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conferenceseries.com
Brain Injury 2018
7th International Conference on
Brain Injury &
Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Posters
conferenceseries.com Ashnaa Rao et. al, J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Tobacco abuse worsening outcome in neuromyelitis optica
Ashnaa Rao, Hemanth Rao and Rushil Shah
Johns Hopkins University, USA
N euromyelitis optica (NMO) is a severe inflammatory autoimmune disease of the central nervous system characterized by spinal
cord and optic nerve involvement. NMO is distinct from MS and its clinical course is typically characterized by exacerbations
and remissions without a progressive course. The treatment of NMO has focused on immunosuppression either acutely with
steroids or longer-term with chemotherapeutic agents or disease modifying therapies used in MS. We have done an analysis of 7
patients diagnosed with NMO followed by EDSS scores over a 24 month period of time and looked at comorbid conditions such as
hypertension, diabetes, dyslipidemia, alcohol and tobacco use. 3 out of the 7 patients were smokers, the smoking group started off
with higher EDSS scores (3.5) compared to the non-smoking group (2.5) and over a 24 month period of time had a greater decline
in their EDSS scores (smoking group - 5.5 and non-smoking group - 3.0). Other factors did not appear to correlate significantly
to EDSS scores initially or at the end of the 24 month period. This finding raises the possibility of reducing exacerbations and
worsening in the clinical course of NMO patients by using smoking cessation strategies. Further studies are required to confirm the
positive impact of smoking cessation on this group of patients.
Biography
Ashnaa Rao holds an Undergraduate Degree from Johns Hopkins University and will be completing her Master’s in May, 2018 from the Bloomberg School of Public
Health, Johns Hopkins University, Baltimore, Maryland. She has published several articles and is currently participating in several research clinical studies in the
field of Neurology including a large multicenter study on frontotemporal dementia.
ashark1@yahoo.com
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 56
conferenceseries.com Damla Anil, J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Effects of nesfatin-1 on rat model of Parkinson’s disease induced by 6-hydroxydopamine
Damla Anil
Marmara University, Turkey
P arkinson's disease (PD) is the second most common neurodegenerative disease which is characterized by dopaminergic neuronal
loss in substantia nigra pars compacta and a significant amount of dopamine depletion in the striatum. Peripheral use of nesfatin-1,
which is recently discovered brain-gut peptide showed anti-apoptotic and anti-inflammatory effects in rats with brain injury and
subarachnoid hemorrhage. Effects of nesfatin-1 on rat model of PD induced by 6-hydroxydopamine (6-OHDA) is not known yet,
however protective effects of nesfatin-1 was determined on the rotenone and MPTP-induced animal models of PD. In our study, we
aimed to examine the effects of nesfatin-1 on gastric emptying and neuronal damage in 6-OHDA-induced PD model in Wistar rats.
Unilaterally 6-OHDA-lesioned rats were treated daily with nesfatin-1 (1 μg/kg, s.c.) for 28 days. Locomotor activities and weight
loss were measured and apomorphine-induced rotational behaviour was assessed. At the end of the experiment, rats were decapitated
to determine gastric emptying rate and in another set of rats, brains, gastrointestinal tissues were evaluated histologically. Our results
indicated that altered locomotor activities and rotational behaviour in 6-OHDA-lesioned rats were reversed with the nesfatin-1
treatment (p
conferenceseries.com Jing Fu et al,, J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Novel lignan derivatives from the twigs of Cinnamomum cassia and their potential neuroprotective effects
Jing Fu, Guo Yuan Zhu, Zhi Hong Jiang, Xin Liu, Ji Yang and Xiao Jun Yao
Macau University of Science and Technology, China
C innamomum cassia Presl. (Lauaceace) has been used as flavor additive for foods and traditional medicine for thousands of years.
However, the bio-active compounds from Cinnamomum cassia are still not fully understood. In this study, a series of column
chromatographic methods monitored with UPLC-TOF-MS were applied to isolate the compouds from the twigs of Cinnamomum
cassia. Their structures were elucidated by NMR and HRMS spectroscopic data, calculated ECD and CD experiments analyses.
Furthermore, the neuroprotective activities were identified on endoplasmic reticulum (ER) stress-induced neural cell injure models.
