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VOL. 187 | NO. 6 | September 15, 2011 | Pages 2839–3454
2839 IN THIS ISSUE
Brief Reviews
2841 The BTB-ZF Family of Transcription Factors: Key Regulators of Lineage Commitment and Effector
Function Development in the Immune System
Aimee M. Beaulieu and Derek B. Sant’Angelo
CUTTING EDGE
2849 Cutting Edge: Crohn’s Disease-Associated Nod2 Mutation Limits Production of Proinflammatory
Cytokines To Protect the Host from Enterococcus faecalis-Induced Lethality
~ez
Yun-Gi Kim, Michael H. Shaw, Neil Warner, Jong-Hwan Park, Felicia Chen, Yasunori Ogura, and Gabriel Nun
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
2853 Cytoplasmic Iga Serine/Threonines Fine-Tune Iga Tyrosine Phosphorylation and Limit Bone Marrow
Plasma Cell Formation
Heide Christine Patterson, Manfred Kraus, Donghai Wang, Aliakbar Shahsafaei, Joel M. Henderson, Jane Seagal,
Kevin L. Otipoby, To-Ha Thai, and Klaus Rajewsky
2859 Development of Memory-Like Autoregulatory CD8+ T Cells Is CD4+ T Cell Dependent
Afshin Shameli, Xavier Clemente-Casares, Jinguo Wang, and Pere Santamaria
2867 Long-Lived Plasma Cells from Human Small Intestine Biopsies Secrete Immunoglobulins for Many Weeks
In Vitro
Luka Mesin, Roberto Di Niro, Keith M. Thompson, Knut E. A. Lundin, and Ludvig M. Sollid
2875 Suppressor of Cytokine Signaling 2 Is a Feedback Inhibitor of TLR-Induced Activation in Human
Monocyte-Derived Dendritic Cells
Gernot Posselt, Harald Schwarz, Albert Duschl, and Jutta Horejs-Hoeck
On the cover: Immunofluorescent staining of splenic sections with anti-IgM (red) and MOMA-1 (green) revealed a profound
decrease of marginal zone B cells in mice genetically deficient for the actin-binding protein L-plastin. Original magnification
3200. Todd, E. M., L. E. Deady, and S. C. Morley. 2011. The actin-bundling protein L-plastin is essential for marginal
zone B cell development. J. Immunol. 187: 3015–3025.
The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists,
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Copyright Ó 2011 by The American Association of Immunologists, Inc.2885 Heterogeneous and Tissue-Specific Regulation of Effector T Cell Responses by IFN-g during Plasmodium
berghei ANKA Infection
Ana Villegas-Mendez, J. Brian de Souza, Linda Murungi, Julius C. R. Hafalla, Tovah N. Shaw, Rachel Greig,
Eleanor M. Riley, and Kevin N. Couper
2898 NKT Cells Are Required for Complete Freund’s Adjuvant-Mediated Protection from Autoimmune
Diabetes
I-Fang Lee, Peter van den Elzen, Rusung Tan, and John J. Priatel
2905 CD204 Suppresses Large Heat Shock Protein-Facilitated Priming of Tumor Antigen gp100-Specific
T Cells and Chaperone Vaccine Activity against Mouse Melanoma
Jie Qian, Huanfa Yi, Chunqing Guo, Xiaofei Yu, Daming Zuo, Xing Chen, John M. Kane, III, Elizabeth A. Repasky,
John R. Subjeck, and Xiang-Yang Wang
2915 Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally
Induced Model
Tom L. Van Belle, Enric Esplugues, Jeanette Liao, Therese Juntti, Richard A. Flavell, and Matthias G. von Herrath
2923 The Impact of Pre-Existing Memory on Differentiation of Newly Recruited Naive CD8 T Cells
Matthew D. Martin, Thomas C. Wirth, Peter Lauer, John T. Harty, and Vladimir P. Badovinac
2932 HIV-Mediated Phosphatidylinositol 3-Kinase/Serine–Threonine Kinase Activation in APCs Leads to
Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells
