

      Peace – Europe’s
      Polyphonic Promise
       Brussels determines the direction in many policy fields, but in European foreign,
       security and defense policy, it’s the member states that set the tone – not the EU.
       When it comes to international peace talks or emergency meetings, such as the one
       held recently over the crisis in Ukraine, it’s the national foreign ministers and not
       the EU foreign policy chief taking the lead. However, given the challenges for peace
       and security in Europe, our author holds that this is an outdated model: it’s time
       for the member states to act in concert.

       TEXT CAROLYN MOSER

       T
                     he hostilities in Ukraine came as a shock    sis and its devastating socio-economic effects have un-
                     to most European citizens, many of whom      dermined the cohesion within the European Union,
                     had lived their lives to date without the    a war between EU member states is unthinkable.
                     shadow of war looming over them. This             In 2012, the European Union was awarded the
                     stable and long-lasting period of peace in   Nobel Prize for Peace for this great accomplishment.
       Europe, a continent formerly shaken by armed con-          The jury’s decision can also be read as a friendly re-
       flict, is largely the achievement of the European in-      minder to Brussels to safeguard (social) peace in times
       tegration process, which has succeeded in reversing        of increasing internal friction. Accepting the prize,
                                                                  Herman van Rompuy, then President of the Europe-
                                                                  an Council, described Europe’s situation as follows:
                                                                  “Peace is now self-evident. War has become incon-
 War between EU member states is                                  ceivable.” He also added words of warning whose
                                                                  meaning is intensified in light of the ongoing crisis
               unthinkable today                                  in Ukraine: “Yet ‘inconceivable’ does not mean ‘im-
                                                                  possible’. And that is why we are gathered here to-
       the centuries-old paradigm of peace as an interlude        day. Europe must keep its promise of peace.”
       between wars. Today, peace has become the rule in               Keeping this promise is no easy task, as peace does
                                                                                                                             Photo: dpa Picture-Alliance

       Europe, while military violence is the exception.          not equate with the mere absence of war. Moreover,
           It seems to have been forgotten in both public per-    peace depends on both internal and external dynam-
       ception and public opinion that the European proj-         ics, which are often intertwined. In recent years, the
       ect has, despite its shortcomings, founded a peaceful      impact on the European Union and its member states
       entity made of democracies built on the rule of law        of external or externally influenced events has repeat-
       and respect for human rights. Even if the financial cri-   edly become apparent.                                  >

