REPORT 2021 - The Hospital Research Foundation

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REPORT 2021 - The Hospital Research Foundation
REPORT 2021
REPORT 2021 - The Hospital Research Foundation
Thank you for your support of
                                The Hospital Research Foundation Group.
                                      Together, we are having an

                                EVEN BIGGER IMPACT

                                                   SUPERCYCLE

                         We are proud to fund research and patient care activities at the
                           following hospitals and healthcare providers (and more):

 Royal     The Queen        Lyell       Jamie                   Flinders                       Women's and
                                                   Modbury                 South Australian                  Noarlunga
Adelaide    Elizabeth      McEwin     Larcombe                  Medical                         Children's
                                                   Hospital                Country Hospitals                  Hospital
Hospital    Hospital       Hospital    Centre                   Centre                           Hospital

                        We also provide funding for lifesaving clinical and scientific research
                                at the following research institutes and universities:
REPORT 2021 - The Hospital Research Foundation
Table of contents
Thank You                          4   Infectious diseases                      52

Highlights                         6   Equipment                                53

Cancer                            10   Gut health and nutrition                 54
  Breast cancer                   12
                                       Inflammatory bowel disease               55
  Prostate cancer                 16
                                       Pregnancy and birth                      56
  Bowel cancer                    18
  Proton therapy                  20   Childhood disorders                      58
  Other cancers                   22   Creative health                          60
  The Longest Table               24
                                       Palliative care                          64
Gift of hope                      27
                                       Volunteers                               69
Under Our Roof                    28
                                       Mental health                            70
Heart disease                     30
                                       Military and Emergency Services Health   71
Stroke                            34
                                       Arthritis and pain                       74
Parkinson’s                       35
                                       Sleep                                    75
Dementia                          40
                                       Surgery                                  76
Aged care                         42
                                       Indigenous health                        77
Diabetes                          44
                                       Country health                           78
Kidney disease and pancreatitis   46
                                       Improving care for all                   80
Biospherix chamber                48
                                       How can you join the fight?              82
Partnerships                      49

COVID-19                          50

                                                                                     | 3
REPORT 2021 - The Hospital Research Foundation
THANK YOU

     Thank you for joining our mission for a healthy
     community and wellbeing for everyone
     With your generous support in 2021, you have brought
     hope to the many people fighting cancer, heart disease,
     dementia and more than 50 areas of medical research
     and healthcare. Thank you!

    Our promise to you:

           PRIVACY
           Always respect your privacy and never
           share your data with anyone.                                             100%
                                                                                    of YOUR
                                                                                    donation
           CONTACT
           Keep you updated on the impact and outcomes of
           your support, in the manner in which you prefer.
                                                                        When you give to THRF Group,
                                                                        100% of your donation, plus
           FEEDBACK
           Welcome your feedback at all times.
                                                                        more, goes directly to research
                                                                        and patient care grants!
                                                                        This is because our administration
           TRANSPARENCY                                                 costs are covered by our commercial
           Be open and transparent with how your gifts are used,        business activities which also boosts
           and use them carefully and cost effectively as you intend.
                                                                        our funds to research and patient
                                                                        care each year. So as a supporter,
            THANK YOU                                                   you can feel proud that all of your
            Always say thank you, no matter                             donation gets to the intended cause!
            how big or small your contribution.

4 | The Hospital Research Foundation Group Impact Report 2021
REPORT 2021 - The Hospital Research Foundation
THANK YOU

How you joined the fight
                                                        Donations
                                                        in Memory
31%   Gifts in Wills
                                                              Events

22%   Major Giving
      (donations over $5,000)
                                            Monthly
                                            Giving
19%   Community Fundraising
      (includes The Longest Table                                     Gifts
      and Mercer SuperCycle)                                        in Wills
                                      Individual

15%   Individual Giving
                                        Giving
                                                   Thank
                                                    you!
8%    Monthly Giving
                                          Community
                                          Fundraising
3%    Donations in Memory                                     Major
                                                              Giving

2%    Events

                                    Sadly though, a number of medical
                                    research and patient care projects
                                    miss out on funding every year.
                                    It is only together with your help that we can
                                    continue the fight for cures and improved
                                    treatments for our loved ones. We look forward
                                    to your ongoing support in 2022 and beyond.

                                                                                     | 5
REPORT 2021 - The Hospital Research Foundation
HIGHLIGHTS

    Disease doesn’t stop for COVID
    That’s why in 2021 we’ve been busier than ever fighting for your health!

                                     Proton
                                    therapy

                                           Breast cancer
                                         researcher A/Prof
                                            Phil Gregory

        $3.25 million for NEW
        cancer-fighting projects
        Announced a $2 million grant to the revolutionary
        Australian Bragg Centre for Proton Therapy and
        Research, plus many new projects in breast,
        prostate and childhood cancer.

        Services expand for                                  New grants for the
        Parkinson’s and stroke                               diseases most important
        A Clinical Nurse Consultant joined                   to YOU!
        the team, plus an additional Exercise
                                                             Provided translational grants which will
        Physiologist and Occupational
                                                             be patient-ready sooner in heart disease,
        Therapist! More activity groups and
                                                             dementia, aged care, mental health,
        wellbeing support are also available.
                                                             endometriosis and more!

                                    Nurse Jo Dalton           Dr Jiawen Li,
                                  (left) working with        heart research
                                       client Kate           grant recipient

6 | The Hospital Research Foundation Group Impact Report 2021
REPORT 2021 - The Hospital Research Foundation
HIGHLIGHTS

                                                                     More highlights >>>

COVID crisis support                            THRF Group's Paul Flynn
                                                with Dr David Panter, ECH
Organised gifts for frontline hospital staff,
plus care packs for families waiting in
lengthy testing lines. SA-based research
also continued, with a world-first ‘one year
later’ immunology study published.

                                                New partners
                                                joined the fight!
                                                Welcomed more corporate partners in
                                                2021 including ECH, Woodville West
                                                Torrens Football Club, Hither & Yon and
                                                the Adelaide 36ers, joining existing
                                                partners Drakes, Zorich Group and
                                                Scott Salisbury Group.

Support for grassroots
charities
Provided significant grants to grassroots
charities such as the Childhood Dementia
Initiative, HAS Foundation (palliative care),
                                                        Woodville West
Treasure Boxes (disadvantaged families),
                                                        Torrens Football Club
Taboo (period poverty) and more.

                                                                            Adelaide
                                                                            36ers

Greta (middle) lives
with Rett Syndrome

                                                                                           | 7
REPORT 2021 - The Hospital Research Foundation
HIGHLIGHTS

        Miniature horse                                          Biospherix Chamber
        service saved                                            built
        Secured the future of Nolton Park                        Opened a $1.4 million state-of-the-art
        Horses Healing Hearts pet therapy                        Biospherix Chamber to treat chronic
        service to bring comfort to people                       pancreatitis, cementing Adelaide as
        in hospitals, hospices and aged                          a leading centre of excellence for
        care facilities.                                         a unique pancreatectomy and islet
                                                                 transplant procedure.