Karuppiah Muthumani, Devon J. Shedlock, Daniel K. Choo, Paolo Fagone, Omkar U. Kawalekar, Jonathan Goodman,
Chaoran B. Bian, Aarti A. Ramanathan, Parikh Atman, Pablo Tebas, Michael A. Chattergoon, Andrew Y. Choo,
and David B. Weiner
2944 IL-10 Restricts Activation-Induced Death of NK Cells during Acute Murine Cytomegalovirus Infection
Maria A. Stacey, Morgan Marsden, Eddie C. Y. Wang, Gavin W. G. Wilkinson, and Ian R. Humphreys
2953 TLR9 in Peritoneal B-1b Cells Is Essential for Production of Protective Self-Reactive IgM To Control Th17
Cells and Severe Autoimmunity
Alexander D. Stoehr, Carolin T. Schoen, Maria M. M. Mertes, Susanne Eiglmeier, Vivien Holecska, Alexandra K. Lorenz,
Tim Schommartz, Anna-Lena Schoen, Constanze Hess, Andr e Winkler, Hedda Wardemann, and Marc Ehlers
2966 Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells
Günther Baravalle, Hyesuk Park, Megan McSweeney, Mari Ohmura-Hoshino, Yohei Matsuki, Satoshi Ishido,
and Jeoung-Sook Shin
2974 Stem Cell Factor Consistently Improves Thymopoiesis after Experimental Transplantation of Murine or
Human Hematopoietic Stem Cells in Immunodeficient Mice
Evert-Jan Wils, Elwin J. C. Rombouts, Irene van Mourik, Hergen Spits, Nicolas Legrand, Eric Braakman,
and Jan J. Cornelissen
2982 Miz-1 Is Required To Coordinate the Expression of TCRb and p53 Effector Genes at the Pre-TCR
“b-Selection” Checkpoint
Ingrid Saba, Christian Kosan, Lothar Vassen, Ludger Klein-Hitpass, and Tarik Möröy
2993 Caveolin-1 Orchestrates TCR Synaptic Polarity, Signal Specificity, and Function in CD8 T Cells
Tamar Tomassian, Lisa A. Humphries, Scot D. Liu, Oscar Silva, David G. Brooks, and M. Carrie Miceli
3003 Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via
TGF-b1–Dependent and –Independent Mechanisms
Su Mi, Zhe Li, Hong-Zhen Yang, Hong Liu, Jia-Ping Wang, Yong-Gang Ma, Xiao-Xing Wang, Han-Zhi Liu, Wei Sun,
and Zhuo-Wei Hu
3015 The Actin-Bundling Protein L-Plastin Is Essential for Marginal Zone B Cell Development
Elizabeth M. Todd, Lauren E. Deady, and Sharon Celeste Morley3026 EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and
Nonlymphoid Tissues
~ P. Pereira, Tangsheng Yi, Ying Xu, and Jason G. Cyster
Lisa M. Kelly, Joao
3033 CpG and Non-CpG Oligodeoxynucleotides Directly Costimulate Mouse and Human CD4+ T Cells
through a TLR9- and MyD88-Independent Mechanism
Angela Landrigan, Michael T. Wong, and Paul J. Utz
3044 Mucosa-Associated Epithelial Chemokine/CCL28 Expression in the Uterus Attracts CCR10+ IgA Plasma
Cells following Mucosal Vaccination via Estrogen Control
Hye-Ran Cha, Hyun-Jeong Ko, Eun-Do Kim, Sun-Young Chang, Sang-Uk Seo, Nicolas Cuburu, Sangryeol Ryu,
Sunghoon Kim, and Mi-Na Kweon
3053 Myosin 1c Participates in B Cell Cytoskeleton Rearrangements, Is Recruited to the Immunologic Synapse,
and Contributes to Antigen Presentation
e L. Maravillas-Montero, Peter G. Gillespie, Genaro Patin~o-L
Jos opez, Stephen Shaw, and Leopoldo Santos-Argumedo
3064 Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease
Shuo-Wang Qiao, Melinda R
aki, Kristin S. Gunnarsen, Geir-Åge Løset, Knut E. A. Lundin, Inger Sandlie,
and Ludvig M. Sollid
3072 The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and
Phagolysosome Maturation
Katja Seider, Sascha Brunke, Lydia Schild, Nadja Jablonowski, Duncan Wilson, Olivia Majer, Dagmar Barz, Albert Haas,
Karl Kuchler, Martin Schaller, and Bernhard Hube