10   MaxPlanckResearch 2 | 15
VIEWPOINT_Foreign Affairs

   2 | 15 MaxPlanckResearch   11
VIEWPOINT_Foreign Affairs

        The CHARLIE HEBDO attacks in Paris, in which transna-       pace to move forward with integration with respect
        tionally acting terrorist groups were involved, are still   to security, defense and foreign affairs.
        fresh in our memories. We have also witnessed civil             Informal consultations laid the foundations for
        wars in Libya and Syria, leading to a considerable in-      the Common Foreign and Security Policy (CFSP) in-
        crease in asylum seekers in European countries. Cur-        troduced in 1993 by the Treaty of Maastricht, as well
        rently, the Union is additionally faced with war in a       as for the post of High Representative for the Com-
        country that shares a common border with several of         mon Foreign and Security Policy that was established
        its member states, namely Ukraine.                          six years later by the Treaty of Amsterdam and that
            These events illustrate that peace in and around        was first held by Javier Solana.
        Europe can’t be taken for granted, and that a vari-             In the wake of the Kosovo crisis – when, after the
        ety of security challenges lie ahead. So the time has       Balkan wars, European nations were again unable to
        come for member states to reinforce unity in foreign        properly respond to the atrocities committed in their
        policy, security and defense matters. While this            own backyard – a Common Security and Defence Pol-
        might seem obvious to the reader, it doesn’t corre-         icy (CSDP) was added to the CSFP in 1999. Its aim
        spond to reality.                                           was to bundle resources, share expertise and increase
            Contrary to the motto of the Union, “United in          coordination to allow for concerted action.
        diversity,” there is a great deal more cacophony than           The CSDP went through its baptism of fire short-
        unity among member states when it comes to issues           ly thereafter when, in 2003, the Union sent its first
        with foreign affairs, security and defense implica-         civilian police mission to Bosnia and Herzegovina,
        tions. Concerted action in this area would certainly        and began its first military deployment in Macedo-
                                                                    nia. To date, the Union has launched more than thir-
                                                                    ty civilian missions and military operations, varying
                                                                    in geographic focus (Europe, Asia, Africa) and the-
 3,000 military staff are deployed in                               matic span.
            five military operations                                    Civilian missions range from border assistance
                                                                    and monitoring to rule of law support, police train-
                                                                    ing and police capacity building to security sector re-
        help cope with existing and forthcoming threats to          form assistance and military capacity building. Mili-
        stability and peace in Europe, as would a strong in-        tary operations comprise training missions for armed
        ternational standing of the Union.                          forces, military advice and naval anti-piracy activi-
            Member states have existing structures and exper-       ties, as well as combat and humanitarian tasks. To en-
        tise on which to build. The Union has progressively         able the Union to undertake this wide array of activ-
        been equipped with a security and defense strand,           ities, member states have progressively created
        which has already enabled the EU to launch a vari-          Brussels-based structures vested with planning, deci-
        ety of civilian missions and military operations.           sion-making and implementation capacities.
            Since 2003, thousands of civilian experts and mil-          Yet, after brisk activity in the Solana era, the Com-
        itary staff – including judges, police officers, infantry   mon Security and Defence Policy almost came to a
        and navy soldiers and officers, or monitors – have          standstill in the wake of the financial crisis when
        been sent out with the Union’s flag on their uniforms       member states accorded a lower profile to foreign af-
        and vehicles to contribute to the process of restoring      fairs, security and defence policy questions at the EU
        stability in countries or regions shaken by crises. At      level. The EU’s international standing has declined as
        the time of writing, some 3,000 civilians are working       a result. But Brussels can’t be blamed for this deteri-
        in twelve civilian missions, and another 3,000 mili-        oration, given that decision-making in this policy
        tary staff are deployed in five military operations.        area rests quasi-exclusively with member states and
            One or two decades ago, only resolute optimists         their representatives in Brussels.
        would have thought such united external efforts pos-            The legal, institutional and procedural frame-
        sible. After the failure of the European Defence Com-       work of the Common Security and Defence Policy
        munity – an ambitious project envisaging a Europe-          (CSDP) and of the Common Foreign and Security
        an army – in 1954, member states adopted a slower           Policy (CFSP) are shaped predominantly by inter-