                                   Kimberly
                                  Bartlett with
                                   miniature
                                  horse Moét

                                                                                  Professor Toby Coates
                                                                                 with pancreatitis patient
                                                                                       Chelsea Holloway

        Art prize inspired by healing
        More than 400 artworks were submitted for the
        inaugural Centre for Creative Health Art Prize,
        which had $51,000 in prizes available. All works
        focused on healing, with 40 finalists exhibited.

                                          Artist Jasmine Crisp
                                           with Ruby Allegra,
                                                and artist
                                            Ida Sophia (left)

8 | The Hospital Research Foundation Group Impact Report 2021
REPORT 2021 - The Hospital Research Foundation
HIGHLIGHTS

                                               Dr Sharon Mascall-Dare (left),
More support for                                   and the Invictus team

service members
The StoryRight and MindRight
programs were added to Military
and Emergency Services Health
Australia’s offerings, plus a
$250,000 grant secured the future
of the Invictus Pathways Program!

                                       Getting close to
                                       our community
                                       Launched new ‘Together.Fight.’ adverts,
                                       involving 100+ community volunteers!

World-first Parkinson’s                                          WATCH

projects                               Scan the QR code          VIDEO

                                       to watch the video
Developed a world-first app for
people with Young Onset Parkinson’s,
plus funded research to test spider
venom on live brain neurons to stop
degeneration of the disease.

                                                  We also loved meeting
                                                   you all at our events
                                                   throughout the year!

                                                                                 | 9
REPORT 2021 - The Hospital Research Foundation
CANCER                                                            Thanks to your
                                                                    donations
                                                                  our hard-working and
                                                                 passionate researchers
                                                                  can continue the fight
                                                                     against cancer.

10 | The Hospital Research Foundation Group Impact Report 2021
CANCER

 Everyone knows someone           In 2021, your support extended
 affected by cancer. In fact,     across many different cancers:
 nearly one in two Australians    • Breast cancer
 will be diagnosed with cancer    • Prostate cancer
 by the age of 85.                • Bowel (colorectal) cancer
                                  • Brain cancer
 The good news is that survival
                                  • Childhood cancers
 rates are improving, thanks
 to earlier diagnosis, better     • Leukaemia

 treatments and improved care     • Lung cancer

 that is only possible with the   • Neuroendocrine cancers
 support of people like you.      • Abdominal cancers
                                    (liver, pancreas, ovarian)
                                  • Oesophageal cancer
                                  • Multiple myeloma
                                  • Cancer treating equipment
                                  • Revolutionary proton therapy

Dr Zeyad Nassar and team

                                                                       | 11
CANCER

                                                           One in seven women
                                                                 in Australia face a breast
                                                                    cancer diagnosis in
                                                                      their lifetime.

    Breast cancer
    Breast cancer affects mostly women over 50 years old,
    however it is also the most common type of cancer in
    young women. Thanks to you, our dedicated researchers
    are working hard to find new breast cancer treatments and
    protect those most at risk of deadly forms of the disease.

    Your impact in 2021:

           Progressed work to improve the diagnosis                Educated women and influenced policy
           of triple negative breast cancer to                     about breast density and its implications
           enable earlier treatment options and                    for identifying breast cancer
           prevent the spread of this most deadly
           form of the disease                                     Explored a number of different inhibitors
                                                                   which show promise in blocking a protein
           Found new targets for chemotherapy-                     called Aquaporin 1, which has been proven
           resistant breast cancer, focusing on a                  to play a key role in helping breast cancer
           little-known protein called Basconuclin-2               cells moving to other parts of the body
           Helped identify whether other medications
                                                                   Designed future clinical trials to test a list
           often being taken by breast cancer
                                                                   of new and existing drugs which show
           patients will interfere with their cancer
                                                                   promise in changing an offending
           treatment
                                                                   hormone receptor from cancer-promoting
                                                                   to cancer-inhibiting
           Continued investigations into a protein
           called Creld2, which causes breast cancer
                                                                   Progressed investigations into a lesser-
           to develop and grow more quickly, and
                                                                   studied physical force experienced by
           discovering agents which can destroy or
                                                                   breast cancer cells known as compressive
           block this protein
                                                                   force, to find ways to slow, stop or reverse
                                                                   rapidly growing cancer cells.

                                                                                                 Central Adelaide
                                                                                                  Local Health
                                                                                                    Network

12 | The Hospital Research Foundation Group Impact Report 2021
CANCER

 Who your donations help!
 At only 36 years old, Michelle
 (pictured) fought a terrifying battle
 with triple negative breast cancer –
 the deadliest breast cancer type.

 Having supported her mum through
 the same battle a few years earlier,
 Michelle endured surgeries, chemo-
 therapy and an intense fear of leaving
 behind her four-year-old son, Nate.

 “I felt desperate and hopeless. I just
 needed somebody to fix me so I could
 stay here for my son,” she said.

 Fortunately, because of your support,
 researchers like Associate Professor
 Phil Gregory (right) are on the verge
 of an exciting breakthrough in the
 treatment of triple negative breast
 cancer, bringing hope to women like
 Michelle and her family! Thank you!

Do you understand what breast density is?
Dense breast tissue is normal and common,
but it can hide cancers and increase cancer risk.

Thanks to your donations, Associate Professor
Wendy Ingman has developed an animation to
help women better understand breast density and
how it can complicate mammogram screening.

                                                     Scan the
                                                    QR code to
                                                    watch the
                                                      video

                                          WATCH
                                          VIDEO

                                                                     | 13
CANCER

                                         “We can’t thank you enough for your support!
                                          Thanks to you, we’ve been able to continue our
                                          investigations into why breast cancer cells become
                                          resistant to chemotherapy and hope to use these
                                          insights to identify a new target for therapy or
                                          enhance the effectiveness of current therapies.”
                                           Dr Cameron Bracken,
                                           Centre for Cancer Biology

    Beverley’s loyal support
    Beverley is a long-term and loyal donor to
    The Hospital Research Foundation Group.

    And after a breast cancer scare in 2007, just
    before her 70th birthday, she saw firsthand
    how medical research can save lives.

    Thank you Beverley for your kind support!
    If you would like to join Beverley in the
    fight against deadly diseases, simply
    contact us on (08) 8244 1100
    or visit www.HospitalResearch.org.au

14 | The Hospital Research Foundation Group Impact Report 2021
CANCER

Fundraising in honour of a friend
Nicole Steigen was confronted with the stark        “Having just lost Tash, we knew it would be
realities of breast cancer when she lost her        a great opportunity to honour her memory
close friend Tash, who had also left behind a       and create awareness for breast cancer and
husband and two young children.                     raise funds for research. The dress code
                                                    was of course pink and on the day, it was so
"What hit home the most was if anyone could         rewarding seeing this massive sea of pink no
have fought off cancer, it would have been          matter which direction you looked.”
Tash. To watch her be taken so quickly, despite
all of the treatment she had undergone, was         If you would like to hold a fundraiser in
devastating," Nicole said.                          2022, we would love to hear from you!
                                                    Please contact us on (08) 8244 1100 or
Nicole decided she wanted to do something to        visit www.HospitalResearch.org.au
help so held a Ladies Day fundraiser at her local   to find out more.
Nedlands Rugby Union Football Club in Perth,
raising an incredible $2,200!

