FY 2020 Results presentation - February 25, 2021

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FY 2020 Results presentation - February 25, 2021
FY 2020
Results presentation
February 25, 2021
FY 2020 Results presentation - February 25, 2021
Agenda

Highlights                                                     4

Strategic priorities                                           7

Business update                                               13

Financials                                                    21

Outlook                                                       25

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021        2
FY 2020 Results presentation - February 25, 2021
Disclaimer

The shares of Evolva Holding (“Evolva”) are traded on the SIX Swiss Stock
Exchange (ticker: “EVE”).

This presentation may contain specific forward-looking statements, relating
to Evolva's future business, development and economic performance.
e.g., statements including terms like "believe", "assume", "expect" or similar
expressions. Such forward-looking statements are subject to known and unknown
risks, uncertainties and other factors which may result in a substantial divergence
between the actual results, financial situation, development or performance of
Evolva and those explicitly or implicitly presumed in these statements.

Against the background of these uncertainties, readers should not rely on
forward-looking statements.

Evolva assumes no responsibility to update forward-looking statements or to
adapt them to future events or developments.

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                           3
FY 2020 Results presentation - February 25, 2021
Highlights

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021   4
FY 2020 Results presentation - February 25, 2021
Significant increase in customer demand for
Health Ingredients and product expansion
                                                               •       Total order intake exceeded CHF 10m for the first time (+71%
                                                                       over 2019 with an order backlog of CHF 3.6m) with market gains
                                                                       across segments. Strong momentum in Health Ingredients with
                                                                       growing demand for resveratrol
                                                               •       Organic sales growth of 18% over prior year – significantly
                                                                       behind potential due to delays in manufacturing and sluggish
                                                                       demand in Flavors and Fragrances
                                                               •       Further progress in portfolio expansion. After nootkatone in
                                                                       Health Protection, the launch of L-arabinose was a further
                                                                       important step in growing our health offering
                                                               •       Planned updates of CMO network completed, but scaling up
                                                                       of manufacturing resveratrol at new CMOs delayed as the
                                                                       pandemic continued
                                                               •       Extraordinary costs of CHF 3.6m mainly related to scaling up
                                                                       manufacturing driving reported EBITDA loss of CHF 16.7m
                                                               •       On comparable basis, product-based EBITDA loss adjusted for
                                                                       extraordinary costs1) reduced to CHF 14.1m from CHF 18.4m in
                                                                       2019
                                                              1)   EBITDA excluding revenues and expenses from R&D contracts and adjusting for extraordinary costs
© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021        related to delays in scaling up manufacturing at new CMOs and increase of DTRA accrual          5
FY 2020 Results presentation - February 25, 2021
FY 2020 Highlights
                                                                            EBITDA
Product revenue                                       0                                                      Cash
                                                      -5
CHF 6.5m, +18%                                      -10                                                      CHF 19.7m
                                                    -15                 -12.3
Order backlog of CHF 3.6m                           -20        -16.7
                                                                                        -14.1                Available unused financing
                                                                                                 -18.4
(at the end of December 2020)                                 EB ITDA r eported     EB ITDA p roduct-based   lines of CHF 14m
                                                                         FY 2020   FY 2019
Accelerated order momentum
positively influencing H1 2021
                                                    Product-based EBITDA improved excluding
                                                         extraordinary costs of CHF 3.6m

                                                                 Product innovation
                                                      Multiple new product variants launched, such as        L-Arabinose successfully
     New products in the pipeline                   Veri-te Aqua™ and Evevalencene 94%™. Progress in          launched end of 2020
                                                    developing end user applications with NootkaShieldTM

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                               6
FY 2020 Results presentation - February 25, 2021
Strategic priorities

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021   7
On track to achieve strategic mid-term targets

Sustainable innovation                                  Productivity                         Profitable growth

• Registered nootkatone with                            • Planned updates of CMO             • Successfully leveraged
  EPA as first novel active                               network completed                    market segment-specific
• Launched L-arabinose                                  • Scaling up of manufacturing          commercial approach
  in late 2020                                            of resveratrol delayed             • Expanded product portfolio
• Signed new agreement with                             • Initiatives implemented at           and significantly grew
  IFF on vanillin                                         CMOs to support future growth        customer demand
• Launched several important                              at positive product margins        • Clear differentiation from
  product variants expanding                            • Strengthened organization by         competition
  our ingredient systems for                              attracting and developing talent   • Increased scalability across
  resveratrol and valencene                                                                    the organization