12   MaxPlanckResearch 2 | 15
governmental features. Indicative hereof is the fact        the European External Action Service (EEAS): in es-
                              that the main actors and decision makers are the Eu-        sence, the cryptic acronym stands for nothing less
                              ropean Council (composed of heads of state and              than the nucleus of an EU ministry of foreign af-
                              government) and the Council of the European                 fairs. And yet, appearances matter, so the seeming-
                              Union (constituted by representatives of member             ly neutral designation EEAS was eventually chosen
                              states’ governments). Unlike in other policy areas,
                              the European Commission and the European Parlia-
                              ment play only a minor role in matters related to
                              foreign affairs, security and defence, and the Court           A security strategy that combines
                              of Justice of the European Union generally has no              all elements of foreign policy
                              jurisdiction in this field.
                                  In addition, the principle of unanimity prevails
                              here, with some minor exceptions, in contrast to            over a more political denomination (such as minis-
                              other policy areas. All 28 member states need to be         try of foreign affairs), potentially stirring up fears
                              in consensus to define a common position or to              of losing sovereignty to Brussels.
                              launch a civilian mission or military operation. In             Considering these underlying patterns, it is ap-
                              the event of disagreement among member states,              parent that there is little leeway for the Union to re-
                              the EU’s security and defense are paralyzed. This has       act to external threats. Faced with civil wars across
                              repeatedly happened in crisis situations – the Arab         the Mediterranean, ongoing hostilities in Ukraine
                              Spring, the fall of the Gaddafi regime in Libya and         and the reemergence of Cold War rhetoric, it might
                              the humanitarian crisis in Syria, for instance – when       be time to reverse this situation – and stand firm and
                              the European Union’s lack of response was a disap-          united. This implies not only conceding to concert-
                              pointment to many.                                          ed action, but also providing the necessary means
                                  Even the Treaty of Lisbon (2009) did nothing to         to carry out joint activities. In this context, EU
                              change the fact that member states are strongly fa-         member states might have to rethink Europe’s secu-
                              vored – and not the European Union. Most issues             rity and defence apparatus and increasingly engage
                              with foreign affairs, security and defense implications     in pooling, sharing or better coordinating equip-
                              are still handled by national governments, and not          ment and resources.
                              by the High Representative of the Union for Foreign             This leads to yet another challenge, namely the
                              Affairs and Security Policy, a position currently held      question of whether and under what conditions the
                              by Federica Mogherini. However, a Union with a low          Union should resort to military means to maintain
                              international profile, together with members states         or restore peace (provided there is a UN mandate).
                              divided over security and defense issues, is not the        For most people, military activity is associated with
                              most desirable message to convey to the world.              member states deploying troops (mainly in the con-
                                  The path to more security and defense cohesion          text of NATO operations), not the EU. The Union’s
                              in the future is thus not without obstacles. The first      international standing and self-image has, to a large
                              difficulty to be tackled relates to defining a common       extent, been coined by its non-belligerent nature.
                              European stance. Especially in crisis situations, na-       Consequently, the EU has adopted a security strate-
                              tional players are likely to fall back on national insti-   gy that combines all elements of foreign policy (di-
                              tutions and mechanisms. In addition, as questions of        plomacy, trade, aid and military and non-military in-
                              security and defense traditionally belong to the realm      struments) and clearly prefers conflict prevention
                              of the executive, governments are generally wary of         over armed intervention. In fact, civilian missions ac-
                              renouncing their prerogatives and responsibilities in       count for almost two-thirds of EU-led crisis manage-
Photo: dpa Picture-Alliance

                              favor of common decision-making or implementa-              ment activities.
                              tion structures.                                                For some member states, including Scandinavian
                                  The UK’s strong opposition to a change in the           countries and Germany, the use of military force is
                              status quo and to further integration in foreign af-        not readily compatible with the Union’s civilian char-
                              fairs, security and defense on the road to the Trea-        acter. For other member states, like France, military
                              ty of Lisbon is a case in point. Another example is         interventions are considered to be an essential aspect

                                                                                                                              2 | 15 MaxPlanckResearch   13
of a Union that wants to affirm its international role.    mer Federal President Horst Köhler insinuated in an
        So to what end(s) should military force be employed?       interview that military intervention could, under cer-
        Should the Union intervene militarily to prevent           tain circumstances, be required to safeguard the coun-
        atrocities from being committed? So far, member            try’s interests, including free trade routes and the pre-
        states have, for pragmatic reasons, opted to carry out     vention of regional instabilities. At the time he made
        humanitarian interventions, as in Libya, under the         his statement, German navy forces had already been
        NATO framework, if at all, and not under the auspic-       patrolling the Gulf of Aden for two years – appar-
        es of the Union.                                           ently unnoticed by the German public.
            Also, what about sending armed forces, not to              The episode reveals another stumbling block for
        maintain, but to restore peace? In several EU opera-       European security and defense: the fact that member
        tions, the use of force has been authorized to curb in-    states can avoid blame under the cloak of the Union.
        ternal conflicts and prevent regional instabilities –      By engaging in EU military operations relatively un-
        such as in the Central African Republic in 2014.
            And yet, it is no simple task to gather military
        personnel and resources for these undertakings. Par-
        is is often willing to send soldiers and contribute           A general tendency to blame
        materials. Berlin, on the other hand, is known to be          Brussels
        a more reluctant contributor to military operations,
        and has a clear preference for civilian missions. As
        for the EU operation in the Central African Repub-         known to the wider public, member states reduce the
        lic, France accounted for the majority of troops,          risk of nasty questions or bad press at home. And if
        while Germany committed military transport air-            anything goes wrong in an operation, national capi-
        craft to carry the wounded. The same division of la-       tals can blame the Union for the failure. Although
        bor for combat tasks and logistical support – “exem-       this might sound cynical, it’s not a far-fetched sce-
        plary,” as some might say – has also been applied in       nario, bearing in mind the general tendency of na-
        other operations.                                          tional players to blame Brussels for all sorts of unde-
            In different circumstances, member states have         sired policy outcomes. The Union should therefore
        shown greater resolve to contribute armed forces.          make its external activities more accessible to the
        This has been the case with, for instance, Atalanta,       general public.
        the EU-led naval anti-piracy operation off the Soma-           Ultimately, there is the challenge for the Union
        li coast. More than 20 member states (including Lux-       to live up to its own expectations, which in turn
        emburg, a landlocked country with no naval forces)         feeds into legitimacy questions. In the absence of
        and some non-EU countries are contributing to the          proper scrutiny by the European Parliament in mat-
        operation. Apart from providing protection to vessels      ters related to foreign affairs, security and defense
        of the World Food Programme delivering food to So-         policy, and given the lack of jurisdiction of the Eu-
        malia, the operation is mandated to deter, prevent         ropean Court of Justice over these same matters, the
        and repress acts of piracy and armed robbery at sea        Union seems to fall short of the values it seeks to
        with a view to ensuring that international trade is not    promote abroad, namely democracy and the rule of
        disrupted, and to use force if necessary.                  law. But applying double standards entails a consid-
            The Gulf of Aden is indeed one of the most im-         erable reputational risk.
        portant international commercial maritime routes,              This also holds true for transparency issues. For-
        not least because tankers loaded with crude oil are        eign affairs, as well as security and defense matters,
                                                                                                                               Photo: dpa Picture-Alliance