                              This lifesaving research is supported through our Group charity
                              Australian Breast Cancer Research, which is focused on the
                              prevention, detection, management and treatment of breast cancer.
                              www.AustralianBreastCancer.org.au
                                                                            a charity of THRF Group

                                                                                                      | 15
CANCER

                                                          One in six Australian men
                                                            will develop prostate cancer
                                                                 before the age of 85.

    Prostate cancer
    Advances in research have improved prostate cancer
    survival rates, however sadly 3,000 men still die each year
    from the disease. With your support, improving treatments
    and preventing the disease from progressing to advanced
    incurable stages has been a focus of our research.

    Your impact in 2021:
           Progressed pre-clinical work to improve               Started developing a unique prostate
           the performance of common prostate                    cancer ‘report card’ which outlines
           cancer medication Zytiga, to speed up                 the outcomes of various treatments to
           the drug’s digestion and enhance                      help patients make informed treatment
           absorption in the body                                choices upon diagnosis

           Explored how prostate cancer cells                    Designed clinical trials for an exciting
           become resistant to existing therapies, with          list of new and existing drugs which
           insights being used to identify biomarkers            show promise in changing an offending
           for patients who may respond best to a                hormone receptor from cancer-
           promising drug called Ribociclib                      promoting to cancer-inhibiting

           Progressed work on improving the early                Supported the South Australian Prostate
           detection of patients whose cancer is likely          Cancer Clinical Outcomes Collaborative
           to spread to advanced, incurable stages               (SA-PCCOC) database which now holds
           by establishing biomarkers which can                  data for more than 18,000 men to
           distinguish high-risk patients                        assist research insights and inform best
                                                                 approaches to care.
           Tested a new class of drugs called CDK9
           inhibitors in the hope they show promise in
           stopping prostate cancer from spreading

                                                                            Central Adelaide
                                                                             Local Health
                                                                               Network

16 | The Hospital Research Foundation Group Impact Report 2021
CANCER

                                                      Maggie’s fight for all the men in her life!
                                                      Dr Maggie Centenera’s research is driven
                                                      by a deeply personal link to the disease.

                                                      Sadly, her grandfather died with prostate cancer,
                                                      and her dad and four uncles all have prostate
                                                      cancer; which makes her very worried for her
                                                      brother and son who are at a much higher risk.

                                                      “During my dad’s cancer journey, his biggest
                                                      frustration has been that his doctors aren’t
                                                      definitive in how he should be treated,” she said.

                                                      “Prostate cancer patients are fortunate to have
                                                      a few treatment options and drugs available to
                                                      them, but it is currently unclear which would
                                                      work best for which patient.”

                                                      “My research will focus on identifying biomarkers
                                                      to determine which patients Ribociclib (a
                                                      promising new drug) will work best for, in order
                                                      for doctors to be better informed when making
                                                      treatment decisions and ultimately improve
                                                      survival rates for men with advanced prostate
                                                      cancer," Dr Centenera (below) said.

Kieran Anderson (above left) raised
                                                                                    “Thank you to all
an outstanding $3,680 for prostate                                                  the donors who are
cancer research by shaving his                                                      supporting my work!”
beard and hair in memory of his
best friend Patrick.
“We have known each other since we
were four years old. He died at 62 after
not picking up on the cancer early
enough and it spread to other parts of
his body,” Kieran said.

“I wanted to raise awareness of the
necessity to have physical checks on a
regular basis. Don’t just rely on blood
tests - whilst they can be a good guide,
you can’t beat the physical examination.”

                             These ground-breaking studies are supported through our Group
                             charity Australian Prostate Cancer, which is dedicated to the
                             detection, treatment and management of prostate cancer.
                             www.AustralianProstateCancer.org.au
                                                                              a charity of THRF Group

                                                                                                        | 17
CANCER

                                                           Bowel cancer (also known as
                                                          colorectal cancer) affects about
                                                                15,500 men and
                                                               women each year.

    Bowel cancer
    Worringly, half of all bowel cancer diagnoses will spread
    to the liver, where it is often unresponsive to current
    treatments. Thanks to you, we are improving awareness for
    screening, earlier diagnosis and better treatments to help
    prevent the disease progressing to these deadly stages.

    Your impact in 2021:
          Trialled a more personalised treatment                 Collaborated and analysed the outcomes
          approach to aggressive bowel cancer called             of thousands of bowel cancer surgery
          Total Neoadjuvant Therapy (pTNT) with                  patients to learn best practice for quality
          50 patients from across SA, Alice Springs,             of life
          Broken Hill and Darwin. This included
                                                                 Discovered the mechanisms responsible
          follow-ups and data capture, to improve
                                                                 for some bowel cancers progressing more
          outcomes for these patients
                                                                 rapidly than others, involving a protein
          Funded the Jodi Lee Foundation’s                       called ROCK and its recruitment of white
          awareness campaign and workplace                       blood cells to form invasive tumours
          prevention program to increase awareness
                                                                 Continued to build a biobank of liver
          in the community of the importance of
                                                                 metastatic bowel cancer tissue to analyse
          taking a bowel cancer screening test
                                                                 and identify biomarkers to help predict
                                                                 whether bowel cancer is likely to spread.

                                       Central Adelaide
                                        Local Health
                                          Network

                                    “Our research is very patient-centred and the first question
                                    we always ask ourselves when we’re thinking about a research
                                    project is – is there a direct benefit to the next patient we see?"
                                    Associate Professor Tarik Sammour,
                                    Royal Adelaide Hospital

18 | The Hospital Research Foundation Group Impact Report 2021
CANCER
“I was very lucky because
 even though the tumour was
 a decent size, it wasn’t very
 advanced and hadn’t spread to
 the gut or the lymph system.”

 How the poo test saved Clive’s life!
 Professor Clive Prestidge is a self-proclaimed
 “poster boy” for the poo test.

 Three years ago he received a positive result from     “I was very lucky though because even though
 the bowel cancer screening kit mailed to over          the tumour was a decent size, it wasn’t very
 50s, which triggered him to see his GP and have        advanced and hadn’t spread to the gut or the
 a further colonoscopy.                                 lymph system.”

 “I wasn’t worried at first because                     Now, having won his personal battle against
 those poo tests can bring a lot of                     cancer, he can continue the fight where he is
                                                        more comfortable – in the lab conducting world-
 false positives… but I got my results
                                                        leading cancer research. He also represented his
 back and they said they’d found a                      journey in our 2021 ‘Together Fight’ commercials.
 tumour in my bowel,” he said.
                                                        “Cancer diagnoses are unfortunately increasing,
 “My life was thrown completely upside down.            but with research, we can play a role in saving
 Three weeks later I was having surgery, a full hemi-   people’s lives. And that’s what ‘Together Fight’ is
 colectomy where I had half my colon removed.           all about,” he said.

                                                                                                              | 19
CANCER

    Proton therapy given $2 million boost
    Imagine being a young person with cancer in the brain or spine, and the
    best treatment option is only available on the other side of the world?
    Soon, this will be a thing of the past with Adelaide
    set to become home to the first proton therapy
    centre in the southern hemisphere.

    The Australian Bragg Centre for Proton Therapy
    and Research will transform the way cancer is
    treated, particularly for young people whose
    rapidly growing and developing cells are more
    susceptible to damage from radiation.

    Due to open in 2023, the facility will see about
    800 patients a year.