3087 TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell
Cross-Priming of T Cells
Mitsuhiro Iyori, Tong Zhang, Haddon Pantel, Bethany A. Gagne, and Charles L. Sentman
3096 Recognition and Killing of Human and Murine Pancreatic b Cells by the NK Receptor NKp46
Chamutal Gur, Jonatan Enk, Sameer A. Kassem, Yaron Suissa, Judith Magenheim, Miri Stolovich-Rain, Tomer Nir,
Hagit Achdout, Benjamin Glaser, James Shapiro, Yaakov Naparstek, Angel Porgador, Yuval Dor, and Ofer Mandelboim
3104 Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant gd T Cells in the Murine Epidermis
Stephanie Kadow, Bettina Jux, Sonja P. Zahner, Britta Wingerath, Stefanie Chmill, Björn E. Clausen, Jan Hengstler,
and Charlotte Esser
3111 Hierarchical IL-5 Expression Defines a Subpopulation of Highly Differentiated Human Th2 Cells
Bhaskar Upadhyaya, Yuzhi Yin, Brenna J. Hill, Daniel C. Douek, and Calman Prussin
3121 Functional Gap Junctions Accumulate at the Immunological Synapse and Contribute to T Cell Activation
Ariadna Mendoza-Naranjo, Gerben Bouma, Cristi an Pereda, Marcos Ramírez, Kevin F. Webb, Andr e s Tittarelli,
Mercedes N. L
opez, Alexis M. Kalergis, Adrian J. Thrasher, David L. Becker, and Flavio Salazar-Onfray
3133 Development and Function of Innate Polyclonal TCRab+ CD8+ Thymocytes
Moutih Rafei, Marie-Pierre Hardy, Patrick Williams, Juan Ruiz Vanegas, Kathy-Ann Forner, Ga€
el Dulude,
Nathalie Labrecque, Jacques Galipeau, and Claude Perreault
3145 Multiple CD4+ T Cell Subsets Produce Immunomodulatory IL-10 During Respiratory Syncytial Virus
Infection
Kayla A. Weiss, Allison F. Christiaansen, Ross B. Fulton, David K. Meyerholz, and Steven M. Varga
3155 T Cell-Derived Act1 Is Necessary for IL-25–Mediated Th2 Responses and Allergic Airway Inflammation
Shadi Swaidani, Katarzyna Bulek, Zizhen Kang, Muhammet Fatih Gulen, Caini Liu, Weiguo Yin, Amina Abbadi,
Mark Aronica, and Xiaoxia Li3165 Novel Highly Sensitive IL-10–b-Lactamase Reporter Mouse Reveals Cells of the Innate Immune System as
a Substantial Source of IL-10 In Vivo
Hicham Bouabe, Yunying Liu, Markus Moser, Michael R. Bösl, and Jürgen Heesemann
3177 Gai2 and ZAP-70 Mediate RasGRP1 Membrane Localization and Activation of SDF-1–Induced T Cell
Functions
Kimberly N. Kremer, Ashok Kumar, and Karen E. Hedin
3186 Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction
Wolfgang Kastenmuller, Georg Gasteiger, Naeha Subramanian, Tim Sparwasser, Dirk H. Busch, Yasmine Belkaid,
Ingo Drexler, and Ronald N. Germain
MOLECULAR AND STRUCTURAL IMMUNOLOGY
3198 Intra-Golgi Formation of IgM–Glycosaminoglycan Complexes Promotes Ig Deposition
Salar N. Khan, John V. Cox, Satoru K. Nishimoto, Ching Chen, Marvin J. Fritzler, Linda M. Hendershot, Martin Weigert,
and Marko Radic
3208 Structural Basis for FcgRIIa Recognition of Human IgG and Formation of Inflammatory Signaling
Complexes
Paul A. Ramsland, William Farrugia, Tessa M. Bradford, Caroline Tan Sardjono, Sandra Esparon, Halina M. Trist,
Maree S. Powell, Peck Szee Tan, Angela C. Cendron, Bruce D. Wines, Andrew M. Scott, and P. Mark Hogarth
3218 Nephrotic Syndrome and Subepithelial Deposits in a Mouse Model of Immune-Mediated Anti-Podocyte
Glomerulonephritis
Catherine Meyer-Schwesinger, Silke Dehde, Philipp Klug, Jan U. Becker, Sabrina Mathey, Kazem Arefi, Stefan Balabanov,
Simone Venz, Karl-Hans Endlich, Marcela Pekna, J. Engelbert Gessner, Friedrich Thaiss, and Tobias N. Meyer
