Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...

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Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...
Update on COVID-19 Projections
  Science Advisory and Modelling Consensus Tables
                 February 11, 2021
Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...
Key Findings

• Public health measures are paying off in declining mobility, cases, positivity,
  and hospitalizations.
• Focussing vaccination on long-term care homes is paying off with declining
  daily deaths.
• ICU occupancy is flat and the access to care deficit continues to grow.
• The B.1.1.7 Variant of Concern is spreading. Cases will likely grow again in
  late February with ICU admissions increasing afterwards.
• Aggressive vaccination and sticking with stay-at-home order will help avoid
  a third wave and a third lockdown.
• Some key mental health indicators are unchanged. However, important
  measures such as emergency department admissions, opioid deaths and
  care for eating disorders are worsening.

                                                                                    2
Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...
Declines in mobility have helped reduce cases

                                                British Columbia
                                                Manitoba
                                                Alberta

                                                Quebec

                                                Ontario

                                                                   3
Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...
4   4
Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...
5   5
Cases and percent positivity declined across age groups.

                                                           6
Cumulative COVID-19 vaccine dose administrations
 (426,834 doses to Feb 10, 2021)
 Vaccine dose administrations
 Current status
                                                                                                                                                                                                Cumulative COVID-19 Vaccinations
 Since December 15, 2020, 426,834                                                                        450
                                                                                                                                                                                                                                                                                                                                426,834

                                                                                         Thousands
 vaccine dose administrations have                                                                       400
 been reported in COVax.
                                                                                                         350
 These administrations include Pfizer
                                                                                                         300
 and Moderna vaccines.
                                                                                    Doses Administered
                                                                                                         250
 92% of vaccine administrations have
                                                                                                         200
 been since Jan 1, 2021.
                                                                                                         150

                                                                                                         100

                                                                                                         50

                                                                                                          0

                                                                                                                                                                                                                                                                                                                                       01-Feb

                                                                                                                                                                                                                                                                                                                                                03-Feb

                                                                                                                                                                                                                                                                                                                                                         05-Feb

                                                                                                                                                                                                                                                                                                                                                                    07-Feb

                                                                                                                                                                                                                                                                                                                                                                             09-Feb
                                                                                                               15-Dec

                                                                                                                        17-Dec

                                                                                                                                 19-Dec

                                                                                                                                          21-Dec

                                                                                                                                                   23-Dec

                                                                                                                                                            25-Dec

                                                                                                                                                                     27-Dec

                                                                                                                                                                              29-Dec

                                                                                                                                                                                       31-Dec

                                                                                                                                                                                                02-Jan

                                                                                                                                                                                                         04-Jan

                                                                                                                                                                                                                  06-Jan

                                                                                                                                                                                                                           08-Jan

                                                                                                                                                                                                                                    10-Jan

                                                                                                                                                                                                                                             12-Jan

                                                                                                                                                                                                                                                      14-Jan

                                                                                                                                                                                                                                                               16-Jan

                                                                                                                                                                                                                                                                        18-Jan

                                                                                                                                                                                                                                                                                 20-Jan

                                                                                                                                                                                                                                                                                          22-Jan

                                                                                                                                                                                                                                                                                                   24-Jan

                                                                                                                                                                                                                                                                                                            26-Jan

                                                                                                                                                                                                                                                                                                                     28-Jan

                                                                                                                                                                                                                                                                                                                              30-Jan
                                                                                                                                                                              2020                         2021                                                                                                                                                   Source: COVAX

Data Source: COVax. Data to Jan 22nd extracted from COVax Dose Admin by Day Report. Jan
23rd-Feb 7th: COVax daily reports (Health Data Branch, MOH). Includes Pfizer and Moderna
vaccines. Excludes records where status is not known.

                                                                                                                                                                                                                                                                                                                                                                                      7
The majority of deaths arise from long-term care.

                                                    Analysis: COVID-19 ModCollab.   8
                                                                       Data: CCM+
Long-term care key indicators improved.