        transiting through the Gulf to reach nations all over      are traditionally decided upon and conducted be-
        the world. Geo-strategic considerations and econom-        hind a veil of secrecy. While restricted disclosure of
        ic interests clearly played a role in member states’ de-   documents and access to information makes sense
        cision to take part in the operation.                      when it comes to military operations, it’s hard to
            Against this backdrop, it is astonishing that, in      understand why there is little information dissemi-
        2010, the German public was outraged when the for-         nated on the outcomes of military missions or, even

14   MaxPlanckResearch 2 | 15
VIEWPOINT_Foreign Affairs

                                more so, on civilian missions that deal, for instance,
                                with the rule of law or policing.
                                     Furthermore, it would be important to establish
                                accountability mechanisms with respect to matters
                                of foreign, security and defense policy. The institu-
                                tional and procedural setup of the Common Securi-
                                ty and Defence Policy, subject to little parliamentary
                                scrutiny and lacking judicial review at the European
                                level, seems conducive to circumventing accountabil-
                                ity. The corruption scandal that hit the Union’s flag-
                                ship last November, the rule of law mission EULEX
                                Kosovo, is one pertinent example.
                                     It was leaked to the press that high-ranking EU of-
                                ficials had allegedly been involved in corruption.
                                Even more problematic was the fact that representa-
                                tives of the mission and Brussels-based structures
                                seem to have attempted to cover up the story instead        THE AUTHOR
                                of properly investigating the allegations brought           Carolyn Moser is a member of academic staff at the
                                forth by a seconded prosecutor. These entanglements         Max Planck Institute for Comparative Public Law
                                prompted the High Representative Federica Mogheri-          and International Law. She studied law, politics and
                                ni, on one of her first days in office, to appoint an ex-   economics at Sciences Po Paris and the Fletcher
                                ternal expert to review and report on the incident.         School of Law and Diplomacy (Tufts University) in
                                Still, the Union and the mission have already suffered      Boston. She spent the period between 2011 and 2013
                                reputational damage. The scandal has indeed caused          at the Basel Institute on Governance, where she
                                much bad press for the good EU cop.                         worked on projects to promote the rule of law and
                                     So, how to proceed? Jean-Claude Juncker, Presi-        fight corruption in Asia, Europe and North Africa for
                                dent of the European Commission, recently made a            various organizations, including the World Bank
                                controversial suggestion as to how to react to exter-       and the OSCE. Since 2013 she has been working on
                                nal threats and to restore the Union’s international        her Ph.D. at the Max Planck Institute for Compara-
                                standing: he resuscitated the ambitious project of a        tive Public Law and International Law with research
                                European army (in parallel with NATO structures).           residencies in Utrecht.
                                     Juncker’s proposal was met with mixed reac-
                                tions: foreseeably enough, the UK government re-
                                jected the plan in no uncertain terms, stating that
                                defense was undeniably a matter of national re-
                                sponsibility, whereas the German minister of de-
                                fense, Ursula von der Leyen, welcomed the prospect
                                of a common army.
                                     The interlude shows that, even more than six de-
                                cades after the failure of the European Defence Com-
                                munity project, the time is still not ripe for a Europe-
Photo: Maurice Weiss/Ostkreuz