3230 Activation of TLR2 Enhances Tight Junction Barrier in Epidermal Keratinocytes
Takuo Yuki, Hiroyuki Yoshida, Yumiko Akazawa, Aya Komiya, Yoshinori Sugiyama, and Shintaro Inoue
3238 Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the
Noncovalent CH3–CH3 Interaction Strength
Aran F. Labrijn, Theo Rispens, Joyce Meesters, Rebecca J. Rose, Tamara H. den Bleker, Stefan Loverix,
Ewald T. J. van den Bremer, Joost Neijssen, Tom Vink, Ignace Lasters, Rob C. Aalberse, Albert J. R. Heck,
Jan G. J. van de Winkel, Janine Schuurman, and Paul W. H. I. Parren
3247 Separation of Mutational and Transcriptional Enhancers in Ig Genes
Naga Rama Kothapalli, Kaitlin M. Collura, Darrell D. Norton, and Sebastian D. Fugmann
3256 Antioxidant c-FLIP Inhibits Fas Ligand-Induced NF-kB Activation in a Phosphatidylinositol
3-Kinase/Akt-Dependent Manner
Anand Krishnan V. Iyer, Neelam Azad, Siera Talbot, Christian Stehlik, Bin Lu, Liying Wang, and Yon Rojanasakul
3267 Recognition of Class I MHC by a Rat Ly49 NK Cell Receptor Is Dependent on the Identity of the P2 Anchor
Amino Acid of Bound Peptide
Brian J. Ma and Kevin P. Kane
3277 Differential Regulation of Proximal and Distal Vb Segments Upstream of a Functional VDJb1
Rearrangement upon b-Selection
Brenna L. Brady and Craig H. Bassing
IMMUNOGENETICS
3286 The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell
Proliferation
David M. Kofler, Christopher A. Severson, Narine Mousissian, Philip L. De Jager, and David A. Hafler
3292 Two-Step Binding of Transcription Factors Causes Sequential Chromatin Structural Changes at the
Activated IL-2 Promoter
Satoru Ishihara and Ronald H. SchwartzHOST DEFENSE
3300 Mutations in a Dominant Nef Epitope of Simian Immunodeficiency Virus Diminish TCR:Epitope Peptide
Affinity but not Epitope Peptide:MHC Class I Binding
Evan M. Cale, Heidi S. Bazick, Tony A. Rianprakaisang, S. Munir Alam, and Norman L. Letvin
3314 The Transport and Inactivation Kinetics of Bacterial Lipopolysaccharide Influence Its Immunological
Potency In Vivo
Mingfang Lu and Robert S. Munford
3321 B Cells and TCR Avidity Determine Distinct Functions of CD4+ T Cells in Retroviral Infection
Micka€
el J.-Y. Ploquin, Urszula Eksmond, and George Kassiotis
INFLAMMATION
3331 NLRP3/Caspase-1–Independent IL-1b Production Mediates Diesel Exhaust Particle-Induced Pulmonary
Inflammation
Sharen Provoost, Tania Maes, Nele S. Pauwels, Tom Vanden Berghe, Peter Vandenabeele, Bart N. Lambrecht, Guy F. Joos,
and Kurt G. Tournoy
3338 Autoreactive Memory CD4+ T Lymphocytes That Mediate Chronic Uveitis Reside in the Bone Marrow
through STAT3-Dependent Mechanisms
Hyun-Mee Oh, Cheng-Rong Yu, YongJun Lee, Chi-Chao Chan, Arvydas Maminishkis, and Charles E. Egwuagu
3347 Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced
Liver Injury
James W. Dear, Kenneth J. Simpson, Melianthe P. J. Nicolai, James H. Catterson, Jonathan Street, Tineke Huizinga,
Darren G. Craig, Kevin Dhaliwal, Sheila Webb, D. Nicholas Bateman, and David J. Webb
3353 Membrane-Associated CD93 Regulates Leukocyte Migration and C1q-Hemolytic Activity during Murine
Peritonitis
Mallary C. Greenlee-Wacker, Carlos Brisen~o, Manuel Galvan, Gabriela Moriel, Peter Vel
azquez, and Suzanne S. Bohlson
3362 MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-g Pathway, Th1
Polarization, and the Severity of Delayed-Type Hypersensitivity
Thomas X. Lu, Jochen Hartner, Eun-Jin Lim, Victoria Fabry, Melissa K. Mingler, Eric T. Cole, Stuart H. Orkin,