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                   8
Move towards a commercial company
with a product-based revenue model
                                Revenue FY 2019                                                           Revenue FY 2020
                                                                                                                 0.6
                                                                                                           0.4

                           4.1
                                                 5.5
                                                                              Growth                                   6.5
                                                                             product
                                                                             revenues
                                      2

              Product Revenue    R&D revenue (excl. BARDA)   BARDA revenue              Product Revenue    R&D revenue (excl. BARDA)   BARDA revenue

                47% product-based revenues (CHF 5.5m);                                         87% product-based (CHF 6.5m);
                      53% discretionary projects                                                  13% discretionary projects
© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                                            9
Attractive addressable markets across products
                              Market
                              share
                                  4

                                High
                                                                                                                                        Nootkatone, F&F
                                  3                                                                                                     (7/12-15%)

                             Medium                                                                                                     Resveratrol, Health Ingredients
                                                                                                                                        (60/+10%)

                                  2

                                 Low                                                                                                    Valencene, F&F
                                                                                                                                        (16/12-15%)
                                                                                                                                                                 Vanillin, F&F
                                  1                                                                                                                              (48/6-7%)
                           Market yet                                                                                                    L-Arabinose, F&F (F&B) / Health Ingredients
                        to be opened                                                                                                     (ca. 250/>5%)
                                                                                                                                                                  Nootkatone, Health Protection
                                                                                                                                                                  (300-350/6-7%)
                                  0
                                      2013     2014     2015     2016      2017     2018     2019      2020     2021     2022      Year of
                                                                                                                                   launch

                                        Note:
                                        • Bubbles indicate current size of addressed market and the year generating first product revenues
                                        • Numbers in brackets indicate addressed market size in CHFm and CAGR

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                                                                                 10
Progress in scaling-up manufacturing to support
future growth at positive product margins
                                                                               “Initial” CMO              “Commercial-scale” CMO
                                                                                       Recurring                           Recurring        Commercial
Business segment       Product       Revenue model       Development   Scale up                            Scale up
                                                                                      manufacturing                       manufacturing       sales
Flavors &
                       Valencene     Product sales            ü           ü                    ü               ü               ü             since 2019
Fragrances
                       Nootkatone    Product sales            ü           ü                    ü               ü               ü             since 2015
                                                                                                                                              initial: 2014
                       Vanillin      Product sales            ü           ü                    ü             2021           2021/2022
                                                                                                                                          full-fledged: 2022
                       L-Arabinose Product sales              ü        on track         Q2/Q3 2021         2021/2022          2022         from late 2020
Health Ingredients     Resveratrol   Product sales            ü           ü                    ü          taking longer     Q2 2021          since 2014
                       L-Arabinose Product sales                        see information under Flavors & Fragrances                              2022
Health Protection      Nootkatone    Product sales            ü            ü             Q4 2021               ü              2023           2021/2022
Other                  Stevia        Royalties                ü            ü                   ü               ü               ü             since 2018

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                                                 11
Evolva focused on overcoming manufacturing
and supply chain challenges in 2021

  Challenges                                                  Measures
  •     COVID-19                                              ü Finding effective modus operandi with
  •     Integration and setting up of new                       CMOs during pandemic
        manufacturing equipment to support                    ü Hired leader for Operations function with
        significant growth                                      a solid background in biotechnology and
  •     Processes to scale up made even more                    manufacturing
        demanding during the pandemic                         ü Increase of resources in Operations function
                                                                to provide additional support in optimizing
                                                                and scaling up processes at CMOs

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                    12
Business
update

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021   13
Our key business segments

FLAVORS & FRAGRANCES                                      HEALTH INGREDIENTS                        HEALTH PROTECTION
We provide nature-based flavors and                       We provide nature-based dietary           We offer nature-based products with
fragrances’ ingredients such as                           supplements’ ingredients that can         high efficacy that can protect health-
nootkatone, valencene and vanillin.                       contribute to the health and wellbeing.   conscious consumers globally.