    And with your kind donations, The Hospital
    Research Foundation Group has contributed $2
    million to the centre’s critical start-up operations!
    Thank you!

    How does proton therapy work?                           Who will it benefit?
    Proton beam therapy is a type of radiotherapy           Nurse Kate Pagnozzi was
    that targets tumours with high-energy, positively       20 years old when she
    charged particles (protons). It is a more precise       discovered “out of the blue”
    alternative to X-ray (photon) radiation therapy,        she had a tumour the size of
    which is more commonly used to treat cancers.           a tennis ball in her brain.

    The precise nature of proton therapy, with the          Brain surgery removed 98% of the tumour, but 18
    ability to target cancer cells at a specific depth      months later she received the frightening news
    inside the patient, means there is less radiation       that the tumour was growing again. With options
    delivered to healthy tissue surrounding the             exhausted locally, Kate did her own research and
    tumour.                                                 found state-of-the-art proton therapy available in
                                                            the United States.
    This enables treatment with less side effects for
    paediatric, adolescent and young adult patients         “Having proton therapy in Adelaide
    and those with rare cancers.
                                                            will be a game-changer,” Kate said.
               Scan the QR code to see
               how proton therapy works
                                                            “People will no longer have to pack
                                                            their entire belongings and move
                                                            halfway across the world to access
                                                            this life-changing treatment.”
       WATCH
       VIDEO

20 | The Hospital Research Foundation Group Impact Report 2021
CANCER

What will the $2 million go towards?
Key medical specialists will be recruited as part     Some of the specialists have already started
of a $1.4 million grant over three years, including   (pictured above with Paul Flynn, THRF Group
a Clinical Project Manager, Medical Physicist,        CEO). They are thrilled to be part of the team
Radiation Therapist, Paediatric Medical               transforming the cancer treatment landscape
Oncologist and part-time Radiation Oncologist         in Australasia!
for the SAHMRI-based facility.

A further $628,000 over two years will establish
the Australian Proton Therapy Clinical Quality
Registry. The registry will collect and record
cancer treatment details and patient outcomes
from across the country, providing further
information on the types of cases that would
benefit from proton beam therapy.

  How you can help!
  Monthly giving is one of the simplest ways you can support                           Scan the QR code
  lifesaving research and patient care like revolutionary                                to learn more
  proton therapy. By choosing a tax-deductible amount to                  LEARN
  give each month, you will help provide a consistent stream              MORE

  of funding our researchers can count on!

  Learn more at www.HospitalResearch.org.au

                                                                                                       | 21
CANCER                                                             Cancer does not
                                                                    discriminate.
                                                                   It affects people of any
                                                                    age and background.

    Fighting rare and
    common cancers
    We are proud to fight against many rare and common cancers,
    across children and adults, to give hope through research, care
    and equipment to everyone suffering from these awful diseases.

    Your impact in 2021:
    Childhood cancers                                      Neuroendocrine cancer
    • Supported research into new therapeutic              • Supported the treatment and ongoing
      targets for young children with high-risk              evaluation of patients with neuroendocrine
      neuroblastoma, as an important alternative             tumours, including an important data registry
      to current toxic treatments which have side            which captures clinical and quality-of-life
      effects that often leave them with life-long           information on recipients of LuTate therapy.
      impairments
    • Started developing an online tool to enhance         Abdominal cancers
      routine follow-up care for children recovering       • Delivered six applications of pressurised
      from solid cancers and better manage their             intraperitoneal aerosol chemotherapy (PIPAC)
      ongoing quality-of-life assessments                    for patients with bowel, ovarian, stomach and
    • Completed important immune profiling for a             pancreatic cancers.
      new CAR T-cell therapy to progress to phase 1
      clinical trials in children with diffuse intrinsic   Lung cancer
      pontine glioma (DIPG).
                                                           • Continued research into ways to inhibit a family
                                                             of 14-3-3 proteins which are found in abnormally
    Blood cancers
                                                             high numbers in lung cancer cells.
    • Made significant findings in ways to starve
      cancer cells to death, particularly cancer           Brain cancer
      cells with IDH1 gene mutations such as IDH1-
                                                           • Continued pre-clinical trials on a new
      mutated leukaemia
                                                             CAR T-cell therapy for adults and children
    • Continued to investigate new targeted                  with relapsed Glioblastoma.
      therapies for acute myeloid leukaemia (AML),
      with promising results for a specific SK1            Indigenous cancer care
      enzyme inhibitor showing to kill AML cells
                                                           • Supported an Aboriginal Cancer Healing Centre
    • Recruited 80 newly-diagnosed multiple
                                                             to improve the uptake of services closer to
      myeloma patients to participate in a study
                                                             people’s home communities, their health and life
      focused on a protein called DSG2 which is
                                                             expectancy outcomes, with an evidence-based,
      thought to be overexpressed in patients with
                                                             cost-effective community-approved model.
      the poorest prognosis.

22 | The Hospital Research Foundation Group Impact Report 2021
CANCER

TQEH team saving lives: A/Prof Gabrielle Cehic AM,
Jessica Mercurio and Davina Nicholls

10 years of life-changing
cancer treatment
2021 marked 10 years of Lutetium Octreotate
(LuTate) therapy being available in South
Australia for people with neuroendocrine
tumours (NETs).

LuTate is a targeted internal radiotherapy
treatment for NETs, given intravenously (via a
drip) to help deliver a targeted high dose of
radiation directly to the cancer cells.

More than 177 treatments have been delivered
to patients at The Queen Elizabeth Hospital
during this time – helping people like Tayla
(pictured left), who was first diagnosed at just
12 years old, live a better life!

                                                     | 23
CANCER

                                                                   Thank you
                                                                    from our
                                                                 ambassadors

    The Longest Table
    raises $303,886
    Thank you to all of the outstanding Longest
    Table hosts who raised $303,886 for cancer
    research in 2021!

    Cancer doesn’t stop for COVID-19 and our
    passionate Forkstars held a fantastic array of
    events to #ForkCancer within their communities.

    Ambassadors Adelady and G-Fresh held their
    fourth consecutive event and raised an incredible
    $55,000!

    Loyal hosts Trish Fuss, Sarah Waldron and Michelle
    Mackman, along with first-time hosts Estelle Green
    and Erin Launer, each raised exceptional totals of                         Jo Lambrakis
    over $16,000 in honour of their loved ones.

    Thank you to everyone who participated! Big or
    small, your donation makes a huge difference to
    the cancer projects supported by The Hospital
    Research Foundation Group.

        You can help too!
        The Longest Table is THRF Group’s annual
        cancer fundraiser where you and your friends
        get together for a night of food, fun, friendship
        and fundraising to save lives from cancer.

        You too can host a Longest Table in 2022 – visit
        www.TheLongestTable.com.au to find out more!

24 | The Hospital Research Foundation Group Impact Report 2021
Cancer
Thank you to our outstanding
  Longest Table hosts who
raised a record $303,886 for
   cancer research in 2021!

                    Thank you to all
                    of our hosts!

                                | 25
CANCER

    Furry fighter
    Arlo comforts
    people with
    cancer
    Meet Arlo, one of our cutest
    and proudest ambassadors!
    Arlo is a cancer therapy dog who loves
    visiting patients and hardworking
    hospital staff to brighten up their day.