As a result, 7 new α, β-diphenyl-γ-butyrolactones, 3 new lignans, 5 new neolignans, 2 new biphenylpropanoids and a new flavonol
glycoside-lignan ester, together with 43 known compounds were isolated from the twigs of Cinnamomum cassia, among which
compounds 11 and 12 are novel neolignans possessing a dioxetane ring. Pretreatment with compounds 11 and 12 significantly
reduced the ER stress-induced neuron cytotoxicity on SH-SY5Y cells. In conclusion, compounds 11 and 12 are new natural products
and may be developed as a new type of neuroprotective agents.
Biography
Fu Jing has worked in Macau Institute for Applied Research in Medicine and Health as research assistant since 2016.
jfu@must.edu.mo
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 58
conferenceseries.com
Brain Injury 2018
7th International Conference on
Brain Injury &
Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Accepted Abstractsconferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Clinical study on management of depression through Ayurveda
Aarti Sharma
Govindrakshak Ayurvedic and Acupuncture Resource center, India
D epression is very common mental health disorder which affects person’s way of thinking and behavior. The present study was
conducted at my clinic on sixty-three male patients between 40 to 45 years age who were clinically diagnosed of moderate
depression on the basis of Hamilton Depression Rating Scale. These patients were divided into three groups (A, B and C). They
were given Ayurvedic treatment along with psychological counselling. Group A had 20 patients who were prescribed Shavasan
and Anulom vilom pranayama. Group B had 17 patients who were given panchkarma treatment of Shirodhara in addition to above
mentioned yoga and pranayama. Group C had 25 patients who were prescribed two ayurvedic formulations namely Saraswatarishta
and Ashwagandharishta along with treatment prescribed to Groups A and B. These patients were clinically assessed after 7, 30, 60
and 90 days by Hamilton Depression Rating Scale. Results obtained after seven days, showed 15, 24 and 28 percent improvement
in group A, B and C respectively. The patients showed gradual improvement and their anxiety level decreased, their interest in life
increased. After one month, 35, 54 and 56 percent improvement in group A, B and C was observed. The patients exhibited more
positivity in thoughts with an improvement in sleep. After two months of treatment, patients in group A, B and C showed 50, 66
and 72 percent of improvement respectively. Their persistent sadness, feeling of guilt gradually reduced. After three months of
treatment, an improvement of 60, 72 and 84 percent, respectively was noticed in three groups. A remarkable improvement with
positivity in thoughts and feeling of happiness was noticed. Results obtained showed that mental health disorders like depression can
be effectively managed by Ayurveda along with psychological counselling.
govind8rakshak@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 60conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Benefits of acute intermittent hypoxia for treating spinal cord injury
Atiq Hassan
Avalon University School of Medicine, USA
M ost spinal cord injuries (SCIs) in humans and animals are incomplete and partial recovery arises as a result of plasticity within
neural circuitry. Many experimental therapies have been used to improve recovery after SCI, Acute intermittent hypoxia (AIH-
brief exposures to reduced O2 levels alternating with normal O2 levels) in one of them. AIH treatment elicits plasticity in respiratory
and non-respiratory spinal systems in experimental animals. AIH treatment has also been shown to improve walking abilities in
persons with chronic incomplete SCI. In this study, I have examined the effect of AIH treatment, alone or in combination with motor
training, on functional recovery and the effect of AIH on the expression of plasticity and hypoxia-related proteins in the spinal cords
of SCI rats. Rats were trained to cross a horizontal ladder and foot slip errors were measured before surgery, four weeks post-surgery,
each day of AIH treatment, and 1, 2, 4 and 8 weeks after treatment. AIH treatment consisted of 10 episodes of AIH: (5 min 11%
O2: 5 min 21% O2) for 7 days. Motor training +AIH-treated rats made fewer footslips on the ladder task compared to normoxia-
treated control rats after four days of treatment and this improvement was sustained for eight weeks post-treatment. Importantly,
AIH treatment + motor training also increased the expression of Hypoxia-inducible factor-1α, Vascular endothelial growth factor,
Brain-derived neurotrophic factor, tyrosine kinase B receptors and phospho-trkB in spinal motor neurons in SCI rats compared to
normoxia-treated SCI rats. Taken together with the promising findings from human SCI studies, the results of this study suggest that
AIH has potential as an effective therapy to restore motor function after nervous system injury.
atiqhassan@gmail.com
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 61conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Risk factors of stroke among young adults in Senegal
Daniel Gams Massi
Cheikh Anta Diop University, Senegal
S troke is a sudden and severe neurological disorder. Young adults represent 10-15% of stroke patients and this percentage is
increasing worldwide, especially in Africa. The aim of our study was to determine risk factor of stroke among young adults
received in our department. We conducted a two-year retrospective and analytic study in the neurosciences department of Fann
national teaching hospital in Dakar, Senegal from January 2014 to December 2015. Medical file of all stroke patients admitted for
stroke were recorded and we carefully selected young patients (≤45 years old). Analysis was performed using SPSS 23.0 software.