Bruce J. Aronow, and Marc E. Rothenberg
3374 MAPK Kinase 3 Specifically Regulates Fc«RI-Mediated IL-4 Production by Mast Cells
Adam J. MacNeil, Yong Jun Yang, and Tong-Jun Lin
CLINICAL IMMUNOLOGY
3383 Epidermal Growth Factor Receptor (EGFR) Antibody-Induced Antibody-Dependent Cellular Cytotoxicity
Plays a Prominent Role in Inhibiting Tumorigenesis, Even of Tumor Cells Insensitive to EGFR Signaling
Inhibition
Marije B. Overdijk, Sandra Verploegen, Jeroen H. van den Brakel, Jeroen J. Lammerts van Bueren, Tom Vink,
Jan G. J. van de Winkel, Paul W. H. I. Parren, and Wim K. Bleeker
3391 HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA
Are Undetectable
Stephen C. De Rosa, Evan P. Thomas, John Bui, Yunda Huang, Allan deCamp, Cecilia Morgan, Spyros A. Kalams,
Georgia D. Tomaras, Rama Akondy, Rafi Ahmed, Chuen-Yen Lau, Barney S. Graham, Gary J. Nabel, M. Juliana McElrath,
and the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
3402 IL-12p35 Subunit Contributes to Autoimmunity by Limiting IL-27–Driven Regulatory Responses
Rita Vasconcellos, Natalie A. Carter, Elizabeth C. Rosser, and Claudia Mauri
3413 Activated Protein C Attenuates Systemic Lupus Erythematosus and Lupus Nephritis in MRL-Fas(lpr) Mice
Julia Lichtnekert, Khader Valli Rupanagudi, Onkar P. Kulkarni, Murthy Narayana Darisipudi, Ramanjaneyulu Allam,
and Hans-Joachim Anders3422 Decreased AIRE Expression and Global Thymic Hypofunction in Down Syndrome
Flavia A. Lima, Carlos A. Moreira-Filho, Patrícia L. Ramos, Helena Brentani, Leandro de A. Lima, Magaly Arrais,
Luiz C. Bento-de-Souza, Luciana Bento-de-Souza, Maria I. Duarte, Antonio Coutinho, and Magda Carneiro-Sampaio
3431 Simvastatin Inhibits IFN Regulatory Factor 4 Expression and Th17 Cell Differentiation in CD4+ T Cells
Derived from Patients with Multiple Sclerosis
Xin Zhang, Yazhong Tao, Luigi Troiani, and Silva Markovic-Plese
3438 Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of
Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells
Paul V. Beum, Elizabeth M. Peek, Margaret A. Lindorfer, Frank J. Beurskens, Patrick J. Engelberts, Paul W. H. I. Parren,
Jan G. J. van de Winkel, and Ronald P. Taylor
LETTERS OF RETRACTION
3448 Retraction: Stimulation of FcgRI on Primary Sensory Neurons Increases Insulin-Like Growth Factor-I
Production, Thereby Reducing Reperfusion-Induced Renal Injury in Mice
Naoaki Harada, Juan Zhao, Hiroki Kurihara, Naomi Nakagata, and Kenji Okajima
CORRECTIONS
3449 Correction: Salmonella Synthesizing 1-Monophosphorylated Lipopolysaccharide Exhibits Low Endotoxic
Activity while Retaining Its Immunogenicity
Qingke Kong, David A. Six, Kenneth L. Roland, Qing Liu, Lillian Gu, C. Michael Reynolds, Xiaoyuan Wang,
Christian R. H. Raetz, and Roy Curtiss, III
3450 Correction: Slam Haplotypes Modulate the Response to Lipopolysaccharide In Vivo through Control of
NKT Cell Number and Function
Idil Aktan, Alan Chant, Zachary D. Borg, David E. Damby, Paige C. Leenstra, Graham W. G. Lilley, Joseph Petty,
Benjamin T. Suratt, Cory Teuscher, Edward K. Wakeland, Matthew E. Poynter, and Jonathan E. Boyson
3451 Correction: Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral
Myocarditis
Jing Yuan, Miao Yu, Qiong-Wen Lin, Ai-Lin Cao, Xian Yu, Ji-Hua Dong, Jin-Ping Wang, Jing-Hui Zhang, Min Wang,
He-Ping Guo, Xiang Cheng, and Yu-Hua Liao
3453 AUTHOR INDEXYou can also read