    He has already saved one life, that
    of his owner Nick, who recently
    battled an aggressive tongue and
    throat cancer which also took a
    big toll on his mental health.

    Now they work together to bring joy to
    people who are undergoing treatment
    for cancer.

    Arlo is becoming a huge celebrity
    in his own right – amassing a huge
    Instagram following at
    @arlo_the_cancer_service_dog

    He is also selling his own doggie
    bandanas to raise money for THRF
    Group! If you’d like to purchase a
    bandana or support Arlo’s fight,
    learn more at www.arlo.raisely.com

                         Scan to check
                         out the full Arlo
              SUPPORT
                          merch range
               ARLO

26 | The Hospital Research Foundation Group Impact Report 2021
HOPE
“I’ve been through quite a few health
issues myself and with our family, so
with this gift, maybe we can avoid a
few of these things in the future.”
Barry Hankins, 75, and wife Wendy

  The gift of hope for
  future generations
                                                                 “I see the value of medical research
                                                                 as clinical trials kept my son alive
                                                                 for five more years. I won’t always
  Leaving a gift in your Will is one of                          be here, so leaving a gift in my Will
                                                                 allows me to help future generations.”
  the most significant ways you can                              Sylvia Bridgman, 91
  have an impact on the health and
  wellbeing of future generations.
  A charitable bequest ensures you will be            You will also be joining our esteemed Basil
  remembered as someone who is committed              Hetzel Society, made up of generous and
  to helping others.                                  compassionate people like yourself who value
                                                      medical research.
  Your Will should always take care of your
  loved ones first. However after this, you may       People like Sylvia Bridgeman, Barry Hankins
  wish to leave a gift to The Hospital Research       and wife Wendy who are profiled above. As
  Foundation or the charity within our Group          members of our Basil Hetzel Society, they also
  you feel most connected to.                         enjoy special events throughout the year to learn
                                                      about the impact of their gifts.
  A gift of as little as 1% of your estate can make
  a big difference to lifesaving medical research     For more information about leaving a lasting
  and patient care in hospitals.                      legacy through a gift in your Will, speak to one of
                                                      our friendly team members on (08) 8244 1100.

                                                                                                            | 27
UNDER OUR ROOF

    Even more regional cancer
    patients helped in 2021
    More country cancer patients are being helped than
    ever before through our Under Our Roof accommodation!
    Four homes were available for the first
    time in 2021 thanks to the opening
    of two family-style apartments at
    Bowden, joining two existing homes
    at Woodville West.

    This allowed 20 cancer patients and
    their families or support networks to
    stay in 2021 – the most we’ve ever had!
    It brings the total number of patients
    helped since 2016 to 80.

    Under Our Roof offers family-style
    accommodation to country cancer
    patients travelling to Adelaide for
    their treatment.

    A huge thank you to the riders and
    support crew from the Mercer
    SuperCycle multi-day cycling event,
    who raised more than $2.8 million over
    10 years towards Under Our Roof. We
    couldn’t have done it without you!

       10 years, four homes and $2.8 million!

       That’s the incredible achievement
       of the team from Mercer SuperCycle
       – a multi-day charity bike ride around
       regional South Australia.

       More than $270,000 was raised in 2021
       – the ride’s 10th year – to bring the total
       to $2.8 million!

       Thank you to everyone who has made
       this possible! You are truly changing
       the lives of cancer patients and their
       families now and into the future.

28 | The Hospital Research Foundation Group Impact Report 2021
UNDER OUR ROOF

Cancer doesn’t stop for COVID
All four Under Our Roof homes were fully             Lisa was finishing her final week of treatment
occupied during South Australia’s COVID-19           when the lockdown hit, but was able to finish
lockdown in July 2021 – much to the                  her treatment and get a medical exemption to
appreciation of patients.                            travel home to be with her partner and three
                                                     daughters.
This included Mount Gambier mother Lisa
Hawkins who stayed in one of the new homes           “It’s such a stressor trying to think of a place to
in Bowden during her three-week radiotherapy         stay while dealing with a cancer diagnosis and
treatment for breast cancer, along with her          these homes definitely ease that burden for
sister Tracy for support.                            rural cancer patients,” Lisa said.

           Mercer House              Dr Jones & Partners House               Mercer Apartment

     These three homes are kindly supported by our sponsors:

                  If you would like to partner with us, chat to our friendly team on
                       (08) 8244 1100 or visit www.HospitalResearch.org.au

                                                                                                           | 29
HEART DISEASE

                                                                    Heart disease is Australia’s
                                                                   biggest killer, with someone
                                                                      dying from the disease
                                                                     every 12 minutes.

    Working hard to
    beat heart disease
    More than four million Australians live with a cardiovascular disease,
    with many of the risk factors preventable. Thanks to your support,
    we are working hard to stop you or your loved ones from falling
    victim to heart disease.

    Your impact in 2021:

         Progressed the development of the                           Continued to analyse sleep data in
         world’s smallest 3D printed catheter                        people with obstructive sleep apnoea to
         to improve the diagnosis of heart                           determine whether wearing a CPAP mask
         blockages in narrow arteries                                can reduce the risk of them developing AF,
                                                                     with promising early results
         Expanded a world-leading clinical
         trial into the care provided to people                      Continued managing a biobank to
         with atrial fibrillation (AF), through the                  enhance cardiovascular research
         ongoing delivery of a personalised and                      and identify biomarkers responsible
         integrated “iCare” clinic                                   for heart disease to aid more research

         Evaluated how many patients                                 Studied whether sub-clinical AF
         continue to experience chest pain                           is associated with risks of dementia
         after elective coronary stenting to                         and whether the screening guidelines
         gain important insights into best care                      for AF need to be adapted
         and avoid unnecessary complications
                                                                     Progressed research to identify predictors
         Assessed whether an aggressive                              for which patients are at risk of an
         approach to weight and lifestyle                            emergency tear in the aorta during surgery
         management can decrease AF                                  to greater inform treatment options
         symptoms and reduce hospitalisations
                                                                     Improved care and outcomes of patients
         Recruited participants to trial a diabetes                  with cardiac implantable electronic
         drug which shows promise in treating AF                     devices by investigating additional areas
                                                                     of service delivery and new technology.

                                              Central & Northern
                                                Adelaide Local
                                               Health Networks

30 | The Hospital Research Foundation Group Impact Report 2021
HEART DISEASE

New tech to find heart blockages
in narrow arteries
In a huge breakthrough for diagnosing heart
blockages, the world’s smallest 3D-printed
catheter is being developed to enable the
high-quality imaging of narrow arteries!

Thanks to your donations, we are proud to
be supporting teams from the University
of Adelaide and Royal Adelaide Hospital to
progress the micro-catheter technology
which will be able to detect cholesterol
crystals which accumulate in the fatty
plaques that form in heart arteries.

Designed by engineer and inventor
Dr Jiawen Li (pictured), the device could
be a game-changer in helping prevent
coronary artery disease!

