RELEVANCE OF THE GUT-BRAIN AXIS TO SKIN AGING - WHO WANTS TO LIVE FOREVER? HEALTHY AGING & ANTI-AGING IN 2020 PATRIZIA A D'ALESSIO MD PHD

WHO WANTS TO LIVE FOREVER?
HEALTHY AGING & ANTI-AGING IN 2020

  * Relevance of the GUT-BRAIN
            AXIS to skin aging
          Patrizia A d’Alessio MD PhD

                          © copyright 2019 by Patrizia A d’Alessio
       Pr Dr University Paris Sud-11 and Genopole d’Evry France

* No conflict of interest

               Patrizia A d’Alessio MD PhD

                         © copyright 2020 by Patrizia A d’Alessio
                                  Pr Dr Genopole d’Evry France

*

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 Bidirectional communication between the gut
 microbiota, the gut, and the brain
   Systemic (HPA system)
   Neural (Vagus)
 Endocrine-, neurocrine- and inflammation-related
 signals are generated by the gut microbiota and
 specialized cells within the gut – that affect the brain.
 In turn, the brain can influence the microbial
 composition and function via endocrine and neural
 mechanisms.

*

Food intake and micronutrient signalling

Relevance to skin health and beauty

*
MICRONUTRIENT SIGNALLING

Network of food, immunity and the microbiota

    The vagus nerve
         forwards
     the gut – brain
   signalling initiated
            by
       food intake

                                               Gastroenterology 2015;148:1107–1119

* Microbiota metabolites are essential for health

                                              Butyrate, Folate,
                                           Propionate produced by:

                                                 Bifidobacteria
                                                    Clostridii
                                               Enterobacterium
                                                 Enterococcus
                                                Ruminococcus
                                                   Roseburia

                            Nature Reviews Microbiology, 2012;10:323–335

Bacterial metabolism of dietary fibers
                      impacts epigenetics

  Acetate,   butyrate,
propionate (SCFA) and folates,
  produced following dietary
  intake of phytochemicals,
   are epigenetic modifiers,
 protecting from cancer and
            aging.

                                              Clinical Epigenetics 2015;7:112

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                   Since the 17th century and during the 18th
                   century, vegetarianism became a
                   treatment for obesity and gout for rich
                   people consuming a lot of meat.

                   But vegetarianism was also beginning to be
                   considered as a solution to avoid wrinkles
                   and lack of radiance in the skin.
Dr George Cheyne
   (1671-1743)

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How do brain homeostatic strategies
challenge the gut-brain connexion?

Thanks to cortisol,
normally you don’t realize
you are under stress

Stress management is introducing imbalance in the gut-brain connection

        STRESS COPING
     MECHANISMS (CORTISOL)
           GENERATE
         GENERALIZED
        INFLAMMATION

    Pharmacological Reviews 2019;71:198-224

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      Cortisol

    Neuroinflammation
        Mood
    and sickness disease

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    * GUT BARRIER DYSFUNCTION AND « SICKNESS DISEASE »

?
How does dysbiosis undermine skin health and beauty ?
     Because the brain talks to the skin as well…

*

    Bioengineering in Wound Healing: A Systems Approach(book), 2017

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    The skin displays a fully functional
         peripheral HPA* system
                          *Hypothalamo-pituitary-adrenal axis

         Infection
        Exsiccation
        Heat/cold
          UV light
           Ozone
       Toxic agents
          Stretch
    Mechanical damage
       Free radicals
         Allergens
    High/low humidity

*

     Gut dysbiosis         Psychbiotics preserve gut
                               barrier function
Compromises the barrier
  function of the skin    and are essential for the skin
                                   compliance

* Psychobiotics can restore dysbiosis causing chronic
     inflammation: skin is the winning partner !

                                     Before       After

                                    PRIME 11:2015; 19-25

* Anti-inflammation by vagus stimulation

   * A taste you like…
       potently induces vagal activation

George Soulié de Morant in : Précis de la vraie acupuncture chinoise Mercure de France, 1932 Paris

* Affectionate touch

Social grooming
                    Emma Thompson & Greg Wise

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 Stress management can destabilize the gut barrier function, thus
  generalizing the inflammatory reaction.

 Chronic inflammation fuels aging, visible in skin.

       Nutrition may become a potent inductor of epigenetic modifications,
       preventing cancer and aging.

  Vagal activation contributes to stop generalized inflammation.

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              Brain

              STRESS       Gut

    YOUTH

            Inflammation

Thank you for your attention

                patriz.dalessio@gmail.com
                          www.aisa-tx.com