                                                    COVID-19 cases and deaths for LTC residents and staff
Current status                  2000

213 LTC homes have COVID-19     1800                 Daily Active Cases Residents

outbreaks (34% of all homes)    1600
                                                     Daily Active Cases Staff
with 90 outbreaks involving     1400
                                                     Cumulative deaths since Sept 1
resident cases.                 1200

25 of 34 PHUs have at least 1   1000

home in outbreak.               800

                                600
Since January 900 LTC
                 1st
                                400
residents and 3 staff have
died of COVID-19. Wave 2        200

deaths (1,821) now roughly        0
                                       Sep   Sep   Oct        Oct           Nov       Nov              Dec               Dec                 Jan             15-                   01-

equal to Wave 1 (1,848).                1     15    1         15             1        15                1                15                   1              Jan                   Feb

                                                                                        Data Source: Ministry of Long Term Care Tracker, Feb 8th extraction based on data reported up to 3:30
                                                                                        pm Feb 7th, 2021. Data are self-reported by the long-term care homes to the Ministry of Long-Term
                                                                                        Care. Daily case and death figures may not immediately match the numbers posted by the local public     9
                                                                                        health units (i.e. iPHIS database) due to lags in reporting time.
Hospitalizations dropped and ICU occupancy stabilized.
          2,000
          1,900
          1,800
          1,700
                            Confirmed COVID-19 Acute Inpatients (excluding ICU)
          1,600             Confirmed COVID-19 ICU Patients
          1,500
          1,400
          1,300
          1,200
          1,100
          1,000
           900
           800
           700
           600
           500
           400
           300
           200
           100
             0

                                                                                                                                                                                                          10
Data Sources: Daily Bed Census Summary COVID-19 Report + Critical Care Information System. Extracted via MOH SAS VA February 9, 2021. Does not include patients in alternative health facilities (AHFs)
The highly transmissible B.1.1.7 variant will soon
 dominate.
• Variants are likely between 5% and
  10% of cases now.
• To prevent an increase in total
  cases Re for B.1.1.7 needs to be
  below 0.7.
• Current Re is between 0.8 and 0.9,
  it has only approached 0.7 once.
• Public Health Measures appear to
  be effective against all variants.
• First cases of B.1.351 (detected in
  South Africa) and P.1 (detected in
  Brazil) detected in Ontario.
                                                                             11
                                                      Predictions: QueensU
To control growth with variants, we must push R to 0.7
                                                           Toronto Forecast OV R = 0.7
                      1800

                      1600

                      1400

                      1200
Daily Counted Cases

                                                                                                           Observed Cases
                      1000                                                                                 Old Variant (Estimated)
                                                                                                           New Variant (Estimated)
                      800                                                                                  Forecast OV R = 0.7
                      600                                                                                  OV Forecast (R = 0.7)
                                                                                                           NV Forecast (R = 0.98)
                      400

                      200

                        0
                       15-Dec-20   04-Jan-21   24-Jan-21   13-Feb-21   05-Mar-21   25-Mar-21   14-Apr-21           Predictions: DLSPH
                                                                                                                                        12
At R=0.9 (just above current) variant triggers exponential
                 growth
                                                           Toronto Forecast OV R = 0.9
                      1800

                      1600

                      1400

                      1200
Daily Counted Cases

                                                                                                           Observed Cases
                      1000                                                                                 Old Variant (Estimated)
                                                                                                           New Variant (Estimated)
                      800
                                                                                                           Forecast OV R = 0.9
                      600                                                                                  OV Forecast (R = 0.9)
                                                                                                           NV Forecast (R = 1.26)
                      400

                      200

                        0
                       15-Dec-20   04-Jan-21   24-Jan-21   13-Feb-21   05-Mar-21   25-Mar-21   14-Apr-21                               13
                                                                                                                  Predictions: DLSPH
If public health measures are lifted, cases could rise
dramatically depending on spread of B.1.1.7.
                                                                                                                                                                         Daily Cases
20,000