We enrolled 89 young adults among 651 stroke patients (hospital-based prevalence of 13.7%). The mean age was 36.6±7 years old
with 52% of male and 48% of female (sex-ratio of 1.1). We found 56% of cerebral infarct and 44% of intracerebral hemorrhage. The
main risk factors found were HBP (38.2%), Diabetes (3.4%), and sickle cell anemia (1.1%). In 58.4%, no risk factors were found.
Stroke was infrequent but not rare among young adults in Senegal. Cardiovascular risk factors especially HBP remained the most
frequent. Prevent these risk factors may contribute to reduce stroke frequency.
danny.gamsmassi@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 62conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Efficacy of Gutenbergia nigritana on manganism induced adult male mice
Fafure Adediran Adedamola
Afe Babalola University, Nigeria
Introduction: Manganese is an important element in the biological system. Excessive exposure may lead to a neurological disorder
known as manganism. Hence, checking the ameliorative effects of Gutenbergia nigritana on the neuronal integrity of the cerebellum
in motor deficit seen in maganism.
Methodology: Fifty adult male mice weighing between 25-30g were divided into five groups (n=10). Animals were given
Manganese only (Group A), Manganese first with later treatment with G. nigritana (Group B), concurrent treatment with manganese
and G. nigritana (Group C), G. nigritana alone (group D) and normal saline (group E). Manganese treatment was for seven days
administered intraperitoneally at the dose of 40mg/kg bw, while G. nigratana treatment was for 14 days and administered orally.
Motor coordination was assessed in the animals using rotarod and parallel bar test. Animals were later sacrificed by chloroform
inhalation, followed by transcardiac perfusion fixation; the region of cerebellum were dissected out, and fixed in 10% formal calcium
for 72 hours, then processed for H&E stain and CFV. Data were analyzed using ANOVA with Newman Post Hoc test when ANOVA
shows significant at pconferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Rain plasticity and cortical dysplasia in epilepsy: A common misconception for epilepsy surgery in children
Fred C C Peng
Taipei Veterans General Hospital, Taiwan
T his article is the second one in a series of two, following the publication of “Dementia in Epilepsy: A Clinical Contribution to
the Metabesity of Epileptology, Geriatrics and Gerontology” as the first one in which Metabesity regarding dementia in epilepsy
is included. This second article, therefore, discusses two things: The first one is the concept of brain plasticity clearly understood by
clinicians in neurology and neurosurgery as well as other neuroscientists throughout the world? And the second one is the objective
of making patients seizure-free sufficient to warrant epilepsy surgery of any form regardless of the post-operative consequences?
This second article was inspired or provoked by the results of epilepsy surgery in children reported extensively in Taipei by Dr. A
Simon Harvey of Melbourne, Australia, and the discussions which took place afterwards and during a lunch break with a female
neurologist. As a behavioral neuroscientist, I was horrified by the detailed visual illustrations of the surgical procedures, including
EEG and other vivid illustrations of MRI, especially the results of epilepsy surgery to remove multiple cortical dysplasias in children,
resulting in frontal lobectomy and/or hemispherectomy. I was also completely bewildered and dumbfounded during a lunch break
following the lecture in a casual non-provoked discussion with a pediatric neurologist and a female neurologist, whose erroneous
comments on brain plasticity triggered the incentive of presenting this article. For this reason, I shall discuss what brain plasticity
means and present a brief description of neuroanatony targeting the comments made after the presentation, as I was shocked to
become speechless while hearing the female neurologist to boast her knowledge regarding the aftermath of lobectomy and/or
hemispherectomy at the age of “seven” then corrected to “five” with no consequential deficits on account of brain plasticity. She
seemed to think that brain plasticity is something like food stored in a refrigerator, which can be taken out for consumption during
the age of five years. However, she added that adults are excepted because there is no more brain plasticity, that is, no more plasticity
(food) is left in the “refrigerator”. The pediatric neurologist sitting next to me was apparently also speechless. I then immediately got
the impression that brain plasticity is not at all clearly understood by clinical practitioners, not only in Taiwan but probably elsewhere
throughout the world. This article is intended to reveal such a situation in medical practice and to clarify at the same time what brain
plasticity means and what it entails anatomo-physiologically in neuroscience and to point out that any epileptic child or an adult
undergoing lobectomy or, worse, hemispherectomy for whatever pathological reason, will become a vegetable as a consequence
and the child will be short-lived for sure, thereafter, in spite of becoming seizure-free The choice by the parents between intractable
seizures of their epileptic child and the unforeseeable consequences of their child becoming a vegetable, in spite of being seizure-
free after the drastic surgery, is a very difficult one; once made, there is no going-back with regrets, as I shall show in this article.