                                an army, even though member states have no choice
                                but to rethink Europe’s security and defense mecha-
                                nisms in the long term. But it also shows that there
                                is a political will among some member states to strive
                                for greater unity in foreign policy, security and de-
                                fense – a unity that is needed to keep the European
                                promise of peace.

                                                                                                                              2 | 15 MaxPlanckResearch   15
Post from London, England

                 Immediate Inspiration
                      Max Planck scientists cooperate with partners in around 120 countries
                     worldwide. Here they relate their personal experiences and impressions.
                        Empathy researcher Esther Kühn commutes back and forth between
                          the Leipzig-based Max Planck Institute for Human Cognitive and
                     Brain Sciences and University College London. She finds this cooperation
                                                  to be extremely fruitful.

                  Anyone who occasionally lands at a bustling airport like London’s Heathrow knows how
                  much the modern world connects us to people – or at least it seems that way. Business trav-
                  elers rush to meetings – they stumble, jostle each other and apologize. Grandparents who
                  have traveled from far away carry grandchildren in their arms. Lovers wait for a special some-
                  one who will soon walk through this sliding door, and who, perhaps, was away for too long.
                  But how do people actually form these connections with each other? Which regions of our
                  brain are active in this process, and how? This question has a long tradition in empathy re-
                  search, and it has been my companion for some time. To be precise, I’m particularly inter-
                  ested in a tiny sub-aspect: What happens in the brain when a person is touched? And what
                  happens when that person merely observes another person being touched?
                  To answer these questions, I went in search of suitable connections with other researchers.
                  The right device, a magnetic resonance scanner, is already available at the Max Planck In-
                  stitute in Leipzig, as are the right subjects. While they lay in the MRI tube, I stroked their
                  fingers with a paintbrush – or they watched films of the same movement being carried out
                  on another person. But this experiment generated huge quantities of data, and accurately
                                                                                                                   Graphic: iStockphoto

                  interpreting this data is a great challenge.
                  Fortunately, during an initial term as a visiting researcher in England, I met my colleague
                  Patrick Haggart from University College London. Then when I was in Leipzig and occasion-
                  ally got stuck, we discussed it over Skype, sometimes even outside of working hours. And

16   MaxPlanckResearch 2 | 15
RUBRIK TITEL

                                                                                                Esther Kü     hn, 31, studied biolog
                                                                                                                                         y in
                                                                                                 Münster before co
                                                                                                                      mpleting her ma
                                                                                                                                         ster’s
                                                                                                 degree in neuros
                                                                                                                    cience in Otago,
                                                                                                                                       New
                                                                                                 Zealand between
                                                                                                                     2007 and 2009. Ba
                                                                                                                                         ck in
                                                                                                 Germany, she co
                                                                                                                   nducted research
                                                                                                                                       as a
                                                                                                doctoral student
                                                                                                                   at the Max Planc
                                                                                                                                      k Institute
                                                                                                for Human Cogn
                                                                                                                  itive and Brain Sc
                                                                                                                                      iences
                                                                                               in Leipzig until 20
                                                                                                                   13. With the aid of
                                                                                                                                        a grant
                                                                                               from the German
                                                                                                                   Academic Exchan
                                                                                                                                       ge
                                                                                               Service (DAAD), sh
                                                                                                                    e spent half a year
                                                                                              at University Colle
                                                                                                                   ge London (UCL).
                                                                                                                                       She
                                                                                              returned to Leipz
                                                                                                                 ig and, since 2014,
                                                                                                                                       has been
                                                                                              a member of Arno
                                                                                                                  Villringer’s Departm
                                                                                                                                          ent of
                                                                                             Neurology. There
                                                                                                                , she is a major co
                                                                                                                                     ntributor
                                                                                             to a strong coopera
                                                                                                                   tion with UCL.