                                                                     Thank you Zorich Group
                                                                     for fundraising for heart
                                                                     research in 2021!
                                                                     If you or your business would like
                                                                     to give back to a disease area
                                                                     close to your heart, contact us
                                                                     on (08) 8244 1100 or visit
                                                                     www.HospitalResearch.org.au

                              Our mission to beat heart disease is enhanced by our Group charity
                              Australian Heart Research which is focused on prevention strategies,
                              treatment and hospital care for patients with heart disease.
                              www.AustralianHeartResearch.org.au
                                                                               a charity of THRF Group

                                                                                                          | 31
HEART DISEASE

                                                        Do you experience heart palpitations
                                                        or shortness of breath?
                                                        If you do, you could be at risk of atrial
                                                        fibrillation (AF) – a dangerous heart arrythmia
                                                        characterised by a rapid and irregular
                                                        heartbeat, and causing issues such as
                                                        fainting, dizziness and chest pain.

                                                        Danny Daminato thought he was just unfit
                               WATCH
                                                        when he was often out of breath.
                             Danny’s story!
                                                        Instead, he was diagnosed with AF and
                                                        needed immediate surgery. He and wife Sandy
                                                        are now managing his condition through
                                                        lifestyle changes and regular check-ups.

                                         WATCH          Your donations are vital to helping us find new
                                         VIDEO
                                                        ways to treat and prevent AF to save the lives
                                                        of people like Danny. Thank you!

32 | The Hospital Research Foundation Group Impact Report 2021
HEART DISEASE
Landing the knockout blow against
atrial fibrillation!
Cardiologist Associate Professor Chris Wong
has spent a lifetime training for the fight –
the fight against deadly heart condition
atrial fibrillation (AF).

With you in his corner, he now has the
power to land the knockout blow!

He is conducting a clinical trial of a new drug
to treat AF’s common risk factors of high
blood pressure, excess weight and diabetes.

He hopes that by focusing on prevention,
rather than treatment, then the deadly
risks and complications arising from AF
will be eliminated.

He was also happy to give back and volunteer
his time for THRF’s 'Together Fight' campaign.

“Medical research benefits us all, we will all
be affected by disease at some point in life.
Volunteering was the least I could do for an
organisation that has supported researchers
like myself and others.”

                                                            | 33
STROKE

                                                                             One person
                                                                           has a stroke every
                                                                             10 minutes
    Stroke care, services                                                        in Australia.

    and research expand
    Stroke often attacks without warning, rapidly killing two million
    brain cells every minute and highlighting the huge need for
    support in stroke prevention, treatment and recovery.
    In 2021, we are proud to have increased our focus on stroke through a merger with Stroke
    SA. Our new division The Hospital Research Foundation Group – Stroke is committed to
    enhancing patient care, services and world-leading research for people impacted by stroke.

    In 2021, our care team and researchers:
         Provided allied health services                         Continued investigations on what causes
         (occupational therapy, counselling and                  Transient Ischaemic Attacks (TIA), or mini
         nurse consultations), specialised support               strokes, to develop a diagnostic test for
         groups, social activities, exercise and                 TIAs which could prevent a major stroke
         education sessions for people impacted
         by stroke and their support networks                    Progressed the Adelaide Stroke Incidence
                                                                 Study to identify stroke trends in Adelaide
         Participated in world-leading clinical                  and evaluate future care and resource
         trials which focus on stroke treatment in               allocation, recruiting 300 patients a year
         the hyper-acute phase using advanced
         clot-busting medication, as well as the                 Continued the investigation and optimal
         subacute phase, secondary prevention                    model of a regional stroke coordinator to
         and recovery                                            improve stroke outcomes in rural SA

         Investigated an algorithm for predicting                Prepared for a study involving therapy dog
         stroke recovery to assess whether it                    visits to the RAH’s Stroke Unit to improve
         would help allied health professionals                  the mood of stroke patients, their visitors
         provide optimal therapy for patients                    and stroke unit staff.

                                                             Central, Southern
                                                             & Regional Local
                                                             Health Networks

                              Together with our charity extension The Hospital Research Foundation
                              Group – Stroke, we are committed to improving the prevention, diagnosis,
                              acute treatment, care and ongoing support of people impacted by stroke.
                              www.stroke.org.au
                                                                                     a charity of THRF Group

34 | The Hospital Research Foundation Group Impact Report 2021
STROKE/
                                                                                              PARKINSON'S

Meet our
Stroke and Parkinson's allied health team!                                          To access these
                                                                                  services, please call:
For the first time, The Hospital Research Foundation Group is                             Stroke
expanding its scope to deliver allied health services to the community.              (08) 8352 4644
                                                                                       Parkinson’s
This includes occupational therapy, counselling and nurse                            (08) 8357 8909
consultations for people impacted by stroke and Parkinson’s.

            Olivia Nassaris                                      Tamika Perrott
            Executive Director                                   Social Worker

Olivia is a hands-on director, assisting clients in   Tamika provides counselling for clients and
their care and wellbeing and continually              their families, helping with trauma, stress,
improving the support and services on offer.          relationships, building confidence and wellbeing.

                                                                 Simone Ridge-Cooke
            Joanne Dalton
                                                                 Client and Community
            Clinical Nurse Consultant
                                                                 Engagement Manager

Jo offers clients a compassionate and holistic        Simone coordinates all our valued group
health assessment, culminating in a personalised      programs, such as art classes, singing groups,
care plan and ongoing advice and care.                and more both in Adelaide and across the state.

                     Christian Burden &                          Toby Yeung
                     Hannah Tavian                               Speech Therapist
                     Occupational Therapists

Christian and Hannah help maximise choice             Toby treats speech, language and swallowing
and independence through a complex                    challenges to help clients maintain their
assessment of client needs, service                   communication, relationships and overall wellbeing.
development and interventions.

                                                                          Tayla Haslam &
            Narelle Lee
                                                                          Sophie Edwards
            Wellbeing Officer
                                                                          Exercise Physiologists

Responsible for client education and support,         Tayla and Sophie love helping clients
Narelle assists clients to better manage their        achieve their fitness and cognitive goals
condition and access appropriate support.             through Brain x Body Fitness Studio’s
                                                      popular, evidence-based exercise programs.

                                                                                                           | 35
PARKINSON’S                                                   Did you know one Australian
                                                             is diagnosed with Parkinson’s
                                                                every three hours?

    Living well with Parkinson’s
    Parkinson’s can affect anyone, from all walks of life. But
    with the right team, you can live well with Parkinson’s!
    The Hospital Research Foundation Group – Parkinson’s (formerly Parkinson’s
    SA) is committed to providing support, education, services and research for
    those living with the progressive neurodegenerative disorder.

    In 2021, our care team and researchers:

         Provided allied health services                          Investigated whether faecal transplants
         (occupational therapy, counselling and                   can help ease the symptoms of Parkinson’s
         nurse consultations), specialised support                by improving people’s gut health and
         groups, social activities, exercise and                  addressing areas such as constipation
         education sessions for people living with
         Parkinson’s and their support networks                   Released a world-first app and website
                                                                  to support people with Young Onset
         Supported new research aimed at preventing               Parkinson’s (aged under 50) called YOP-X
         the degeneration of Parkinson’s by
         investigating whether spider venom can help              Established an SA-first MRI imaging
         restore and repair brain cell energy levels              centre which specialises in advanced
                                                                  F-DOPA scanning to facilitate research
         Progressed trials into Infrared Light Therapy            for Parkinson’s disease
         as a promising treatment for Parkinson’s to
         improve gut microbiome and symptoms                      Delivered health and wellbeing programs
         including balance, gait, cognition and fine              and specialised neuro-physiotherapy,
         motor skills                                             crisis counselling, wellness coaching
                                                                  and occupational therapy to people living
                                                                  with Parkinson’s and those on the NDIS
                                                                  in regional areas.