ccpeng@vghtpe.gov.tw
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 64conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
The evaluation of correlation of amyloid peptides with imaging in the diagnosis of Dementia patients
Hariom Soni
Post Graduate Institute of Medical Education and Research (PGIMER), India
D ementia is a major health problem in elderly in both developed as well as developing countries including India. Alzheimer’s
disease (AD) and vascular dementia are the common causes of dementia among the elderly patients. In AD, pathology starts
with the formation of small, soluble oligomers of Aβ1-42 which on accumulation forms neuronal plaques which lead to the neuronal
death. Though there are several imaging and laboratory biomarkers available for the diagnosis of dementia patients but most are
invasive (CSF) and expensive and not readily available. So plasma sampling will be cheaper, less invasive and well suited for old
age patients. The present study used plasma level of amyloid peptides in the diagnosis of AD. We screened 152 old age patients
and enrolled 47 (>50yrs) demented patients and 33 healthy controls, who fulfilled the diagnostic criteria for dementia, AD and mild
cognitive impairment (MCI). Aβ1–40 and Aβ1–42 plasma level was estimated by ELISA kit. We had also done FDG PET scan of 17
AD, 12 MCI patients and correlate plasma amyloid peptide with PET scan. Aβ1-42 level was significantly high in AD patients as
compared to controls. We found a significant correlation with the FDG PET scan and the ratio of plasma amyloid peptides Aβ1–40 and
Aβ1–42 in the parietal association area, temporal association, frontal association, posterior cingulate and global average. So Aβ1-42
amyloid peptide by ELISA method can be used as an additional diagnostic biomarker in the dementia patients from the diagnosis of
Alzheimer’s disease.
hariom14780@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 65conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Risk of dementia/depression and associated inflammatory mechanisms in spinal cord injury
Junfang Wu
University of Maryland School of Medicine, USA
S pinal cord injury (SCI) research has focused on sensorimotor deficits, neuropathic pain and/or autonomic dysfunction. Although
not well appreciated clinically, SCI can cause cognitive impairment including deficits in learning and memory, executive
function, attention, and processing speed; it also commonly leads to depression. Although cognitive alterations have been discounted
as likely reflecting undiagnosed concurrent head injury (TBI), studies clearly show that SCI patients who present without a history of
TBI may develop cognitive decline and other neuropsychiatric abnormalities. Use of an anti-inflammatory drug in one recent clinical
trial improved mood after SCI. Yet, little basic research has addressed potential mechanisms for cognitive or affective disorders after
injury. We report that cognitive impairment in Y-maze, novel objective recognition, and step-down fear conditioning tasks were
increased in moderate and severe-injury mice that also displayed depressive-like behavior as quantified in the sucrose preference,
tail suspension, and forced swim tests. The potent microglial activator cysteine-cysteine chemokine ligand 21 (CCL21) was elevated
in the brain sites after SCI in association with increased microglial activation. Such inflammation is associated with greater neuronal
endoplasmic reticulum (ER) stress and reduction in the number of newly-generated immature neurons in the hippocampal dentate
gyrus. These findings indicate that SCI causes chronic neuroinflammation that contributes to neuronal loss, impaired hippocampal
neurogenesis and increased neuronal ER stress in important brain regions associated with cognitive decline and physiological
depression. Accumulation of CCL21 in brain may subserve a pathophysiological role in cognitive changes and depression after SCI.
junfang.wu@som.umaryland.edu
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 66conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Chronic smokers vs. non-smokers QEEG pattern, findings in surface maps and low resolution electromagnetic
tomography analysis
Laura García-Rueda, and Rubén Pérez-Elvira
1
NEPSA Rehabilitacion Neurologica, Spain
2
IFEN, Germany
Introduction: Smoking behavior is a public health problem. Nicotine and the other cigarettes substances behave like a psychotropic
medication in some sense. For the moment, there are not protocols to be followed in order to avoid the effect of nicotine and other
substances on the human EEG Analysis.