18,000

16,000

14,000

12,000

10,000

 8,000

 6,000

 4,000

 2,000

    -
         01-01
                 01-03
                         01-05
                                 01-07
                                         01-09
                                                 01-11
                                                         01-13
                                                                 01-15
                                                                         01-17
                                                                                 01-19
                                                                                         01-21
                                                                                                 01-23
                                                                                                         01-25
                                                                                                                 01-27
                                                                                                                         01-29
                                                                                                                                 01-31
                                                                                                                                         02-02
                                                                                                                                                 02-04
                                                                                                                                                         02-06
                                                                                                                                                                 02-08
                                                                                                                                                                         02-10
                                                                                                                                                                                 02-12
                                                                                                                                                                                         02-14
                                                                                                                                                                                                 02-16
                                                                                                                                                                                                         02-18
                                                                                                                                                                                                                 02-20
                                                                                                                                                                                                                         02-22
                                                                                                                                                                                                                                 02-24
                                                                                                                                                                                                                                         02-26
                                                                                                                                                                                                                                                 02-28
                                                                                                                                                                                                                                                         03-02
                                                                                                                                                                                                                                                                 03-04
                                                                                                                                                                                                                                                                         03-06
                                                                                                                                                                                                                                                                                 03-08
                                                                                                                                                                                                                                                                                         03-10
                                                                                                                                                                                                                                                                                                 03-12
                                                                                                                                                                                                                                                                                                         03-14
                                                                                                                                                                                                                                                                                                                 03-16
                                                                                                                                                                                                                                                                                                                         03-18
                                                                                                                                                                                                                                                                                                                                 03-20
                                                                                                                                                                                                                                                                                                                                         03-22
                                                                                                                                                                                                                                                                                                                                                 03-24
                                                                                                                                                                                                                                                                                                                                                         03-26
                                                                                                                                                                                                                                                                                                                                                                 03-28
                                                                                                                                                                                                                                                                                                                                                                         03-30
                                                                                         ON - Daily                              ON - 7-Day Mean                                   ON 5%↓                                Low                         Medium                               High

                                                                                                                                                                                                         Predictions informed by modeling from COVID-19 ModCollab, McMasterU, QueensU, YorkU;
                                                                                                                                                                                                                                                               recent decrease in new daily cases                                                                                14
                                                                                                                                                                                                                                                       Data (Observed Cases): covid-19.ontario.ca
The majority of ICU admissions arise outside of long-term
care homes.

                                                Analysis: COVID-19 ModCollab.   15
                                                                   Data: CCM+
ICU Occupancy will follow changes in case rates by two weeks.
Growth could start as early as the second week in March.
                                                                                                                                                                  ICU Occupancy
700

600

500

400

300

200

100

 0
      01-01
              01-03
                      01-05
                              01-07
                                      01-09
                                              01-11
                                                      01-13
                                                              01-15
                                                                      01-17
                                                                              01-19
                                                                                      01-21
                                                                                              01-23
                                                                                                      01-25
                                                                                                              01-27
                                                                                                                      01-29
                                                                                                                              01-31
                                                                                                                                      02-02
                                                                                                                                              02-04
                                                                                                                                                      02-06
                                                                                                                                                              02-08
                                                                                                                                                                      02-10
                                                                                                                                                                               02-12
                                                                                                                                                                                       02-14
                                                                                                                                                                                               02-16
                                                                                                                                                                                                       02-18
                                                                                                                                                                                                               02-20
                                                                                                                                                                                                                       02-22
                                                                                                                                                                                                                               02-24
                                                                                                                                                                                                                                       02-26
                                                                                                                                                                                                                                               02-28
                                                                                                                                                                                                                                                       03-02
                                                                                                                                                                                                                                                               03-04
                                                                                                                                                                                                                                                                       03-06
                                                                                                                                                                                                                                                                               03-08
                                                                                                                                                                                                                                                                                       03-10
                                                                                                                                                                                                                                                                                               03-12
                                                                                                                                                                                                                                                                                                       03-14
                                                                                                                                                                                                                                                                                                               03-16
                                                                                                                                                                                                                                                                                                                       03-18
                                                                                                                                                                                                                                                                                                                               03-20
                                                                                                                                                                                                                                                                                                                                       03-22
                                                                                                                                                                                                                                                                                                                                               03-24
                                                                                                                                                                                                                                                                                                                                                       03-26
                                                                                                                                                                                                                                                                                                                                                               03-28
                                                                                                                                                                                                                                                                                                                                                                       03-30
                                                                                              ON Observed                         ON Predicted                                Low                      High                    Medium                          Capacity Threshold