                            together we considered how best to handle my data. At some point, he said: “Wouldn’t you
                            be able to answer your questions better if you used my colleague Martin Sereno’s program
                            here in London?”
                            Of course! And since then, I spend a couple of months each year in the British capital. Now
                            one might think that, in London, I need little more than a computer and a full coffee cup,
                            but that’s not quite right. I sit in my office together with Martin, who is known as Marty,
                            and I draw a lot of inspiration from speaking directly with him. It’s a great advantage! After
                            all, he’s a renowned neuroscientist, and the program we work with is his “baby.”
                            I have since even come up with new ideas that have nothing at all to do with my original proj-
                            ect. That’s a tremendous advantage for a junior scientist. It’s also a huge boon for me that my
                            colleague has just as much energy and enthusiasm for my project and spends so much time
                            on it before speeding home on his racing bike in the evening through the rather bicycle-un-
                            friendly streets of central London. For me, it’s then time to go to Pilates, or to my sword-com-
                            bat class. After all, who wants to spend all day in front of the computer monitor?
                            I’ve now spent a total of just over a year in London. And even though, as a native of Leipzig,
                            I consider myself to be spoiled in terms of cultural offerings, London is an incredible step
                            up. The city offers me every opportunity, and sometimes I’m almost overwhelmed by the
                            cultural choices available. Just recently, I again attended a number of concerts and a classi-
                            cal ballet performance. Nevertheless, it really did take me quite a while to find my place
                            here. London is a logistical challenge, and it’s changing so fast. As an example, even today,
Photo: Private collection

                            I can’t estimate how long I’ll need for any given route – I’m simply always late.
                            When I arrive back at Leipzig/Halle Airport after my adventures in London, everything feels
                            much smaller. I’d say, compared with London, Leipzig is my living room. My home. But I’ve
                            changed, and I’m full of new ideas. And even if my future research location hasn’t yet been
                            entirely decided, I’m sure of one thing: my future in science has begun.

                                                                                                                      2 | 15 MaxPlanckResearch      17
FOCUS_Light

Tweezers Made of Light
Many biomolecules move through cells like microscopic machines. Often, however, it isn’t
known what forces these molecules generate or how fast the molecules act or move. That’s why
Stephan Grill from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden
decided to specialize in measuring molecular forces. He uses optical tweezers to pull gently on
DNA strands. His method is shedding light on the proteins that read genetic information.

TEXT TIM SCHRÖDER

S
          prings are ubiquitous in the      determines the spring constant. The         croscopic machines powered by tiny
          modern world, whether in pens     spring constant is measured by deter-       forces. This is tremendously fascinat-
          or on the grips of garden clip-   mining how much force is needed to          ing.” Our muscles contract, for exam-
          pers. A spring is compressed or   stretch or compress a spring through a      ple, because millions of elongated pro-
          stretched, depending on its       given distance. The force required de-      teins slide along each other over min-
function. This requires force, as the       pends on the thickness and material of      iscule distances. By combining all these
spring resists any attempt to change its    the spring. For example, stiff shock ab-    tiny shifts, muscles are able to carry out
shape. Springs can be very strong: the      sorbers for sports cars shorten by just     large movements.
leaf springs of trucks, for example, eas-   one millimeter in response to a force of        The movements that interest Grill,
ily support 20 to 30 tons.                  70 newtons acting on them – corre-          however, are smaller than those asso-
    To express the strength of a spring,    sponding to the force generated as a car    ciated with muscle proteins. He wants
physicists perform a measurement that       drives over cobblestones.                   to understand how RNA polymerase
                                                                                        travels along DNA molecules while
                                            TINY POWER PACKS                            reading the genetic information the
                                                                                        DNA encodes – a process known as
                                            Stephan Grill has nothing to do with        transcription.
                                            shock absorbers, sports cars or leaf            After decades of intensive research,
                                            springs. He deals with forces on a com-     biologists, biophysicists and geneticists
                                            pletely different scale. The physicist      now understand which molecules are
                                            from the Max Planck Institute of Mo-        involved in transcription, what interme-
                                            lecular Cell Biology and Genetics mea-      diate products are formed, and where
                                            sures forces that are a billion times       the energy for the finely tuned genetic
                                            weaker than these.                          machinery comes from – but not the
                                                Grill isn’t interested in newtons and   forces that are involved. “If we really
                                            kilonewtons, the units of force in every-   want to understand the transcription
                                                                                                                                     Photos: Sven Doering