Aim: The aim of this study was to identify the QEEG surface and LORETA pattern in chronic smokers.
Method: The EEG of 20 young people (21-32-year-old) was recorded. Thirteen of them were smokers (65%) and 7 (35%) non-
smokers. In addition, Fagerström Test was completed by the smokers in order to control the addiction level.
Results: Significant differences were found between smokers and non-smokers. In both, surface and LORETA analysis, mainly in
Delta, Beta and Alpha bands.
Discussion: These findings are congruent with previous literature on this subject and they would be take in mind when clinicians run
a basic QEEG study, because tobacco seems to alter the normal EEG.
hariom14780@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 67conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Riboflavin: beneficial effects on neurological motor disability but not spatial learning and memory consolidation
in murine model of multiple sclerosis
Mahshid Naghashpour1,2 and Reza Amani3
1
Abadan School of Medical Sciences, Iran
2
Ahvaz Jundishapur University of Medical Sciences, Iran
3
Isfahan University of Medical Sciences, Iran
T his experimental study assessed the effects of riboflavin on motor disability, spatial learning, and memory in experimental
autoimmune encephalomyelitis (EAE). The C57BL/6 female mice (n=56) were assigned into seven groups: sham operated 1
(SO1), healthy mice received PBS (phosphate buffer saline); sham operated 2 (SO2), healthy mice received PBS and riboflavin;
sham treatment 1 (ST1), EAE mice received water; sham treatment 2 (ST2), EAE mice received sodium acetate buffer; treatment
1 (T1), EAE mice received interferon beta-1a (INF-β1a); treatment 2 (T2), EAE mice received riboflavin; treatment 3 (T3), EAE
mice received INFβ-1a and riboflavin. After EAE induction, scoring was performed based on clinical signs. By detecting score 0.5,
riboflavin at 10mg/kg of body weight and/or INFβ-1a at 150IU/g of body weight administration were started for two weeks. The
brain and spinal cord levels of brain-derived neurotrophic factor (BDNF) were studied using real-time PCR and ELISA methods.
Spatial learning and memory were assessed through the Morris water maze (MWM). BDNF mRNA expression and BDNF levels
increased significantly in the brain of T3 group compared to the T2 or T1 groups (Pconferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Serum levels of high molecular weight adiponectin and leptin in elderly patients with dementia
Samer G Hanna, Marwa A Saad, Mohamed A Mehanna and Dalia A Alneily
Alexandria University, Egypt
D ementia is a progressive impairment of cognitive function sufficient to cause functional decline. It may affect up to 28 million
individuals world-wide; 30% of those older than 85 years. Adiponectin is a cytokine released by the adipose tissue and presents in
the cerebrospinal fluid of human. It has important functions in the central nervous system. Leptin is another cytokine, was implicated
in cognitive decline and dementia processes. We aimed in the present study to determine the serum levels of adiponectin and leptin in
elderly patient with dementia. Sixty subjects aged 65 years and older were involved, divided into two groups; Group (I): 40 demented
patients, and Group (II): 20 age and sex matched healthy subjects as a control group. Participants with dyslipidemia, hypertension,
diabetes mellitus, chronic liver diseases, chronic kidney diseases, thyroid disorders or morbid obesity were excluded from the study.
All participants were subjected to MMSE and MOCA tests, serum adiponectin and leptin were measured. Serum adiponectin was
higher, while leptin levels were lower in demented patients. A significant negative correlation between serum levels of adiponectin
and both MMSE and MOCA scores, while a high positive correlation was noted between serum levels of leptin and both MMSE and
MOCA scores. We concluded that serum adiponectin and leptin were strongly associated with dementia in elderly patients, which may
help in understanding of its pathogenesis and emergence of new drugs for better outcome of this devastated disease.
drmarwasaad74@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 69conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Early endovascular treatment of ruptured brain aneurysms is directed against rupture of aneurysm
Mirza Khinikadze1,2,3
1
S. Khechinashvili University Hospital, Georgia
2
EVEX – Medical Corporation, Georgia
3
West Georgia Medical Center, Georgia
Introduction: Early endovascular treatment of ruptured brain aneurysms is directed against rupture of aneurysm, which can cause in
70% deep invalidation or lethality. Endovascular embolization of ruptured aneurysm practically excludes rupture. Early intervention
may enable a decrease in neurological disability and increase in good outcome.