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                                  14
Flavors and Fragrances: Lower demand related
to COVID-19 impact
New product variant:                                  •       Lower sales growth related to the pandemic,
Valencene 94% is                                              especially for applications in beverages and fine
Evolva’s highest purity                                       fragrances. Situation expected to continue at least
natural valencene meeting                                     for H1 2021
the Flavouring Regulation                             •       Launched three new product variants – including
(EC) No. 1334/2008’s                                          Valencene 94% – to meet customers’ needs and to
minimum purity level of                                       expand addressable market
94%.
                                                      •       Also launched innovative product, L-arabinose, at the
                                                              end of 2020 (with growing supply volumes from Q2/Q3
                                                              2021)
                                                      •       Good progress in optimizing vanillin for expanded
                                                              commercialization in future years

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021
Health Ingredients saw significant uptake in
customer demand
New product variant:                                  •       Growing demand for resveratrol, which has been
                                                              boosted by the pandemic due to different tangible
Veri-te Aqua™ is a
soluble resveratrol                                           health benefits demonstrated in clinical studies
addressing market needs                               •       With more than 13’000 published studies, resveratrol
especially in functional                                      is one of the most studied molecules
beverages, for a
completely transparent                                •       The results of studies, including RESHAW
and fully solubilized                                         (Resveratrol Supporting Healthy Aging in Women)
resveratrol solution.                                         significantly increased interest in resveratrol. This
                                                              includes global healthcare companies and FMCGs
                                                      •       After launching Veri-te Aqua™ in 2020, launch of
                                                              L-arabinose, a natural sugar blocker

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021
L-Arabinose, a natural sugar blocker and
reducing sugar
•    L-Arabinose is a natural sugar blocker for application in food and   • Made by fermentation
     beverages. Studies show that L-arabinose as a sugar blocker can      • Fully renewable and
     support healthy blood sugar levels and weight management.              sustainable
     Further, it has potential application as a prebiotic.                • High-purity level (>99%)
                                                                          • No hydrochloric acid
•    L-Arabinose is a reducing sugar frequently applied in the              used in the
     production of maillard reaction flavors, which are a key building      manufacturing process
     block for savoury flavors such as chicken and beef. L-Arabinose      • FEMA GRAS approved
                                                                            for use in food and
     may also contribute to bakery products by improving crust and          beverages
     crumb structure and preventing premature staleness.

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                            17
L-Arabinose mode of action as a sugar blocker:
Inhibition of sucrase¹
    Studies demonstrated that L-arabinose selectively inhibits intestinal sucrase activity –
    Resulting in lower levels of glucose in the blood after sucrose ingestion

                                                                                                                  Lower levels of
              Sucrose                              Fructose        Glucose                 Glucose                glucose in the
                                Sucrase                                                                           blood

    Usual breakdown of sucrose (common sugar) into fructose and glucose –
    Resulting in glucose uptake into the blood

                                                                                                     Absorption   Elevated levels of
              Sucrose                              Fructose        Glucose                Glucose                 glucose in the
                                Sucrase                                                                           blood

    1)
         Sucrase is the intestinal enzyme that breaks sucrose into fructose and glucose

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                            18
Health Protection: US EPA registration of
nootkatone as a novel active ingredient
Nootkatone is an ingredient                            •      US EPA registration of nootkatone in August pivotal step
found in minute quantities in the                             on this product’s regulatory path
bark of the Alaska yellow cedar
and in the skin of grapefruit.                         •      Ten-year exclusivity in an estimated USD 350m US market
It has been tested against a
variety of biting pests, including                     •      Investment in the development and registration
the ticks that are responsible for                            of own formulations
spreading Lyme disease and
mosquitoes.                                            •      To register consumer products, submission of registration
                                                              package (efficacy, safety and product characterization)
                                                       •      First sales expected in 2022 as formulation work being
                                                              delayed due to the pandemic
                                                       •      Expansion beyond US to countries based
                                                              on US regulatory approval

