Sarcopenia e low grade systemic inflammation: quali interventi nutrizionali? Stefano Volpato - Tavola Rotonda Nutrizione e sarcopenia un continuum ...
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Tavola Rotonda
Nutrizione e sarcopenia un continuum bidirezionale
Sarcopenia e low grade systemic
inflammation: quali interventi
nutrizionali?
Stefano Volpato
Meccanismi biologici implicati nella sarcopenia
Cruz-Jentoft A J Lancet 2019
The origins of age-related proinflammatory state
Ferrucci L et al. Blood 2005;105:2294-9
Potential pathways linking inflammaging and sarcopenia
SARCOPENIA
Draganidis et al. J Nutr 2016;146:1940-1952
Change in muscle strength explains accelerated decline of
physical function in older women with high IL-6 serum levels
Ferrucci L et al. JAGS 2002; 50:1947–54
Change in muscle strength explains accelerated decline of
physical function in older women with high IL-6 serum levels
Ferrucci L et al. JAGS 2002; 50:1947–54
Inflammatory Markers and Loss of Muscle Mass and Strength
986 men and women older than 65 yrs; 3-years follow-up;
Loss of muscle strenght defined as loss >40% from baselline
Schaap L et al. Am Journal of Med 2006;119:52652e9-526.e17
Prevalence and Clinical Correlates of Sarcopenia in
Community-Dwelling Older People: Application of the
EWGSOP Definition and Diagnostic Algorithm
Volpato Set al. J Gerontol A Biol Sci Med Sci 2014;69:438-46
Inflammation and sarcopenia:
systematic review and meta-analysis
Forrest plot of serum high sensitivity C-reactive protein (CRP) in
sarcopenic vs. no sarcopenic subjects
Bano G et al. Maturitas 2017;96:10-15.
Inflammation and sarcopenia:
systematic review and meta-analysis
Forrest plot of serum IL6 and TNF-α in sarcopenic vs. no
sarcopenic subjects
Bano G et al. Maturitas 2017;96:10-15.Può l’intervento nutrizionale prevenire/trattare la sarcopenia
modulando lo stato infiammatorio cronico?
• Dieta Mediterranea
• Antiossidanti
– Vitamina E
– Carotenoidi
• Acidi grassi
• Proteine e aminoacidi
• Vitamina D
• ProbioticiFigure 3 Box 1Mediterranean diet in 9 points
Nutrition Reviews, Volume 75, Issue 6, June 2017, Pages 442–455Potential myoprotective mechanisms
of Mediterranean diet
Granic A et al. Nutrients 2019;11:E745Mediterranean Diet attenuates risk of frailty and sarcopenia:
New insights and future directions
McClure R et al. J of Chacexia Sarcopenai and Muscle 2017Mediterranean Diet attenuates risk of frailty and sarcopenia:
New insights and future directions
McClure R et al. J of Chacexia Sarcopenai and Muscle 2017Silva R et al. J Nutr Health Aging 2018;22:655-663
Lower Plasma Vitamin E Levels Are Associated With
the Frailty Syndrome: The InCHIANTI Study
Log (VE) was significantly related with lower extremity muscle
strength (r: 0.09, p < .006),
Blè A et al. J Gerontol Med Sci 2006 61: 278-83Low plasma carotenoids and skeletal muscle strength decline over 6 years
(InChianti Study)
Total carotenoids: α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxantihn , lycopene
Lauretani F et al. J Gerontol Med Sci 2008 63: 376-83Working mechanisms of omega-3 PUFAs on sarcopenia
Dupont J et al. Aging Clin Exp Res. 2019;31:825-836Potential mechanisms of action by which omega-3 PUFAs EPA and
DHA may influence skeletal muscle health and function
Stewart J et al. Mar Drugs 2015Interleukin-6 CRP
Custodero C. Aging Research Review 2018;46:42-59Effect of omega-3 fatty acid supplementation on
the muscle protein synthesis rate
Mixed skeletal muscle protein fractional synthesis rate (FSR), during basal, postabsorptive
conditions and during the hyperaminoacidemic-hyperinsulinemic clamp before and after 8
wk of supplementation with either corn oil (n = 7) or omega-3 fatty acids (n = 8).
Smith G et al. Am J Clin Nutr 2010;93:402-412Overview of interventional study on omega-3 PUFAs and
sarcopenia
Dupont J et al. Aging Clin Exp Res. 2019;31:825-836PutativePasini.
mechanistic link between
et al. Am J Cardiol,protein
2008 intake,
inflammaging and sarcopenia
Draganidis et al. J Nutr 2016;146:1940-1952Effect of protein intake on subsequent change in muscle strength over the follow-up
Lower protein intake was associated
with decline in muscle strength in
persons with high levels of inflammatory
markers
JAGS 2012;60:480-484Whey protein, amino acids, and vitamin D supplementation with
physical activity …in sarcopenic elderly
Rondanelli M. Am J Clin Nutr 2016;103:830-40Whey protein, amino acids, and vitamin D supplementation with
physical activity …in sarcopenic elderly
Rondanelli M. Am J Clin Nutr 2016;103:830-40Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis
Interleukin-6 CRP
Custodero C. Aging Research Review 2018;46:42-59Conclusioni • L’infiammazione sistemica è considerata uno dei meccanismi patogenetici fondamentali per lo sviluppo di sarcopenia • La relazione tra biomarcatori circolanti di infiammazione e presenza/insorgenza di sarcopenia è ancora incerta • Diversi nutrienti con effetto antiinfiammatorio sembrano avere un effetto protettivo sulla sarcopenia e/o su forza e massa muscolare • Sono necessari tuttavia più RCT per poter definire il reale meccanismo protettivo
You can also read