Methods: It has been performed endovascular embolization on 45 patients, during year 2016, with diagnosis of acute subarachnoidal
hemorrhage. In all cases, embolization was performed during the first 72 hours after the rupture. Before operation, patient’s conditions
were assessment by Hunt-Hess scale. In compensation condition (By Hunt-Hess 1-2 point), 15 patients (33.3%), Sub-compensation
condition (By Hunt-Hess 3 points) 18 patients (40%) and decompensation condition (By Hunt-Hess 4 point) 12 patients (26.7%)
Results: After operation, mortality was 13.3% (6 patients) After operation, patients’ condition was evaluated by Glasgow Outcome
Scale (GOS)–GOS (5) 29 patients (64.5%), GOS (4) -6 patients (13.3%); GOS (3-2) -4 patients (8.9%).
Conclusions: In the case of acute subarachnoid hemorrhage, in respect to avoidance of rupture, urgent endovascular treatment is
indicated. Findings indicate, that early endovascular treatment improves outcome of the disease.
mirza-neuro@mail.ru
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 70conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Analysing emotions in speech signals through EEG brain images
Priyanka Abhang
Dr. Babasaheb Ambedkar Marathwada University, India
T he major objective of this research is to detect the variation of emotions appeared in speech signals using EEG brain images. The
area of brain (Motor cortex, Broca’s area, Wernicke’s area and Glia cell) are responsible for speech and various speech disorders.
The prefrontal, frontal, temporal lobes, are responsible for speech, emotions, planning, thinking and many more such tasks, these
differences in brain regions are seen during the experiments. The task paradigm was designed to acquire speech and EEG signal
simultaneously. The database for 10 subjects was studied. The acoustic features like pitch, energy and intensity were calculated using
PRAAT software, for analyzing EEG images, active brain electrodes and active brain area are being calculated using non-invasive
RMS EEG 32 channel 19 electrode machine. This study will be useful in research areas like emotion recognition, understanding
speech and language disorders with the help of EEG images.
priyanka.abhang@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 71conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Lyme disease qEEG pattern
Rubén Pérez-Elvira
NEPSA Rehabilitacion Neurologica, Spain
L yme Disease (LD) is an infectious disease caused by Borrelia. The most common sign of this infection is an area of redness on the
skin, and some symptoms like fever, headache, and tiredness usually could be present. Long term symptoms could include facial
palsy; join pain, severe headaches, heart palpitations and others. In addition to these symptoms, patients with LD could have some
cognitive impairment (neuroborreliosis). These cognitive manifestations involve: memory impairments, problems with language
comprehension and expression, lack of efficacy in visual processing, lack of speed of processing and problems with abstract reasoning.
We hypothesized that the qEEG patterns of these patients would be different to healthy volunteers qEEG patterns. Comparisons
were established between two groups (LD group and healthy volunteers). Significant differences were found in qEEG patterns. The
differential qEEG patterns in LD could be a tool for early detection of neuroborreliosis or cognitive impairments in these patients.
rubenperezelvira@gmail.com
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 72conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Lexical- semantic deficits in Sinhala speaking persons with post stroke aphasia: Evidence from single word
auditory comprehension task
D W M S Samarathunga and Nuwani Dharmarathne
University of Kelaniya, Sri Lanka
I n aphasia, various levels of symbolic language processing (semantics) are affected. It is shown that persons with aphasia (PWA)
often experience more problems comprehending some categories of words than others. The study aimed to determine lexical
semantic deficits seen in auditory comprehension (AC) and to describe lexical-semantic deficits across six selected word categories.