                                                                                                                                                                                                                                                                                                                   Predictions: COVID-19 ModCollab.                            16
                                                                                                                                                                                                                                                                                                               Data (Observed ICU Occupancy): CCSO
The impact of the Pandemic has been inequitable and
will continue to be inequitable

                                          Analysis: COVID Heterogeneity Research Group    17
                                                                             Data: ICES
Mental health medication dispensing has been stable
       Individuals dispensed benzodiazepines (per 1,000 population) [ICES data]

                                                                                  WHO pandemic
                                                                                   declaration

                                                                                                                                       Analysis: ODPRN       18
                                                                                  Data: ICES data is updated quarterly, with up to a 3 month reporting lag
Emergency department visits for mental health and
addictions care have declined
            30%
                             WHO pandemic
                                                                                                Mental Health-related ED visits            Substance Use-related ED visits
                              declaration
            20%

            10%
                                                                                                           6%

             0%
                                                                                                                                            -2%
  Percent

            -10%
                                                                                                                                                                               -15%

            -20%
                                                                                                                                                                               -17%

            -30%
                                        -38%

            -40%
                                        -43%

            -50%
              2020-02-23   2020-03-23     2020-04-23   2020-05-23   2020-06-23   2020-07-23   2020-08-23     2020-09-23      2020-10-23   2020-11-23       2020-12-23    2021-01-23

                                                                                                                                                                         Analysis: OH MHA Centre of Excellence     19
                                                                                                                                                       Data: Electronic Canadian Triage and Acuity Scale (eCTAS)
Overdose deaths have continued to climb
                                                                                                                                      WHO pandemic
                                                                                                                                       declaration

Notes:
Data provided by the office of the Chief Coroner of Ontario (OCC); Suspect drug-related deaths are identified based on preliminary information reported by the investigating
coroners to the office of the Chief Coroner of Ontario. It takes several months for these investigations to be completed and acute drug toxicity deaths to be confirmed; Opioid-
related deaths includes confirmed and probable, and are considered preliminary; Once investigations are complete, acute opioid toxicity is typically deemed to be at least one of                 Analysis: ODPRN    20
the substances directly contributing to about 65%-80% of suspected-drug related deaths (depending on the time period)                                                               Data: Chief Coroner of Ontario
Eating disorder visits and admissions have increased.
                                           Hospitalizations and emergency department visits* for eating disorders among children and adolescents (3
                                                                to 17 years) in Ontario by 4-week average, Jan 2017 to Sept 2020
                                                                     Emergency department visits                    Hospitalizations

                                     3.5

                                      3
 Crude rate per 100,000 population

                                     2.5

                                      2

                                     1.5

                                      1

                                     0.5

                                      0
                                           Apr-17
                                            Jan-17

                                           Mar-17

                                           Oct-17

                                           Apr-18
                                             Jul-17

                                           Oct-18
                                           Aug-17

                                            Jan-18

                                           Mar-18

                                           Apr-19

                                           Oct-19
                                           Jun-17

                                             Jul-18
                                           Aug-18

                                            Jan-19

                                           Mar-19

                                           Apr-20
                                           Jun-18

                                             Jul-19
                                           Aug-19

                                            Jan-20

                                           Mar-20
                                           May-17

                                           Jun-19

                                             Jul-20
                                           Aug-20
                                           Jun-20
                                           Feb-17