                                            day life, but in piconewtons, less than     engine, we need to find out what drives
                                            a billionth of a newton, to express the     it,” says Grill. “It’s like any other ma-
                                            forces acting between biomolecules.         chine. If you don’t know how much
                                            “Biomolecules aren’t rigid and static,”     force it generates, you don’t really un-
                                            says Grill. “Some proteins resemble mi-     derstand how it works.”                  >

18   MaxPlanckResearch 2 | 15
Left: A foam box protects the optical
tweezers from environmental factors such
as temperature fluctuations and noise
vibrations. A hoist can be used to lift the
entire box or to open the lid.
Right: Stephan Grill can load the sample to
be investigated, or make changes to the
setup through the open lid. The researcher
wears special goggles to protect his eyes
against the laser light.
Measuring forces – at the molecular            ments, there can be no movements,”           used a trick based on a finely focused
level, this is no easy feat. For this, Grill   says Ehrlich. “After all, we’re dealing      laser beam. Like billiard balls, the pho-
constructed a sophisticated experimen-         with a high level of precision to within     tons impinge on the bead from all di-
tal setup when he was leader of a joint        a millionth of a millimeter.”                rections and hold it in place. It’s possi-
group at the Max Planck Institute of           What occupies a large box and a whole        ble to capture and balance a ping pong
Molecular Cell Biology and Genetics            laboratory room is known by experts          bead on the stream of air from a hair
and the Max Planck Institute for the           simply as optical tweezers. The sole pur-    dryer. Ashkin achieved essentially the
Physics of Complex Systems before              pose of the entire apparatus is to cap-      same thing with molecules and light.
2013. Together with his colleagues, he         ture a protein, pull on it as if it were a       Many research groups have since re-
combines mirrors, lenses and high-pre-         spring, and measure its resistance. It’s     fined this prototype of optical tweezers.
cision lasers to form an optoelectronic        difficult to imagine how laser light can     In recent years, researchers have used
maze. And his tool for measuring bio-          capture molecules, but the method, de-       optical tweezers to study various bio-
molecular forces is light.                     veloped by US physicist Arthur Ashkin        molecules, including myosin and kine-
    Grill, who is now also a professor at      in the 1980s, is well established.           sin. Myosin, a motor protein that is
the TU Dresden, is in the process of                                                        present in all our muscle cells, moves
moving and shuttles back and forth be-         BILLIARDS WITH PHOTONS                       in 14-nanometer increments. As it does
tween the Max Planck Institute and the                                                      so, it causes muscle fibers to contract.
TU laboratories – four minutes by bike.        The dual nature of light as a wave and       Kinesin moves through the cell in
The laboratory at the Max Planck Insti-        a particle has been known for a centu-       8-nanometer steps as it transports cell
tute is currently housed in a small room       ry. Light particles, called photons, pos-    components. “We’ve perfected our op-
that is almost entirely filled by a large      sess momentum that can be imparted           tical tweezers to the extent that we can
gray styrofoam box. Next to it are a           to an object. This happens, for example,     even measure the movements of RNA
chair and a table on which three com-          when a photon flies through a tiny           polymerase, which are ten times small-
puter monitors sit. Grill’s colleague          transparent bead and is deflected from       er,” says Grill.
Christoph Ehrlich opens the lid of the         its path by light refraction. The photon         DNA is the blueprint according to
styrofoam box. Inside is a perforated          propels itself away, pushing against the     which the cell produces proteins. For
                                                                                                                                           Photo: Sven Doering

plate the size of a tabletop. Mounted on       bead. If the light is strong enough, the     polymerase to read the genetic infor-
the plate are lenses, mirrors and thin         bead can actually be nudged to the side.     mation contained in genes, it must first
tubes that end in fist-sized chunks of             But Arthur Ashkin wanted to achieve      open up the DNA molecule, which con-
stainless steel. “When the system is           the opposite effect, namely to capture       sists of two intertwined strands, like a
running and we’re taking measure-              the beads with laser light. To do so, he     zipper. It travels, like the slide of a zip-