Thirteen (n=13) persons diagnosed with post stroke aphasia (PSA) were recruited to perform an AC task. Foods, objects, clothes,
vehicles, body parts and animals were selected as the six categories. Picture stimulus was adapted from the pictures developed by
Snodgrass and Vanderwart and a pilot study was conducted with five non brain damaged healthy adults to develop applicable test
materials. In the main study, participants were scored based on the accuracy and number of errors shown. Similar trends were reported
confirming literature that ‘animals’ to be the easiest category to comprehend and ‘body parts’ were most difficult. Mann-Whitney U
test indicated that no statistical significance was found between the errors and the type of aphasia reflecting similar patterns described
in aphasia literature on other languages. The current study indicates the presence of selectivity of lexical semantic deficits in AC
and a hierarchy was developed based on the complexity of the categories to comprehend by Sinhala speaking PWA, which might be
clinically beneficial when improving language skills of Sinhala speaking persons with post-stroke aphasia. However, further studies
on aphasia should be conducted with larger samples for a longer period to study deficits in Sinhala and other Sri Lankan languages.
dwms91@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 73conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
White matter microstructural abnormalities in amnestic mild cognitive impairment
Tatia M C Lee, Junhong Yu and Charlene L M Lam
The University of Hong Kong, China
S tudies that examined white matter alterations in amnestic mild cognitive impairment (aMCI) abound. We conducted this meta-
analysis on 77 studies. Among the many significant ROI-related findings, reliable FA and MD alterations in the fornix, uncinate
fasciculus, and Parahippocampal cingulum were observed in aMCI. Larger effects were observed in MD relative to FA. The ALE
meta-analysis revealed a significant FA decrease among aMCI subjects in the posterior corona radiata. These results provide robust
evidence of the presence of white matter abnormalities in aMCI. Our findings also highlight the importance of carrying out both ROI-
based and whole-brain-based research to obtain a complete picture of white matter abnormalities in aMCI.
tmclee@hku.hk
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 74conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
Epidermoid cyst located in the fourth ventricle: A case report
Wei-Yang Chen
Buddhist Tzu Chi General Hospital, Taiwan
T he case study begins with a 64-year-old woman with no significant past medical history was evaluated for dizziness and unsteady
gait for two months. There was no history of headache, vomiting, tinnitus, difficulty in hearing and limb weakness. Examinations
revealed no neurological deficit. Cerebellar signs were absent. Plain and CEMRI brain revealed an epidermoid cyst in the fourth
ventricle and anteriorly compressing the pons and medulla. The lesion also extends to bilateral foramens of Luschka. Through a
suboccipital craniectomy, the encapsulated epidermal cyst, developed from the fourth ventricle, could be totally removed without any
attachment to the floor of the fourth ventricle .The histopathological study showed capsular tissue rich in keratin and protein, findings
consistent with epidermoid cyst. There were no complications in the postoperative period and the patient developed clinically well
during follow-up of six months.
willyned55@gmail.com
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
Page 75conferenceseries.com J Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C1-027
7th International Conference on
Brain Injury & Neurological Disorders
April 10-12, 2018 | Amsterdam, Netherlands
A new experimental protocol for hemorrhage research using traumatic brain injury animal model induced by
controlled cortical impact
Youngmin Bu, Hyejin Joo, Jinhyun Bae, Yumi Bang, Junseon Lee, Byoung Dae Lee, Beomjun Lee, Jaewoo Park and Kyungjin Lee
KyungHee University, South Korea
T o date, the targets in TBI researches might be neuronal cell focused targets including neuronal apoptosis, neuroinflammation.
Whereas, another important phenomenon might be cerebral hemorrhage (Hrr) which, by itself, adversely affects the cerebral
vasculature and neurons by deleterious mechanisms and formed space occupying hematoma. However, there has been few researches
about those. Therefore, in the current study, we’d like to suggest new protocol for the evaluation of hrr in TBI model. Controlled
cortical impact induced TBI model was induced by impactor (Leica) with the set condition. Mice was fixed with transcranial perfusion
at 1, 3, 5 and 7 days after TBI. Mice head was decapitated and post-fixed for 24 hours. Brain was then isolated with the skull remained
and post-fixed again for 24 hours. Hrr was measured by image J (NIH) after taking photos in the middle of brain slicing using Cryocut.
Hemorrhage was occurred simultaneously with impact and located parietal cortex and the surrounding-area of hippocampus. The
color of the Hrr was bright red before 3rd day, but it turns to dark red color and formed hematoma after 3rd day. In addition, hemorrhage
reached peaked at 3rd day and then gradually decreased to normal range on the 7th day. We found that one natural compound of herbal
medicine increases the blood clearance at five days after TBI. In conclusion, the current method might be useful to investigate Hrr-
related pathological or pharmacological researches in the field of TBI.
ymbu@khu.ac.kr
Notes:
Journal of Neurological Disorders
ISSN: 2329-6895
Brain Injury 2018 Volume 6
April 10-12, 2018
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