                                              Australasian   Central Adelaide
                                               Research       Local Health
                                                Institute       Network

                                     “The support from the whole team has been
                                     extraordinary. You couldn’t ask for a better service.”
                                     Kate, newly diagnosed with Parkinson’s

36 | The Hospital Research Foundation Group Impact Report 2021
PARKINSON’S

Can spider venom be used to treat Parkinson’s?
A cure or ways to stop the progression                 spend on the business-as-usual activities such as
of Parkinson’s is the holy grail of research           repairing themselves,” A/Prof Bardy said.
into the disease.
                                                       “Artificially raising the energy in brain cells is not
Now, thanks to your contribution to a global           easy, but what if we could give the cells a break
research and funding collaboration also involving      from too much activity? A few hours break each
the Michael J. Fox Foundation and Shake It Up          day could be enough to give these brain cells a
Australia, this holy grail could be one step closer!   chance to restore their energy levels and repair
                                                       themselves from all the extra work.”
Adelaide neurobiology expert Associate
Professor Cedric Bardy is leading a trial              This is where natural venoms come in, which
which aims to address the ‘tug of war’ that is         have shown to be full of ion channel modulators
experienced by the brain neurons of people with        that could be effective in re-prioritising cellular
Parkinson’s.                                           signalling.
“In Parkinson’s disease, fewer dopamine cells are      If successful, a therapeutic breakthrough
left behind to do the work of thousands of cells       that can slow down neurodegeneration in
that died too early. This in turn stresses those       Parkinson’s disease will change the lives of
remaining cells and gives them less energy to          millions of people worldwide!

                                                                                                                | 37
PARKINSON’S

    Brain x Body Fitness Studio
    The Brain x Body Fitness Studio at Unley is the
    first exercise physiology service of its kind to
    focus on body and brain health through exercise
    and encourage neuroplasticity.

    Neuroplasticity is the ability of the brain to
    grow and change in response to physical and
    mental activities throughout life. By consistently
    challenging the brain with exercise and fresh
    mental activities, the brain continues to
    restructure, rewire and build new connections
    – perfect for people with movement disorders
    but also anyone advancing in age.

    Run by our Parkinson’s team, it is particularly
    useful for people with a neurodegenerative
    disorder like Parkinson’s and those recovering
    from stroke.

    Want to become a member?
    Call 0499 088 725 or visit www.bbfs.com.au

    Good news! A new Brain x Body Fitness Studio
    will be opening in Woodville in 2022!

38 | The Hospital Research Foundation Group Impact Report 2021
PARKINSON’S

Brain and body fitness a game-changer
for Crows champion                                                       WATCH his
                                                                          journey
Adelaide Crows inaugural Club Champion
Mark Mickan knows the benefits of regular                    WATCH
exercise. But when he was diagnosed with                     VIDEO

Parkinson’s in 2016, he struggled to find the
motivation to stay active.

That was until he found the Brain x Body
Fitness Studio at Unley.

“It’s really special coming here,
everything’s geared towards your
own situation. This place has been
a saviour, not only for myself but for
everyone else who comes here too.”

   In the prime of his life
   As a father-of-two and successful school
   principal, Todd Murfitt was only 35 years
   old when he was suddenly diagnosed
   with Young Onset Parkinson’s (YOP).

   With no known family history of the disease,
   Todd had mistakenly attributed his initial
   tremors to stress and drinking too much coffee.

   “It's not easy to hear you've been diagnosed
   with what is commonly perceived as an ‘old            “An elderly person diagnosed with
   person's disease’, especially when you're in the      Parkinson's is in a very different stage of
   prime of your life,” Todd said.                       life compared to a person living with YOP.
                                                         The YOP-X app, which brings all of this
   There was a distinct lack of information
                                                         information together, will become a go-to
   available for people with Young Onset
                                                         resource for people with YOP.”
   Parkinson’s, so when Todd was asked to
   participate in developing the world-first YOP-X       Search YOP-X in your app store or visit
   app, he knew it would be life-changing.               www.YoungOnsetParkinsons.org.au

                                We’re proud to be providing support and information to people
                                living with Parkinson’s and other movement disorders, their carers,
                                family, community and health professionals through The Hospital
                                Research Foundation Group – Parkinson’s.
                                www.FightingParkinsons.org.au
                                                                                 a charity of THRF Group

                                                                                                           | 39
DEMENTIA
                                                       An estimated 472,000 people
                                                        live with dementia in Australia,
                                                           and a further 1.6 million
                                                          people care for someone with
                                                           the progressive condition.

    Helping our loved
    ones with dementia
    While the fight for a cure continues, research focusing on the
    prevention and care of people with dementia can also help
    the many families dealing with this devastating disease.

    Your impact in 2021:

         Supported a state-wide screening clinic                 Planned the upgrade of the Whittaker
         to allow South Australians at risk of                   dementia ward at Noarlunga Hospital
         dementia more access to clinical trials                 to provide a more adaptable space
         and early diagnosis                                     which caters for the special needs of
                                                                 people with dementia
         Helped people who are newly diagnosed
         with dementia to ‘take charge’ of                       Progressed the design of new trauma-
         their condition, with evidence-based                    informed guidelines to improve care
         interventions for the first few weeks and               in hospitals for people with dementia,
         months following diagnosis and also for                 reduce patient distress and prevent
         the long-term                                           challenging behaviours

         Commenced a project to help older                       Continued an evidence-based ‘Eat
         adults reduce their likelihood of getting               Walk Engage’ program in hospitalised
         dementia, including guidelines on sleep,                elderly people to improve their health
         diet and physical activity                              outcomes, particularly in regards to
                                                                 delirium and functional decline.
         Continued research into whether a
         common heart disorder is associated with
         a higher risk of dementia and whether
         screening guidelines need to be adapted

                                                         Central, Northern
                                                        & Southern Adelaide
                                                       Local Health Networks

40 | The Hospital Research Foundation Group Impact Report 2021
DEMENTIA

 Can you prevent dementia?
 Yes, according to the latest research!

 “How people use their time (ie. sleeping,
 sitting, being physically active) and what
 they eat can increase or decrease their
 future dementia risk,” Dr Ashleigh Smith said.           Dr Smith and her team are co-developing
 “Previously, these factors have been                     a ‘Your Best Day’ tool to be used by older
 considered independently – but they                      adults and their primary care team to
 are not independent. Instead, daily                      provide tailored, evidence-based and
 activity and diet interact with each                     personalised dementia prevention advice.
 other to influence dementia risk.                        Thank you for supporting this important tool!

New dementia screening
clinic improving care
Thanks to your support, a new state-wide screening
clinic is available for people to access the latest
dementia treatments and early interventions.

The SAHMRI-based clinic offers state-of-the-art
diagnostic scans, which can help detect people at risk
of Alzheimer’s 15 to 20 years before symptoms appear!