20   MaxPlanckResearch 2 | 15
FOCUS_Light

                           Left: While Veronika Fitz and Stephan Grill
                           look at data on the screen, Marcus Jahnel
                           (left) prepares the optical tweezers for a
                           new experiment.
                           Right: RNA polymerase II reading a gene.
                           The enzyme (blue) moves along the coiled
                           DNA strands (yellow, pink), untwists them
                           and transcribes the genetic information
                           into an RNA molecule (orange). If the
                           polymerase makes an error, the faulty RNA
                           section is snipped off. The molecule then
                           reverses and reads the gene segment again.
                           The RNA molecule eventually serves as a
                           template for protein synthesis.

                           per, from one DNA building block to           the two beads closer together until the        detectors sense this deviation. A com-
                           the next, always in 0.34-nanometer            DNA from the first bead binds to the           puter program then converts the devi-
                           steps. These building blocks, called di-      second bead, thus forming a tether be-         ation of the beads away from the cen-
                           nucleotides, represent the letters of the     tween the two beads. The pair of beads         ter of the traps into the force that the
                           genetic alphabet.                             connected by the long DNA strand re-           polymerase generates.
                               As it reads the DNA molecule, poly-       sembles a tiny dumbbell.                           What’s more, the researchers are
                           merase strings together the RNA coun-             At first, nothing happens, because         also able to move the two beads back
                           terparts of the dinucleotides, thus cre-      the polymerase requires energy to trav-        and forth, pulling on the DNA like a
                           ating an RNA copy of the DNA strand.          el along the DNA. Only when the re-            miniscule spring. The spring constant
                           “We want to know the strength of the          searchers add energy-rich RNA nucle-           of DNA is infinitesimally small: stretch-
                           forces involved as polymerase moves           otides as fuel do things get moving.           ing a DNA molecule by one micron re-
                           along the strand of DNA, and how              The polymerase moves in increments             quires a spring force of just one tenth
                           quickly the enzyme progresses,” says          from one nucleotide to the next. But           of a piconewton. And because the
                           Grill. “This is extremely difficult in        because the two beads are held firmly          polymerase is bound to and moves
                           view of the short increments involved.”       in the traps, a tensile force is created be-   along the DNA, it has to act against
                               The trick Grill and his colleagues        tween the beads, like a rope on which          these forces.
                           use to measure the forces is impressive.      two opponents are pulling in a tug-of-
                           Because the RNA-polymerase complex            war match.                                     BEADS IN THE TRAP
                           can’t be captured easily in an optical            The polymerase must therefore ex-
                           trap, Grill uses a kind of support struc-     ert a force to move from nucleotide to         Although the laser technique is extreme-
                           ture: two small plastic beads measuring       nucleotide. After each step, it remains        ly complex, and the mirror laser beams
                           just a few micrometers across. He at-         stationary for a few seconds, during           must be precisely adjusted, the trap is
                           taches a polymerase molecule to one of        which the force on the other bead re-          amazingly simple to operate. Grill’s doc-
                           the plastic beads, and a DNA strand to        mains constant. When the polymerase            toral student Veronika Fitz holds a joy-
                           the other. This is where the optical          takes the next step, it has to apply even      stick while gazing at a computer screen.
Photo: SPL-Agentur Focus

                           tweezers – or more precisely, two opti-       more force against the growing resis-          Somewhere in the depths of the styro-
                           cal tweezers – come into play. Grill and      tance. While the polymerase progress-          foam box, the beads move through a
                           his colleagues use one to hold the bead       es and the tension on the DNA increas-         small container, and their magnified im-
                           with the attached polymerase-DNA              es, the beads are gradually pulled out of      ages appear as tiny dots on the screen.
                           construct, and the other to hold the          the focus of the laser beams by just a         The light beams of the two traps appear
                           second bead. They then carefully move         few nanometers. High-resolution light          on the screen as crosshairs.            >

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