                                           Sep-17

                                           Dec-17

                                           May-18
                                           Nov-17

                                           Feb-18

                                           Sep-18

                                           Dec-18

                                           May-19
                                           Nov-18

                                           Feb-19

                                           Sep-19

                                           Dec-19

                                           May-20
                                           Nov-19

                                           Feb-20

                                           Sep-20
                                                                                               4-week average
                                                                                                                                              Analysis: OH MHA Centre of Excellence   21
                                                                                                                                                                        Data: ICES)
Key Findings

• Public health measures are paying off in declining mobility, cases, positivity,
  and hospitalizations.
• Focussing vaccination on long-term care homes is paying off with declining
  daily deaths.
• ICU occupancy is flat and the access to care deficit continues to grow.
• The B.1.1.7 Variant of Concern is spreading. Cases will likely grow again in
  late February with ICU admissions increasing afterwards.
• Aggressive vaccination and sticking with stay-at-home order will help avoid
  a third wave and a third lockdown.
• Some key mental health indicators are unchanged. However, important
  measures such as emergency department admissions, opioid deaths and
  care for eating disorders are worsening.

                                                                                    22
Contributors
• COVID Heterogeneity Research Group: Rafal Kustra, Huiting Ma, Siyi Wang, Gary Moloney, Kristy Yiu, Beate
  Sander, Jeff Kwong, Stefan Baral, Sharmistha Mishra
• COVID-19 Modeling Collaborative: Kali Barrett, Stephen Mac, David Naimark, Aysegul Erman, Yasin Khan,
  Raphael Ximenes, Sharmistha Mishra, Beate Sander
• DLSPH: Ashleigh Tuite, David Fisman
• Fields Institute: Kumar Murty
• QueensU: Troy Day
• McMasterU: Michael Li, Irena Papst, Ben Bolker, Jonathan Dushoff, David Earn
• YorkU: Jianhong Wu, Francesca Scarabel, Bushra Majeed
• MOHLTC: Michael Hillmer, Kamil Malenvov, Qing Huang, Jagadish Rangrej, Nam Bains, Jennifer Bridge
• OH: Erik Hellsten, Stephen Petersen, Anna Lambrinos, Chris Lau, Access to Care Team, Michelle Rossi, Paul
  Kurdyak (also DLSPH and CAMH)
• ODPRN: Tara Gomes
• PHO: Sarah Buchan, Kevin Brown

                                                                                                              23
Content provided by Modelling Consensus and Scientific
Advisory Table members and secretariat
Beate Sander,* Peter Juni, Brian Schwartz,* Kumar Murty,* Upton Allen, Vanessa Allen, Nicholas
Bodmer, Isaac Bogoch, Kevin Brown, Sarah Buchan, Yoojin Choi, Troy Day, David Earn, Gerald Evans,
David Fisman, Jennifer Gibson, Anna Greenberg, Anne Hayes, Michael Hillmer, Jessica Hopkins, Jeff
Kwong, Audrey Laporte, John Lavis, Gerald Lebovic, Brian Lewis, Linda Mah, Kamil Malikov, Antonina
Maltsev, Doug Manuel, Allison McGeer, David McKeown, John McLaughlin, Sharmistha Mishra,
Justin Morgenstern, Samira Mubareka, Laveena Munshi, Christopher Mushquash, Ayodele Odutayo,
Shahla Oskooei, Samir Patel, Bill Praamsma, Justin Presseau, Fahad Razak, Rob Reid, Paula Rochon,
Laura Rosella, Arjumand Siddiqi, Chris Simpson, Arthur Slutsky, Janet Smylie, Nathan Stall, Ashleigh
Tuite, Jennifer Walker, Tania Watts, Ashini Weerasinghe, Scott Weese, Xiaolin Wei, Jianhong Wu,
Diana Yan, Emre Yurga

* Chairs of Scientific Advisory or Modelling Consensus Tables

                                                                                                       24
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