More than 100 people have already been screened
by the clinic, which is part of the national Australian
Dementia Network (ADNet).

THRF Group has provided a $106,000 grant to support
the clinic, where people undergo MRI and PET scans,
interviews, neuropsychological assessments, blood
collection and a discussion of personal results and a
potential referral to clinical trials.

Contact (08) 8128 4202 or
adnet@sahmri.com for more information.

                                                                                                          | 41
AGED CARE
                                                                         With people living longer, our
                                                                                 quality of life
                                                                               as we age has never
                                                                              been more important.

    Living your best
    life as you age
    Your support has been vital in helping fund
    projects which enhance the physical, social and
    mental health of older Australians and help reduce
    their time spent in hospitals or care. Thank you!

    Your impact in 2021:

         Supported older people’s transition                           Improved aged care residents’ access to
         from hospital to home through a trial                         rehabilitation following a hip fracture to
         at the RAH which delivers person-centred                      improve their long-term outcomes
         follow-up care after an unplanned
         presentation or admission                                     Investigated whether a Mediterranean diet
                                                                       can have a positive impact on the health
         Evaluated the care and services delivered                     of people in residential aged care
         by ECH’s new short-stay and respite Care
         Hotel to determine if it can prevent hospital                 Investigated the health economic
         admissions and improve patient outcomes                       implications of aged care quality
                                                                       and safety
         Continued to evaluate the wellbeing of
         people in aged care through the Registry                      Continued healthy ageing research
         of Older South Australians (ROSA),                            and developed a frailty-risk index to
         informing key policies within the Royal                       inform the equitable and effective
         Aged Care Commission                                          provision of health services.

                                                  Central & Southern
                                                    Adelaide Local
                                                   Health Networks

42 | The Hospital Research Foundation Group Impact Report 2021
AGED CARE

ECH partnership focusing on healthy ageing

In 2021, we were proud to begin a partnership
with ECH to pioneer new technologies and
models of care for older Australians.

At the heart of this is the evaluation of ECH’s
new Care Hotel at College Grove, Walkerville
(pictured above), which provides a range of
options for short-term care and respite needs.

The Care Hotel, named Dandelion, is the
first of its kind in Australia and aims to change
the landscape of how people can be supported
as they age.

Providing a similar experience to a hotel stay,
it has been specifically designed to challenge
the current limitations in existing care models,
minimise hospital visits and to empower and
treat people as individuals.

Do you or a loved one live in an ECH community
or use their services? Contact us on (08) 8244
1100 or visit www.HospitalResearch.org.au to
find out ways you can support this work.            THRF Group CEO Paul Flynn and ECH
                                                    CEO Dr David Panter

                                                                                        | 43
DIABETES                                                                   It is estimated
                                                                          280 people
                                                                  develop diabetes each day
                                                                   in Australia, contributing
                                                                  to one of the nation’s most
                                                                  concerning health issues.

    Reducing the
    diabetes burden
    With many serious health problems linked to diabetes, we are
    committed to finding new ways to treat and prevent diabetes
    and ultimately eliminate this disease from our community.

    Your impact in 2021:

         Continued making advancements in 3D                     Progressed insights into how ‘good
         printing islet cells for transplant into people         cholesterol’ or high-density lipoproteins
         with severe Type 1 diabetes, to avoid the               improved wound healing in diabetics
         reliance on a deceased donor
                                                                 Showed positive results in whether
         Found a promising new target to promote                 bitter supplements can reduce people’s
         blood vessel growth in people with diabetes             appetites and become a therapy for Type 2
         who are more prone to impaired wound                    diabetes and obesity
         healing and amputations
                                                                 Continued research into time restricted
         Discovered how telehealth can improve                   eating (also known as intermittent fasting)
         the treatment of chronic foot wounds for                and whether it can prevent Type 2 diabetes
         diabetics in rural and remote areas, to help
         reduce the disproportionately higher rates              Conducted important phenotyping
         of amputation in these areas                            work and community engagement to
                                                                 address diabetes inequality in Indigenous
         Discovered that low-calorie sweeteners                  Australians
         actually worsen blood glucose levels in
         patients with Type 2 diabetes, rather than              Continued studies into life-threatening
         alleviate them                                          diabetic ketoacidosis (when a person’s
                                                                 blood sugar is very high and acidic
                                                                 ketones build up to dangerous levels in
                                                                 the body) for people undergoing surgery.

                                             Central Adelaide
                                             & Regional Local
                                             Health Networks

44 | The Hospital Research Foundation Group Impact Report 2021
DIABETES

Did you know?
Worldwide, a limb is amputated every
30 seconds because of diabetes.

This is a very scary statistic, but one PhD
student Emma Solly (right) hopes to fix by
finding new ways to help the body grow
new blood vessels – a process which is
often hampered in people with diabetes.

Thanks to your support, she is targeting a
microRNA called miR-181c that has shown
promise in regulating blood vessel growth
but has not yet been tested in diabetes.

Home Lottery boosts funds
to research and healthcare
Thank you to all our ticket buyers
in The Hospital Research Foundation
Home Lottery!

Proceeds from the Home Lottery go
directly to funding medical research
and improved healthcare initiatives
across all public hospitals and
communities in South Australia.

You can feel proud knowing your
support makes a huge impact to
the health and wellbeing of our
community. Thank you!

                                                   | 45
KIDNEY DISEASE                                                        People with chronic
AND PANCREATITIS
                                                                   kidney disease face many
                                                                   life-long health battles.

    Better treatments for kidney
    disease and pancreatitis
    Kidney disease can be caused by genetic factors or conditions
    such as diabetes, pancreatitis and high blood pressure. Together
    with your support, we can enable new and better treatments to
    those suffering from these debilitating conditions.

    Your impact in 2021:

         Established a state-of-the-art Biospherix                  Investigated various diet recommendations
         Chamber in Adelaide to enable faster and                   to improve the overall gut health in kidney
         safer Total Pancreatectomy with Islet Auto                 transplant recipients and prevent diarrhoea
         Transplantation (TP-IAT) procedures to cure                immediately after transplant
         people of debilitating pancreatitis
                                                                    Finalised research into the prevalence of
         Supported women with kidney disease to                     hereditary pancreatitis and its gene profile
         overcome their challenges to become mothers                and will use these insights to lobby for
                                                                    TP-IAT to be added to the Medicare
         Delivered key milestones in research which                 Benefits Schedule
         aims to reduce the need for anti-rejection
         medications for transplant patients                        Discovered people who are deficient in the
                                                                    gene Nedd4-2 are more prone to kidney
         Progressed ways to improve the dialysis                    disease particularly when their salt intake
         experience for patients and support a                      is excessive.
         sustainable renal nursing workforce

                                               Central, Southern
                                               & Regional Local
                                               Health Networks

                                 As part of THRF Group, Kidney, Transplant & Diabetes Research
                                 Australia supports medical research aimed at developing new
                                 therapies to enhance organ transplantation, treat diabetes and
                                 kidney disease, and ultimately eliminate these diseases.
                                 www.KidneyDiabetesResearch.org.au
                                                                                      a charity of THRF Group

46 | The Hospital Research Foundation Group Impact Report 2021
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