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021
Other products: Royalty income from
EVERSWEET™ expected to grow over time
EVERSWEET™ is a calorie-                               •      Evolva receives royalty payments on all EVERSWEET™ sales
free stevia sweetener. Not only
does it deliver a high-quality                         •      The first commercial-scale production of EVERSWEET™
sweetness profile, it’s also                                  has started on November 14, 2019 at Cargill's fermentation
sustainable.
                                                              production facility in Blair, Nebraska, USA
                                                       •      Registrations of EVERSWEET™ in US and Mexico
                                                              (more markets expected to follow soon)
                                                       •      Positive momentum with customers
                                                       •      Based on this, Evolva anticipates its royalty income to
                                                              grow over time

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021
Financials

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021   21
Key Figures
                                                                                                             1)   Including extraordinary
                                                  FY 2020             FY 2020     FY 2019          FY 2019        costs related to delays in
in CHF million                                   Reported       Product-based    Reported    Product-based        manufacturing of CHF
                                                                                                                  2.9m
Order backlog                                             3.6             3.6         0.4              0.4   2)
                                                                                                                  Increase of DTRA accrual
                                                                                                                  by CHF 0.7m
Product revenue                                           6.5             6.5         5.5              5.5   3)   Capitalized development
                                                                                                                  expenses in 2019 in an
R&D revenue                                               1.0                -        6.1                -        amount of CHF 2.7m have
                                                                                                                  been reclassified to cash
Total revenue                                             7.5             6.5        11.6              5.5        flow from investing
                                                                                                                  activities
Gross profit                                             -1.9           -2.61)        5.4             -0.7
Gross profit excl. e.o. costs1)                                           0.3                         -0.7
Total operating expenses                               -14.8           -14.82)      -17.7            -17.7
EBITDA                                                 -16.7            -17.7       -12.3            -18.4
EBITDA excl. e.o. costs1)                                               -14.1                        -18.4
Operating cash flow                                    -23.4                       -11.43)
Cash (end of period)                                    19.7                         39.9

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                               22
Product-based EBITDA excluding extraordinary
costs significantly improved
                                             Product-based EBITDA
 in CHF million
                                             excl. extraordinary costs

     -12,3
                        6,1                                           -14,1         2,9
                                                              4,3
                                                                                                  0,7            1,0         -16,7
                                        -18,4
   FY 2019           FY 2019          FY 2019       Organizational   FY 2020       Costs       Increase of     FY 2020      FY 2020
   Reported          EBITDA           Product-       efficiencies    Product-    related to   DTRA accrual     EBITDA       Reported
   EBITDA          contribution        based                          based       delays in                  contribution   EBITDA
                    from R&D          EBITDA                         EBITDA     manufacturing                 from R&D

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                            23
Operating free cash flow in line with guidance
                                                                            FY 2020                         FY 2019
in CHF million                                                             Reported                        Reported
Cash position at beginning                                                         39.9                            60.4
Cash flow from operating activities                                               -23.4                         -11.51)
Cash flow from investing activities                                                 -5.6                          -8.12)
Cash flow from financing activities                                                8.83)                            -0.9
Cash position end of period                                                        19.7                            39.9

1)   Capitalized development expenses in 2019 in an amount of 2.7m CHF have been reclassified to cash flow from investing activities
2)
     Cash flow from investing activities in 2019 including contractual obligations to EVERSWEET™ of 5.2m CHF
3)   Cash flow from financing activities in 2020 mainly reflects 3 tranches of the agreement for the issuance and subscription of convertible notes
     with Nice & Green SA

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                                                                                           24
Outlook

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021   25
2021 Outlook

As the pandemic continues, the guidance assumes there will not be a return to normal
for most of the year. Evolva expects ongoing growing demand for Health Ingredients,
but sluggish demand in Flavors and Fragrances.

Supply volumes are expected to gradually increase in the course of 2021 as a result of
the emphasis on overcoming manufacturing challenges – especially for resveratrol –,
with a larger contribution to sales and profit in the second half of the year.

The extraordinary costs related to scaling up manufacturing of resveratrol and L-
arabinose are in total estimated CHF 6.1m in 2021. Nevertheless, EBITDA is expected
to somewhat improve over prior year levels.

© EVOLVA 2021 FY 2020 RESULTS PRESENTATION 25 February 2021                              26
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